Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HBL8_LEIBR

TriTrypDb:

LbrM.21.0250 , LBRM2903_210006900

Length:

724

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	10
GO:0042995	cell projection	2	10
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0110165	cellular anatomical entity	1	10
GO:0120025	plasma membrane bounded cell projection	3	10

Expansion

Sequence features

A4HBL8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBL8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	154	158	PF00656	0.679
CLV_C14_Caspase3-7	520	524	PF00656	0.706
CLV_NRD_NRD_1	207	209	PF00675	0.635
CLV_NRD_NRD_1	271	273	PF00675	0.448
CLV_NRD_NRD_1	280	282	PF00675	0.485
CLV_NRD_NRD_1	400	402	PF00675	0.522
CLV_NRD_NRD_1	455	457	PF00675	0.571
CLV_NRD_NRD_1	5	7	PF00675	0.576
CLV_NRD_NRD_1	596	598	PF00675	0.638
CLV_PCSK_KEX2_1	207	209	PF00082	0.635
CLV_PCSK_KEX2_1	271	273	PF00082	0.480
CLV_PCSK_KEX2_1	400	402	PF00082	0.522
CLV_PCSK_KEX2_1	5	7	PF00082	0.537
CLV_PCSK_KEX2_1	596	598	PF00082	0.663
CLV_PCSK_SKI1_1	164	168	PF00082	0.543
CLV_PCSK_SKI1_1	271	275	PF00082	0.476
CLV_PCSK_SKI1_1	511	515	PF00082	0.704
CLV_PCSK_SKI1_1	533	537	PF00082	0.646
CLV_PCSK_SKI1_1	575	579	PF00082	0.429
CLV_PCSK_SKI1_1	6	10	PF00082	0.277
CLV_PCSK_SKI1_1	95	99	PF00082	0.586
CLV_Separin_Metazoa	556	560	PF03568	0.401
DEG_APCC_DBOX_1	538	546	PF00400	0.405
DEG_ODPH_VHL_1	550	563	PF01847	0.467
DEG_SCF_FBW7_2	649	655	PF00400	0.539
DEG_SPOP_SBC_1	469	473	PF00917	0.303
DOC_CKS1_1	649	654	PF01111	0.534
DOC_CYCLIN_RxL_1	268	278	PF00134	0.552
DOC_CYCLIN_RxL_1	572	582	PF00134	0.523
DOC_CYCLIN_yCln2_LP_2	544	547	PF00134	0.558
DOC_MAPK_gen_1	207	214	PF00069	0.512
DOC_MAPK_gen_1	281	287	PF00069	0.343
DOC_MAPK_gen_1	400	410	PF00069	0.388
DOC_MAPK_gen_1	425	433	PF00069	0.484
DOC_MAPK_gen_1	5	11	PF00069	0.502
DOC_MAPK_gen_1	537	544	PF00069	0.436
DOC_MAPK_MEF2A_6	634	641	PF00069	0.471
DOC_MAPK_MEF2A_6	95	103	PF00069	0.562
DOC_PP1_RVXF_1	4	11	PF00149	0.552
DOC_PP2B_LxvP_1	274	277	PF13499	0.499
DOC_PP2B_LxvP_1	544	547	PF13499	0.558
DOC_PP4_FxxP_1	609	612	PF00568	0.405
DOC_USP7_MATH_1	136	140	PF00917	0.609
DOC_USP7_MATH_1	215	219	PF00917	0.700
DOC_USP7_MATH_1	338	342	PF00917	0.619
DOC_USP7_MATH_1	43	47	PF00917	0.510
DOC_USP7_MATH_1	535	539	PF00917	0.632
DOC_USP7_MATH_1	625	629	PF00917	0.562
DOC_WW_Pin1_4	126	131	PF00397	0.657
DOC_WW_Pin1_4	44	49	PF00397	0.465
DOC_WW_Pin1_4	521	526	PF00397	0.677
DOC_WW_Pin1_4	59	64	PF00397	0.558
DOC_WW_Pin1_4	620	625	PF00397	0.623
DOC_WW_Pin1_4	648	653	PF00397	0.533
DOC_WW_Pin1_4	72	77	PF00397	0.729
LIG_14-3-3_CanoR_1	207	214	PF00244	0.650
LIG_14-3-3_CanoR_1	252	257	PF00244	0.474
LIG_14-3-3_CanoR_1	281	286	PF00244	0.503
LIG_14-3-3_CanoR_1	394	398	PF00244	0.424
LIG_14-3-3_CanoR_1	432	437	PF00244	0.500
LIG_14-3-3_CanoR_1	456	462	PF00244	0.548
LIG_14-3-3_CanoR_1	511	521	PF00244	0.756
LIG_14-3-3_CanoR_1	559	564	PF00244	0.554
LIG_14-3-3_CanoR_1	575	585	PF00244	0.482
LIG_14-3-3_CanoR_1	689	697	PF00244	0.560
LIG_14-3-3_CanoR_1	84	89	PF00244	0.706
LIG_Actin_WH2_2	178	196	PF00022	0.453
LIG_Actin_WH2_2	364	380	PF00022	0.258
LIG_Actin_WH2_2	419	434	PF00022	0.499
LIG_Actin_WH2_2	632	647	PF00022	0.523
LIG_Actin_WH2_2	676	691	PF00022	0.533
LIG_AP_GAE_1	361	367	PF02883	0.523
LIG_BIR_II_1	1	5	PF00653	0.640
LIG_BIR_III_2	133	137	PF00653	0.455
LIG_BIR_III_4	616	620	PF00653	0.684
LIG_BRCT_BRCA1_1	395	399	PF00533	0.513
LIG_Clathr_ClatBox_1	124	128	PF01394	0.698
LIG_deltaCOP1_diTrp_1	675	684	PF00928	0.478
LIG_FHA_1	50	56	PF00498	0.527
LIG_FHA_1	558	564	PF00498	0.425
LIG_FHA_1	59	65	PF00498	0.559
LIG_FHA_1	621	627	PF00498	0.635
LIG_FHA_1	717	723	PF00498	0.574
LIG_FHA_2	348	354	PF00498	0.502
LIG_FHA_2	518	524	PF00498	0.716
LIG_GBD_Chelix_1	573	581	PF00786	0.558
LIG_Integrin_isoDGR_2	234	236	PF01839	0.512
LIG_Integrin_RGD_1	236	238	PF01839	0.758
LIG_IRF3_LxIS_1	684	691	PF10401	0.508
LIG_LIR_Apic_2	606	612	PF02991	0.432
LIG_LIR_Gen_1	246	256	PF02991	0.519
LIG_LIR_Gen_1	471	480	PF02991	0.436
LIG_LIR_Gen_1	494	503	PF02991	0.550
LIG_LIR_Gen_1	576	586	PF02991	0.483
LIG_LIR_Gen_1	651	660	PF02991	0.491
LIG_LIR_Gen_1	675	685	PF02991	0.476
LIG_LIR_Gen_1	703	713	PF02991	0.365
LIG_LIR_Nem_3	246	251	PF02991	0.503
LIG_LIR_Nem_3	361	367	PF02991	0.446
LIG_LIR_Nem_3	471	477	PF02991	0.451
LIG_LIR_Nem_3	494	498	PF02991	0.530
LIG_LIR_Nem_3	53	59	PF02991	0.457
LIG_LIR_Nem_3	651	656	PF02991	0.493
LIG_LIR_Nem_3	675	681	PF02991	0.455
LIG_LIR_Nem_3	703	708	PF02991	0.440
LIG_Pex14_2	342	346	PF04695	0.563
LIG_RPA_C_Fungi	317	329	PF08784	0.331
LIG_RPA_C_Fungi	389	401	PF08784	0.522
LIG_SH2_CRK	248	252	PF00017	0.527
LIG_SH2_CRK	474	478	PF00017	0.534
LIG_SH2_GRB2like	314	317	PF00017	0.541
LIG_SH2_NCK_1	140	144	PF00017	0.527
LIG_SH2_NCK_1	632	636	PF00017	0.274
LIG_SH2_SRC	381	384	PF00017	0.532
LIG_SH2_STAP1	314	318	PF00017	0.493
LIG_SH2_STAP1	632	636	PF00017	0.416
LIG_SH2_STAT5	140	143	PF00017	0.357
LIG_SH2_STAT5	173	176	PF00017	0.506
LIG_SH2_STAT5	373	376	PF00017	0.519
LIG_SH2_STAT5	404	407	PF00017	0.437
LIG_SH2_STAT5	476	479	PF00017	0.540
LIG_SH3_1	73	79	PF00018	0.531
LIG_SH3_3	163	169	PF00018	0.527
LIG_SH3_3	180	186	PF00018	0.520
LIG_SH3_3	73	79	PF00018	0.702
LIG_Sin3_3	365	372	PF02671	0.503
LIG_Sin3_3	705	712	PF02671	0.359
LIG_SUMO_SIM_anti_2	217	229	PF11976	0.519
LIG_SUMO_SIM_anti_2	505	510	PF11976	0.705
LIG_SUMO_SIM_anti_2	540	546	PF11976	0.398
LIG_SUMO_SIM_anti_2	703	710	PF11976	0.369
LIG_SUMO_SIM_par_1	218	229	PF11976	0.519
LIG_SUMO_SIM_par_1	252	258	PF11976	0.479
LIG_SUMO_SIM_par_1	272	278	PF11976	0.286
LIG_SUMO_SIM_par_1	365	370	PF11976	0.319
LIG_SUMO_SIM_par_1	99	104	PF11976	0.326
LIG_TRAF2_1	110	113	PF00917	0.630
MOD_CDK_SPxxK_3	44	51	PF00069	0.353
MOD_CK1_1	139	145	PF00069	0.544
MOD_CK1_1	218	224	PF00069	0.757
MOD_CK1_1	538	544	PF00069	0.484
MOD_CK1_1	576	582	PF00069	0.500
MOD_CK1_1	69	75	PF00069	0.691
MOD_CK1_1	78	84	PF00069	0.805
MOD_CK2_1	252	258	PF00069	0.452
MOD_CK2_1	446	452	PF00069	0.551
MOD_CK2_1	576	582	PF00069	0.435
MOD_GlcNHglycan	141	144	PF01048	0.551
MOD_GlcNHglycan	153	156	PF01048	0.622
MOD_GlcNHglycan	194	197	PF01048	0.454
MOD_GlcNHglycan	240	243	PF01048	0.432
MOD_GlcNHglycan	498	501	PF01048	0.489
MOD_GlcNHglycan	68	71	PF01048	0.653
MOD_GSK3_1	10	17	PF00069	0.476
MOD_GSK3_1	188	195	PF00069	0.467
MOD_GSK3_1	215	222	PF00069	0.673
MOD_GSK3_1	281	288	PF00069	0.593
MOD_GSK3_1	475	482	PF00069	0.468
MOD_GSK3_1	513	520	PF00069	0.690
MOD_GSK3_1	559	566	PF00069	0.555
MOD_GSK3_1	576	583	PF00069	0.457
MOD_GSK3_1	684	691	PF00069	0.546
MOD_GSK3_1	712	719	PF00069	0.537
MOD_N-GLC_1	35	40	PF02516	0.365
MOD_N-GLC_1	457	462	PF02516	0.536
MOD_N-GLC_1	511	516	PF02516	0.663
MOD_NEK2_1	1	6	PF00069	0.626
MOD_NEK2_1	10	15	PF00069	0.467
MOD_NEK2_1	243	248	PF00069	0.283
MOD_NEK2_1	285	290	PF00069	0.566
MOD_NEK2_1	367	372	PF00069	0.405
MOD_NEK2_1	41	46	PF00069	0.549
MOD_NEK2_1	431	436	PF00069	0.449
MOD_NEK2_1	513	518	PF00069	0.737
MOD_NEK2_1	573	578	PF00069	0.455
MOD_NEK2_1	58	63	PF00069	0.587
MOD_NEK2_1	684	689	PF00069	0.447
MOD_PIKK_1	207	213	PF00454	0.510
MOD_PIKK_1	285	291	PF00454	0.565
MOD_PIKK_1	514	520	PF00454	0.754
MOD_PK_1	457	463	PF00069	0.531
MOD_PK_1	559	565	PF00069	0.551
MOD_PKA_1	207	213	PF00069	0.510
MOD_PKA_1	281	287	PF00069	0.586
MOD_PKA_2	206	212	PF00069	0.765
MOD_PKA_2	354	360	PF00069	0.379
MOD_PKA_2	393	399	PF00069	0.510
MOD_PKA_2	431	437	PF00069	0.419
MOD_PKA_2	538	544	PF00069	0.644
MOD_PKA_2	688	694	PF00069	0.531
MOD_Plk_1	156	162	PF00069	0.526
MOD_Plk_1	338	344	PF00069	0.627
MOD_Plk_1	35	41	PF00069	0.360
MOD_Plk_1	457	463	PF00069	0.537
MOD_Plk_1	478	484	PF00069	0.524
MOD_Plk_1	605	611	PF00069	0.534
MOD_Plk_2-3	113	119	PF00069	0.595
MOD_Plk_4	14	20	PF00069	0.530
MOD_Plk_4	156	162	PF00069	0.428
MOD_Plk_4	178	184	PF00069	0.494
MOD_Plk_4	188	194	PF00069	0.560
MOD_Plk_4	220	226	PF00069	0.518
MOD_Plk_4	243	249	PF00069	0.533
MOD_Plk_4	314	320	PF00069	0.525
MOD_Plk_4	347	353	PF00069	0.505
MOD_Plk_4	354	360	PF00069	0.473
MOD_Plk_4	393	399	PF00069	0.455
MOD_Plk_4	457	463	PF00069	0.499
MOD_Plk_4	540	546	PF00069	0.420
MOD_Plk_4	580	586	PF00069	0.544
MOD_Plk_4	605	611	PF00069	0.651
MOD_Plk_4	701	707	PF00069	0.485
MOD_ProDKin_1	126	132	PF00069	0.662
MOD_ProDKin_1	44	50	PF00069	0.473
MOD_ProDKin_1	521	527	PF00069	0.669
MOD_ProDKin_1	59	65	PF00069	0.558
MOD_ProDKin_1	620	626	PF00069	0.608
MOD_ProDKin_1	648	654	PF00069	0.535
MOD_ProDKin_1	72	78	PF00069	0.732
MOD_SUMO_for_1	50	53	PF00179	0.566
MOD_SUMO_rev_2	66	75	PF00179	0.727
TRG_DiLeu_BaEn_1	258	263	PF01217	0.351
TRG_DiLeu_BaEn_1	54	59	PF01217	0.349
TRG_DiLeu_BaEn_1	540	545	PF01217	0.623
TRG_DiLeu_BaLyEn_6	269	274	PF01217	0.327
TRG_DiLeu_BaLyEn_6	363	368	PF01217	0.389
TRG_DiLeu_BaLyEn_6	549	554	PF01217	0.373
TRG_ENDOCYTIC_2	248	251	PF00928	0.478
TRG_ENDOCYTIC_2	295	298	PF00928	0.435
TRG_ENDOCYTIC_2	474	477	PF00928	0.495
TRG_ER_diArg_1	270	272	PF00400	0.311
TRG_ER_diArg_1	333	336	PF00400	0.643
TRG_ER_diArg_1	399	401	PF00400	0.484
TRG_ER_diArg_1	447	450	PF00400	0.581
TRG_ER_diArg_1	536	539	PF00400	0.655
TRG_NES_CRM1_1	178	190	PF08389	0.320
TRG_NES_CRM1_1	661	676	PF08389	0.506
TRG_Pf-PMV_PEXEL_1	271	275	PF00026	0.346
TRG_Pf-PMV_PEXEL_1	519	523	PF00026	0.679
TRG_Pf-PMV_PEXEL_1	567	571	PF00026	0.535
TRG_Pf-PMV_PEXEL_1	575	580	PF00026	0.518

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWM2	Leptomonas seymouri	56%	99%
A0A1X0NXC5	Trypanosomatidae	34%	97%
A0A3Q8IB10	Leishmania donovani	85%	100%
A4HZA6	Leishmania infantum	84%	100%
D0A1L2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9AUY6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4QCJ6	Leishmania major	85%	100%
V5BG13	Trypanosoma cruzi	30%	100%