Clathrin heavy chain

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HBL3_LEIBR

TriTrypDb:

LbrM.21.0200 , LBRM2903_210006400

Length:

569

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HBL3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBL3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	548	552	PF00656	0.473
CLV_NRD_NRD_1	342	344	PF00675	0.482
CLV_NRD_NRD_1	494	496	PF00675	0.399
CLV_NRD_NRD_1	499	501	PF00675	0.387
CLV_NRD_NRD_1	542	544	PF00675	0.414
CLV_NRD_NRD_1	561	563	PF00675	0.675
CLV_NRD_NRD_1	84	86	PF00675	0.399
CLV_PCSK_FUR_1	82	86	PF00082	0.470
CLV_PCSK_KEX2_1	176	178	PF00082	0.501
CLV_PCSK_KEX2_1	494	496	PF00082	0.364
CLV_PCSK_KEX2_1	499	501	PF00082	0.373
CLV_PCSK_KEX2_1	542	544	PF00082	0.414
CLV_PCSK_KEX2_1	561	563	PF00082	0.675
CLV_PCSK_KEX2_1	84	86	PF00082	0.397
CLV_PCSK_PC1ET2_1	176	178	PF00082	0.519
CLV_PCSK_PC7_1	495	501	PF00082	0.391
CLV_PCSK_SKI1_1	108	112	PF00082	0.383
CLV_PCSK_SKI1_1	138	142	PF00082	0.375
CLV_PCSK_SKI1_1	148	152	PF00082	0.327
CLV_PCSK_SKI1_1	24	28	PF00082	0.410
CLV_PCSK_SKI1_1	298	302	PF00082	0.452
CLV_PCSK_SKI1_1	33	37	PF00082	0.277
CLV_PCSK_SKI1_1	388	392	PF00082	0.341
CLV_Separin_Metazoa	5	9	PF03568	0.382
DEG_APCC_DBOX_1	32	40	PF00400	0.347
DEG_APCC_DBOX_1	542	550	PF00400	0.454
DEG_Nend_UBRbox_2	1	3	PF02207	0.370
DEG_ODPH_VHL_1	10	22	PF01847	0.329
DEG_SCF_FBW7_1	290	297	PF00400	0.455
DEG_SPOP_SBC_1	12	16	PF00917	0.483
DEG_SPOP_SBC_1	256	260	PF00917	0.395
DOC_CKS1_1	291	296	PF01111	0.462
DOC_CKS1_1	330	335	PF01111	0.432
DOC_CYCLIN_RxL_1	295	304	PF00134	0.529
DOC_CYCLIN_RxL_1	81	91	PF00134	0.356
DOC_MAPK_gen_1	176	182	PF00069	0.479
DOC_MAPK_gen_1	27	36	PF00069	0.542
DOC_MAPK_gen_1	542	549	PF00069	0.460
DOC_PP1_RVXF_1	136	142	PF00149	0.371
DOC_PP1_RVXF_1	146	152	PF00149	0.354
DOC_PP1_RVXF_1	188	195	PF00149	0.470
DOC_PP1_RVXF_1	296	303	PF00149	0.400
DOC_PP1_RVXF_1	376	383	PF00149	0.426
DOC_PP1_RVXF_1	82	89	PF00149	0.390
DOC_PP4_FxxP_1	270	273	PF00568	0.527
DOC_USP7_MATH_1	12	16	PF00917	0.471
DOC_USP7_MATH_1	294	298	PF00917	0.425
DOC_USP7_MATH_1	68	72	PF00917	0.418
DOC_WW_Pin1_4	113	118	PF00397	0.431
DOC_WW_Pin1_4	269	274	PF00397	0.597
DOC_WW_Pin1_4	290	295	PF00397	0.441
DOC_WW_Pin1_4	329	334	PF00397	0.419
DOC_WW_Pin1_4	394	399	PF00397	0.337
DOC_WW_Pin1_4	448	453	PF00397	0.384
DOC_WW_Pin1_4	507	512	PF00397	0.453
LIG_14-3-3_CanoR_1	167	171	PF00244	0.559
LIG_14-3-3_CanoR_1	219	225	PF00244	0.438
LIG_14-3-3_CanoR_1	322	327	PF00244	0.456
LIG_14-3-3_CanoR_1	421	425	PF00244	0.265
LIG_14-3-3_CanoR_1	542	547	PF00244	0.505
LIG_BRCT_BRCA1_1	106	110	PF00533	0.346
LIG_deltaCOP1_diTrp_1	363	369	PF00928	0.377
LIG_deltaCOP1_diTrp_1	381	387	PF00928	0.375
LIG_deltaCOP1_diTrp_1	435	443	PF00928	0.486
LIG_deltaCOP1_diTrp_1	75	83	PF00928	0.305
LIG_EVH1_2	220	224	PF00568	0.489
LIG_FHA_1	122	128	PF00498	0.383
LIG_FHA_1	14	20	PF00498	0.554
LIG_FHA_1	145	151	PF00498	0.315
LIG_FHA_1	152	158	PF00498	0.295
LIG_FHA_1	233	239	PF00498	0.413
LIG_FHA_1	258	264	PF00498	0.410
LIG_FHA_1	291	297	PF00498	0.542
LIG_FHA_1	40	46	PF00498	0.487
LIG_FHA_1	460	466	PF00498	0.331
LIG_FHA_2	381	387	PF00498	0.491
LIG_FHA_2	412	418	PF00498	0.490
LIG_FHA_2	468	474	PF00498	0.559
LIG_FHA_2	523	529	PF00498	0.488
LIG_FHA_2	533	539	PF00498	0.442
LIG_LIR_Apic_2	486	491	PF02991	0.376
LIG_LIR_Apic_2	505	511	PF02991	0.380
LIG_LIR_Gen_1	325	334	PF02991	0.561
LIG_LIR_Gen_1	423	432	PF02991	0.246
LIG_LIR_Gen_1	75	83	PF02991	0.315
LIG_LIR_Gen_1	97	106	PF02991	0.326
LIG_LIR_Nem_3	325	330	PF02991	0.575
LIG_LIR_Nem_3	366	372	PF02991	0.338
LIG_LIR_Nem_3	386	390	PF02991	0.334
LIG_LIR_Nem_3	423	427	PF02991	0.262
LIG_LIR_Nem_3	435	440	PF02991	0.421
LIG_LIR_Nem_3	75	80	PF02991	0.296
LIG_LIR_Nem_3	97	102	PF02991	0.367
LIG_PCNA_PIPBox_1	225	234	PF02747	0.337
LIG_PCNA_yPIPBox_3	322	330	PF02747	0.558
LIG_Pex14_2	170	174	PF04695	0.485
LIG_REV1ctd_RIR_1	299	309	PF16727	0.456
LIG_SH2_CRK	146	150	PF00017	0.348
LIG_SH2_CRK	508	512	PF00017	0.412
LIG_SH2_NCK_1	303	307	PF00017	0.316
LIG_SH2_PTP2	424	427	PF00017	0.232
LIG_SH2_PTP2	488	491	PF00017	0.367
LIG_SH2_SRC	566	569	PF00017	0.531
LIG_SH2_STAP1	146	150	PF00017	0.323
LIG_SH2_STAP1	41	45	PF00017	0.498
LIG_SH2_STAT5	146	149	PF00017	0.377
LIG_SH2_STAT5	159	162	PF00017	0.424
LIG_SH2_STAT5	232	235	PF00017	0.319
LIG_SH2_STAT5	327	330	PF00017	0.477
LIG_SH2_STAT5	41	44	PF00017	0.529
LIG_SH2_STAT5	424	427	PF00017	0.242
LIG_SH2_STAT5	488	491	PF00017	0.429
LIG_SH3_3	214	220	PF00018	0.448
LIG_SH3_3	270	276	PF00018	0.430
LIG_SH3_3	281	287	PF00018	0.412
LIG_SUMO_SIM_anti_2	2	9	PF11976	0.475
LIG_SUMO_SIM_par_1	239	247	PF11976	0.377
LIG_SUMO_SIM_par_1	451	457	PF11976	0.337
LIG_SUMO_SIM_par_1	545	552	PF11976	0.392
LIG_TRAF2_1	15	18	PF00917	0.457
LIG_TRAF2_1	454	457	PF00917	0.532
LIG_TRAF2_1	525	528	PF00917	0.352
LIG_TYR_ITIM	144	149	PF00017	0.360
LIG_UBA3_1	19	27	PF00899	0.377
MOD_CDK_SPK_2	394	399	PF00069	0.337
MOD_CK1_1	118	124	PF00069	0.477
MOD_CK2_1	11	17	PF00069	0.490
MOD_CK2_1	166	172	PF00069	0.627
MOD_CK2_1	251	257	PF00069	0.587
MOD_CK2_1	380	386	PF00069	0.502
MOD_CK2_1	467	473	PF00069	0.558
MOD_CK2_1	522	528	PF00069	0.582
MOD_CK2_1	532	538	PF00069	0.377
MOD_GlcNHglycan	24	27	PF01048	0.447
MOD_GlcNHglycan	551	554	PF01048	0.607
MOD_GSK3_1	118	125	PF00069	0.342
MOD_GSK3_1	151	158	PF00069	0.369
MOD_GSK3_1	247	254	PF00069	0.561
MOD_GSK3_1	290	297	PF00069	0.455
MOD_N-GLC_1	322	327	PF02516	0.456
MOD_N-GLC_1	448	453	PF02516	0.449
MOD_NEK2_1	151	156	PF00069	0.338
MOD_NEK2_1	22	27	PF00069	0.552
MOD_NEK2_1	301	306	PF00069	0.457
MOD_NEK2_1	372	377	PF00069	0.489
MOD_NEK2_1	411	416	PF00069	0.306
MOD_NEK2_1	420	425	PF00069	0.213
MOD_NEK2_1	459	464	PF00069	0.372
MOD_NEK2_1	532	537	PF00069	0.443
MOD_NEK2_1	88	93	PF00069	0.361
MOD_NEK2_2	98	103	PF00069	0.454
MOD_PIKK_1	352	358	PF00454	0.347
MOD_PIKK_1	363	369	PF00454	0.308
MOD_PIKK_1	516	522	PF00454	0.565
MOD_PK_1	322	328	PF00069	0.459
MOD_PKA_1	542	548	PF00069	0.406
MOD_PKA_2	166	172	PF00069	0.559
MOD_PKA_2	420	426	PF00069	0.317
MOD_PKA_2	542	548	PF00069	0.406
MOD_PKB_1	113	121	PF00069	0.439
MOD_Plk_1	294	300	PF00069	0.404
MOD_Plk_1	322	328	PF00069	0.459
MOD_Plk_1	411	417	PF00069	0.375
MOD_Plk_4	115	121	PF00069	0.505
MOD_Plk_4	151	157	PF00069	0.324
MOD_Plk_4	322	328	PF00069	0.459
MOD_Plk_4	420	426	PF00069	0.311
MOD_Plk_4	484	490	PF00069	0.383
MOD_Plk_4	542	548	PF00069	0.544
MOD_ProDKin_1	113	119	PF00069	0.424
MOD_ProDKin_1	269	275	PF00069	0.589
MOD_ProDKin_1	290	296	PF00069	0.435
MOD_ProDKin_1	329	335	PF00069	0.416
MOD_ProDKin_1	394	400	PF00069	0.332
MOD_ProDKin_1	448	454	PF00069	0.379
MOD_ProDKin_1	507	513	PF00069	0.461
MOD_SUMO_rev_2	397	406	PF00179	0.368
MOD_SUMO_rev_2	510	519	PF00179	0.483
MOD_SUMO_rev_2	545	552	PF00179	0.518
TRG_DiLeu_BaEn_1	402	407	PF01217	0.345
TRG_DiLeu_BaEn_1	528	533	PF01217	0.450
TRG_DiLeu_BaEn_2	385	391	PF01217	0.347
TRG_DiLeu_BaEn_3	17	23	PF01217	0.442
TRG_DiLeu_BaEn_4	353	359	PF01217	0.463
TRG_DiLeu_BaLyEn_6	295	300	PF01217	0.472
TRG_DiLeu_BaLyEn_6	423	428	PF01217	0.323
TRG_ENDOCYTIC_2	146	149	PF00928	0.402
TRG_ENDOCYTIC_2	327	330	PF00928	0.568
TRG_ENDOCYTIC_2	424	427	PF00928	0.230
TRG_ER_diArg_1	494	496	PF00400	0.396
TRG_ER_diArg_1	499	501	PF00400	0.379
TRG_ER_diArg_1	541	543	PF00400	0.390
TRG_ER_diArg_1	83	85	PF00400	0.396
TRG_NES_CRM1_1	473	486	PF08389	0.508
TRG_NLS_MonoExtN_4	340	347	PF00514	0.478
TRG_Pf-PMV_PEXEL_1	283	288	PF00026	0.507

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4X2	Leptomonas seymouri	76%	85%
A0A0S4IQX1	Bodo saltans	45%	100%
A0A1X0NXS1	Trypanosomatidae	64%	83%
A0A3S7WWA1	Leishmania donovani	93%	89%
A4HZJ6	Leishmania infantum	93%	84%
D0A1K7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	63%	88%
E9AUY1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	89%
Q4QCK1	Leishmania major	91%	100%
V5DGX7	Trypanosoma cruzi	64%	84%