LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4HBK4_LEIBR
TriTrypDb:
LbrM.21.0110 , LBRM2903_210005600 *
Length:
347

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0016020 membrane 2 3
GO:0110165 cellular anatomical entity 1 3

Expansion

Sequence features

A4HBK4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBK4

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 141 143 PF00675 0.306
CLV_NRD_NRD_1 172 174 PF00675 0.485
CLV_NRD_NRD_1 300 302 PF00675 0.408
CLV_NRD_NRD_1 46 48 PF00675 0.314
CLV_PCSK_KEX2_1 141 143 PF00082 0.306
CLV_PCSK_KEX2_1 171 173 PF00082 0.500
CLV_PCSK_KEX2_1 300 302 PF00082 0.408
CLV_PCSK_KEX2_1 329 331 PF00082 0.676
CLV_PCSK_PC1ET2_1 329 331 PF00082 0.606
CLV_PCSK_SKI1_1 121 125 PF00082 0.374
CLV_PCSK_SKI1_1 175 179 PF00082 0.372
CLV_PCSK_SKI1_1 206 210 PF00082 0.512
CLV_PCSK_SKI1_1 326 330 PF00082 0.678
CLV_PCSK_SKI1_1 343 347 PF00082 0.693
CLV_PCSK_SKI1_1 88 92 PF00082 0.410
DEG_MDM2_SWIB_1 155 162 PF02201 0.662
DEG_SPOP_SBC_1 259 263 PF00917 0.617
DEG_SPOP_SBC_1 288 292 PF00917 0.736
DOC_CKS1_1 220 225 PF01111 0.705
DOC_CYCLIN_RxL_1 171 180 PF00134 0.640
DOC_MAPK_gen_1 300 306 PF00069 0.445
DOC_MAPK_gen_1 326 334 PF00069 0.474
DOC_MAPK_MEF2A_6 189 196 PF00069 0.568
DOC_MAPK_MEF2A_6 305 313 PF00069 0.430
DOC_USP7_MATH_1 216 220 PF00917 0.516
DOC_USP7_MATH_1 253 257 PF00917 0.782
DOC_USP7_MATH_1 28 32 PF00917 0.566
DOC_USP7_MATH_1 288 292 PF00917 0.712
DOC_USP7_MATH_2 109 115 PF00917 0.481
DOC_WW_Pin1_4 219 224 PF00397 0.713
DOC_WW_Pin1_4 58 63 PF00397 0.579
LIG_14-3-3_CanoR_1 112 117 PF00244 0.614
LIG_14-3-3_CanoR_1 277 282 PF00244 0.655
LIG_14-3-3_CanoR_1 88 97 PF00244 0.609
LIG_14-3-3_CterR_2 343 347 PF00244 0.508
LIG_Actin_WH2_2 302 320 PF00022 0.609
LIG_AP2alpha_2 168 170 PF02296 0.618
LIG_BIR_II_1 1 5 PF00653 0.677
LIG_Clathr_ClatBox_1 193 197 PF01394 0.569
LIG_FHA_1 212 218 PF00498 0.520
LIG_FHA_1 261 267 PF00498 0.633
LIG_FHA_1 69 75 PF00498 0.485
LIG_FHA_2 159 165 PF00498 0.537
LIG_FHA_2 223 229 PF00498 0.698
LIG_GBD_Chelix_1 324 332 PF00786 0.608
LIG_LIR_Gen_1 158 167 PF02991 0.696
LIG_LIR_Gen_1 37 46 PF02991 0.523
LIG_LIR_Nem_3 122 127 PF02991 0.653
LIG_LIR_Nem_3 158 162 PF02991 0.635
LIG_LIR_Nem_3 37 42 PF02991 0.526
LIG_LIR_Nem_3 61 66 PF02991 0.529
LIG_NRBOX 308 314 PF00104 0.487
LIG_PCNA_PIPBox_1 96 105 PF02747 0.595
LIG_PDZ_Class_2 342 347 PF00595 0.535
LIG_Pex14_2 155 159 PF04695 0.649
LIG_Pex14_2 170 174 PF04695 0.682
LIG_Pex14_2 184 188 PF04695 0.461
LIG_SH2_STAT3 212 215 PF00017 0.716
LIG_SH2_STAT3 270 273 PF00017 0.773
LIG_SH2_STAT5 151 154 PF00017 0.535
LIG_SH3_3 263 269 PF00018 0.672
LIG_SH3_3 317 323 PF00018 0.270
LIG_TRAF2_1 225 228 PF00917 0.658
LIG_WRC_WIRS_1 113 118 PF05994 0.572
LIG_WRC_WIRS_1 36 41 PF05994 0.346
MOD_CDK_SPxxK_3 219 226 PF00069 0.633
MOD_CK1_1 219 225 PF00069 0.397
MOD_CK1_1 261 267 PF00069 0.705
MOD_CK1_1 291 297 PF00069 0.707
MOD_CK1_1 4 10 PF00069 0.684
MOD_CK1_1 61 67 PF00069 0.343
MOD_CK2_1 158 164 PF00069 0.560
MOD_CK2_1 222 228 PF00069 0.543
MOD_GlcNHglycan 134 137 PF01048 0.443
MOD_GlcNHglycan 144 148 PF01048 0.456
MOD_GlcNHglycan 201 204 PF01048 0.533
MOD_GlcNHglycan 255 258 PF01048 0.637
MOD_GlcNHglycan 263 266 PF01048 0.655
MOD_GlcNHglycan 293 296 PF01048 0.666
MOD_GlcNHglycan 320 323 PF01048 0.437
MOD_GlcNHglycan 42 45 PF01048 0.374
MOD_GlcNHglycan 68 71 PF01048 0.450
MOD_GSK3_1 111 118 PF00069 0.359
MOD_GSK3_1 272 279 PF00069 0.615
MOD_GSK3_1 287 294 PF00069 0.554
MOD_GSK3_1 7 14 PF00069 0.564
MOD_LATS_1 110 116 PF00433 0.577
MOD_LATS_1 341 347 PF00433 0.532
MOD_NEK2_1 1 6 PF00069 0.565
MOD_NEK2_1 102 107 PF00069 0.608
MOD_NEK2_1 177 182 PF00069 0.366
MOD_NEK2_1 281 286 PF00069 0.564
MOD_NEK2_1 40 45 PF00069 0.360
MOD_PIKK_1 211 217 PF00454 0.638
MOD_PIKK_1 272 278 PF00454 0.791
MOD_PIKK_1 4 10 PF00454 0.565
MOD_PIKK_1 88 94 PF00454 0.585
MOD_PKA_2 111 117 PF00069 0.422
MOD_PKA_2 276 282 PF00069 0.815
MOD_Plk_1 232 238 PF00069 0.556
MOD_Plk_1 34 40 PF00069 0.366
MOD_Plk_2-3 158 164 PF00069 0.378
MOD_Plk_4 112 118 PF00069 0.351
MOD_Plk_4 216 222 PF00069 0.374
MOD_Plk_4 35 41 PF00069 0.374
MOD_ProDKin_1 219 225 PF00069 0.637
MOD_ProDKin_1 58 64 PF00069 0.454
TRG_DiLeu_BaLyEn_6 323 328 PF01217 0.462
TRG_DiLeu_BaLyEn_6 94 99 PF01217 0.347
TRG_ER_diArg_1 140 142 PF00400 0.341
TRG_ER_diArg_1 170 173 PF00400 0.612
TRG_ER_diArg_1 21 24 PF00400 0.402
TRG_ER_diArg_1 299 301 PF00400 0.460
TRG_NES_CRM1_1 150 165 PF08389 0.354

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I4B3 Leptomonas seymouri 46% 97%
A0A3Q8IA76 Leishmania donovani 76% 100%
A4HZL1 Leishmania infantum 75% 100%
E9AUX3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 74% 100%
Q4QCK9 Leishmania major 74% 99%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS