Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WD domain, G-beta repeat, putative

Species:

Leishmania braziliensis

UniProt:

A4HBK3_LEIBR

TriTrypDb:

LbrM.21.0100 , LBRM2903_210005500

Length:

424

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 8

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	13
GO:0032991	protein-containing complex	1	13
GO:0043226	organelle	2	13
GO:0043228	non-membrane-bounded organelle	3	13
GO:0043229	intracellular organelle	3	13
GO:0043232	intracellular non-membrane-bounded organelle	4	13
GO:0110165	cellular anatomical entity	1	13
GO:1990904	ribonucleoprotein complex	2	13
GO:0005737	cytoplasm	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

A4HBK3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBK3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	10	14	PF00656	0.754
CLV_NRD_NRD_1	133	135	PF00675	0.312
CLV_PCSK_KEX2_1	133	135	PF00082	0.297
CLV_PCSK_KEX2_1	311	313	PF00082	0.461
CLV_PCSK_PC1ET2_1	311	313	PF00082	0.461
CLV_PCSK_SKI1_1	110	114	PF00082	0.476
CLV_PCSK_SKI1_1	162	166	PF00082	0.299
CLV_PCSK_SKI1_1	312	316	PF00082	0.390
CLV_PCSK_SKI1_1	85	89	PF00082	0.518
CLV_PCSK_SKI1_1	95	99	PF00082	0.435
DEG_SCF_FBW7_1	146	152	PF00400	0.541
DOC_CKS1_1	146	151	PF01111	0.541
DOC_MAPK_DCC_7	405	415	PF00069	0.537
DOC_MAPK_gen_1	357	366	PF00069	0.487
DOC_MAPK_gen_1	414	423	PF00069	0.537
DOC_MAPK_gen_1	93	100	PF00069	0.544
DOC_MAPK_MEF2A_6	357	366	PF00069	0.314
DOC_PP4_FxxP_1	370	373	PF00568	0.522
DOC_PP4_FxxP_1	408	411	PF00568	0.281
DOC_USP7_MATH_1	149	153	PF00917	0.464
DOC_USP7_MATH_1	156	160	PF00917	0.453
DOC_USP7_MATH_1	321	325	PF00917	0.565
DOC_USP7_MATH_1	39	43	PF00917	0.678
DOC_USP7_MATH_1	6	10	PF00917	0.506
DOC_USP7_MATH_1	70	74	PF00917	0.665
DOC_USP7_MATH_1	99	103	PF00917	0.450
DOC_USP7_UBL2_3	31	35	PF12436	0.707
DOC_WW_Pin1_4	145	150	PF00397	0.519
LIG_14-3-3_CanoR_1	179	184	PF00244	0.506
LIG_14-3-3_CanoR_1	231	237	PF00244	0.515
LIG_14-3-3_CanoR_1	85	91	PF00244	0.556
LIG_Actin_WH2_2	385	403	PF00022	0.408
LIG_BRCT_BRCA1_1	151	155	PF00533	0.471
LIG_CtBP_PxDLS_1	243	249	PF00389	0.373
LIG_FHA_1	126	132	PF00498	0.463
LIG_FHA_1	161	167	PF00498	0.525
LIG_FHA_1	180	186	PF00498	0.337
LIG_FHA_1	203	209	PF00498	0.462
LIG_FHA_1	345	351	PF00498	0.507
LIG_FHA_1	376	382	PF00498	0.458
LIG_FHA_1	52	58	PF00498	0.588
LIG_FHA_1	6	12	PF00498	0.705
LIG_FHA_1	74	80	PF00498	0.498
LIG_FHA_2	184	190	PF00498	0.523
LIG_FHA_2	278	284	PF00498	0.445
LIG_FHA_2	339	345	PF00498	0.543
LIG_FHA_2	389	395	PF00498	0.411
LIG_FHA_2	42	48	PF00498	0.632
LIG_IBAR_NPY_1	284	286	PF08397	0.540
LIG_LIR_Apic_2	367	373	PF02991	0.531
LIG_LIR_Apic_2	407	411	PF02991	0.445
LIG_LIR_Nem_3	272	276	PF02991	0.360
LIG_LIR_Nem_3	283	289	PF02991	0.479
LIG_LIR_Nem_3	82	87	PF02991	0.448
LIG_Pex14_2	87	91	PF04695	0.427
LIG_SH2_CRK	286	290	PF00017	0.439
LIG_SH2_PTP2	417	420	PF00017	0.547
LIG_SH2_STAT5	301	304	PF00017	0.360
LIG_SH2_STAT5	417	420	PF00017	0.456
LIG_SH3_3	103	109	PF00018	0.436
LIG_SH3_3	279	285	PF00018	0.529
LIG_SUMO_SIM_anti_2	120	125	PF11976	0.445
LIG_SUMO_SIM_par_1	387	394	PF11976	0.429
LIG_SUMO_SIM_par_1	70	78	PF11976	0.541
LIG_TRAF2_1	44	47	PF00917	0.502
LIG_TYR_ITIM	415	420	PF00017	0.527
MOD_CK1_1	171	177	PF00069	0.482
MOD_CK1_1	187	193	PF00069	0.321
MOD_CK1_1	297	303	PF00069	0.425
MOD_CK1_1	338	344	PF00069	0.513
MOD_CK1_1	41	47	PF00069	0.634
MOD_CK1_1	73	79	PF00069	0.456
MOD_CK2_1	171	177	PF00069	0.488
MOD_CK2_1	277	283	PF00069	0.463
MOD_CK2_1	41	47	PF00069	0.728
MOD_Cter_Amidation	309	312	PF01082	0.482
MOD_GlcNHglycan	151	154	PF01048	0.266
MOD_GlcNHglycan	198	201	PF01048	0.250
MOD_GSK3_1	1	8	PF00069	0.699
MOD_GSK3_1	145	152	PF00069	0.487
MOD_GSK3_1	156	163	PF00069	0.425
MOD_GSK3_1	167	174	PF00069	0.494
MOD_GSK3_1	179	186	PF00069	0.414
MOD_GSK3_1	198	205	PF00069	0.455
MOD_GSK3_1	335	342	PF00069	0.493
MOD_GSK3_1	70	77	PF00069	0.564
MOD_N-GLC_1	15	20	PF02516	0.685
MOD_N-GLC_1	171	176	PF02516	0.471
MOD_N-GLC_1	183	188	PF02516	0.192
MOD_N-GLC_2	296	298	PF02516	0.590
MOD_N-GLC_2	3	5	PF02516	0.731
MOD_NEK2_1	1	6	PF00069	0.700
MOD_NEK2_1	154	159	PF00069	0.409
MOD_NEK2_1	183	188	PF00069	0.494
MOD_NEK2_1	196	201	PF00069	0.362
MOD_NEK2_1	232	237	PF00069	0.519
MOD_NEK2_1	262	267	PF00069	0.413
MOD_NEK2_1	287	292	PF00069	0.443
MOD_NEK2_2	335	340	PF00069	0.557
MOD_NMyristoyl	1	7	PF02799	0.730
MOD_PIKK_1	15	21	PF00454	0.640
MOD_PIKK_1	252	258	PF00454	0.303
MOD_Plk_1	117	123	PF00069	0.435
MOD_Plk_1	15	21	PF00069	0.654
MOD_Plk_1	160	166	PF00069	0.509
MOD_Plk_1	183	189	PF00069	0.478
MOD_Plk_1	202	208	PF00069	0.450
MOD_Plk_1	319	325	PF00069	0.545
MOD_Plk_1	52	58	PF00069	0.704
MOD_Plk_4	297	303	PF00069	0.487
MOD_Plk_4	335	341	PF00069	0.528
MOD_Plk_4	53	59	PF00069	0.639
MOD_Plk_4	70	76	PF00069	0.590
MOD_Plk_4	86	92	PF00069	0.511
MOD_ProDKin_1	145	151	PF00069	0.519
MOD_SUMO_rev_2	215	224	PF00179	0.468
MOD_SUMO_rev_2	354	358	PF00179	0.406
TRG_ENDOCYTIC_2	273	276	PF00928	0.376
TRG_ENDOCYTIC_2	286	289	PF00928	0.314
TRG_ENDOCYTIC_2	417	420	PF00928	0.474
TRG_ER_diArg_1	132	134	PF00400	0.350
TRG_ER_diArg_1	413	416	PF00400	0.442

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I307	Leptomonas seymouri	64%	98%
A0A0S4J1I0	Bodo saltans	39%	94%
A0A0S4JE21	Bodo saltans	29%	100%
A0A0S4JL38	Bodo saltans	27%	79%
A0A1X0NQI7	Trypanosomatidae	24%	100%
A0A1X0NYQ0	Trypanosomatidae	39%	94%
A0A3Q8IBR2	Leishmania donovani	79%	100%
A0A3R7KUH0	Trypanosoma rangeli	27%	100%
A0A3R7M2T7	Trypanosoma rangeli	26%	100%
A0A3S7XBP3	Leishmania donovani	21%	83%
A0A422N1P8	Trypanosoma rangeli	25%	95%
A0A422N793	Trypanosoma rangeli	39%	95%
A1CF18	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	27%	97%
A1CUD6	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	24%	91%
A4HZL2	Leishmania infantum	79%	100%
A4IDR0	Leishmania infantum	21%	83%
A4R3M4	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	28%	92%
A7S338	Nematostella vectensis	26%	100%
A8IZG4	Chlamydomonas reinhardtii	25%	100%
B0XM00	Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163)	24%	91%
B4KT48	Drosophila mojavensis	21%	100%
B6GZD3	Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255)	25%	91%
B6QC56	Talaromyces marneffei (strain ATCC 18224 / CBS 334.59 / QM 7333)	26%	92%
B7FNU7	Phaeodactylum tricornutum (strain CCAP 1055/1)	27%	97%
B8M0Q1	Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)	26%	92%
B8P4B0	Postia placenta (strain ATCC 44394 / Madison 698-R)	26%	97%
B8PD53	Postia placenta (strain ATCC 44394 / Madison 698-R)	26%	99%
C4JZS6	Uncinocarpus reesii (strain UAMH 1704)	25%	95%
C4YFX2	Candida albicans (strain WO-1)	23%	83%
C5FWH1	Arthroderma otae (strain ATCC MYA-4605 / CBS 113480)	27%	92%
C7Z6H2	Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)	24%	95%
D0A1J9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	98%
D0A8Z9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
D3BUN1	Polysphondylium pallidum (strain ATCC 26659 / Pp 5 / PN500)	23%	100%
D4AZ50	Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371)	26%	92%
D4DG66	Trichophyton verrucosum (strain HKI 0517)	26%	92%
E9ATR6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	22%	83%
E9AUX2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
O13615	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	21%	90%
O14435	Cryphonectria parasitica	23%	100%
O24076	Medicago sativa	21%	100%
O74319	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	21%	66%
P0CY34	Candida albicans (strain SC5314 / ATCC MYA-2876)	23%	83%
P25387	Chlamydomonas reinhardtii	26%	100%
P39014	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	66%
P69103	Trypanosoma brucei brucei	25%	100%
P69104	Trypanosoma brucei rhodesiense	25%	100%
P83774	Candida albicans (strain SC5314 / ATCC MYA-2876)	22%	100%
Q09855	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	84%
Q0P593	Bos taurus	25%	100%
Q1LV15	Danio rerio	22%	100%
Q2GT28	Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)	23%	94%
Q2TBP4	Bos taurus	26%	100%
Q39190	Arabidopsis thaliana	20%	89%
Q39836	Glycine max	21%	100%
Q3Y8L7	Chlamydomonas reinhardtii	24%	95%
Q42384	Arabidopsis thaliana	22%	87%
Q4ICM0	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	25%	92%
Q4Q0T1	Leishmania major	21%	83%
Q4QCL0	Leishmania major	78%	100%
Q4WLM7	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	24%	91%
Q5A7Q3	Candida albicans (strain SC5314 / ATCC MYA-2876)	26%	100%
Q5BE22	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	23%	94%
Q5RAC9	Pongo abelii	23%	70%
Q676U5	Homo sapiens	24%	70%
Q6CB13	Yarrowia lipolytica (strain CLIB 122 / E 150)	23%	75%
Q6L4F8	Oryza sativa subsp. japonica	25%	100%
Q75BY3	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	27%	100%
Q7T394	Danio rerio	27%	100%
Q8I0F4	Dictyostelium discoideum	28%	100%
Q93794	Caenorhabditis elegans	28%	72%
V5BFZ8	Trypanosoma cruzi	43%	100%
V5BP59	Trypanosoma cruzi	25%	100%
V5DUL4	Trypanosoma cruzi	26%	95%