Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HBL5_LEIBR

TriTrypDb:

LbrM.21.0220 , LBRM2903_210006600

Length:

720

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	10
GO:0042995	cell projection	2	10
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0110165	cellular anatomical entity	1	10
GO:0120025	plasma membrane bounded cell projection	3	10
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

A4HBL5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBL5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	275	279	PF00656	0.533
CLV_C14_Caspase3-7	459	463	PF00656	0.641
CLV_NRD_NRD_1	138	140	PF00675	0.597
CLV_NRD_NRD_1	172	174	PF00675	0.600
CLV_NRD_NRD_1	494	496	PF00675	0.545
CLV_NRD_NRD_1	700	702	PF00675	0.561
CLV_NRD_NRD_1	711	713	PF00675	0.431
CLV_PCSK_KEX2_1	138	140	PF00082	0.610
CLV_PCSK_KEX2_1	172	174	PF00082	0.600
CLV_PCSK_KEX2_1	494	496	PF00082	0.545
CLV_PCSK_KEX2_1	700	702	PF00082	0.584
CLV_PCSK_KEX2_1	713	715	PF00082	0.494
CLV_PCSK_PC1ET2_1	713	715	PF00082	0.350
CLV_PCSK_PC7_1	709	715	PF00082	0.332
CLV_PCSK_SKI1_1	198	202	PF00082	0.530
CLV_PCSK_SKI1_1	274	278	PF00082	0.288
CLV_PCSK_SKI1_1	332	336	PF00082	0.491
CLV_Separin_Metazoa	673	677	PF03568	0.289
CLV_Separin_Metazoa	697	701	PF03568	0.341
DEG_APCC_DBOX_1	197	205	PF00400	0.288
DEG_APCC_DBOX_1	273	281	PF00400	0.286
DEG_SCF_FBW7_1	585	592	PF00400	0.545
DEG_SPOP_SBC_1	448	452	PF00917	0.509
DOC_CDC14_PxL_1	572	580	PF14671	0.554
DOC_CKS1_1	586	591	PF01111	0.553
DOC_CKS1_1	77	82	PF01111	0.548
DOC_CYCLIN_RxL_1	532	541	PF00134	0.497
DOC_MAPK_gen_1	709	718	PF00069	0.507
DOC_MAPK_MEF2A_6	712	720	PF00069	0.501
DOC_USP7_MATH_1	141	145	PF00917	0.659
DOC_USP7_MATH_1	4	8	PF00917	0.595
DOC_USP7_MATH_1	448	452	PF00917	0.720
DOC_USP7_MATH_1	636	640	PF00917	0.538
DOC_USP7_MATH_1	647	651	PF00917	0.467
DOC_WW_Pin1_4	19	24	PF00397	0.650
DOC_WW_Pin1_4	204	209	PF00397	0.522
DOC_WW_Pin1_4	40	45	PF00397	0.728
DOC_WW_Pin1_4	585	590	PF00397	0.516
DOC_WW_Pin1_4	76	81	PF00397	0.607
DOC_WW_Pin1_4	90	95	PF00397	0.563
LIG_14-3-3_CanoR_1	216	222	PF00244	0.473
LIG_14-3-3_CanoR_1	253	257	PF00244	0.526
LIG_14-3-3_CanoR_1	328	336	PF00244	0.482
LIG_14-3-3_CanoR_1	35	40	PF00244	0.625
LIG_14-3-3_CanoR_1	410	418	PF00244	0.415
LIG_14-3-3_CanoR_1	53	59	PF00244	0.431
LIG_14-3-3_CanoR_1	664	671	PF00244	0.470
LIG_14-3-3_CanoR_1	676	682	PF00244	0.257
LIG_Actin_WH2_2	642	658	PF00022	0.480
LIG_Actin_WH2_2	671	687	PF00022	0.344
LIG_BRCT_BRCA1_1	466	470	PF00533	0.490
LIG_BRCT_BRCA1_1	552	556	PF00533	0.306
LIG_EH1_1	123	131	PF00400	0.587
LIG_FAT_LD_1	671	679	PF03623	0.541
LIG_FHA_1	106	112	PF00498	0.383
LIG_FHA_1	19	25	PF00498	0.537
LIG_FHA_1	375	381	PF00498	0.451
LIG_FHA_1	464	470	PF00498	0.709
LIG_FHA_1	505	511	PF00498	0.513
LIG_FHA_1	512	518	PF00498	0.450
LIG_FHA_1	586	592	PF00498	0.485
LIG_FHA_1	611	617	PF00498	0.419
LIG_FHA_1	627	633	PF00498	0.473
LIG_FHA_1	694	700	PF00498	0.554
LIG_FHA_1	90	96	PF00498	0.520
LIG_FHA_2	227	233	PF00498	0.398
LIG_FHA_2	4	10	PF00498	0.628
LIG_FHA_2	402	408	PF00498	0.520
LIG_FHA_2	486	492	PF00498	0.574
LIG_GBD_Chelix_1	54	62	PF00786	0.594
LIG_LIR_Apic_2	440	446	PF02991	0.613
LIG_LIR_Apic_2	583	589	PF02991	0.297
LIG_LIR_Gen_1	144	151	PF02991	0.548
LIG_LIR_Gen_1	193	204	PF02991	0.378
LIG_LIR_Gen_1	255	264	PF02991	0.282
LIG_LIR_Gen_1	427	436	PF02991	0.450
LIG_LIR_Gen_1	595	606	PF02991	0.233
LIG_LIR_Gen_1	639	649	PF02991	0.456
LIG_LIR_LC3C_4	101	106	PF02991	0.560
LIG_LIR_Nem_3	144	149	PF02991	0.558
LIG_LIR_Nem_3	193	199	PF02991	0.386
LIG_LIR_Nem_3	255	259	PF02991	0.264
LIG_LIR_Nem_3	427	431	PF02991	0.459
LIG_LIR_Nem_3	595	601	PF02991	0.444
LIG_LIR_Nem_3	639	645	PF02991	0.427
LIG_NRBOX	28	34	PF00104	0.357
LIG_NRBOX	626	632	PF00104	0.529
LIG_NRBOX	670	676	PF00104	0.499
LIG_PCNA_yPIPBox_3	5	16	PF02747	0.664
LIG_PDZ_Class_2	715	720	PF00595	0.459
LIG_Pex14_1	378	382	PF04695	0.271
LIG_PTB_Apo_2	566	573	PF02174	0.418
LIG_SH2_NCK_1	472	476	PF00017	0.648
LIG_SH2_SRC	472	475	PF00017	0.671
LIG_SH2_STAP1	396	400	PF00017	0.403
LIG_SH2_STAT5	256	259	PF00017	0.260
LIG_SH3_3	339	345	PF00018	0.283
LIG_SH3_3	481	487	PF00018	0.706
LIG_SH3_3	510	516	PF00018	0.718
LIG_SH3_3	62	68	PF00018	0.401
LIG_SH3_3	72	78	PF00018	0.583
LIG_SUMO_SIM_anti_2	100	108	PF11976	0.530
LIG_SUMO_SIM_anti_2	227	232	PF11976	0.523
LIG_SUMO_SIM_anti_2	297	304	PF11976	0.284
LIG_SUMO_SIM_anti_2	666	673	PF11976	0.535
LIG_SUMO_SIM_par_1	160	166	PF11976	0.515
LIG_SUMO_SIM_par_1	229	234	PF11976	0.535
LIG_SUMO_SIM_par_1	535	541	PF11976	0.495
LIG_SUMO_SIM_par_1	592	597	PF11976	0.444
LIG_SUMO_SIM_par_1	628	633	PF11976	0.523
LIG_SUMO_SIM_par_1	677	683	PF11976	0.535
LIG_TRAF2_1	45	48	PF00917	0.431
LIG_TRAF2_1	560	563	PF00917	0.513
MOD_CK1_1	117	123	PF00069	0.457
MOD_CK1_1	144	150	PF00069	0.555
MOD_CK1_1	153	159	PF00069	0.603
MOD_CK1_1	160	166	PF00069	0.616
MOD_CK1_1	185	191	PF00069	0.427
MOD_CK1_1	210	216	PF00069	0.452
MOD_CK1_1	220	226	PF00069	0.527
MOD_CK1_1	43	49	PF00069	0.695
MOD_CK1_1	450	456	PF00069	0.699
MOD_CK1_1	529	535	PF00069	0.443
MOD_CK1_1	60	66	PF00069	0.603
MOD_CK1_1	650	656	PF00069	0.524
MOD_CK1_1	98	104	PF00069	0.497
MOD_CK2_1	3	9	PF00069	0.493
MOD_CK2_1	452	458	PF00069	0.762
MOD_CK2_1	485	491	PF00069	0.582
MOD_CK2_1	557	563	PF00069	0.395
MOD_CK2_1	60	66	PF00069	0.644
MOD_CK2_1	94	100	PF00069	0.457
MOD_GlcNHglycan	119	123	PF01048	0.583
MOD_GlcNHglycan	155	159	PF01048	0.683
MOD_GlcNHglycan	184	187	PF01048	0.520
MOD_GlcNHglycan	28	32	PF01048	0.556
MOD_GlcNHglycan	324	327	PF01048	0.494
MOD_GlcNHglycan	454	457	PF01048	0.723
MOD_GlcNHglycan	465	469	PF01048	0.529
MOD_GlcNHglycan	62	65	PF01048	0.642
MOD_GlcNHglycan	632	635	PF01048	0.501
MOD_GSK3_1	110	117	PF00069	0.371
MOD_GSK3_1	141	148	PF00069	0.551
MOD_GSK3_1	150	157	PF00069	0.552
MOD_GSK3_1	19	26	PF00069	0.624
MOD_GSK3_1	190	197	PF00069	0.445
MOD_GSK3_1	220	227	PF00069	0.465
MOD_GSK3_1	318	325	PF00069	0.496
MOD_GSK3_1	370	377	PF00069	0.375
MOD_GSK3_1	447	454	PF00069	0.688
MOD_GSK3_1	476	483	PF00069	0.522
MOD_GSK3_1	550	557	PF00069	0.347
MOD_GSK3_1	585	592	PF00069	0.487
MOD_GSK3_1	626	633	PF00069	0.445
MOD_GSK3_1	647	654	PF00069	0.560
MOD_GSK3_1	679	686	PF00069	0.511
MOD_GSK3_1	90	97	PF00069	0.433
MOD_N-GLC_1	322	327	PF02516	0.370
MOD_N-GLC_1	589	594	PF02516	0.233
MOD_NEK2_1	118	123	PF00069	0.625
MOD_NEK2_1	162	167	PF00069	0.747
MOD_NEK2_1	190	195	PF00069	0.413
MOD_NEK2_1	231	236	PF00069	0.421
MOD_NEK2_1	242	247	PF00069	0.429
MOD_NEK2_1	257	262	PF00069	0.300
MOD_NEK2_1	318	323	PF00069	0.423
MOD_NEK2_1	406	411	PF00069	0.385
MOD_NEK2_1	449	454	PF00069	0.721
MOD_NEK2_1	571	576	PF00069	0.485
MOD_NEK2_1	594	599	PF00069	0.344
MOD_NEK2_1	604	609	PF00069	0.344
MOD_NEK2_1	630	635	PF00069	0.379
MOD_NEK2_1	73	78	PF00069	0.478
MOD_NEK2_1	89	94	PF00069	0.450
MOD_NEK2_2	327	332	PF00069	0.419
MOD_NMyristoyl	1	7	PF02799	0.456
MOD_PIKK_1	259	265	PF00454	0.506
MOD_PIKK_1	43	49	PF00454	0.576
MOD_PIKK_1	529	535	PF00454	0.469
MOD_PIKK_1	647	653	PF00454	0.558
MOD_PKA_2	153	159	PF00069	0.656
MOD_PKA_2	252	258	PF00069	0.499
MOD_PKA_2	327	333	PF00069	0.557
MOD_PKA_2	34	40	PF00069	0.545
MOD_PKA_2	411	417	PF00069	0.414
MOD_PKA_2	463	469	PF00069	0.711
MOD_PKA_2	663	669	PF00069	0.578
MOD_PKB_1	152	160	PF00069	0.677
MOD_Plk_1	179	185	PF00069	0.350
MOD_Plk_1	27	33	PF00069	0.481
MOD_Plk_1	511	517	PF00069	0.736
MOD_Plk_1	589	595	PF00069	0.447
MOD_Plk_4	157	163	PF00069	0.708
MOD_Plk_4	179	185	PF00069	0.436
MOD_Plk_4	226	232	PF00069	0.502
MOD_Plk_4	252	258	PF00069	0.352
MOD_Plk_4	374	380	PF00069	0.445
MOD_Plk_4	57	63	PF00069	0.599
MOD_Plk_4	589	595	PF00069	0.487
MOD_Plk_4	604	610	PF00069	0.344
MOD_Plk_4	626	632	PF00069	0.529
MOD_Plk_4	82	88	PF00069	0.546
MOD_ProDKin_1	19	25	PF00069	0.639
MOD_ProDKin_1	204	210	PF00069	0.524
MOD_ProDKin_1	40	46	PF00069	0.716
MOD_ProDKin_1	585	591	PF00069	0.508
MOD_ProDKin_1	76	82	PF00069	0.604
MOD_ProDKin_1	90	96	PF00069	0.557
MOD_SUMO_for_1	312	315	PF00179	0.391
TRG_DiLeu_BaEn_1	100	105	PF01217	0.570
TRG_DiLeu_BaEn_1	125	130	PF01217	0.530
TRG_DiLeu_BaEn_1	298	303	PF01217	0.285
TRG_DiLeu_BaLyEn_6	268	273	PF01217	0.386
TRG_DiLeu_BaLyEn_6	314	319	PF01217	0.613
TRG_DiLeu_BaLyEn_6	91	96	PF01217	0.504
TRG_ENDOCYTIC_2	256	259	PF00928	0.260
TRG_ER_diArg_1	151	154	PF00400	0.425
TRG_ER_diArg_1	211	214	PF00400	0.521
TRG_ER_diArg_1	345	348	PF00400	0.506
TRG_ER_diArg_1	410	413	PF00400	0.441
TRG_ER_diArg_1	501	504	PF00400	0.632
TRG_ER_diArg_1	699	701	PF00400	0.588
TRG_ER_diArg_1	711	714	PF00400	0.480
TRG_NLS_Bipartite_1	700	716	PF00514	0.328
TRG_NLS_MonoExtN_4	709	716	PF00514	0.327
TRG_Pf-PMV_PEXEL_1	271	275	PF00026	0.392
TRG_Pf-PMV_PEXEL_1	423	427	PF00026	0.448
TRG_Pf-PMV_PEXEL_1	700	704	PF00026	0.556

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4I3	Leptomonas seymouri	47%	93%
A0A1X0NYX0	Trypanosomatidae	30%	100%
A0A3S7WWC7	Leishmania donovani	81%	96%
A4HZA3	Leishmania infantum	81%	96%
D0A1K9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9AUY3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	97%
Q4QCJ9	Leishmania major	81%	100%
V5BQ33	Trypanosoma cruzi	30%	94%