Putative amastin-like surface protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

amastin-like surface protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HBJ2_LEIBR

TriTrypDb:

LbrM.20.4320 , LBRM2903_200055700

Length:

208

Annotations

LeishMANIAdb annotations

Publication identifier(s): 26641088 15760660
Part of the greater amastin family, a cell adhesion protein critical for intracellular parasitism. Localization: Cell surface (experimental)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 9
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 16

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 11, no: 200
NetGPI	no	yes: 0, no: 211

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	188
GO:0110165	cellular anatomical entity	1	188

Expansion

Sequence features

A4HBJ2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBJ2

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0016485	protein processing	5	1
GO:0016540	protein autoprocessing	6	1
GO:0019538	protein metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044238	primary metabolic process	2	1
GO:0051604	protein maturation	4	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004175	endopeptidase activity	4	1
GO:0004197	cysteine-type endopeptidase activity	5	1
GO:0008233	peptidase activity	3	1
GO:0008234	cysteine-type peptidase activity	4	1
GO:0016787	hydrolase activity	2	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	55	59	PF00656	0.196
CLV_NRD_NRD_1	73	75	PF00675	0.473
CLV_PCSK_FUR_1	71	75	PF00082	0.408
CLV_PCSK_KEX2_1	2	4	PF00082	0.309
CLV_PCSK_KEX2_1	73	75	PF00082	0.482
CLV_PCSK_PC1ET2_1	2	4	PF00082	0.308
CLV_PCSK_SKI1_1	37	41	PF00082	0.410
DEG_Nend_UBRbox_1	1	4	PF02207	0.647
DOC_CKS1_1	23	28	PF01111	0.347
DOC_MAPK_gen_1	2	9	PF00069	0.461
DOC_MAPK_MEF2A_6	107	115	PF00069	0.559
DOC_MAPK_MEF2A_6	134	143	PF00069	0.199
DOC_MAPK_MEF2A_6	2	9	PF00069	0.557
DOC_SPAK_OSR1_1	173	177	PF12202	0.469
DOC_SPAK_OSR1_1	74	78	PF12202	0.207
DOC_USP7_MATH_1	82	86	PF00917	0.345
DOC_WW_Pin1_4	22	27	PF00397	0.358
DOC_WW_Pin1_4	56	61	PF00397	0.337
LIG_14-3-3_CanoR_1	31	36	PF00244	0.258
LIG_14-3-3_CanoR_1	41	46	PF00244	0.363
LIG_14-3-3_CanoR_1	51	61	PF00244	0.304
LIG_Actin_WH2_2	91	109	PF00022	0.354
LIG_APCC_ABBA_1	176	181	PF00400	0.474
LIG_APCC_ABBAyCdc20_2	175	181	PF00400	0.474
LIG_DLG_GKlike_1	31	39	PF00625	0.194
LIG_FHA_1	110	116	PF00498	0.360
LIG_FHA_1	118	124	PF00498	0.383
LIG_FHA_1	156	162	PF00498	0.266
LIG_FHA_1	34	40	PF00498	0.309
LIG_FHA_2	200	206	PF00498	0.588
LIG_FHA_2	23	29	PF00498	0.376
LIG_GBD_Chelix_1	12	20	PF00786	0.214
LIG_LIR_Gen_1	104	113	PF02991	0.514
LIG_LIR_Gen_1	142	151	PF02991	0.194
LIG_LIR_Nem_3	104	108	PF02991	0.557
LIG_LIR_Nem_3	142	146	PF02991	0.301
LIG_Pex14_2	101	105	PF04695	0.364
LIG_Pex14_2	15	19	PF04695	0.256
LIG_SH2_CRK	10	14	PF00017	0.378
LIG_SH2_NCK_1	10	14	PF00017	0.214
LIG_SH2_SRC	10	13	PF00017	0.224
LIG_SH2_STAT3	76	79	PF00017	0.194
LIG_SH2_STAT5	76	79	PF00017	0.206
LIG_SH3_3	20	26	PF00018	0.363
LIG_SUMO_SIM_par_1	19	25	PF11976	0.321
LIG_TYR_ITIM	8	13	PF00017	0.477
LIG_Vh1_VBS_1	88	106	PF01044	0.370
MOD_CK1_1	189	195	PF00069	0.579
MOD_CK1_1	197	203	PF00069	0.597
MOD_CK1_1	53	59	PF00069	0.369
MOD_CK2_1	130	136	PF00069	0.197
MOD_CK2_1	190	196	PF00069	0.605
MOD_CK2_1	199	205	PF00069	0.609
MOD_GlcNHglycan	183	186	PF01048	0.494
MOD_GSK3_1	126	133	PF00069	0.285
MOD_GSK3_1	186	193	PF00069	0.578
MOD_GSK3_1	31	38	PF00069	0.297
MOD_GSK3_1	52	59	PF00069	0.305
MOD_NEK2_1	1	6	PF00069	0.642
MOD_NEK2_1	101	106	PF00069	0.317
MOD_NEK2_1	128	133	PF00069	0.468
MOD_NEK2_1	155	160	PF00069	0.303
MOD_NEK2_1	35	40	PF00069	0.338
MOD_PIKK_1	199	205	PF00454	0.591
MOD_PKA_2	50	56	PF00069	0.346
MOD_Plk_4	101	107	PF00069	0.373
MOD_Plk_4	41	47	PF00069	0.320
MOD_Plk_4	82	88	PF00069	0.303
MOD_ProDKin_1	22	28	PF00069	0.358
MOD_ProDKin_1	56	62	PF00069	0.337
TRG_ENDOCYTIC_2	10	13	PF00928	0.432
TRG_ER_diArg_1	70	73	PF00400	0.396

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2C4	Leptomonas seymouri	31%	100%
A0A0N0P547	Leptomonas seymouri	43%	100%
A0A0N0P6P9	Leptomonas seymouri	28%	90%
A0A0N1HWY5	Leptomonas seymouri	27%	100%
A0A0N1PDH0	Leptomonas seymouri	35%	100%
A0A1X0NQ58	Trypanosomatidae	30%	100%
A0A1X0NUH1	Trypanosomatidae	30%	92%
A0A1X0NVN5	Trypanosomatidae	29%	100%
A0A1X0NVT7	Trypanosomatidae	30%	100%
A0A1X0NX02	Trypanosomatidae	28%	100%
A0A1X0NX81	Trypanosomatidae	29%	100%
A0A1X0P2R3	Trypanosomatidae	28%	99%
A0A1X0P988	Trypanosomatidae	39%	100%
A0A381MTA7	Leishmania infantum	49%	100%
A0A381MTB8	Leishmania infantum	48%	100%
A0A381MTC7	Leishmania infantum	48%	100%
A0A381MTN2	Leishmania infantum	43%	100%
A0A381MVY0	Leishmania infantum	49%	100%
A0A3Q8ID16	Leishmania donovani	27%	100%
A0A3Q8IE85	Leishmania donovani	55%	100%
A0A3Q8IEC2	Leishmania donovani	46%	100%
A0A3Q8IEI1	Leishmania donovani	48%	100%
A0A3Q8IF65	Leishmania donovani	39%	100%
A0A3Q8IFB9	Leishmania donovani	37%	100%
A0A3Q8IFH7	Leishmania donovani	48%	100%
A0A3Q8IH65	Leishmania donovani	48%	100%
A0A3Q8IHN2	Leishmania donovani	52%	100%
A0A3Q8IHW7	Leishmania donovani	46%	100%
A0A3Q8IHZ6	Leishmania donovani	52%	99%
A0A3Q8IIH1	Leishmania donovani	49%	100%
A0A3Q8IL03	Leishmania donovani	44%	100%
A0A3Q8IMR4	Leishmania donovani	22%	100%
A0A3Q8IUK8	Leishmania donovani	44%	100%
A0A3Q8IUR5	Leishmania donovani	43%	100%
A0A3S5H662	Leishmania donovani	39%	100%
A0A3S5H663	Leishmania donovani	39%	100%
A0A3S5H665	Leishmania donovani	38%	100%
A0A3S5H666	Leishmania donovani	44%	100%
A0A3S5H667	Leishmania donovani	40%	100%
A0A3S5H7D2	Leishmania donovani	30%	100%
A0A3S5H7L2	Leishmania donovani	43%	100%
A0A3S5H7V9	Leishmania donovani	44%	100%
A0A3S5H7W2	Leishmania donovani	31%	100%
A0A3S5H7W6	Leishmania donovani	47%	100%
A0A3S7WQA0	Leishmania donovani	38%	100%
A0A3S7WQA8	Leishmania donovani	54%	100%
A0A3S7WQC1	Leishmania donovani	51%	100%
A0A3S7X2E6	Leishmania donovani	42%	100%
A0A3S7X357	Leishmania donovani	27%	94%
A0A3S7X453	Leishmania donovani	38%	100%
A0A3S7X472	Leishmania donovani	39%	100%
A0A3S7X7E5	Leishmania donovani	51%	83%
A0A3S7X7M4	Leishmania donovani	52%	99%
A0A3S7X7U1	Leishmania donovani	49%	99%
A0A3S7X7U4	Leishmania donovani	48%	80%
A0A3S7X7W2	Leishmania donovani	48%	99%
A0A3S7X7Y0	Leishmania donovani	47%	100%
A4H595	Leishmania braziliensis	48%	100%
A4H596	Leishmania braziliensis	49%	100%
A4H597	Leishmania braziliensis	49%	100%
A4H5D1	Leishmania braziliensis	47%	97%
A4H5D2	Leishmania braziliensis	41%	100%
A4H5G0	Leishmania braziliensis	42%	95%
A4H5G4	Leishmania braziliensis	47%	100%
A4H5G6	Leishmania braziliensis	50%	100%
A4H5G7	Leishmania braziliensis	47%	100%
A4H5G9	Leishmania braziliensis	53%	100%
A4H5H0	Leishmania braziliensis	53%	100%
A4H5H1	Leishmania braziliensis	48%	96%
A4H5H2	Leishmania braziliensis	50%	100%
A4H5H3	Leishmania braziliensis	47%	100%
A4H6C8	Leishmania braziliensis	44%	95%
A4H7D7	Leishmania braziliensis	50%	97%
A4H9E8	Leishmania braziliensis	51%	100%
A4H9E9	Leishmania braziliensis	52%	100%
A4HAJ4	Leishmania braziliensis	51%	100%
A4HAJ5	Leishmania braziliensis	47%	100%
A4HAJ6	Leishmania braziliensis	48%	100%
A4HAL2	Leishmania braziliensis	31%	100%
A4HAM2	Leishmania braziliensis	61%	100%
A4HAM4	Leishmania braziliensis	61%	100%
A4HAR1	Leishmania braziliensis	55%	100%
A4HAZ8	Leishmania braziliensis	53%	100%
A4HB00	Leishmania braziliensis	55%	100%
A4HB02	Leishmania braziliensis	49%	97%
A4HB47	Leishmania braziliensis	36%	100%
A4HBJ0	Leishmania braziliensis	47%	99%
A4HBJ1	Leishmania braziliensis	60%	100%
A4HDI3	Leishmania braziliensis	33%	86%
A4HDI4	Leishmania braziliensis	27%	100%
A4HDL3	Leishmania braziliensis	31%	100%
A4HDL4	Leishmania braziliensis	28%	100%
A4HI43	Leishmania braziliensis	26%	98%
A4HTM3	Leishmania infantum	45%	100%
A4HTM4	Leishmania infantum	54%	100%
A4HTM5	Leishmania infantum	45%	100%
A4I0W3	Leishmania infantum	22%	100%
A4I0W4	Leishmania infantum	30%	100%
A4I0W5	Leishmania infantum	27%	100%
A4I0W6	Leishmania infantum	22%	70%
A4I4J2	Leishmania infantum	45%	100%
A4I4J3	Leishmania infantum	46%	81%
A4I5B9	Leishmania infantum	27%	94%
A4I6E5	Leishmania infantum	39%	100%
A4I9Q4	Leishmania infantum	45%	100%
A4I9R4	Leishmania infantum	31%	100%
A4I9R5	Leishmania infantum	37%	100%
A4I9R7	Leishmania infantum	53%	100%
A4I9W8	Leishmania infantum	47%	80%
A4I9X0	Leishmania infantum	48%	99%
A4IA59	Leishmania infantum	43%	80%
A4IAL7	Leishmania infantum	47%	100%
A4IAM1	Leishmania infantum	48%	100%
A4IAM2	Leishmania infantum	47%	100%
C6K3X9	Leptomonas seymouri	22%	100%
E8NHC3	Leishmania infantum	40%	100%
E8NHD3	Leishmania infantum	44%	100%
E8NHD9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	48%	100%
E8NHE0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	50%	100%
E8NHF4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	100%
E8NHF5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	100%
E8NHF7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E8NHG2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	99%
E8NHH5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	99%
E8NHH9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	51%	100%
E8NHI3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	100%
E8NHI5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	51%	100%
E8NHK7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	99%
E8NHK9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	50%	100%
E8NHL7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	52%	100%
E8NHL9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	54%	100%
E8NHM0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	100%
E8NHM1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	100%
E8NHM3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	99%
E8NHM5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	99%
E8NHM6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E8NHM7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E8NHP0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	48%	100%
E8NHQ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	100%
E8NHQ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	100%
E8NHR7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	100%
E8NHR8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	53%	100%
E8NHS2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	99%
E8NHS5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	67%
E9AG81	Leishmania infantum	40%	100%
E9AG82	Leishmania infantum	41%	100%
E9AG83	Leishmania infantum	41%	100%
E9AG85	Leishmania infantum	43%	100%
E9AHI9	Leishmania infantum	43%	100%
E9AHT2	Leishmania infantum	53%	99%
E9AME9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
E9AMF0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
E9AMF1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	100%
E9AMF2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	100%
E9AMF3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	100%
E9AMF4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	81%
E9AMF5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	100%
E9AMF7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
E9AMF8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	100%
E9AMF9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	100%
E9ASP7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	100%
E9AWW7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9AWW8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
E9AWW9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9AWX0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9B0L6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	94%
E9B1J3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	100%
E9B1J4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	100%
E9B1J5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	99%
E9B4L9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
E9B4R7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	52%	100%
E9B4R8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	50%	100%
E9B4R9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
E9B4S0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9B4Y3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
Q4Q1U9	Leishmania major	50%	97%
Q4Q305	Leishmania major	48%	97%
Q4Q309	Leishmania major	50%	98%
Q4Q313	Leishmania major	48%	97%
Q4Q317	Leishmania major	46%	100%
Q4Q325	Leishmania major	47%	99%
Q4Q327	Leishmania major	47%	97%
Q4Q329	Leishmania major	49%	97%
Q4Q333	Leishmania major	48%	97%
Q4Q335	Leishmania major	49%	97%
Q4Q337	Leishmania major	51%	100%
Q4Q339	Leishmania major	48%	97%
Q4Q341	Leishmania major	55%	99%
Q4Q397	Leishmania major	49%	100%
Q4Q3A7	Leishmania major	30%	100%
Q4Q3A8	Leishmania major	38%	100%
Q4Q3A9	Leishmania major	49%	99%
Q4Q3F7	Leishmania major	47%	100%
Q4Q6L8	Leishmania major	39%	95%
Q4Q7L6	Leishmania major	29%	100%
Q4QAK4	Leishmania major	24%	95%
Q4QAK5	Leishmania major	28%	100%
Q4QAK6	Leishmania major	32%	96%
Q4QAK7	Leishmania major	24%	95%
Q4QI84	Leishmania major	51%	100%
Q4QI85	Leishmania major	46%	100%
Q4QI86	Leishmania major	51%	100%
Q4QI87	Leishmania major	47%	97%
Q4QI88	Leishmania major	48%	97%
Q4QI92	Leishmania major	43%	100%
Q4QI93	Leishmania major	43%	100%
Q4QI95	Leishmania major	43%	100%
Q4QI97	Leishmania major	42%	100%
Q4QIA0	Leishmania major	43%	98%
Q4QIA1	Leishmania major	42%	98%