Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HBK2_LEIBR

TriTrypDb:

LbrM.21.0090 , LBRM2903_210005400

Length:

493

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HBK2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBK2

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	1
GO:0006720	isoprenoid metabolic process	4	1
GO:0008152	metabolic process	1	1
GO:0008299	isoprenoid biosynthetic process	4	1
GO:0008610	lipid biosynthetic process	4	1
GO:0009058	biosynthetic process	2	1
GO:0009987	cellular process	1	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044255	cellular lipid metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	465	471	PF00089	0.360
CLV_NRD_NRD_1	12	14	PF00675	0.403
CLV_NRD_NRD_1	246	248	PF00675	0.424
CLV_NRD_NRD_1	376	378	PF00675	0.455
CLV_NRD_NRD_1	95	97	PF00675	0.442
CLV_PCSK_KEX2_1	12	14	PF00082	0.402
CLV_PCSK_KEX2_1	320	322	PF00082	0.402
CLV_PCSK_KEX2_1	376	378	PF00082	0.475
CLV_PCSK_PC1ET2_1	320	322	PF00082	0.436
CLV_PCSK_SKI1_1	158	162	PF00082	0.396
CLV_PCSK_SKI1_1	21	25	PF00082	0.370
CLV_PCSK_SKI1_1	217	221	PF00082	0.303
CLV_PCSK_SKI1_1	351	355	PF00082	0.334
CLV_PCSK_SKI1_1	64	68	PF00082	0.338
DEG_APCC_DBOX_1	262	270	PF00400	0.393
DOC_CKS1_1	438	443	PF01111	0.465
DOC_CYCLIN_RxL_1	61	71	PF00134	0.367
DOC_CYCLIN_yClb5_NLxxxL_5	286	295	PF00134	0.314
DOC_MAPK_gen_1	247	253	PF00069	0.453
DOC_MAPK_gen_1	376	384	PF00069	0.406
DOC_MAPK_gen_1	480	490	PF00069	0.345
DOC_MAPK_MEF2A_6	483	490	PF00069	0.329
DOC_PP1_RVXF_1	156	163	PF00149	0.416
DOC_PP1_RVXF_1	84	90	PF00149	0.492
DOC_USP7_MATH_1	413	417	PF00917	0.548
DOC_USP7_MATH_1	68	72	PF00917	0.383
DOC_WW_Pin1_4	12	17	PF00397	0.350
DOC_WW_Pin1_4	302	307	PF00397	0.561
DOC_WW_Pin1_4	437	442	PF00397	0.462
LIG_14-3-3_CanoR_1	189	199	PF00244	0.368
LIG_14-3-3_CanoR_1	308	316	PF00244	0.524
LIG_14-3-3_CanoR_1	91	95	PF00244	0.580
LIG_Actin_WH2_2	62	79	PF00022	0.353
LIG_BIR_II_1	1	5	PF00653	0.454
LIG_BIR_III_4	99	103	PF00653	0.443
LIG_Clathr_ClatBox_1	334	338	PF01394	0.271
LIG_eIF4E_1	19	25	PF01652	0.501
LIG_FHA_1	109	115	PF00498	0.537
LIG_FHA_1	118	124	PF00498	0.659
LIG_FHA_1	164	170	PF00498	0.506
LIG_FHA_1	185	191	PF00498	0.491
LIG_FHA_1	2	8	PF00498	0.532
LIG_FHA_1	273	279	PF00498	0.567
LIG_FHA_1	82	88	PF00498	0.375
LIG_FHA_2	162	168	PF00498	0.373
LIG_FHA_2	373	379	PF00498	0.498
LIG_FXI_DFP_1	269	273	PF00024	0.267
LIG_FXI_DFP_1	283	287	PF00024	0.403
LIG_LIR_Apic_2	436	441	PF02991	0.405
LIG_LIR_Gen_1	149	157	PF02991	0.230
LIG_LIR_Gen_1	258	266	PF02991	0.356
LIG_LIR_Gen_1	311	319	PF02991	0.449
LIG_LIR_Gen_1	366	373	PF02991	0.374
LIG_LIR_Nem_3	137	142	PF02991	0.390
LIG_LIR_Nem_3	149	154	PF02991	0.250
LIG_LIR_Nem_3	258	262	PF02991	0.310
LIG_LIR_Nem_3	311	316	PF02991	0.512
LIG_LIR_Nem_3	347	353	PF02991	0.356
LIG_LIR_Nem_3	366	370	PF02991	0.206
LIG_LIR_Nem_3	390	396	PF02991	0.394
LIG_LYPXL_SIV_4	18	26	PF13949	0.424
LIG_Pex14_1	85	89	PF04695	0.357
LIG_Pex14_2	349	353	PF04695	0.434
LIG_SH2_CRK	208	212	PF00017	0.374
LIG_SH2_CRK	313	317	PF00017	0.449
LIG_SH2_CRK	367	371	PF00017	0.366
LIG_SH2_SRC	313	316	PF00017	0.592
LIG_SH2_STAP1	19	23	PF00017	0.497
LIG_SH2_STAP1	367	371	PF00017	0.306
LIG_SH2_STAT5	168	171	PF00017	0.490
LIG_SH2_STAT5	315	318	PF00017	0.476
LIG_SH2_STAT5	393	396	PF00017	0.392
LIG_SH2_STAT5	419	422	PF00017	0.479
LIG_SH3_3	281	287	PF00018	0.423
LIG_SH3_CIN85_PxpxPR_1	59	64	PF14604	0.434
LIG_SUMO_SIM_anti_2	20	26	PF11976	0.494
LIG_SxIP_EBH_1	387	400	PF03271	0.440
LIG_UBA3_1	66	74	PF00899	0.508
LIG_WW_3	305	309	PF00397	0.549
MOD_CDC14_SPxK_1	305	308	PF00782	0.557
MOD_CDK_SPK_2	437	442	PF00069	0.307
MOD_CDK_SPxK_1	302	308	PF00069	0.554
MOD_CK1_1	2	8	PF00069	0.470
MOD_CK1_1	386	392	PF00069	0.482
MOD_CK1_1	422	428	PF00069	0.400
MOD_CK1_1	90	96	PF00069	0.469
MOD_CK2_1	255	261	PF00069	0.449
MOD_CK2_1	323	329	PF00069	0.603
MOD_CK2_1	372	378	PF00069	0.515
MOD_GlcNHglycan	124	127	PF01048	0.542
MOD_GlcNHglycan	148	151	PF01048	0.480
MOD_GlcNHglycan	154	157	PF01048	0.391
MOD_GlcNHglycan	308	311	PF01048	0.563
MOD_GlcNHglycan	316	319	PF01048	0.474
MOD_GlcNHglycan	322	326	PF01048	0.480
MOD_GlcNHglycan	329	332	PF01048	0.392
MOD_GlcNHglycan	366	370	PF01048	0.339
MOD_GlcNHglycan	411	414	PF01048	0.471
MOD_GlcNHglycan	415	418	PF01048	0.521
MOD_GlcNHglycan	77	80	PF01048	0.491
MOD_GSK3_1	109	116	PF00069	0.574
MOD_GSK3_1	297	304	PF00069	0.560
MOD_GSK3_1	323	330	PF00069	0.483
MOD_GSK3_1	37	44	PF00069	0.511
MOD_GSK3_1	383	390	PF00069	0.434
MOD_GSK3_1	394	401	PF00069	0.512
MOD_GSK3_1	409	416	PF00069	0.404
MOD_GSK3_1	422	429	PF00069	0.338
MOD_N-GLC_2	36	38	PF02516	0.402
MOD_NEK2_1	113	118	PF00069	0.454
MOD_NEK2_1	272	277	PF00069	0.374
MOD_NEK2_1	291	296	PF00069	0.434
MOD_NEK2_1	383	388	PF00069	0.409
MOD_NEK2_1	396	401	PF00069	0.442
MOD_NEK2_1	486	491	PF00069	0.329
MOD_NEK2_1	67	72	PF00069	0.406
MOD_NEK2_1	87	92	PF00069	0.386
MOD_PIKK_1	221	227	PF00454	0.404
MOD_PIKK_1	394	400	PF00454	0.616
MOD_PKA_1	320	326	PF00069	0.487
MOD_PKA_2	320	326	PF00069	0.436
MOD_PKA_2	422	428	PF00069	0.437
MOD_PKA_2	90	96	PF00069	0.540
MOD_Plk_1	108	114	PF00069	0.622
MOD_Plk_1	365	371	PF00069	0.331
MOD_Plk_4	109	115	PF00069	0.562
MOD_Plk_4	128	134	PF00069	0.536
MOD_Plk_4	255	261	PF00069	0.359
MOD_Plk_4	389	395	PF00069	0.483
MOD_Plk_4	415	421	PF00069	0.461
MOD_Plk_4	422	428	PF00069	0.352
MOD_Plk_4	474	480	PF00069	0.664
MOD_Plk_4	486	492	PF00069	0.349
MOD_ProDKin_1	12	18	PF00069	0.342
MOD_ProDKin_1	302	308	PF00069	0.564
MOD_ProDKin_1	437	443	PF00069	0.468
TRG_DiLeu_BaEn_1	20	25	PF01217	0.510
TRG_DiLeu_BaEn_1	6	11	PF01217	0.535
TRG_DiLeu_BaLyEn_6	401	406	PF01217	0.459
TRG_ENDOCYTIC_2	139	142	PF00928	0.391
TRG_ENDOCYTIC_2	19	22	PF00928	0.496
TRG_ENDOCYTIC_2	208	211	PF00928	0.328
TRG_ENDOCYTIC_2	313	316	PF00928	0.459
TRG_ENDOCYTIC_2	350	353	PF00928	0.306
TRG_ENDOCYTIC_2	367	370	PF00928	0.307
TRG_ENDOCYTIC_2	393	396	PF00928	0.487
TRG_ER_diArg_1	11	13	PF00400	0.417
TRG_Pf-PMV_PEXEL_1	12	17	PF00026	0.482
TRG_Pf-PMV_PEXEL_1	189	194	PF00026	0.455

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWC8	Leptomonas seymouri	48%	97%
A0A1X0NXR3	Trypanosomatidae	27%	92%
A0A3Q8IBT1	Leishmania donovani	81%	100%
A0A3R7K7L8	Trypanosoma rangeli	28%	94%
A4HZL3	Leishmania infantum	81%	100%
D0A1J8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	96%
E9AUX1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4QCL1	Leishmania major	80%	100%
V5BQ24	Trypanosoma cruzi	25%	100%