Rhomboid domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HBK8_LEIBR

TriTrypDb:

LbrM.21.0150 , LBRM2903_210006000

Length:

192

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

A4HBK8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBK8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	121	123	PF00675	0.353
CLV_NRD_NRD_1	143	145	PF00675	0.540
CLV_NRD_NRD_1	167	169	PF00675	0.591
CLV_NRD_NRD_1	171	173	PF00675	0.573
CLV_NRD_NRD_1	58	60	PF00675	0.448
CLV_PCSK_KEX2_1	121	123	PF00082	0.364
CLV_PCSK_KEX2_1	171	173	PF00082	0.574
CLV_PCSK_KEX2_1	23	25	PF00082	0.720
CLV_PCSK_PC1ET2_1	23	25	PF00082	0.720
CLV_PCSK_SKI1_1	24	28	PF00082	0.671
CLV_PCSK_SKI1_1	60	64	PF00082	0.295
DEG_Nend_Nbox_1	1	3	PF02207	0.424
DOC_CYCLIN_yCln2_LP_2	75	81	PF00134	0.449
DOC_MAPK_gen_1	168	179	PF00069	0.450
DOC_MAPK_gen_1	8	16	PF00069	0.473
DOC_MAPK_MEF2A_6	70	79	PF00069	0.487
DOC_MAPK_RevD_3	109	122	PF00069	0.363
DOC_PP1_RVXF_1	119	126	PF00149	0.328
DOC_PP2B_LxvP_1	75	78	PF13499	0.344
DOC_PP4_FxxP_1	31	34	PF00568	0.344
DOC_USP7_MATH_1	32	36	PF00917	0.449
DOC_WW_Pin1_4	1	6	PF00397	0.577
DOC_WW_Pin1_4	95	100	PF00397	0.421
LIG_14-3-3_CanoR_1	121	126	PF00244	0.476
LIG_14-3-3_CanoR_1	15	25	PF00244	0.528
LIG_14-3-3_CanoR_1	59	65	PF00244	0.606
LIG_Actin_WH2_2	106	123	PF00022	0.475
LIG_APCC_ABBA_1	146	151	PF00400	0.382
LIG_APCC_ABBAyCdc20_2	145	151	PF00400	0.367
LIG_eIF4E_1	127	133	PF01652	0.399
LIG_FHA_1	25	31	PF00498	0.407
LIG_LIR_Apic_2	124	128	PF02991	0.328
LIG_LIR_Apic_2	28	34	PF02991	0.288
LIG_LIR_Nem_3	124	130	PF02991	0.334
LIG_LIR_Nem_3	136	140	PF02991	0.338
LIG_LIR_Nem_3	159	164	PF02991	0.411
LIG_LIR_Nem_3	35	40	PF02991	0.328
LIG_LIR_Nem_3	63	69	PF02991	0.566
LIG_LIR_Nem_3	83	89	PF02991	0.145
LIG_LYPXL_yS_3	127	130	PF13949	0.328
LIG_Pex14_2	52	56	PF04695	0.490
LIG_SH2_CRK	37	41	PF00017	0.344
LIG_SH2_CRK	66	70	PF00017	0.559
LIG_SH2_STAT5	134	137	PF00017	0.344
LIG_SH2_STAT5	61	64	PF00017	0.600
LIG_SH2_STAT5	86	89	PF00017	0.328
LIG_SUMO_SIM_par_1	42	49	PF11976	0.449
LIG_WRC_WIRS_1	134	139	PF05994	0.396
MOD_CDK_SPxxK_3	1	8	PF00069	0.515
MOD_CK1_1	4	10	PF00069	0.514
MOD_CK1_1	88	94	PF00069	0.333
MOD_CK2_1	6	12	PF00069	0.566
MOD_GlcNHglycan	41	44	PF01048	0.449
MOD_GlcNHglycan	8	11	PF01048	0.684
MOD_GlcNHglycan	82	85	PF01048	0.391
MOD_GSK3_1	109	116	PF00069	0.449
MOD_GSK3_1	91	98	PF00069	0.441
MOD_NEK2_1	133	138	PF00069	0.363
MOD_NEK2_1	46	51	PF00069	0.414
MOD_NEK2_1	62	67	PF00069	0.550
MOD_NEK2_1	85	90	PF00069	0.475
MOD_PIKK_1	46	52	PF00454	0.414
MOD_PKA_1	121	127	PF00069	0.476
MOD_PKA_2	121	127	PF00069	0.487
MOD_Plk_4	113	119	PF00069	0.333
MOD_Plk_4	121	127	PF00069	0.481
MOD_Plk_4	26	32	PF00069	0.285
MOD_Plk_4	70	76	PF00069	0.542
MOD_Plk_4	88	94	PF00069	0.193
MOD_ProDKin_1	1	7	PF00069	0.574
MOD_ProDKin_1	95	101	PF00069	0.419
MOD_SUMO_rev_2	163	170	PF00179	0.474
MOD_SUMO_rev_2	174	184	PF00179	0.355
TRG_DiLeu_BaLyEn_6	125	130	PF01217	0.328
TRG_ENDOCYTIC_2	126	129	PF00928	0.328
TRG_ENDOCYTIC_2	134	137	PF00928	0.328
TRG_ENDOCYTIC_2	143	146	PF00928	0.339
TRG_ENDOCYTIC_2	37	40	PF00928	0.328
TRG_ENDOCYTIC_2	61	64	PF00928	0.543
TRG_ENDOCYTIC_2	66	69	PF00928	0.557
TRG_ENDOCYTIC_2	86	89	PF00928	0.145
TRG_ER_diArg_1	120	122	PF00400	0.565
TRG_ER_diArg_1	171	173	PF00400	0.394

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HUX4	Leptomonas seymouri	78%	100%
A0A0S4J4Z5	Bodo saltans	43%	100%
A0A1X0NXC0	Trypanosomatidae	60%	100%
A0A3R7K403	Trypanosoma rangeli	63%	100%
A0A3S7WW99	Leishmania donovani	90%	100%
A4HZK8	Leishmania infantum	89%	100%
D0A1K2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	59%	100%
E9AUX7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	99%
Q4QCK5	Leishmania major	89%	100%
V5BKK7	Trypanosoma cruzi	65%	88%