Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HBK6_LEIBR

TriTrypDb:

LbrM.21.0130 , LBRM2903_210005800

Length:

184

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 17
NetGPI	no	yes: 0, no: 17

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	16
GO:0110165	cellular anatomical entity	1	16

Expansion

Sequence features

A4HBK6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBK6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	175	177	PF00675	0.365
CLV_NRD_NRD_1	87	89	PF00675	0.298
CLV_PCSK_KEX2_1	175	177	PF00082	0.365
CLV_PCSK_KEX2_1	87	89	PF00082	0.298
CLV_PCSK_SKI1_1	120	124	PF00082	0.560
CLV_PCSK_SKI1_1	33	37	PF00082	0.186
CLV_PCSK_SKI1_1	88	92	PF00082	0.301
DEG_APCC_DBOX_1	13	21	PF00400	0.494
DEG_APCC_DBOX_1	32	40	PF00400	0.348
DEG_Nend_UBRbox_2	1	3	PF02207	0.689
DOC_MAPK_gen_1	87	95	PF00069	0.466
DOC_MAPK_gen_1	9	19	PF00069	0.614
DOC_MAPK_MEF2A_6	87	95	PF00069	0.465
DOC_MAPK_MEF2A_6	9	17	PF00069	0.574
DOC_MAPK_NFAT4_5	88	96	PF00069	0.494
DOC_USP7_MATH_1	161	165	PF00917	0.695
DOC_USP7_MATH_1	174	178	PF00917	0.672
DOC_USP7_MATH_1	65	69	PF00917	0.277
DOC_WW_Pin1_4	80	85	PF00397	0.618
LIG_14-3-3_CanoR_1	175	184	PF00244	0.730
LIG_deltaCOP1_diTrp_1	110	119	PF00928	0.315
LIG_FHA_1	23	29	PF00498	0.238
LIG_GBD_Chelix_1	28	36	PF00786	0.186
LIG_LIR_Gen_1	127	137	PF02991	0.362
LIG_LIR_Nem_3	127	132	PF02991	0.324
LIG_LIR_Nem_3	142	146	PF02991	0.334
LIG_PDZ_Class_2	179	184	PF00595	0.670
LIG_Pex14_2	135	139	PF04695	0.332
LIG_SH2_SRC	76	79	PF00017	0.587
LIG_SH2_STAP1	146	150	PF00017	0.530
LIG_SH2_STAT5	34	37	PF00017	0.354
LIG_SH2_STAT5	53	56	PF00017	0.361
LIG_SH3_3	64	70	PF00018	0.363
LIG_WRC_WIRS_1	96	101	PF05994	0.405
MOD_CDK_SPxxK_3	80	87	PF00069	0.610
MOD_CK1_1	83	89	PF00069	0.611
MOD_GlcNHglycan	165	168	PF01048	0.421
MOD_GlcNHglycan	67	70	PF01048	0.382
MOD_GSK3_1	124	131	PF00069	0.292
MOD_GSK3_1	144	151	PF00069	0.242
MOD_NEK2_1	128	133	PF00069	0.325
MOD_NEK2_1	139	144	PF00069	0.300
MOD_NEK2_2	112	117	PF00069	0.221
MOD_PIKK_1	161	167	PF00454	0.671
MOD_PIKK_1	176	182	PF00454	0.641
MOD_PKA_2	174	180	PF00069	0.708
MOD_Plk_4	112	118	PF00069	0.244
MOD_Plk_4	124	130	PF00069	0.305
MOD_Plk_4	139	145	PF00069	0.332
MOD_ProDKin_1	80	86	PF00069	0.615
TRG_DiLeu_BaLyEn_6	67	72	PF01217	0.313
TRG_ENDOCYTIC_2	53	56	PF00928	0.350
TRG_ER_diArg_1	12	15	PF00400	0.497
TRG_Pf-PMV_PEXEL_1	176	180	PF00026	0.514

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5I2	Leptomonas seymouri	25%	67%
A0A0N1ILT5	Leptomonas seymouri	28%	100%
A0A0N1PC80	Leptomonas seymouri	67%	100%
A0A0S4J4Y6	Bodo saltans	32%	100%
A0A0S4JQJ3	Bodo saltans	30%	100%
A0A1X0NXC4	Trypanosomatidae	41%	100%
A0A3Q8IF10	Leishmania donovani	79%	100%
A0A3Q8IQ96	Leishmania donovani	27%	100%
A0A422N768	Trypanosoma rangeli	40%	100%
A4HG55	Leishmania braziliensis	26%	100%
A4HZL0	Leishmania infantum	79%	100%
A4I386	Leishmania infantum	27%	100%
E9AUX5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
E9AZH4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
Q4Q8Q7	Leishmania major	25%	100%
Q4QCK7	Leishmania major	80%	99%