Putative syntaxin

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Putative syntaxin

Gene product:

syntaxin, putative

Species:

Leishmania braziliensis

UniProt:

A4HBK1_LEIBR

TriTrypDb:

LbrM.21.0080 , LBRM2903_210005300

Length:

233

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	14
GO:0110165	cellular anatomical entity	1	14
GO:0005886	plasma membrane	3	1
GO:0012505	endomembrane system	2	1
GO:0031201	SNARE complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0098796	membrane protein complex	2	1

Expansion

Sequence features

A4HBK1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBK1

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	5
GO:0006886	intracellular protein transport	4	1
GO:0006887	exocytosis	4	1
GO:0006906	vesicle fusion	6	1
GO:0006996	organelle organization	4	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0016043	cellular component organization	3	1
GO:0016050	vesicle organization	5	1
GO:0016192	vesicle-mediated transport	4	5
GO:0022406	membrane docking	2	1
GO:0032940	secretion by cell	3	1
GO:0033036	macromolecule localization	2	1
GO:0045184	establishment of protein localization	3	1
GO:0046903	secretion	4	1
GO:0046907	intracellular transport	3	1
GO:0048278	vesicle docking	4	1
GO:0048284	organelle fusion	5	1
GO:0051179	localization	1	5
GO:0051234	establishment of localization	2	5
GO:0051640	organelle localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0061024	membrane organization	4	1
GO:0061025	membrane fusion	5	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0090174	organelle membrane fusion	6	1
GO:0140056	organelle localization by membrane tethering	3	1
GO:0140352	export from cell	2	1

Molecular functions
Term	Name	Level	Count
GO:0000149	SNARE binding	3	1
GO:0005484	SNAP receptor activity	3	1
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0030674	protein-macromolecule adaptor activity	2	1
GO:0060090	molecular adaptor activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	57	61	PF00082	0.364
CLV_Separin_Metazoa	58	62	PF03568	0.539
DEG_Nend_Nbox_1	1	3	PF02207	0.735
DOC_MAPK_gen_1	211	219	PF00069	0.455
DOC_MAPK_MEF2A_6	185	194	PF00069	0.519
DOC_MAPK_MEF2A_6	213	221	PF00069	0.297
DOC_USP7_MATH_1	115	119	PF00917	0.655
DOC_USP7_MATH_1	206	210	PF00917	0.458
DOC_USP7_MATH_2	130	136	PF00917	0.531
DOC_WW_Pin1_4	32	37	PF00397	0.612
LIG_14-3-3_CanoR_1	154	158	PF00244	0.622
LIG_Actin_WH2_2	148	165	PF00022	0.605
LIG_Actin_WH2_2	180	197	PF00022	0.519
LIG_AP2alpha_2	5	7	PF02296	0.543
LIG_APCC_ABBA_1	167	172	PF00400	0.695
LIG_CaM_IQ_9	187	202	PF13499	0.496
LIG_FHA_1	154	160	PF00498	0.653
LIG_FHA_1	173	179	PF00498	0.573
LIG_LIR_LC3C_4	16	19	PF02991	0.533
LIG_PCNA_yPIPBox_3	193	205	PF02747	0.467
LIG_PTB_Apo_2	1	8	PF02174	0.499
LIG_REV1ctd_RIR_1	227	233	PF16727	0.186
LIG_SH2_STAP1	101	105	PF00017	0.545
LIG_SH3_3	116	122	PF00018	0.642
LIG_SH3_3	30	36	PF00018	0.647
LIG_TRAF2_1	48	51	PF00917	0.559
LIG_TYR_ITIM	99	104	PF00017	0.435
LIG_UBA3_1	204	213	PF00899	0.464
LIG_UBA3_1	52	57	PF00899	0.611
MOD_CK1_1	135	141	PF00069	0.653
MOD_CK1_1	35	41	PF00069	0.614
MOD_CK1_1	89	95	PF00069	0.527
MOD_CK2_1	35	41	PF00069	0.596
MOD_CK2_1	45	51	PF00069	0.543
MOD_CK2_1	7	13	PF00069	0.583
MOD_CK2_1	73	79	PF00069	0.545
MOD_GlcNHglycan	106	109	PF01048	0.420
MOD_GlcNHglycan	134	137	PF01048	0.514
MOD_GlcNHglycan	37	40	PF01048	0.367
MOD_GlcNHglycan	47	50	PF01048	0.411
MOD_GlcNHglycan	75	78	PF01048	0.409
MOD_GSK3_1	82	89	PF00069	0.608
MOD_N-GLC_1	7	12	PF02516	0.339
MOD_NEK2_1	162	167	PF00069	0.603
MOD_NEK2_1	204	209	PF00069	0.499
MOD_NEK2_1	7	12	PF00069	0.537
MOD_PIKK_1	172	178	PF00454	0.701
MOD_PIKK_1	26	32	PF00454	0.645
MOD_PKA_2	153	159	PF00069	0.617
MOD_PKA_2	162	168	PF00069	0.633
MOD_PKA_2	42	48	PF00069	0.615
MOD_PKA_2	82	88	PF00069	0.530
MOD_Plk_1	115	121	PF00069	0.531
MOD_Plk_1	185	191	PF00069	0.374
MOD_Plk_1	7	13	PF00069	0.544
MOD_Plk_4	82	88	PF00069	0.508
MOD_ProDKin_1	32	38	PF00069	0.609
MOD_SUMO_rev_2	143	147	PF00179	0.672
MOD_SUMO_rev_2	38	48	PF00179	0.607
TRG_DiLeu_BaEn_1	13	18	PF01217	0.486
TRG_DiLeu_BaEn_3	50	56	PF01217	0.588
TRG_ENDOCYTIC_2	101	104	PF00928	0.617
TRG_ER_diArg_1	111	114	PF00400	0.678
TRG_ER_diArg_1	192	195	PF00400	0.500
TRG_ER_FFAT_2	131	138	PF00635	0.628
TRG_NES_CRM1_1	50	65	PF08389	0.549
TRG_Pf-PMV_PEXEL_1	12	16	PF00026	0.381
TRG_Pf-PMV_PEXEL_1	160	164	PF00026	0.453
TRG_Pf-PMV_PEXEL_1	88	93	PF00026	0.341

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4C8	Leptomonas seymouri	69%	98%
A0A0N1IK90	Leptomonas seymouri	38%	90%
A0A0S4J237	Bodo saltans	29%	81%
A0A0S4JJL1	Bodo saltans	29%	95%
A0A1X0NSP4	Trypanosomatidae	29%	97%
A0A1X0NXA4	Trypanosomatidae	43%	100%
A0A3Q8IBW4	Leishmania donovani	84%	100%
A0A3R7M3G3	Trypanosoma rangeli	42%	100%
A4HES4	Leishmania braziliensis	37%	93%
A4HZL4	Leishmania infantum	84%	100%
D0A1J7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9AUX0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4QCL2	Leishmania major	83%	100%