DNA topoisomerase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

DNA topoisomerase

Gene product:

DNA topoisomerase 1A

Species:

Leishmania braziliensis

UniProt:

A4HBL0_LEIBR

TriTrypDb:

LbrM.21.0170 , LBRM2903_210006200

Length:

799

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HBL0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBL0

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006259	DNA metabolic process	4	12
GO:0006265	DNA topological change	5	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0006996	organelle organization	4	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016043	cellular component organization	3	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0046483	heterocycle metabolic process	3	12
GO:0051276	chromosome organization	5	12
GO:0071103	DNA conformation change	6	12
GO:0071704	organic substance metabolic process	2	12
GO:0071840	cellular component organization or biogenesis	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003677	DNA binding	4	12
GO:0003824	catalytic activity	1	12
GO:0003916	DNA topoisomerase activity	3	12
GO:0003917	DNA topoisomerase type I (single strand cut, ATP-independent) activity	4	12
GO:0005488	binding	1	12
GO:0016853	isomerase activity	2	12
GO:0097159	organic cyclic compound binding	2	12
GO:0140097	catalytic activity, acting on DNA	3	12
GO:0140640	catalytic activity, acting on a nucleic acid	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	118	122	PF00656	0.533
CLV_C14_Caspase3-7	238	242	PF00656	0.469
CLV_C14_Caspase3-7	724	728	PF00656	0.513
CLV_NRD_NRD_1	106	108	PF00675	0.219
CLV_NRD_NRD_1	148	150	PF00675	0.282
CLV_NRD_NRD_1	172	174	PF00675	0.356
CLV_NRD_NRD_1	3	5	PF00675	0.470
CLV_NRD_NRD_1	378	380	PF00675	0.359
CLV_NRD_NRD_1	398	400	PF00675	0.305
CLV_NRD_NRD_1	445	447	PF00675	0.265
CLV_NRD_NRD_1	747	749	PF00675	0.409
CLV_NRD_NRD_1	791	793	PF00675	0.585
CLV_PCSK_KEX2_1	106	108	PF00082	0.207
CLV_PCSK_KEX2_1	148	150	PF00082	0.188
CLV_PCSK_KEX2_1	172	174	PF00082	0.481
CLV_PCSK_KEX2_1	3	5	PF00082	0.470
CLV_PCSK_KEX2_1	378	380	PF00082	0.280
CLV_PCSK_KEX2_1	383	385	PF00082	0.428
CLV_PCSK_KEX2_1	398	400	PF00082	0.158
CLV_PCSK_KEX2_1	445	447	PF00082	0.289
CLV_PCSK_KEX2_1	747	749	PF00082	0.409
CLV_PCSK_KEX2_1	776	778	PF00082	0.630
CLV_PCSK_KEX2_1	791	793	PF00082	0.596
CLV_PCSK_PC1ET2_1	383	385	PF00082	0.455
CLV_PCSK_PC1ET2_1	776	778	PF00082	0.454
CLV_PCSK_PC7_1	379	385	PF00082	0.280
CLV_PCSK_PC7_1	394	400	PF00082	0.147
CLV_PCSK_SKI1_1	148	152	PF00082	0.272
CLV_PCSK_SKI1_1	20	24	PF00082	0.240
CLV_PCSK_SKI1_1	307	311	PF00082	0.428
CLV_PCSK_SKI1_1	320	324	PF00082	0.299
CLV_PCSK_SKI1_1	383	387	PF00082	0.254
CLV_PCSK_SKI1_1	591	595	PF00082	0.246
CLV_PCSK_SKI1_1	641	645	PF00082	0.345
CLV_PCSK_SKI1_1	67	71	PF00082	0.264
CLV_PCSK_SKI1_1	733	737	PF00082	0.361
CLV_PCSK_SKI1_1	784	788	PF00082	0.596
CLV_PCSK_SKI1_1	90	94	PF00082	0.252
DEG_MDM2_SWIB_1	96	103	PF02201	0.506
DEG_Nend_Nbox_1	1	3	PF02207	0.534
DOC_CDC14_PxL_1	719	727	PF14671	0.379
DOC_CKS1_1	221	226	PF01111	0.232
DOC_CYCLIN_RxL_1	378	390	PF00134	0.324
DOC_CYCLIN_RxL_1	87	97	PF00134	0.350
DOC_MAPK_gen_1	148	156	PF00069	0.371
DOC_MAPK_gen_1	3	14	PF00069	0.427
DOC_MAPK_gen_1	445	451	PF00069	0.343
DOC_MAPK_gen_1	457	465	PF00069	0.198
DOC_MAPK_gen_1	544	550	PF00069	0.401
DOC_MAPK_HePTP_8	146	158	PF00069	0.445
DOC_MAPK_MEF2A_6	148	156	PF00069	0.385
DOC_MAPK_MEF2A_6	220	228	PF00069	0.246
DOC_MAPK_MEF2A_6	445	453	PF00069	0.428
DOC_MAPK_MEF2A_6	457	465	PF00069	0.305
DOC_MAPK_MEF2A_6	559	566	PF00069	0.280
DOC_PP1_RVXF_1	65	72	PF00149	0.411
DOC_PP2B_LxvP_1	154	157	PF13499	0.401
DOC_PP2B_LxvP_1	651	654	PF13499	0.348
DOC_USP7_MATH_1	296	300	PF00917	0.262
DOC_USP7_MATH_1	393	397	PF00917	0.178
DOC_USP7_MATH_1	553	557	PF00917	0.190
DOC_USP7_MATH_1	655	659	PF00917	0.555
DOC_USP7_MATH_1	756	760	PF00917	0.575
DOC_USP7_MATH_1	790	794	PF00917	0.463
DOC_USP7_UBL2_3	784	788	PF12436	0.697
DOC_WW_Pin1_4	14	19	PF00397	0.401
DOC_WW_Pin1_4	220	225	PF00397	0.242
DOC_WW_Pin1_4	267	272	PF00397	0.379
DOC_WW_Pin1_4	313	318	PF00397	0.331
DOC_WW_Pin1_4	558	563	PF00397	0.294
DOC_WW_Pin1_4	606	611	PF00397	0.246
DOC_WW_Pin1_4	69	74	PF00397	0.429
DOC_WW_Pin1_4	700	705	PF00397	0.619
DOC_WW_Pin1_4	758	763	PF00397	0.502
DOC_WW_Pin1_4	786	791	PF00397	0.589
LIG_14-3-3_CanoR_1	262	269	PF00244	0.342
LIG_14-3-3_CanoR_1	3	7	PF00244	0.445
LIG_14-3-3_CanoR_1	445	450	PF00244	0.246
LIG_14-3-3_CanoR_1	582	587	PF00244	0.232
LIG_14-3-3_CanoR_1	620	624	PF00244	0.302
LIG_14-3-3_CanoR_1	683	693	PF00244	0.496
LIG_14-3-3_CanoR_1	733	742	PF00244	0.373
LIG_14-3-3_CanoR_1	791	797	PF00244	0.469
LIG_BRCT_BRCA1_1	154	158	PF00533	0.421
LIG_BRCT_BRCA1_1	489	493	PF00533	0.379
LIG_Clathr_ClatBox_1	12	16	PF01394	0.419
LIG_CSL_BTD_1	70	73	PF09270	0.436
LIG_deltaCOP1_diTrp_1	36	39	PF00928	0.401
LIG_deltaCOP1_diTrp_1	486	493	PF00928	0.246
LIG_EH1_1	321	329	PF00400	0.324
LIG_EVH1_2	318	322	PF00568	0.246
LIG_EVH1_2	562	566	PF00568	0.280
LIG_FHA_1	122	128	PF00498	0.421
LIG_FHA_1	221	227	PF00498	0.232
LIG_FHA_1	244	250	PF00498	0.247
LIG_FHA_1	446	452	PF00498	0.339
LIG_FHA_1	456	462	PF00498	0.356
LIG_FHA_1	606	612	PF00498	0.276
LIG_FHA_2	128	134	PF00498	0.408
LIG_FHA_2	361	367	PF00498	0.246
LIG_FHA_2	407	413	PF00498	0.354
LIG_FHA_2	419	425	PF00498	0.452
LIG_FHA_2	468	474	PF00498	0.296
LIG_FHA_2	47	53	PF00498	0.506
LIG_FHA_2	504	510	PF00498	0.268
LIG_FHA_2	701	707	PF00498	0.457
LIG_FHA_2	81	87	PF00498	0.461
LIG_Integrin_RGD_1	494	496	PF01839	0.161
LIG_LIR_Gen_1	260	271	PF02991	0.164
LIG_LIR_Gen_1	372	380	PF02991	0.266
LIG_LIR_Gen_1	60	69	PF02991	0.405
LIG_LIR_Gen_1	734	742	PF02991	0.327
LIG_LIR_Gen_1	97	108	PF02991	0.424
LIG_LIR_Nem_3	197	203	PF02991	0.232
LIG_LIR_Nem_3	260	266	PF02991	0.164
LIG_LIR_Nem_3	372	377	PF02991	0.266
LIG_LIR_Nem_3	525	531	PF02991	0.234
LIG_LIR_Nem_3	584	589	PF02991	0.232
LIG_LIR_Nem_3	60	66	PF02991	0.428
LIG_LIR_Nem_3	621	626	PF02991	0.245
LIG_LIR_Nem_3	669	674	PF02991	0.293
LIG_LIR_Nem_3	734	738	PF02991	0.317
LIG_LIR_Nem_3	97	103	PF02991	0.411
LIG_LYPXL_yS_3	586	589	PF13949	0.232
LIG_PCNA_PIPBox_1	196	205	PF02747	0.246
LIG_PCNA_PIPBox_1	739	748	PF02747	0.331
LIG_PCNA_yPIPBox_3	106	116	PF02747	0.424
LIG_PCNA_yPIPBox_3	144	153	PF02747	0.421
LIG_PCNA_yPIPBox_3	733	746	PF02747	0.338
LIG_Pex14_1	489	493	PF04695	0.246
LIG_Pex14_2	631	635	PF04695	0.232
LIG_Pex14_2	667	671	PF04695	0.282
LIG_Pex14_2	96	100	PF04695	0.506
LIG_SH2_CRK	210	214	PF00017	0.379
LIG_SH2_CRK	374	378	PF00017	0.246
LIG_SH2_CRK	441	445	PF00017	0.264
LIG_SH2_CRK	452	456	PF00017	0.264
LIG_SH2_GRB2like	210	213	PF00017	0.379
LIG_SH2_NCK_1	184	188	PF00017	0.276
LIG_SH2_NCK_1	210	214	PF00017	0.379
LIG_SH2_PTP2	598	601	PF00017	0.232
LIG_SH2_SRC	210	213	PF00017	0.379
LIG_SH2_SRC	239	242	PF00017	0.280
LIG_SH2_STAP1	337	341	PF00017	0.419
LIG_SH2_STAT5	115	118	PF00017	0.500
LIG_SH2_STAT5	239	242	PF00017	0.368
LIG_SH2_STAT5	337	340	PF00017	0.318
LIG_SH2_STAT5	354	357	PF00017	0.327
LIG_SH2_STAT5	598	601	PF00017	0.232
LIG_SH2_STAT5	662	665	PF00017	0.289
LIG_SH2_STAT5	674	677	PF00017	0.293
LIG_SH2_STAT5	745	748	PF00017	0.363
LIG_SH3_1	559	565	PF00018	0.247
LIG_SH3_3	12	18	PF00018	0.401
LIG_SH3_3	218	224	PF00018	0.291
LIG_SH3_3	312	318	PF00018	0.322
LIG_SH3_3	430	436	PF00018	0.379
LIG_SH3_3	557	563	PF00018	0.238
LIG_SH3_3	577	583	PF00018	0.124
LIG_SUMO_SIM_anti_2	10	17	PF11976	0.250
LIG_SUMO_SIM_anti_2	284	290	PF11976	0.161
LIG_SUMO_SIM_par_1	10	17	PF11976	0.236
LIG_SUMO_SIM_par_1	225	231	PF11976	0.232
LIG_SUMO_SIM_par_1	264	270	PF11976	0.185
LIG_TRAF2_1	426	429	PF00917	0.280
LIG_UBA3_1	146	153	PF00899	0.385
LIG_UBA3_1	571	576	PF00899	0.246
LIG_WRC_WIRS_1	664	669	PF05994	0.286
LIG_WRC_WIRS_1	732	737	PF05994	0.475
LIG_WRC_WIRS_1	93	98	PF05994	0.506
LIG_WW_2	562	565	PF00397	0.289
MOD_CDC14_SPxK_1	17	20	PF00782	0.401
MOD_CDK_SPK_2	786	791	PF00069	0.576
MOD_CDK_SPxK_1	14	20	PF00069	0.401
MOD_CDK_SPxK_1	786	792	PF00069	0.532
MOD_CDK_SPxxK_3	267	274	PF00069	0.379
MOD_CDK_SPxxK_3	313	320	PF00069	0.220
MOD_CDK_SPxxK_3	606	613	PF00069	0.246
MOD_CK1_1	242	248	PF00069	0.461
MOD_CK1_1	298	304	PF00069	0.292
MOD_CK1_1	397	403	PF00069	0.256
MOD_CK1_1	619	625	PF00069	0.379
MOD_CK1_1	666	672	PF00069	0.383
MOD_CK1_1	698	704	PF00069	0.536
MOD_CK1_1	768	774	PF00069	0.637
MOD_CK2_1	227	233	PF00069	0.321
MOD_CK2_1	242	248	PF00069	0.326
MOD_CK2_1	406	412	PF00069	0.327
MOD_CK2_1	422	428	PF00069	0.251
MOD_CK2_1	46	52	PF00069	0.506
MOD_CK2_1	467	473	PF00069	0.220
MOD_CK2_1	521	527	PF00069	0.310
MOD_CK2_1	62	68	PF00069	0.424
MOD_CK2_1	630	636	PF00069	0.280
MOD_Cter_Amidation	104	107	PF01082	0.222
MOD_Cter_Amidation	381	384	PF01082	0.351
MOD_DYRK1A_RPxSP_1	220	224	PF00069	0.232
MOD_GlcNHglycan	298	301	PF01048	0.338
MOD_GlcNHglycan	399	402	PF01048	0.266
MOD_GlcNHglycan	433	436	PF01048	0.413
MOD_GlcNHglycan	489	492	PF01048	0.381
MOD_GlcNHglycan	632	635	PF01048	0.449
MOD_GlcNHglycan	696	700	PF01048	0.407
MOD_GlcNHglycan	752	755	PF01048	0.562
MOD_GlcNHglycan	762	765	PF01048	0.532
MOD_GSK3_1	152	159	PF00069	0.443
MOD_GSK3_1	235	242	PF00069	0.343
MOD_GSK3_1	261	268	PF00069	0.167
MOD_GSK3_1	301	308	PF00069	0.462
MOD_GSK3_1	336	343	PF00069	0.243
MOD_GSK3_1	35	42	PF00069	0.519
MOD_GSK3_1	353	360	PF00069	0.189
MOD_GSK3_1	365	372	PF00069	0.232
MOD_GSK3_1	393	400	PF00069	0.302
MOD_GSK3_1	418	425	PF00069	0.320
MOD_GSK3_1	463	470	PF00069	0.205
MOD_GSK3_1	615	622	PF00069	0.247
MOD_GSK3_1	662	669	PF00069	0.286
MOD_GSK3_1	685	692	PF00069	0.387
MOD_GSK3_1	69	76	PF00069	0.472
MOD_GSK3_1	695	702	PF00069	0.486
MOD_GSK3_1	752	759	PF00069	0.473
MOD_GSK3_1	765	772	PF00069	0.598
MOD_GSK3_1	775	782	PF00069	0.547
MOD_GSK3_1	786	793	PF00069	0.578
MOD_N-GLC_1	121	126	PF02516	0.202
MOD_N-GLC_1	521	526	PF02516	0.333
MOD_N-GLC_1	655	660	PF02516	0.403
MOD_NEK2_1	2	7	PF00069	0.445
MOD_NEK2_1	202	207	PF00069	0.232
MOD_NEK2_1	303	308	PF00069	0.259
MOD_NEK2_1	341	346	PF00069	0.346
MOD_NEK2_1	39	44	PF00069	0.503
MOD_NEK2_1	57	62	PF00069	0.338
MOD_NEK2_1	615	620	PF00069	0.240
MOD_NEK2_1	667	672	PF00069	0.211
MOD_NEK2_1	738	743	PF00069	0.442
MOD_NEK2_1	92	97	PF00069	0.436
MOD_NEK2_2	779	784	PF00069	0.457
MOD_PIKK_1	261	267	PF00454	0.249
MOD_PIKK_1	298	304	PF00454	0.255
MOD_PKA_1	445	451	PF00069	0.264
MOD_PKA_1	775	781	PF00069	0.570
MOD_PKA_2	2	8	PF00069	0.431
MOD_PKA_2	261	267	PF00069	0.393
MOD_PKA_2	393	399	PF00069	0.289
MOD_PKA_2	418	424	PF00069	0.232
MOD_PKA_2	445	451	PF00069	0.289
MOD_PKA_2	467	473	PF00069	0.251
MOD_PKA_2	581	587	PF00069	0.232
MOD_PKA_2	619	625	PF00069	0.389
MOD_PKA_2	790	796	PF00069	0.592
MOD_Plk_1	35	41	PF00069	0.406
MOD_Plk_1	360	366	PF00069	0.246
MOD_Plk_1	423	429	PF00069	0.280
MOD_Plk_1	67	73	PF00069	0.460
MOD_Plk_4	203	209	PF00069	0.232
MOD_Plk_4	235	241	PF00069	0.310
MOD_Plk_4	284	290	PF00069	0.374
MOD_Plk_4	323	329	PF00069	0.324
MOD_Plk_4	365	371	PF00069	0.369
MOD_Plk_4	589	595	PF00069	0.256
MOD_Plk_4	622	628	PF00069	0.246
MOD_Plk_4	663	669	PF00069	0.276
MOD_ProDKin_1	14	20	PF00069	0.401
MOD_ProDKin_1	220	226	PF00069	0.242
MOD_ProDKin_1	267	273	PF00069	0.379
MOD_ProDKin_1	313	319	PF00069	0.331
MOD_ProDKin_1	558	564	PF00069	0.294
MOD_ProDKin_1	606	612	PF00069	0.246
MOD_ProDKin_1	69	75	PF00069	0.429
MOD_ProDKin_1	700	706	PF00069	0.614
MOD_ProDKin_1	758	764	PF00069	0.500
MOD_ProDKin_1	786	792	PF00069	0.591
MOD_SUMO_for_1	22	25	PF00179	0.411
MOD_SUMO_rev_2	113	120	PF00179	0.467
MOD_SUMO_rev_2	230	236	PF00179	0.247
MOD_SUMO_rev_2	25	34	PF00179	0.475
MOD_SUMO_rev_2	524	531	PF00179	0.393
MOD_SUMO_rev_2	633	639	PF00179	0.294
TRG_DiLeu_BaLyEn_6	381	386	PF01217	0.280
TRG_ENDOCYTIC_2	374	377	PF00928	0.246
TRG_ENDOCYTIC_2	441	444	PF00928	0.232
TRG_ENDOCYTIC_2	586	589	PF00928	0.232
TRG_ENDOCYTIC_2	598	601	PF00928	0.232
TRG_ENDOCYTIC_2	732	735	PF00928	0.360
TRG_ER_diArg_1	106	108	PF00400	0.407
TRG_ER_diArg_1	147	149	PF00400	0.482
TRG_ER_diArg_1	171	173	PF00400	0.479
TRG_ER_diArg_1	2	4	PF00400	0.485
TRG_ER_diArg_1	377	379	PF00400	0.280
TRG_ER_diArg_1	444	446	PF00400	0.289
TRG_ER_diArg_1	746	748	PF00400	0.396
TRG_ER_diArg_1	790	792	PF00400	0.652
TRG_Pf-PMV_PEXEL_1	106	110	PF00026	0.211
TRG_Pf-PMV_PEXEL_1	384	388	PF00026	0.379
TRG_Pf-PMV_PEXEL_1	438	442	PF00026	0.259
TRG_Pf-PMV_PEXEL_1	613	617	PF00026	0.324

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDE4	Leptomonas seymouri	68%	93%
A0A0S4JDQ6	Bodo saltans	39%	98%
A0A0S4JI21	Bodo saltans	22%	82%
A0A1X0NXB2	Trypanosomatidae	51%	93%
A0A3S7WW83	Leishmania donovani	85%	99%
A0A422N774	Trypanosoma rangeli	51%	95%
A0R5D9	Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155)	27%	85%
A0R979	Bacillus thuringiensis (strain Al Hakam)	25%	100%
A4HZ99	Leishmania infantum	85%	99%
D0A1K4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	99%
E9AUX9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	99%
O27661	Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)	24%	100%
O28469	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	27%	100%
O34204	Fervidobacterium islandicum	26%	100%
O51768	Borreliella burgdorferi (strain ATCC 35210 / DSM 4680 / CIP 102532 / B31)	25%	94%
O58356	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	23%	100%
O67226	Aquifex aeolicus (strain VF5)	25%	69%
O69548	Mycobacterium leprae (strain TN)	27%	84%
O83409	Treponema pallidum (strain Nichols)	27%	100%
P06612	Escherichia coli (strain K12)	26%	92%
P0A2I1	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	26%	92%
P0A2I2	Salmonella typhi	26%	92%
P0A621	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	27%	86%
P0C2W6	Staphylococcus aureus (strain bovine RF122 / ET3-1)	21%	100%
P14294	Escherichia coli (strain K12)	21%	100%
P40687	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	22%	100%
P43012	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	25%	92%
P43704	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	21%	100%
P46799	Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)	24%	100%
P47368	Mycoplasma genitalium (strain ATCC 33530 / DSM 19775 / NCTC 10195 / G37)	25%	100%
P55991	Helicobacter pylori (strain ATCC 700392 / 26695)	26%	100%
P57371	Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS)	24%	93%
P73810	Synechocystis sp. (strain PCC 6803 / Kazusa)	29%	89%
P78032	Mycoplasma pneumoniae (strain ATCC 29342 / M129 / Subtype 1)	25%	100%
P96583	Bacillus subtilis (strain 168)	25%	100%
P9WG48	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	27%	86%
P9WG49	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	27%	86%
Q06AK7	Staphylococcus aureus	25%	100%
Q1RIM1	Rickettsia bellii (strain RML369-C)	26%	100%
Q2FEN5	Staphylococcus aureus (strain USA300)	22%	100%
Q2FHI8	Staphylococcus aureus (strain USA300)	26%	100%
Q2FW03	Staphylococcus aureus (strain NCTC 8325 / PS 47)	22%	100%
Q2FZ32	Staphylococcus aureus (strain NCTC 8325 / PS 47)	26%	100%
Q2YXL8	Staphylococcus aureus (strain bovine RF122 / ET3-1)	25%	100%
Q49X35	Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41)	25%	100%
Q4L5V2	Staphylococcus haemolyticus (strain JCSC1435)	26%	100%
Q4QCK3	Leishmania major	86%	100%
Q4UM42	Rickettsia felis (strain ATCC VR-1525 / URRWXCal2)	25%	100%
Q59046	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	23%	100%
Q5HDV4	Staphylococcus aureus (strain COL)	22%	100%
Q5HGI2	Staphylococcus aureus (strain COL)	26%	100%
Q5HLZ4	Staphylococcus epidermidis (strain ATCC 35984 / RP62A)	22%	100%
Q5UQB5	Acanthamoeba polyphaga mimivirus	24%	94%
Q5WAX6	Alkalihalobacillus clausii (strain KSM-K16)	24%	100%
Q63GK5	Bacillus cereus (strain ZK / E33L)	25%	100%
Q65N90	Bacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / CCUG 7422 / NBRC 12200 / NCIMB 9375 / NCTC 10341 / NRRL NRS-1264 / Gibson 46)	25%	100%
Q68X45	Rickettsia typhi (strain ATCC VR-144 / Wilmington)	26%	100%
Q6G767	Staphylococcus aureus (strain MSSA476)	22%	100%
Q6G9W3	Staphylococcus aureus (strain MSSA476)	26%	100%
Q6GEH9	Staphylococcus aureus (strain MRSA252)	21%	100%
Q6GHI5	Staphylococcus aureus (strain MRSA252)	26%	100%
Q6HP19	Bacillus thuringiensis subsp. konkukian (strain 97-27)	25%	100%
Q73E74	Bacillus cereus (strain ATCC 10987 / NRS 248)	25%	100%
Q7A075	Staphylococcus aureus (strain MW2)	22%	100%
Q7A455	Staphylococcus aureus (strain N315)	22%	100%
Q7A5Y5	Staphylococcus aureus (strain N315)	26%	100%
Q81IH1	Bacillus cereus (strain ATCC 14579 / DSM 31 / CCUG 7414 / JCM 2152 / NBRC 15305 / NCIMB 9373 / NCTC 2599 / NRRL B-3711)	26%	100%
Q81Z97	Bacillus anthracis	25%	100%
Q87AQ6	Xylella fastidiosa (strain Temecula1 / ATCC 700964)	27%	98%
Q8CRF7	Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)	22%	100%
Q8K9P7	Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)	24%	94%
Q8NWZ9	Staphylococcus aureus (strain MW2)	26%	100%
Q8Z6F5	Salmonella typhi	22%	100%
Q92IH1	Rickettsia conorii (strain ATCC VR-613 / Malish 7)	26%	100%
Q97ZF5	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	26%	69%
Q99S17	Staphylococcus aureus (strain Mu50 / ATCC 700699)	22%	100%
Q99UM1	Staphylococcus aureus (strain Mu50 / ATCC 700699)	26%	100%
Q9CN30	Pasteurella multocida (strain Pm70)	27%	92%
Q9CP53	Pasteurella multocida (strain Pm70)	22%	100%
Q9HM08	Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)	25%	100%
Q9HZJ5	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	26%	92%
Q9JN65	Mycoplasma gallisepticum (strain R(low / passage 15 / clone 2))	24%	100%
Q9KA23	Halalkalibacterium halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)	25%	100%
Q9KQF5	Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)	23%	100%
Q9KRB2	Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)	26%	91%
Q9PEV8	Xylella fastidiosa (strain 9a5c)	27%	98%
Q9PHK2	Xylella fastidiosa (strain 9a5c)	27%	100%
Q9PLZ2	Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168)	27%	100%
Q9UYS8	Pyrococcus abyssi (strain GE5 / Orsay)	23%	100%
Q9X909	Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)	27%	84%
Q9YB01	Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)	22%	100%
Q9ZDK2	Rickettsia prowazekii (strain Madrid E)	25%	100%
Q9ZMV7	Helicobacter pylori (strain J99 / ATCC 700824)	27%	100%
V5BG04	Trypanosoma cruzi	52%	97%