BAR domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HBJ9_LEIBR

TriTrypDb:

LbrM.21.0060 , LBRM2903_210005100

Length:

231

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 9

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 17
NetGPI	no	yes: 0, no: 17

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HBJ9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBJ9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	136	140	PF00656	0.404
CLV_NRD_NRD_1	114	116	PF00675	0.291
CLV_NRD_NRD_1	126	128	PF00675	0.347
CLV_NRD_NRD_1	150	152	PF00675	0.623
CLV_NRD_NRD_1	167	169	PF00675	0.547
CLV_NRD_NRD_1	223	225	PF00675	0.579
CLV_PCSK_KEX2_1	114	116	PF00082	0.551
CLV_PCSK_KEX2_1	126	128	PF00082	0.550
CLV_PCSK_KEX2_1	149	151	PF00082	0.510
CLV_PCSK_KEX2_1	167	169	PF00082	0.482
CLV_PCSK_KEX2_1	223	225	PF00082	0.547
CLV_PCSK_PC1ET2_1	223	225	PF00082	0.575
CLV_PCSK_SKI1_1	101	105	PF00082	0.483
CLV_PCSK_SKI1_1	115	119	PF00082	0.357
CLV_PCSK_SKI1_1	180	184	PF00082	0.417
CLV_PCSK_SKI1_1	3	7	PF00082	0.489
CLV_PCSK_SKI1_1	9	13	PF00082	0.457
DEG_Nend_UBRbox_1	1	4	PF02207	0.491
DOC_MAPK_gen_1	180	189	PF00069	0.281
DOC_MAPK_gen_1	223	231	PF00069	0.498
DOC_MAPK_MEF2A_6	198	205	PF00069	0.273
DOC_MAPK_RevD_3	111	127	PF00069	0.332
LIG_14-3-3_CanoR_1	114	123	PF00244	0.531
LIG_14-3-3_CanoR_1	150	156	PF00244	0.595
LIG_14-3-3_CanoR_1	90	100	PF00244	0.416
LIG_BRCT_BRCA1_1	61	65	PF00533	0.445
LIG_FHA_1	92	98	PF00498	0.387
LIG_FHA_2	134	140	PF00498	0.536
LIG_FHA_2	211	217	PF00498	0.455
LIG_FHA_2	34	40	PF00498	0.559
LIG_LIR_Gen_1	20	30	PF02991	0.280
LIG_LIR_Gen_1	207	215	PF02991	0.458
LIG_LIR_Gen_1	62	70	PF02991	0.494
LIG_LIR_Nem_3	132	137	PF02991	0.454
LIG_LIR_Nem_3	207	211	PF02991	0.461
LIG_LRP6_Inhibitor_1	125	131	PF00058	0.277
LIG_PCNA_PIPBox_1	78	87	PF02747	0.427
LIG_PDZ_Class_2	226	231	PF00595	0.628
LIG_SH2_CRK	85	89	PF00017	0.273
LIG_SH2_STAP1	85	89	PF00017	0.349
LIG_SH2_STAT5	204	207	PF00017	0.489
LIG_SH2_STAT5	40	43	PF00017	0.290
LIG_SH2_STAT5	85	88	PF00017	0.517
LIG_TYR_ITIM	184	189	PF00017	0.258
LIG_WRC_WIRS_1	205	210	PF05994	0.279
MOD_CK1_1	77	83	PF00069	0.542
MOD_CK2_1	106	112	PF00069	0.504
MOD_CK2_1	139	145	PF00069	0.539
MOD_CK2_1	151	157	PF00069	0.537
MOD_CK2_1	210	216	PF00069	0.451
MOD_CK2_1	33	39	PF00069	0.569
MOD_GlcNHglycan	188	192	PF01048	0.389
MOD_GlcNHglycan	48	51	PF01048	0.454
MOD_GSK3_1	129	136	PF00069	0.437
MOD_GSK3_1	139	146	PF00069	0.511
MOD_GSK3_1	151	158	PF00069	0.551
MOD_GSK3_1	206	213	PF00069	0.464
MOD_GSK3_1	29	36	PF00069	0.423
MOD_NEK2_1	116	121	PF00069	0.509
MOD_NEK2_1	155	160	PF00069	0.448
MOD_NEK2_1	187	192	PF00069	0.505
MOD_NEK2_1	5	10	PF00069	0.454
MOD_NEK2_1	88	93	PF00069	0.518
MOD_PIKK_1	206	212	PF00454	0.397
MOD_PKA_1	143	149	PF00069	0.460
MOD_PKA_1	167	173	PF00069	0.480
MOD_PKA_2	167	173	PF00069	0.480
MOD_PKB_1	149	157	PF00069	0.341
MOD_Plk_1	106	112	PF00069	0.515
MOD_Plk_1	187	193	PF00069	0.370
MOD_Plk_1	24	30	PF00069	0.433
MOD_Plk_2-3	106	112	PF00069	0.561
MOD_Plk_2-3	133	139	PF00069	0.493
MOD_Plk_2-3	39	45	PF00069	0.286
MOD_Plk_4	143	149	PF00069	0.585
MOD_SUMO_for_1	171	174	PF00179	0.288
MOD_SUMO_rev_2	154	160	PF00179	0.610
MOD_SUMO_rev_2	176	184	PF00179	0.532
MOD_SUMO_rev_2	95	103	PF00179	0.493
TRG_DiLeu_BaEn_1	112	117	PF01217	0.489
TRG_ENDOCYTIC_2	186	189	PF00928	0.396
TRG_ENDOCYTIC_2	23	26	PF00928	0.473
TRG_ENDOCYTIC_2	85	88	PF00928	0.443
TRG_ER_diArg_1	113	115	PF00400	0.292
TRG_ER_diArg_1	148	151	PF00400	0.337
TRG_Pf-PMV_PEXEL_1	153	157	PF00026	0.372

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4S1	Leptomonas seymouri	31%	97%
A0A0N1PD85	Leptomonas seymouri	47%	100%
A0A1X0NXA6	Trypanosomatidae	27%	76%
A0A1X0NXA8	Trypanosomatidae	36%	99%
A0A3Q8IKU7	Leishmania donovani	55%	100%
A0A3S5H792	Leishmania donovani	34%	94%
A0A422MZP2	Trypanosoma rangeli	25%	76%
A4HBK0	Leishmania braziliensis	31%	95%
A4HZL5	Leishmania infantum	34%	94%
A4HZL6	Leishmania infantum	55%	100%
E9AUW8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	53%	100%
E9AUW9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	94%
Q4QCL3	Leishmania major	34%	100%
Q4QCL4	Leishmania major	54%	100%
V5BG41	Trypanosoma cruzi	33%	99%
V5BKK3	Trypanosoma cruzi	25%	76%