Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HBJ3_LEIBR

TriTrypDb:

LbrM.20.4330 , LBRM2903_200021500

Length:

560

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HBJ3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBJ3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	361	365	PF00656	0.574
CLV_C14_Caspase3-7	519	523	PF00656	0.587
CLV_MEL_PAP_1	153	159	PF00089	0.557
CLV_NRD_NRD_1	103	105	PF00675	0.484
CLV_NRD_NRD_1	125	127	PF00675	0.650
CLV_NRD_NRD_1	180	182	PF00675	0.506
CLV_NRD_NRD_1	194	196	PF00675	0.399
CLV_NRD_NRD_1	200	202	PF00675	0.428
CLV_NRD_NRD_1	383	385	PF00675	0.499
CLV_NRD_NRD_1	416	418	PF00675	0.547
CLV_NRD_NRD_1	472	474	PF00675	0.507
CLV_NRD_NRD_1	52	54	PF00675	0.485
CLV_NRD_NRD_1	545	547	PF00675	0.528
CLV_PCSK_KEX2_1	103	105	PF00082	0.587
CLV_PCSK_KEX2_1	125	127	PF00082	0.583
CLV_PCSK_KEX2_1	179	181	PF00082	0.554
CLV_PCSK_KEX2_1	200	202	PF00082	0.388
CLV_PCSK_KEX2_1	305	307	PF00082	0.524
CLV_PCSK_KEX2_1	383	385	PF00082	0.499
CLV_PCSK_KEX2_1	416	418	PF00082	0.547
CLV_PCSK_KEX2_1	472	474	PF00082	0.536
CLV_PCSK_KEX2_1	545	547	PF00082	0.528
CLV_PCSK_PC1ET2_1	305	307	PF00082	0.524
CLV_PCSK_PC7_1	468	474	PF00082	0.608
CLV_PCSK_SKI1_1	103	107	PF00082	0.696
CLV_PCSK_SKI1_1	195	199	PF00082	0.521
CLV_PCSK_SKI1_1	387	391	PF00082	0.521
CLV_PCSK_SKI1_1	49	53	PF00082	0.459
CLV_PCSK_SKI1_1	491	495	PF00082	0.665
DEG_APCC_DBOX_1	124	132	PF00400	0.551
DEG_APCC_DBOX_1	190	198	PF00400	0.338
DEG_APCC_DBOX_1	48	56	PF00400	0.518
DEG_SCF_FBW7_1	23	30	PF00400	0.468
DEG_SPOP_SBC_1	394	398	PF00917	0.655
DEG_SPOP_SBC_1	76	80	PF00917	0.517
DOC_CKS1_1	24	29	PF01111	0.470
DOC_CYCLIN_yClb5_NLxxxL_5	311	318	PF00134	0.523
DOC_MAPK_gen_1	100	108	PF00069	0.570
DOC_MAPK_gen_1	125	132	PF00069	0.456
DOC_MAPK_gen_1	179	186	PF00069	0.355
DOC_MAPK_gen_1	383	390	PF00069	0.509
DOC_MAPK_HePTP_8	153	165	PF00069	0.548
DOC_MAPK_HePTP_8	413	429	PF00069	0.616
DOC_MAPK_MEF2A_6	125	134	PF00069	0.547
DOC_MAPK_MEF2A_6	156	165	PF00069	0.639
DOC_MAPK_MEF2A_6	179	186	PF00069	0.447
DOC_PP2B_LxvP_1	20	23	PF13499	0.519
DOC_PP2B_LxvP_1	332	335	PF13499	0.576
DOC_USP7_MATH_1	118	122	PF00917	0.561
DOC_USP7_MATH_1	13	17	PF00917	0.608
DOC_USP7_MATH_1	282	286	PF00917	0.472
DOC_USP7_MATH_1	365	369	PF00917	0.746
DOC_USP7_MATH_1	371	375	PF00917	0.511
DOC_USP7_MATH_1	395	399	PF00917	0.547
DOC_USP7_MATH_1	406	410	PF00917	0.572
DOC_USP7_MATH_1	460	464	PF00917	0.729
DOC_USP7_MATH_1	81	85	PF00917	0.755
DOC_WW_Pin1_4	132	137	PF00397	0.396
DOC_WW_Pin1_4	23	28	PF00397	0.609
DOC_WW_Pin1_4	277	282	PF00397	0.452
DOC_WW_Pin1_4	340	345	PF00397	0.640
DOC_WW_Pin1_4	402	407	PF00397	0.581
DOC_WW_Pin1_4	439	444	PF00397	0.505
LIG_14-3-3_CanoR_1	103	109	PF00244	0.653
LIG_14-3-3_CanoR_1	156	160	PF00244	0.575
LIG_14-3-3_CanoR_1	21	27	PF00244	0.536
LIG_14-3-3_CanoR_1	222	230	PF00244	0.513
LIG_14-3-3_CanoR_1	472	478	PF00244	0.504
LIG_APCC_ABBA_1	318	323	PF00400	0.349
LIG_BRCT_BRCA1_1	108	112	PF00533	0.478
LIG_BRCT_BRCA1_2	108	114	PF00533	0.482
LIG_eIF4E_1	487	493	PF01652	0.618
LIG_FHA_1	148	154	PF00498	0.536
LIG_FHA_1	15	21	PF00498	0.576
LIG_FHA_1	230	236	PF00498	0.378
LIG_FHA_1	34	40	PF00498	0.460
LIG_FHA_1	352	358	PF00498	0.507
LIG_FHA_1	394	400	PF00498	0.494
LIG_FHA_1	43	49	PF00498	0.473
LIG_FHA_1	91	97	PF00498	0.678
LIG_FHA_2	294	300	PF00498	0.497
LIG_FHA_2	39	45	PF00498	0.458
LIG_FHA_2	481	487	PF00498	0.445
LIG_LIR_Gen_1	144	153	PF02991	0.380
LIG_LIR_Gen_1	420	429	PF02991	0.483
LIG_LIR_Gen_1	56	67	PF02991	0.504
LIG_LIR_Nem_3	144	148	PF02991	0.386
LIG_LIR_Nem_3	255	261	PF02991	0.467
LIG_LIR_Nem_3	341	345	PF02991	0.483
LIG_LIR_Nem_3	420	425	PF02991	0.605
LIG_LIR_Nem_3	476	480	PF02991	0.510
LIG_LIR_Nem_3	56	62	PF02991	0.483
LIG_REV1ctd_RIR_1	110	119	PF16727	0.485
LIG_SH2_CRK	34	38	PF00017	0.522
LIG_SH2_CRK	342	346	PF00017	0.491
LIG_SH2_STAP1	212	216	PF00017	0.504
LIG_SH2_STAP1	231	235	PF00017	0.653
LIG_SH2_STAT5	141	144	PF00017	0.513
LIG_SH2_STAT5	231	234	PF00017	0.452
LIG_SH3_3	16	22	PF00018	0.549
LIG_SH3_3	341	347	PF00018	0.487
LIG_SH3_3	499	505	PF00018	0.648
LIG_SH3_3	66	72	PF00018	0.623
LIG_SUMO_SIM_anti_2	150	155	PF11976	0.349
LIG_SUMO_SIM_anti_2	424	429	PF11976	0.562
LIG_TRAF2_1	190	193	PF00917	0.608
LIG_TRAF2_1	300	303	PF00917	0.523
LIG_TRAF2_1	483	486	PF00917	0.438
LIG_WW_3	122	126	PF00397	0.583
MOD_CK1_1	107	113	PF00069	0.629
MOD_CK1_1	4	10	PF00069	0.557
MOD_CK2_1	293	299	PF00069	0.499
MOD_CK2_1	402	408	PF00069	0.648
MOD_CK2_1	480	486	PF00069	0.446
MOD_CK2_1	527	533	PF00069	0.506
MOD_GlcNHglycan	223	226	PF01048	0.510
MOD_GlcNHglycan	243	246	PF01048	0.442
MOD_GlcNHglycan	286	289	PF01048	0.484
MOD_GlcNHglycan	373	376	PF01048	0.504
MOD_GlcNHglycan	540	543	PF01048	0.528
MOD_GlcNHglycan	7	10	PF01048	0.559
MOD_GSK3_1	1	8	PF00069	0.581
MOD_GSK3_1	23	30	PF00069	0.582
MOD_GSK3_1	241	248	PF00069	0.611
MOD_GSK3_1	38	45	PF00069	0.383
MOD_GSK3_1	395	402	PF00069	0.699
MOD_GSK3_1	456	463	PF00069	0.471
MOD_GSK3_1	77	84	PF00069	0.800
MOD_NEK2_1	106	111	PF00069	0.478
MOD_NEK2_1	14	19	PF00069	0.540
MOD_NEK2_1	241	246	PF00069	0.500
MOD_NEK2_1	276	281	PF00069	0.459
MOD_NEK2_2	155	160	PF00069	0.567
MOD_NEK2_2	33	38	PF00069	0.499
MOD_PIKK_1	229	235	PF00454	0.372
MOD_PIKK_1	282	288	PF00454	0.549
MOD_PK_1	104	110	PF00069	0.478
MOD_PKA_2	1	7	PF00069	0.682
MOD_PKA_2	155	161	PF00069	0.563
MOD_PKA_2	221	227	PF00069	0.508
MOD_PKA_2	241	247	PF00069	0.417
MOD_PKA_2	538	544	PF00069	0.550
MOD_Plk_1	407	413	PF00069	0.628
MOD_Plk_4	1	7	PF00069	0.527
MOD_Plk_4	107	113	PF00069	0.658
MOD_Plk_4	149	155	PF00069	0.421
MOD_Plk_4	15	21	PF00069	0.477
MOD_Plk_4	328	334	PF00069	0.558
MOD_ProDKin_1	132	138	PF00069	0.394
MOD_ProDKin_1	23	29	PF00069	0.611
MOD_ProDKin_1	277	283	PF00069	0.447
MOD_ProDKin_1	340	346	PF00069	0.643
MOD_ProDKin_1	402	408	PF00069	0.581
MOD_ProDKin_1	439	445	PF00069	0.506
MOD_SUMO_rev_2	297	307	PF00179	0.523
TRG_DiLeu_BaEn_1	256	261	PF01217	0.466
TRG_DiLeu_BaEn_1	533	538	PF01217	0.455
TRG_ENDOCYTIC_2	34	37	PF00928	0.521
TRG_ENDOCYTIC_2	342	345	PF00928	0.489
TRG_ER_diArg_1	124	126	PF00400	0.589
TRG_ER_diArg_1	179	181	PF00400	0.530
TRG_ER_diArg_1	199	201	PF00400	0.312
TRG_ER_diArg_1	261	264	PF00400	0.583
TRG_ER_diArg_1	383	385	PF00400	0.499
TRG_ER_diArg_1	415	417	PF00400	0.554
TRG_ER_diArg_1	471	473	PF00400	0.456
TRG_ER_diArg_1	544	546	PF00400	0.512

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HY58	Leptomonas seymouri	42%	100%
A0A3Q8II15	Leishmania donovani	65%	100%
A0A422MPI6	Trypanosoma rangeli	25%	100%
A4I9T3	Leishmania infantum	64%	100%
C9ZMU6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
E9B4U4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	63%	99%
Q4Q382	Leishmania major	64%	100%