Histone H4

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Histone H4

Gene product:

histone H4

Species:

Leishmania braziliensis

UniProt:

A4HBJ5_LEIBR

TriTrypDb:

LbrM.21.0020 , LBRM2903_300009500

Length:

106

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 1
NetGPI	no	yes: 0, no: 1

Cellular components
Term	Name	Level	Count
GO:0000786	nucleosome	3	2
GO:0005634	nucleus	5	2
GO:0032991	protein-containing complex	1	2
GO:0032993	protein-DNA complex	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0044815	DNA packaging complex	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4HBJ5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBJ5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003677	DNA binding	4	2
GO:0005198	structural molecule activity	1	2
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0030527	structural constituent of chromatin	2	2
GO:0046982	protein heterodimerization activity	4	2
GO:0046983	protein dimerization activity	3	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	19	21	PF00675	0.441
CLV_NRD_NRD_1	3	5	PF00675	0.817
CLV_NRD_NRD_1	40	42	PF00675	0.779
CLV_PCSK_KEX2_1	19	21	PF00082	0.441
CLV_PCSK_KEX2_1	3	5	PF00082	0.817
CLV_PCSK_KEX2_1	8	10	PF00082	0.699
CLV_PCSK_PC1ET2_1	8	10	PF00082	0.786
CLV_PCSK_PC7_1	4	10	PF00082	0.797
CLV_PCSK_SKI1_1	19	23	PF00082	0.721
CLV_PCSK_SKI1_1	77	81	PF00082	0.741
DOC_MAPK_MEF2A_6	57	65	PF00069	0.842
DOC_MAPK_MEF2A_6	83	90	PF00069	0.738
DOC_PP2B_LxvP_1	94	97	PF13499	0.797
DOC_PP4_FxxP_1	92	95	PF00568	0.796
LIG_14-3-3_CanoR_1	31	39	PF00244	0.739
LIG_14-3-3_CanoR_1	64	72	PF00244	0.818
LIG_BIR_II_1	1	5	PF00653	0.831
LIG_BRCT_BRCA1_1	88	92	PF00533	0.764
LIG_LIR_Apic_2	89	95	PF02991	0.780
LIG_LIR_Gen_1	13	22	PF02991	0.731
LIG_LIR_Gen_1	75	86	PF02991	0.740
LIG_LIR_Nem_3	13	18	PF02991	0.739
LIG_LIR_Nem_3	33	39	PF02991	0.391
LIG_LIR_Nem_3	75	81	PF02991	0.749
LIG_PDZ_Class_2	101	106	PF00595	0.815
LIG_REV1ctd_RIR_1	78	87	PF16727	0.731
LIG_SH2_SRC	15	18	PF00017	0.734
LIG_SH2_STAP1	36	40	PF00017	0.756
LIG_SH2_STAP1	78	82	PF00017	0.737
LIG_SH2_STAT5	25	28	PF00017	0.707
LIG_SH2_STAT5	36	39	PF00017	0.563
LIG_SH2_STAT5	87	90	PF00017	0.752
LIG_WRC_WIRS_1	87	92	PF05994	0.758
MOD_GlcNHglycan	10	13	PF01048	0.764
MOD_GSK3_1	30	37	PF00069	0.732
MOD_GSK3_1	98	105	PF00069	0.805
MOD_N-GLC_1	65	70	PF02516	0.822
MOD_NEK2_1	70	75	PF00069	0.772
MOD_PKA_1	41	47	PF00069	0.800
MOD_PKA_1	8	14	PF00069	0.770
MOD_PKA_2	30	36	PF00069	0.729
MOD_PKA_2	8	14	PF00069	0.770
MOD_Plk_1	65	71	PF00069	0.816
TRG_ENDOCYTIC_2	15	18	PF00928	0.734
TRG_ENDOCYTIC_2	78	81	PF00928	0.734
TRG_ENDOCYTIC_2	87	90	PF00928	0.594
TRG_ER_diArg_1	18	20	PF00400	0.723
TRG_ER_diArg_1	61	64	PF00400	0.842

Homologs


Protein	Taxonomy	Sequence identity	Coverage
P02309	YEAST	64%	100%
P02310	TETPY	57%	100%
P04914	NEUCR	57%	100%
P04915	PHYPO	59%	100%
P08436	VOLCA	64%	100%
P09322	SCHPO	57%	100%
P0CG89	SOYBN	61%	100%
P23750	EMENI	57%	100%
P23751	EMENI	57%	100%
P27996	SOLST	57%	100%
P35057	SOLLC	64%	100%
P35059	ACRFO	59%	100%
P40287	ENTHI	55%	90%
P50566	CHLRE	64%	100%
P59259	ARATH	61%	100%
P62776	HOLTU	57%	100%
P62777	PISBR	57%	100%
P62778	PISOC	57%	100%
P62779	PYCHE	57%	100%
P62780	PARLI	57%	100%
P62781	PSAMI	57%	100%
P62782	LYTPI	57%	100%
P62783	STRPU	57%	100%
P62784	CAEEL	57%	100%
P62785	WHEAT	61%	100%
P62786	WHEAT	61%	100%
P62787	MAIZE	61%	100%
P62788	PEA	61%	100%
P62790	STENO	57%	100%
P62791	STYLE	57%	100%
P62792	PHACH	61%	100%
P62793	AGABI	61%	100%
P62794	URECA	59%	100%
P62795	PLADU	59%	100%
P62796	ORENI	59%	100%
P62797	ONCMY	59%	100%
P62798	XENBO	59%	100%
P62799	XENLA	59%	100%
P62800	CAIMO	59%	100%
P62801	CHICK	59%	100%
P62802	PIG	59%	100%
P62803	BOVIN	59%	100%
P62804	RAT	59%	100%
P62805	HUMAN	59%	100%
P62806	MOUSE	59%	100%
P62887	LOLTE	61%	100%
P69151	TETPY	57%	100%
P69152	TETTS	57%	100%
P70081	CHICK	59%	100%
P80737	BLEJA	58%	100%
P80739	EUPCR	59%	99%
P82888	OLILU	61%	100%
P83865	PENVA	59%	100%
P84040	DROME	59%	100%
P84041	DROER	59%	100%
P84042	DROHY	59%	100%
P84043	DROSI	59%	100%
P84044	DROYA	59%	100%
P84045	TIGCA	59%	100%
P84046	CHITH	59%	100%
P84047	ASEAQ	59%	100%
P84048	ACRAS	59%	100%
P84049	MYRRU	59%	100%
P84050	RHYAM	59%	100%
P90516	BLEJA	53%	100%
P91849	APIME	57%	100%
P91882	DIAPU	57%	100%
P91890	TRICD	55%	100%
Q27443	ASCSU	57%	100%
Q27765	STYPL	59%	100%
Q28DR4	XENTR	59%	100%
Q41811	MAIZE	59%	100%
Q43083	PYRSA	61%	100%
Q4R362	MACFA	59%	100%
Q5RCS7	PONAB	59%	100%
Q6LAF1	DENKL	59%	100%
Q6LAF3	FLATR	61%	100%
Q6PMI5	CHEMJ	61%	100%
Q6V9I2	SOLCH	64%	100%
Q6WV72	MYTTR	59%	100%
Q6WV73	MYTCA	59%	100%
Q6WV74	MYTCH	59%	100%
Q6WV90	MYTGA	59%	100%
Q6WZ83	EUCGL	61%	100%
Q6ZXX3	USTMA	59%	100%
Q711M0	TALFU	57%	100%
Q71V09	CAPAN	64%	100%
Q757K0	ASHGO	59%	100%
Q75AX1	ASHGO	59%	100%
Q76FD9	DROSE	59%	100%
Q76FE7	DROMA	59%	100%
Q76FF1	DROOR	59%	100%
Q76FF5	DROTE	59%	100%
Q76H85	SILLA	61%	100%
Q76MU7	ASPOR	57%	100%
Q76NW2	DICDI	55%	98%
Q7K8C0	MYTED	59%	100%
Q7KQD1	CHAVR	59%	100%
Q7LKT3	ASPFU	57%	100%
Q8I0Y4	OIKDI	59%	100%
Q8J1L3	BLAAD	57%	100%
Q8MTV8	APLCA	59%	100%
Q8NIG3	CANGA	61%	100%
Q8NIQ8	TALFU	57%	100%
Q8T7J8	EIMTE	64%	100%
Q99525	HUMAN	50%	100%
Q9HDF5	MORAP	59%	100%
Q9U7D0	MASBA	64%	98%