BAR domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HBK0_LEIBR

TriTrypDb:

LbrM.21.0070 , LBRM2903_210005200

Length:

243

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 6
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 21

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 10

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 25
NetGPI	no	yes: 0, no: 25

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005886	plasma membrane	3	1
GO:0016020	membrane	2	1
GO:0031090	organelle membrane	3	1
GO:0031253	cell projection membrane	4	1
GO:0060170	ciliary membrane	5	1
GO:0098588	bounding membrane of organelle	4	1
GO:0098590	plasma membrane region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HBK0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBK0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	147	149	PF00675	0.565
CLV_NRD_NRD_1	21	23	PF00675	0.566
CLV_PCSK_FUR_1	21	25	PF00082	0.566
CLV_PCSK_KEX2_1	165	167	PF00082	0.430
CLV_PCSK_KEX2_1	21	23	PF00082	0.479
CLV_PCSK_KEX2_1	221	223	PF00082	0.570
CLV_PCSK_PC1ET2_1	165	167	PF00082	0.350
CLV_PCSK_PC1ET2_1	221	223	PF00082	0.553
CLV_PCSK_PC1ET2_1	23	25	PF00082	0.490
CLV_PCSK_SKI1_1	151	155	PF00082	0.442
CLV_PCSK_SKI1_1	24	28	PF00082	0.444
CLV_PCSK_SKI1_1	5	9	PF00082	0.582
DEG_Nend_Nbox_1	1	3	PF02207	0.575
DOC_MAPK_gen_1	165	173	PF00069	0.289
DOC_USP7_MATH_1	153	157	PF00917	0.361
DOC_USP7_MATH_1	32	36	PF00917	0.450
DOC_USP7_MATH_1	43	47	PF00917	0.457
DOC_USP7_MATH_1	99	103	PF00917	0.450
DOC_USP7_UBL2_3	127	131	PF12436	0.470
DOC_USP7_UBL2_3	23	27	PF12436	0.344
DOC_USP7_UBL2_3	5	9	PF12436	0.590
LIG_14-3-3_CanoR_1	191	199	PF00244	0.524
LIG_14-3-3_CanoR_1	222	230	PF00244	0.300
LIG_Actin_WH2_2	206	223	PF00022	0.516
LIG_APCC_ABBA_1	233	238	PF00400	0.367
LIG_BRCT_BRCA1_1	213	217	PF00533	0.423
LIG_DCNL_PONY_1	1	4	PF03556	0.574
LIG_FHA_1	194	200	PF00498	0.570
LIG_FHA_1	76	82	PF00498	0.318
LIG_FHA_2	12	18	PF00498	0.517
LIG_LIR_Nem_3	214	220	PF02991	0.510
LIG_Rb_pABgroove_1	109	117	PF01858	0.354
LIG_SH2_GRB2like	239	242	PF00017	0.418
LIG_SH2_STAP1	115	119	PF00017	0.385
LIG_SH2_STAT5	159	162	PF00017	0.403
LIG_SH3_3	65	71	PF00018	0.549
LIG_SUMO_SIM_par_1	76	82	PF11976	0.263
LIG_UBA3_1	1	9	PF00899	0.689
MOD_CK1_1	223	229	PF00069	0.424
MOD_CK1_1	35	41	PF00069	0.468
MOD_CK2_1	11	17	PF00069	0.544
MOD_CK2_1	137	143	PF00069	0.459
MOD_GlcNHglycan	105	108	PF01048	0.276
MOD_GlcNHglycan	225	228	PF01048	0.478
MOD_GlcNHglycan	37	40	PF01048	0.529
MOD_GlcNHglycan	93	96	PF01048	0.318
MOD_GSK3_1	137	144	PF00069	0.487
MOD_GSK3_1	3	10	PF00069	0.633
MOD_GSK3_1	71	78	PF00069	0.423
MOD_GSK3_1	99	106	PF00069	0.416
MOD_N-GLC_1	71	76	PF02516	0.484
MOD_NEK2_1	100	105	PF00069	0.311
MOD_NEK2_1	203	208	PF00069	0.493
MOD_NEK2_1	79	84	PF00069	0.520
MOD_PIKK_1	11	17	PF00454	0.381
MOD_PIKK_1	185	191	PF00454	0.332
MOD_PK_1	141	147	PF00069	0.300
MOD_PKA_1	141	147	PF00069	0.449
MOD_PKA_1	221	227	PF00069	0.293
MOD_PKA_2	147	153	PF00069	0.525
MOD_PKA_2	190	196	PF00069	0.282
MOD_PKA_2	221	227	PF00069	0.296
MOD_Plk_1	100	106	PF00069	0.417
MOD_Plk_1	75	81	PF00069	0.434
MOD_Plk_4	100	106	PF00069	0.422
MOD_Plk_4	141	147	PF00069	0.591
MOD_Plk_4	3	9	PF00069	0.448
MOD_SUMO_for_1	119	122	PF00179	0.278
MOD_SUMO_rev_2	106	114	PF00179	0.515
MOD_SUMO_rev_2	174	180	PF00179	0.525
TRG_ER_diArg_1	21	24	PF00400	0.571
TRG_NLS_MonoExtN_4	21	26	PF00514	0.315

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4S1	Leptomonas seymouri	54%	100%
A0A0N1PD85	Leptomonas seymouri	33%	100%
A0A1X0NEE3	Trypanosomatidae	24%	88%
A0A1X0NFG5	Trypanosomatidae	24%	88%
A0A1X0NXA6	Trypanosomatidae	28%	80%
A0A1X0NXA8	Trypanosomatidae	35%	100%
A0A3Q8IKU7	Leishmania donovani	30%	100%
A0A3R7KX22	Trypanosoma rangeli	21%	89%
A0A3S5H792	Leishmania donovani	63%	99%
A0A3S5H7I1	Leishmania donovani	21%	72%
A0A422MZP2	Trypanosoma rangeli	26%	80%
A4HBJ9	Leishmania braziliensis	31%	100%
A4HZL5	Leishmania infantum	63%	99%
A4HZL6	Leishmania infantum	30%	100%
A4I2W4	Leishmania infantum	21%	72%
E9ADF0	Leishmania major	21%	71%
E9AUW8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9AUW9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	60%	99%
E9AZ74	Leishmania mexicana (strain MHOM/GT/2001/U1103)	22%	71%
Q4Q6I6	Leishmania major	23%	100%
Q4QCL3	Leishmania major	60%	100%
Q4QCL4	Leishmania major	30%	100%
V5BG41	Trypanosoma cruzi	34%	100%
V5BKK3	Trypanosoma cruzi	24%	80%