Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HBJ8_LEIBR

TriTrypDb:

LbrM.21.0050

Length:

255

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HBJ8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBJ8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	204	208	PF00656	0.281
CLV_NRD_NRD_1	161	163	PF00675	0.442
CLV_NRD_NRD_1	79	81	PF00675	0.529
CLV_NRD_NRD_1	9	11	PF00675	0.502
CLV_PCSK_KEX2_1	161	163	PF00082	0.442
CLV_PCSK_KEX2_1	69	71	PF00082	0.515
CLV_PCSK_KEX2_1	78	80	PF00082	0.481
CLV_PCSK_KEX2_1	9	11	PF00082	0.519
CLV_PCSK_PC1ET2_1	69	71	PF00082	0.435
CLV_PCSK_PC7_1	5	11	PF00082	0.432
CLV_PCSK_PC7_1	75	81	PF00082	0.561
CLV_PCSK_SKI1_1	140	144	PF00082	0.493
DEG_APCC_DBOX_1	112	120	PF00400	0.386
DEG_APCC_DBOX_1	164	172	PF00400	0.348
DEG_SPOP_SBC_1	23	27	PF00917	0.412
DOC_MAPK_gen_1	235	244	PF00069	0.382
DOC_MAPK_gen_1	75	85	PF00069	0.441
DOC_MAPK_MEF2A_6	100	108	PF00069	0.460
DOC_USP7_MATH_1	24	28	PF00917	0.516
DOC_WW_Pin1_4	122	127	PF00397	0.278
DOC_WW_Pin1_4	163	168	PF00397	0.475
DOC_WW_Pin1_4	193	198	PF00397	0.442
DOC_WW_Pin1_4	62	67	PF00397	0.559
LIG_14-3-3_CanoR_1	140	145	PF00244	0.414
LIG_14-3-3_CanoR_1	43	48	PF00244	0.433
LIG_14-3-3_CanoR_1	5	9	PF00244	0.568
LIG_BIR_II_1	1	5	PF00653	0.494
LIG_BRCT_BRCA1_1	138	142	PF00533	0.353
LIG_BRCT_BRCA1_1	63	67	PF00533	0.322
LIG_BRCT_BRCA1_1	87	91	PF00533	0.364
LIG_BRCT_BRCA1_2	63	69	PF00533	0.350
LIG_CtBP_PxDLS_1	134	140	PF00389	0.339
LIG_FHA_1	127	133	PF00498	0.522
LIG_FHA_2	219	225	PF00498	0.243
LIG_LIR_Apic_2	143	147	PF02991	0.294
LIG_LIR_Gen_1	239	249	PF02991	0.490
LIG_LIR_Gen_1	42	52	PF02991	0.415
LIG_LIR_Nem_3	239	244	PF02991	0.485
LIG_LIR_Nem_3	42	48	PF02991	0.326
LIG_MYND_3	249	253	PF01753	0.456
LIG_PCNA_yPIPBox_3	28	40	PF02747	0.299
LIG_PDZ_Class_3	250	255	PF00595	0.407
LIG_SH2_CRK	144	148	PF00017	0.380
LIG_SH2_CRK	164	168	PF00017	0.342
LIG_SH2_STAT5	225	228	PF00017	0.360
LIG_UBA3_1	248	254	PF00899	0.344
MOD_CDK_SPxxK_3	62	69	PF00069	0.540
MOD_CK1_1	109	115	PF00069	0.283
MOD_CK1_1	188	194	PF00069	0.486
MOD_CK1_1	22	28	PF00069	0.662
MOD_CK2_1	127	133	PF00069	0.494
MOD_CK2_1	218	224	PF00069	0.240
MOD_Cter_Amidation	159	162	PF01082	0.340
MOD_GSK3_1	122	129	PF00069	0.359
MOD_GSK3_1	136	143	PF00069	0.338
MOD_GSK3_1	184	191	PF00069	0.469
MOD_GSK3_1	19	26	PF00069	0.455
MOD_GSK3_1	193	200	PF00069	0.390
MOD_GSK3_1	39	46	PF00069	0.352
MOD_GSK3_1	48	55	PF00069	0.352
MOD_N-GLC_1	149	154	PF02516	0.420
MOD_N-GLC_1	242	247	PF02516	0.293
MOD_N-GLC_1	52	57	PF02516	0.471
MOD_N-GLC_2	97	99	PF02516	0.403
MOD_NEK2_1	106	111	PF00069	0.379
MOD_NEK2_1	11	16	PF00069	0.526
MOD_NEK2_1	149	154	PF00069	0.445
MOD_NEK2_1	185	190	PF00069	0.344
MOD_NEK2_1	19	24	PF00069	0.632
MOD_NEK2_1	205	210	PF00069	0.231
MOD_NEK2_1	34	39	PF00069	0.468
MOD_NEK2_1	4	9	PF00069	0.564
MOD_NEK2_1	48	53	PF00069	0.327
MOD_NEK2_2	197	202	PF00069	0.486
MOD_PKA_2	4	10	PF00069	0.721
MOD_Plk_1	149	155	PF00069	0.424
MOD_Plk_1	218	224	PF00069	0.486
MOD_Plk_4	127	133	PF00069	0.464
MOD_ProDKin_1	122	128	PF00069	0.284
MOD_ProDKin_1	163	169	PF00069	0.475
MOD_ProDKin_1	193	199	PF00069	0.443
MOD_ProDKin_1	62	68	PF00069	0.574
MOD_SUMO_for_1	201	204	PF00179	0.428
MOD_SUMO_rev_2	224	230	PF00179	0.380
TRG_ER_diArg_1	161	163	PF00400	0.442
TRG_ER_diArg_1	77	80	PF00400	0.521
TRG_ER_diArg_1	8	10	PF00400	0.434
TRG_NES_CRM1_1	207	220	PF08389	0.333

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4IYT2	Bodo saltans	29%	79%
A0A1X0NXA5	Trypanosomatidae	30%	94%
A0A3Q8IB00	Leishmania donovani	63%	100%
A0A3R7N8W3	Trypanosoma rangeli	30%	97%
D0A1J5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	85%
E9AGU4	Leishmania infantum	63%	100%
E9AUW7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	64%	100%
Q4QCL5	Leishmania major	65%	100%