Putative ring-box protein 1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ring-box protein 1, putative

Species:

Leishmania braziliensis

UniProt:

A4HBJ7_LEIBR

TriTrypDb:

LbrM.21.0040 , LBRM2903_240023900

Length:

103

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0000151	ubiquitin ligase complex	3	1
GO:0005634	nucleus	5	1
GO:0031461	cullin-RING ubiquitin ligase complex	4	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:0140535	intracellular protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1990234	transferase complex	3	1

Expansion

Sequence features

A4HBJ7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBJ7

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006511	ubiquitin-dependent protein catabolic process	7	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009987	cellular process	1	1
GO:0016567	protein ubiquitination	7	1
GO:0019538	protein metabolic process	3	1
GO:0019941	modification-dependent protein catabolic process	6	1
GO:0032446	protein modification by small protein conjugation	6	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043632	modification-dependent macromolecule catabolic process	5	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0051603	proteolysis involved in protein catabolic process	5	1
GO:0070647	protein modification by small protein conjugation or removal	5	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	8
GO:0008270	zinc ion binding	6	8
GO:0043167	ion binding	2	8
GO:0043169	cation binding	3	8
GO:0046872	metal ion binding	4	8
GO:0046914	transition metal ion binding	5	8
GO:0003824	catalytic activity	1	1
GO:0004842	ubiquitin-protein transferase activity	4	1
GO:0005515	protein binding	2	1
GO:0016740	transferase activity	2	1
GO:0019787	ubiquitin-like protein transferase activity	3	1
GO:0061630	ubiquitin protein ligase activity	5	1
GO:0061659	ubiquitin-like protein ligase activity	4	1
GO:0097602	cullin family protein binding	3	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	81	85	PF00082	0.231
DEG_Nend_UBRbox_2	1	3	PF02207	0.475
DEG_SCF_TRCP1_1	11	16	PF00400	0.364
DOC_MAPK_gen_1	21	28	PF00069	0.396
DOC_MAPK_MEF2A_6	42	50	PF00069	0.431
DOC_USP7_MATH_1	9	13	PF00917	0.521
LIG_FHA_1	35	41	PF00498	0.268
LIG_FHA_1	83	89	PF00498	0.480
LIG_LIR_Gen_1	95	103	PF02991	0.393
LIG_LIR_Nem_3	95	101	PF02991	0.369
LIG_PDZ_Class_2	98	103	PF00595	0.421
LIG_SH2_STAT5	98	101	PF00017	0.469
MOD_CK1_1	54	60	PF00069	0.522
MOD_GlcNHglycan	11	14	PF01048	0.589
MOD_GSK3_1	9	16	PF00069	0.442
MOD_N-GLC_2	87	89	PF02516	0.231
MOD_NEK2_1	4	9	PF00069	0.400
MOD_OFUCOSY	52	58	PF10250	0.286
MOD_Plk_1	61	67	PF00069	0.480

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7V1	Leptomonas seymouri	43%	88%
A0A0N0P965	Leptomonas seymouri	36%	100%
A0A0N1I1Q1	Leptomonas seymouri	30%	100%
A0A0S4IYF9	Bodo saltans	74%	74%
A0A0S4J7B6	Bodo saltans	67%	70%
A0A0S4JR26	Bodo saltans	32%	100%
A0A0S4KL27	Bodo saltans	64%	94%
A0A1X0NQI6	Trypanosomatidae	31%	100%
A0A1X0NXY1	Trypanosomatidae	78%	97%
A0A3S7WW78	Leishmania donovani	89%	97%
A0A3S7WYG9	Leishmania donovani	45%	87%
A0A3S7X9W9	Leishmania donovani	34%	100%
A0A422MW18	Trypanosoma rangeli	31%	100%
A0A422MZP5	Trypanosoma rangeli	77%	79%
A4HDM1	Leishmania braziliensis	45%	87%
A4HNB7	Leishmania braziliensis	34%	100%
A4HZL7	Leishmania infantum	89%	97%
A4IBZ0	Leishmania infantum	34%	100%
C9ZYL4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
D0A1J4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	69%	97%
E9AFS7	Leishmania major	34%	100%
E9AH68	Leishmania infantum	45%	87%
E9AUW6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	97%
E9AX06	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	87%
E9B6X9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
O13959	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	76%	96%
P62877	Homo sapiens	71%	95%
P62878	Mus musculus	71%	95%
Q08273	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	54%	85%
Q20052	Caenorhabditis elegans	33%	76%
Q23457	Caenorhabditis elegans	69%	94%
Q3ZCF6	Bos taurus	39%	100%
Q4QAH0	Leishmania major	45%	100%
Q4QCL6	Leishmania major	90%	100%
Q54K33	Dictyostelium discoideum	63%	99%
Q54L48	Dictyostelium discoideum	41%	100%
Q5R8A2	Pongo abelii	38%	100%
Q8QG64	Salmo salar	71%	95%
Q940X7	Arabidopsis thaliana	72%	87%
Q9CPX9	Mus musculus	38%	100%
Q9M2B0	Arabidopsis thaliana	74%	90%
Q9M9L0	Arabidopsis thaliana	40%	100%
Q9NHX0	Drosophila melanogaster	64%	84%
Q9NYG5	Homo sapiens	38%	100%
Q9UBF6	Homo sapiens	55%	91%
Q9UT86	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	37%	100%
Q9W5E1	Drosophila melanogaster	70%	95%
Q9WTZ1	Mus musculus	55%	91%
V5BCN0	Trypanosoma cruzi	31%	100%
V5DH15	Trypanosoma cruzi	72%	68%