Nucleolar protein 9

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Nucleolar protein 9

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HBL6_LEIBR

TriTrypDb:

LbrM.21.0230 , LBRM2903_210006700

Length:

769

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0030684	preribosome	3	1
GO:0030686	90S preribosome	4	1
GO:0030688	preribosome, small subunit precursor	4	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A4HBL6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBL6

Function

Biological processes
Term	Name	Level	Count
GO:0000054	ribosomal subunit export from nucleus	3	1
GO:0000056	ribosomal small subunit export from nucleus	4	1
GO:0000447	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	10	1
GO:0000469	cleavage involved in rRNA processing	7	1
GO:0000472	endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	10	1
GO:0000478	endonucleolytic cleavage involved in rRNA processing	8	1
GO:0000479	endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	9	1
GO:0000480	endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	10	1
GO:0000966	RNA 5'-end processing	7	1
GO:0000967	rRNA 5'-end processing	9	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006364	rRNA processing	8	1
GO:0006396	RNA processing	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006810	transport	3	1
GO:0006913	nucleocytoplasmic transport	5	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0016072	rRNA metabolic process	7	1
GO:0031503	protein-containing complex localization	2	1
GO:0033750	ribosome localization	3	1
GO:0034470	ncRNA processing	7	1
GO:0034471	ncRNA 5'-end processing	8	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034660	ncRNA metabolic process	6	1
GO:0036260	RNA capping	7	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0046907	intracellular transport	3	1
GO:0051168	nuclear export	6	1
GO:0051169	nuclear transport	4	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051640	organelle localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0051656	establishment of organelle localization	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:0090305	nucleic acid phosphodiester bond hydrolysis	5	1
GO:0090501	RNA phosphodiester bond hydrolysis	6	1
GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic	7	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0005488	binding	1	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	351	355	PF00656	0.670
CLV_C14_Caspase3-7	74	78	PF00656	0.488
CLV_NRD_NRD_1	29	31	PF00675	0.513
CLV_NRD_NRD_1	35	37	PF00675	0.536
CLV_NRD_NRD_1	420	422	PF00675	0.507
CLV_NRD_NRD_1	636	638	PF00675	0.392
CLV_NRD_NRD_1	744	746	PF00675	0.446
CLV_PCSK_KEX2_1	34	36	PF00082	0.528
CLV_PCSK_KEX2_1	420	422	PF00082	0.507
CLV_PCSK_KEX2_1	445	447	PF00082	0.452
CLV_PCSK_KEX2_1	628	630	PF00082	0.508
CLV_PCSK_KEX2_1	636	638	PF00082	0.348
CLV_PCSK_KEX2_1	744	746	PF00082	0.417
CLV_PCSK_KEX2_1	753	755	PF00082	0.413
CLV_PCSK_KEX2_1	9	11	PF00082	0.640
CLV_PCSK_PC1ET2_1	445	447	PF00082	0.452
CLV_PCSK_PC1ET2_1	628	630	PF00082	0.616
CLV_PCSK_PC1ET2_1	753	755	PF00082	0.340
CLV_PCSK_PC1ET2_1	9	11	PF00082	0.640
CLV_PCSK_PC7_1	30	36	PF00082	0.536
CLV_PCSK_SKI1_1	118	122	PF00082	0.390
CLV_PCSK_SKI1_1	309	313	PF00082	0.406
CLV_PCSK_SKI1_1	420	424	PF00082	0.424
CLV_PCSK_SKI1_1	426	430	PF00082	0.396
CLV_PCSK_SKI1_1	446	450	PF00082	0.183
CLV_PCSK_SKI1_1	527	531	PF00082	0.562
CLV_PCSK_SKI1_1	551	555	PF00082	0.398
CLV_PCSK_SKI1_1	667	671	PF00082	0.434
CLV_PCSK_SKI1_1	716	720	PF00082	0.586
CLV_PCSK_SKI1_1	750	754	PF00082	0.578
CLV_PCSK_SKI1_1	764	768	PF00082	0.572
CLV_PCSK_SKI1_1	85	89	PF00082	0.496
DEG_APCC_DBOX_1	572	580	PF00400	0.507
DOC_CDC14_PxL_1	430	438	PF14671	0.465
DOC_CKS1_1	453	458	PF01111	0.596
DOC_CYCLIN_RxL_1	760	769	PF00134	0.633
DOC_MAPK_DCC_7	504	512	PF00069	0.521
DOC_MAPK_gen_1	209	218	PF00069	0.382
DOC_MAPK_gen_1	570	579	PF00069	0.515
DOC_MAPK_gen_1	628	634	PF00069	0.495
DOC_MAPK_HePTP_8	206	218	PF00069	0.424
DOC_MAPK_MEF2A_6	118	125	PF00069	0.391
DOC_MAPK_MEF2A_6	209	218	PF00069	0.394
DOC_MAPK_MEF2A_6	375	384	PF00069	0.512
DOC_MAPK_MEF2A_6	420	429	PF00069	0.402
DOC_MAPK_MEF2A_6	504	512	PF00069	0.486
DOC_PP1_RVXF_1	229	236	PF00149	0.338
DOC_PP2B_LxvP_1	329	332	PF13499	0.442
DOC_PP2B_LxvP_1	407	410	PF13499	0.394
DOC_PP2B_LxvP_1	454	457	PF13499	0.559
DOC_PP4_FxxP_1	431	434	PF00568	0.509
DOC_USP7_MATH_1	135	139	PF00917	0.399
DOC_USP7_MATH_1	210	214	PF00917	0.414
DOC_USP7_MATH_1	274	278	PF00917	0.415
DOC_USP7_MATH_1	348	352	PF00917	0.608
DOC_USP7_MATH_1	376	380	PF00917	0.494
DOC_USP7_MATH_1	457	461	PF00917	0.605
DOC_USP7_MATH_1	472	476	PF00917	0.596
DOC_USP7_MATH_1	558	562	PF00917	0.426
DOC_USP7_MATH_1	690	694	PF00917	0.755
DOC_USP7_MATH_1	698	702	PF00917	0.755
DOC_USP7_MATH_2	11	17	PF00917	0.676
DOC_USP7_UBL2_3	731	735	PF12436	0.273
DOC_WW_Pin1_4	131	136	PF00397	0.395
DOC_WW_Pin1_4	24	29	PF00397	0.591
DOC_WW_Pin1_4	259	264	PF00397	0.484
DOC_WW_Pin1_4	434	439	PF00397	0.433
DOC_WW_Pin1_4	452	457	PF00397	0.549
DOC_WW_Pin1_4	503	508	PF00397	0.498
DOC_WW_Pin1_4	686	691	PF00397	0.760
DOC_WW_Pin1_4	716	721	PF00397	0.623
LIG_14-3-3_CanoR_1	209	215	PF00244	0.479
LIG_14-3-3_CanoR_1	22	28	PF00244	0.557
LIG_14-3-3_CanoR_1	285	293	PF00244	0.438
LIG_14-3-3_CanoR_1	636	646	PF00244	0.444
LIG_14-3-3_CterR_2	764	769	PF00244	0.654
LIG_Actin_RPEL_3	96	115	PF02755	0.419
LIG_Actin_WH2_2	199	214	PF00022	0.511
LIG_BRCT_BRCA1_1	733	737	PF00533	0.465
LIG_eIF4E_1	139	145	PF01652	0.486
LIG_eIF4E_1	306	312	PF01652	0.531
LIG_eIF4E_1	400	406	PF01652	0.399
LIG_FAT_LD_1	141	149	PF03623	0.447
LIG_FHA_1	245	251	PF00498	0.352
LIG_FHA_1	274	280	PF00498	0.511
LIG_FHA_1	333	339	PF00498	0.545
LIG_FHA_1	379	385	PF00498	0.538
LIG_FHA_1	396	402	PF00498	0.488
LIG_FHA_1	435	441	PF00498	0.411
LIG_FHA_1	475	481	PF00498	0.694
LIG_FHA_1	90	96	PF00498	0.344
LIG_FHA_2	156	162	PF00498	0.575
LIG_FHA_2	239	245	PF00498	0.469
LIG_FHA_2	289	295	PF00498	0.339
LIG_FHA_2	606	612	PF00498	0.696
LIG_FHA_2	704	710	PF00498	0.685
LIG_GBD_Chelix_1	316	324	PF00786	0.273
LIG_IRF3_LxIS_1	128	134	PF10401	0.488
LIG_LIR_Gen_1	119	128	PF02991	0.381
LIG_LIR_Gen_1	17	28	PF02991	0.619
LIG_LIR_Gen_1	327	336	PF02991	0.507
LIG_LIR_Gen_1	648	658	PF02991	0.486
LIG_LIR_Gen_1	746	752	PF02991	0.399
LIG_LIR_Gen_1	77	87	PF02991	0.401
LIG_LIR_Nem_3	119	125	PF02991	0.375
LIG_LIR_Nem_3	17	23	PF02991	0.622
LIG_LIR_Nem_3	327	331	PF02991	0.449
LIG_LIR_Nem_3	644	650	PF02991	0.451
LIG_LIR_Nem_3	746	751	PF02991	0.435
LIG_LIR_Nem_3	77	83	PF02991	0.399
LIG_LIR_Nem_3	90	96	PF02991	0.414
LIG_MYND_1	434	438	PF01753	0.529
LIG_NRBOX	140	146	PF00104	0.480
LIG_NRBOX	311	317	PF00104	0.382
LIG_NRBOX	82	88	PF00104	0.424
LIG_PCNA_yPIPBox_3	633	646	PF02747	0.489
LIG_PCNA_yPIPBox_3	753	766	PF02747	0.495
LIG_PTB_Apo_2	541	548	PF02174	0.531
LIG_PTB_Phospho_1	541	547	PF10480	0.281
LIG_Rb_pABgroove_1	425	433	PF01858	0.502
LIG_SH2_CRK	505	509	PF00017	0.516
LIG_SH2_NCK_1	505	509	PF00017	0.495
LIG_SH2_NCK_1	659	663	PF00017	0.509
LIG_SH2_PTP2	122	125	PF00017	0.404
LIG_SH2_PTP2	592	595	PF00017	0.487
LIG_SH2_STAP1	647	651	PF00017	0.444
LIG_SH2_STAP1	659	663	PF00017	0.426
LIG_SH2_STAT3	400	403	PF00017	0.408
LIG_SH2_STAT5	122	125	PF00017	0.404
LIG_SH2_STAT5	139	142	PF00017	0.403
LIG_SH2_STAT5	328	331	PF00017	0.369
LIG_SH2_STAT5	400	403	PF00017	0.430
LIG_SH2_STAT5	51	54	PF00017	0.432
LIG_SH2_STAT5	535	538	PF00017	0.436
LIG_SH2_STAT5	592	595	PF00017	0.401
LIG_SH2_STAT5	741	744	PF00017	0.501
LIG_SH2_STAT5	94	97	PF00017	0.491
LIG_SH3_3	226	232	PF00018	0.592
LIG_SH3_3	328	334	PF00018	0.407
LIG_SH3_3	419	425	PF00018	0.464
LIG_SH3_3	453	459	PF00018	0.565
LIG_SH3_CIN85_PxpxPR_1	232	237	PF14604	0.460
LIG_SUMO_SIM_anti_2	213	218	PF11976	0.417
LIG_SUMO_SIM_anti_2	574	581	PF11976	0.529
LIG_TRAF2_1	249	252	PF00917	0.535
LIG_TRAF2_1	476	479	PF00917	0.470
LIG_TYR_ITIM	120	125	PF00017	0.394
LIG_TYR_ITIM	503	508	PF00017	0.435
LIG_UBA3_1	311	319	PF00899	0.267
LIG_UBA3_1	83	88	PF00899	0.449
MOD_CDC14_SPxK_1	27	30	PF00782	0.372
MOD_CDK_SPxK_1	24	30	PF00069	0.367
MOD_CDK_SPxxK_3	24	31	PF00069	0.589
MOD_CK1_1	182	188	PF00069	0.420
MOD_CK1_1	24	30	PF00069	0.587
MOD_CK1_1	349	355	PF00069	0.694
MOD_CK1_1	359	365	PF00069	0.597
MOD_CK1_1	519	525	PF00069	0.409
MOD_CK1_1	601	607	PF00069	0.662
MOD_CK1_1	641	647	PF00069	0.498
MOD_CK1_1	686	692	PF00069	0.750
MOD_CK1_1	701	707	PF00069	0.456
MOD_CK2_1	155	161	PF00069	0.584
MOD_CK2_1	186	192	PF00069	0.516
MOD_CK2_1	238	244	PF00069	0.505
MOD_CK2_1	259	265	PF00069	0.552
MOD_CK2_1	288	294	PF00069	0.316
MOD_CK2_1	354	360	PF00069	0.676
MOD_CK2_1	472	478	PF00069	0.699
MOD_CK2_1	605	611	PF00069	0.664
MOD_Cter_Amidation	7	10	PF01082	0.704
MOD_GlcNHglycan	152	155	PF01048	0.480
MOD_GlcNHglycan	177	180	PF01048	0.511
MOD_GlcNHglycan	182	185	PF01048	0.413
MOD_GlcNHglycan	3	6	PF01048	0.693
MOD_GlcNHglycan	348	351	PF01048	0.587
MOD_GlcNHglycan	362	365	PF01048	0.626
MOD_GlcNHglycan	459	462	PF01048	0.569
MOD_GlcNHglycan	474	477	PF01048	0.680
MOD_GlcNHglycan	616	619	PF01048	0.692
MOD_GlcNHglycan	685	688	PF01048	0.740
MOD_GlcNHglycan	692	695	PF01048	0.755
MOD_GlcNHglycan	703	706	PF01048	0.679
MOD_GSK3_1	131	138	PF00069	0.381
MOD_GSK3_1	140	147	PF00069	0.354
MOD_GSK3_1	175	182	PF00069	0.498
MOD_GSK3_1	284	291	PF00069	0.516
MOD_GSK3_1	348	355	PF00069	0.648
MOD_GSK3_1	356	363	PF00069	0.691
MOD_GSK3_1	367	374	PF00069	0.478
MOD_GSK3_1	474	481	PF00069	0.671
MOD_GSK3_1	601	608	PF00069	0.580
MOD_GSK3_1	637	644	PF00069	0.514
MOD_GSK3_1	67	74	PF00069	0.504
MOD_GSK3_1	686	693	PF00069	0.695
MOD_GSK3_1	699	706	PF00069	0.621
MOD_N-GLC_1	97	102	PF02516	0.430
MOD_NEK2_1	144	149	PF00069	0.405
MOD_NEK2_1	155	160	PF00069	0.461
MOD_NEK2_1	186	191	PF00069	0.508
MOD_NEK2_1	324	329	PF00069	0.469
MOD_NEK2_1	598	603	PF00069	0.565
MOD_NEK2_1	638	643	PF00069	0.493
MOD_NEK2_1	670	675	PF00069	0.450
MOD_NEK2_2	89	94	PF00069	0.473
MOD_PIKK_1	146	152	PF00454	0.497
MOD_PIKK_1	680	686	PF00454	0.656
MOD_PKA_2	21	27	PF00069	0.551
MOD_PKA_2	284	290	PF00069	0.477
MOD_Plk_1	45	51	PF00069	0.460
MOD_Plk_1	89	95	PF00069	0.468
MOD_Plk_2-3	13	19	PF00069	0.668
MOD_Plk_2-3	288	294	PF00069	0.469
MOD_Plk_4	116	122	PF00069	0.385
MOD_Plk_4	140	146	PF00069	0.388
MOD_Plk_4	182	188	PF00069	0.423
MOD_Plk_4	274	280	PF00069	0.399
MOD_Plk_4	288	294	PF00069	0.421
MOD_Plk_4	324	330	PF00069	0.454
MOD_Plk_4	490	496	PF00069	0.494
MOD_Plk_4	559	565	PF00069	0.449
MOD_Plk_4	583	589	PF00069	0.391
MOD_Plk_4	641	647	PF00069	0.427
MOD_Plk_4	670	676	PF00069	0.478
MOD_Plk_4	71	77	PF00069	0.461
MOD_Plk_4	89	95	PF00069	0.427
MOD_ProDKin_1	131	137	PF00069	0.390
MOD_ProDKin_1	24	30	PF00069	0.593
MOD_ProDKin_1	259	265	PF00069	0.483
MOD_ProDKin_1	434	440	PF00069	0.428
MOD_ProDKin_1	452	458	PF00069	0.552
MOD_ProDKin_1	503	509	PF00069	0.496
MOD_ProDKin_1	686	692	PF00069	0.763
MOD_ProDKin_1	716	722	PF00069	0.615
MOD_SUMO_rev_2	621	630	PF00179	0.519
TRG_DiLeu_BaEn_1	383	388	PF01217	0.523
TRG_DiLeu_BaEn_1	82	87	PF01217	0.416
TRG_DiLeu_BaEn_2	547	553	PF01217	0.511
TRG_DiLeu_BaLyEn_6	307	312	PF01217	0.478
TRG_DiLeu_BaLyEn_6	757	762	PF01217	0.488
TRG_ENDOCYTIC_2	122	125	PF00928	0.385
TRG_ENDOCYTIC_2	328	331	PF00928	0.369
TRG_ENDOCYTIC_2	505	508	PF00928	0.431
TRG_ENDOCYTIC_2	535	538	PF00928	0.422
TRG_ENDOCYTIC_2	592	595	PF00928	0.487
TRG_ENDOCYTIC_2	650	653	PF00928	0.482
TRG_ENDOCYTIC_2	678	681	PF00928	0.427
TRG_ENDOCYTIC_2	730	733	PF00928	0.491
TRG_ER_diArg_1	297	300	PF00400	0.416
TRG_ER_diArg_1	34	36	PF00400	0.543
TRG_ER_diArg_1	419	421	PF00400	0.434
TRG_ER_diArg_1	635	637	PF00400	0.394
TRG_Pf-PMV_PEXEL_1	221	225	PF00026	0.490
TRG_Pf-PMV_PEXEL_1	248	252	PF00026	0.541
TRG_Pf-PMV_PEXEL_1	57	61	PF00026	0.470
TRG_Pf-PMV_PEXEL_1	764	769	PF00026	0.654

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4K4	Leptomonas seymouri	69%	97%
A0A0S4J166	Bodo saltans	34%	100%
A0A1X0NXL8	Trypanosomatidae	41%	97%
A0A3S5IR95	Trypanosoma rangeli	40%	100%
A0A3S7WW94	Leishmania donovani	83%	100%
A4HZA4	Leishmania infantum	83%	100%
D0A1L0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9AUY4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4QCJ8	Leishmania major	82%	99%
V5B0J8	Trypanosoma cruzi	44%	100%