Putative amastin-like surface protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

amastin-like surface protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HBJ0_LEIBR

TriTrypDb:

LbrM.20.4300 , LBRM2903_200055600

Length:

192

Annotations

LeishMANIAdb annotations

Publication identifier(s): 26641088 15760660
Part of the greater amastin family, a cell adhesion protein critical for intracellular parasitism. Localization: Cell surface (experimental)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 9
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 16

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 10, no: 191
NetGPI	no	yes: 0, no: 201

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	179
GO:0110165	cellular anatomical entity	1	179

Expansion

Sequence features

A4HBJ0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBJ0

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0016485	protein processing	5	1
GO:0016540	protein autoprocessing	6	1
GO:0019538	protein metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044238	primary metabolic process	2	1
GO:0051604	protein maturation	4	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004175	endopeptidase activity	4	1
GO:0004197	cysteine-type endopeptidase activity	5	1
GO:0008233	peptidase activity	3	1
GO:0008234	cysteine-type peptidase activity	4	1
GO:0016787	hydrolase activity	2	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	67	69	PF00675	0.487
CLV_NRD_NRD_1	72	74	PF00675	0.485
CLV_PCSK_KEX2_1	67	69	PF00082	0.502
CLV_PCSK_KEX2_1	72	74	PF00082	0.499
CLV_PCSK_PC7_1	68	74	PF00082	0.411
CLV_PCSK_SKI1_1	35	39	PF00082	0.413
DEG_Nend_UBRbox_2	1	3	PF02207	0.549
DOC_CKS1_1	23	28	PF01111	0.352
DOC_CYCLIN_yCln2_LP_2	171	177	PF00134	0.417
DOC_MAPK_MEF2A_6	108	116	PF00069	0.577
DOC_PP2B_LxvP_1	171	174	PF13499	0.496
DOC_SPAK_OSR1_1	75	79	PF12202	0.210
DOC_WW_Pin1_4	22	27	PF00397	0.353
LIG_14-3-3_CanoR_1	35	43	PF00244	0.275
LIG_Actin_WH2_2	165	183	PF00022	0.299
LIG_deltaCOP1_diTrp_1	139	147	PF00928	0.204
LIG_FHA_1	119	125	PF00498	0.400
LIG_FHA_1	130	136	PF00498	0.391
LIG_FHA_1	55	61	PF00498	0.346
LIG_FHA_2	174	180	PF00498	0.664
LIG_FHA_2	23	29	PF00498	0.395
LIG_GBD_Chelix_1	112	120	PF00786	0.315
LIG_GBD_Chelix_1	12	20	PF00786	0.215
LIG_LIR_Gen_1	176	184	PF02991	0.667
LIG_LIR_Nem_3	105	110	PF02991	0.564
LIG_LIR_Nem_3	144	150	PF02991	0.289
LIG_LIR_Nem_3	176	180	PF02991	0.672
LIG_PCNA_yPIPBox_3	33	47	PF02747	0.204
LIG_PTB_Apo_2	164	171	PF02174	0.438
LIG_SH2_CRK	10	14	PF00017	0.370
LIG_SH2_NCK_1	10	14	PF00017	0.216
LIG_SH2_STAT3	36	39	PF00017	0.195
LIG_SH2_STAT5	102	105	PF00017	0.391
LIG_SH2_STAT5	134	137	PF00017	0.274
LIG_SH2_STAT5	175	178	PF00017	0.510
LIG_SH2_STAT5	36	39	PF00017	0.360
LIG_SH2_STAT5	64	67	PF00017	0.385
LIG_SH3_3	20	26	PF00018	0.364
LIG_SUMO_SIM_par_1	19	25	PF11976	0.328
LIG_TRAF2_1	189	192	PF00917	0.569
LIG_TRFH_1	170	174	PF08558	0.272
MOD_CK1_1	145	151	PF00069	0.208
MOD_CK2_1	186	192	PF00069	0.579
MOD_GlcNHglycan	188	191	PF01048	0.338
MOD_GSK3_1	142	149	PF00069	0.251
MOD_GSK3_1	182	189	PF00069	0.548
MOD_GSK3_1	35	42	PF00069	0.296
MOD_GSK3_1	54	61	PF00069	0.343
MOD_N-GLC_1	39	44	PF02516	0.637
MOD_N-GLC_1	54	59	PF02516	0.556
MOD_NEK2_1	1	6	PF00069	0.703
MOD_NEK2_1	180	185	PF00069	0.508
MOD_NEK2_1	54	59	PF00069	0.328
MOD_NEK2_2	102	107	PF00069	0.370
MOD_NEK2_2	142	147	PF00069	0.302
MOD_NEK2_2	83	88	PF00069	0.461
MOD_PIKK_1	35	41	PF00454	0.288
MOD_PKA_1	67	73	PF00069	0.270
MOD_PKA_2	180	186	PF00069	0.513
MOD_PKA_2	67	73	PF00069	0.293
MOD_PKB_1	33	41	PF00069	0.210
MOD_Plk_1	1	7	PF00069	0.411
MOD_Plk_1	39	45	PF00069	0.335
MOD_Plk_4	102	108	PF00069	0.351
MOD_Plk_4	129	135	PF00069	0.309
MOD_Plk_4	142	148	PF00069	0.204
MOD_Plk_4	42	48	PF00069	0.317
MOD_ProDKin_1	22	28	PF00069	0.353
TRG_ENDOCYTIC_2	10	13	PF00928	0.435
TRG_ENDOCYTIC_2	177	180	PF00928	0.509
TRG_ER_diArg_1	32	35	PF00400	0.241
TRG_ER_diArg_1	66	68	PF00400	0.204
TRG_Pf-PMV_PEXEL_1	35	39	PF00026	0.395

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2C4	Leptomonas seymouri	31%	100%
A0A0N0P547	Leptomonas seymouri	41%	100%
A0A0N0P993	Leptomonas seymouri	25%	86%
A0A0N1HWY5	Leptomonas seymouri	24%	98%
A0A0N1PAD5	Leptomonas seymouri	27%	76%
A0A0N1PDH0	Leptomonas seymouri	34%	95%
A0A1X0NQ58	Trypanosomatidae	26%	100%
A0A1X0NUH1	Trypanosomatidae	28%	85%
A0A1X0NX02	Trypanosomatidae	28%	100%
A0A1X0P2R3	Trypanosomatidae	28%	91%
A0A1X0P988	Trypanosomatidae	35%	100%
A0A381MTA7	Leishmania infantum	48%	100%
A0A381MTB8	Leishmania infantum	48%	99%
A0A381MTC7	Leishmania infantum	46%	94%
A0A381MTN2	Leishmania infantum	44%	98%
A0A381MVY0	Leishmania infantum	51%	100%
A0A3Q8ID16	Leishmania donovani	29%	100%
A0A3Q8IE85	Leishmania donovani	56%	100%
A0A3Q8IEC2	Leishmania donovani	50%	99%
A0A3Q8IEI1	Leishmania donovani	45%	100%
A0A3Q8IF65	Leishmania donovani	46%	97%
A0A3Q8IFB9	Leishmania donovani	33%	95%
A0A3Q8IFH7	Leishmania donovani	46%	94%
A0A3Q8IH65	Leishmania donovani	49%	99%
A0A3Q8IHN2	Leishmania donovani	48%	100%
A0A3Q8IHW7	Leishmania donovani	50%	100%
A0A3Q8IHZ6	Leishmania donovani	50%	91%
A0A3Q8IIH1	Leishmania donovani	49%	99%
A0A3Q8IL03	Leishmania donovani	42%	100%
A0A3Q8IUK8	Leishmania donovani	46%	100%
A0A3Q8IUR5	Leishmania donovani	44%	98%
A0A3S5H662	Leishmania donovani	49%	95%
A0A3S5H663	Leishmania donovani	49%	95%
A0A3S5H665	Leishmania donovani	49%	95%
A0A3S5H666	Leishmania donovani	45%	99%
A0A3S5H667	Leishmania donovani	49%	95%
A0A3S5H7D2	Leishmania donovani	29%	100%
A0A3S5H7L2	Leishmania donovani	43%	94%
A0A3S5H7V9	Leishmania donovani	46%	97%
A0A3S5H7W2	Leishmania donovani	27%	99%
A0A3S5H7W6	Leishmania donovani	45%	96%
A0A3S7WQA0	Leishmania donovani	49%	95%
A0A3S7WQA8	Leishmania donovani	52%	100%
A0A3S7WQC1	Leishmania donovani	46%	99%
A0A3S7X2E6	Leishmania donovani	40%	99%
A0A3S7X357	Leishmania donovani	25%	86%
A0A3S7X453	Leishmania donovani	46%	97%
A0A3S7X472	Leishmania donovani	44%	96%
A0A3S7X7E5	Leishmania donovani	49%	77%
A0A3S7X7M4	Leishmania donovani	51%	91%
A0A3S7X7U1	Leishmania donovani	43%	91%
A0A3S7X7U4	Leishmania donovani	51%	74%
A0A3S7X7W2	Leishmania donovani	42%	91%
A0A3S7X7Y0	Leishmania donovani	47%	99%
A4H595	Leishmania braziliensis	72%	100%
A4H596	Leishmania braziliensis	73%	100%
A4H597	Leishmania braziliensis	72%	100%
A4H5D1	Leishmania braziliensis	54%	99%
A4H5D2	Leishmania braziliensis	41%	100%
A4H5G0	Leishmania braziliensis	54%	100%
A4H5G4	Leishmania braziliensis	46%	100%
A4H5G6	Leishmania braziliensis	58%	100%
A4H5G7	Leishmania braziliensis	71%	100%
A4H5G9	Leishmania braziliensis	51%	100%
A4H5H0	Leishmania braziliensis	51%	100%
A4H5H1	Leishmania braziliensis	54%	100%
A4H5H2	Leishmania braziliensis	47%	99%
A4H5H3	Leishmania braziliensis	42%	99%
A4H6C8	Leishmania braziliensis	43%	100%
A4H7D7	Leishmania braziliensis	51%	100%
A4H9E8	Leishmania braziliensis	55%	100%
A4H9E9	Leishmania braziliensis	47%	100%
A4HAJ4	Leishmania braziliensis	56%	100%
A4HAJ5	Leishmania braziliensis	61%	100%
A4HAJ6	Leishmania braziliensis	72%	100%
A4HAL1	Leishmania braziliensis	53%	100%
A4HAL2	Leishmania braziliensis	30%	100%
A4HAM2	Leishmania braziliensis	49%	100%
A4HAM4	Leishmania braziliensis	48%	100%
A4HAR1	Leishmania braziliensis	46%	100%
A4HAZ8	Leishmania braziliensis	47%	99%
A4HB00	Leishmania braziliensis	46%	100%
A4HB02	Leishmania braziliensis	47%	100%
A4HB47	Leishmania braziliensis	31%	100%
A4HBJ1	Leishmania braziliensis	49%	100%
A4HBJ2	Leishmania braziliensis	47%	92%
A4HDI3	Leishmania braziliensis	31%	79%
A4HDI4	Leishmania braziliensis	26%	100%
A4HDL3	Leishmania braziliensis	28%	100%
A4HDL4	Leishmania braziliensis	26%	100%
A4HTM3	Leishmania infantum	46%	99%
A4HTM4	Leishmania infantum	51%	100%
A4HTM5	Leishmania infantum	46%	99%
A4I0W4	Leishmania infantum	29%	100%
A4I0W5	Leishmania infantum	29%	100%
A4I4J2	Leishmania infantum	42%	94%
A4I4J3	Leishmania infantum	48%	74%
A4I5B9	Leishmania infantum	25%	86%
A4I6E5	Leishmania infantum	43%	96%
A4I9Q4	Leishmania infantum	49%	100%
A4I9R4	Leishmania infantum	27%	99%
A4I9R5	Leishmania infantum	33%	95%
A4I9R7	Leishmania infantum	55%	97%
A4I9W8	Leishmania infantum	49%	74%
A4I9X0	Leishmania infantum	42%	91%
A4IA59	Leishmania infantum	44%	74%
A4IAL7	Leishmania infantum	49%	100%
A4IAM1	Leishmania infantum	43%	100%
A4IAM2	Leishmania infantum	47%	100%
E8NHC3	Leishmania infantum	47%	96%
E8NHD3	Leishmania infantum	43%	94%
E8NHD6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	52%	100%
E8NHD9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	100%
E8NHE0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	49%	92%
E8NHF4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	92%
E8NHF5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
E8NHF7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	99%
E8NHG2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	91%
E8NHH5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	91%
E8NHH9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
E8NHI3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	98%
E8NHI5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	100%
E8NHK7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	91%
E8NHK9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	50%	99%
E8NHL7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	99%
E8NHL9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	50%	99%
E8NHM0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
E8NHM1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	98%
E8NHM3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	91%
E8NHM5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	91%
E8NHM6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	100%
E8NHM7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	50%	100%
E8NHP0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	49%	93%
E8NHQ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	92%
E8NHQ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	98%
E8NHR7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	99%
E8NHR8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	99%
E8NHS2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	91%
E9AG81	Leishmania infantum	48%	94%
E9AG82	Leishmania infantum	47%	94%
E9AG83	Leishmania infantum	41%	96%
E9AG85	Leishmania infantum	47%	95%
E9AHI9	Leishmania infantum	43%	99%
E9AHT2	Leishmania infantum	52%	91%
E9AME9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	100%
E9AMF0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
E9AMF1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	92%
E9AMF2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	98%
E9AMF3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	98%
E9AMF4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	75%
E9AMF5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	92%
E9AMF7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	100%
E9AMF8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	99%
E9AMF9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	100%
E9ASP7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	48%	92%
E9AWW8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9AWW9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9B0L6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	86%
E9B1J3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	98%
E9B1J4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	92%
E9B1J5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	91%
E9B4L9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	97%
E9B4R7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	50%	97%
E9B4R8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	50%	98%
E9B4R9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	95%
E9B4S0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9B4Y3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	48%	93%
Q4Q1U9	Leishmania major	48%	99%
Q4Q305	Leishmania major	48%	99%
Q4Q309	Leishmania major	50%	100%
Q4Q313	Leishmania major	48%	99%
Q4Q317	Leishmania major	49%	100%
Q4Q325	Leishmania major	50%	100%
Q4Q327	Leishmania major	47%	99%
Q4Q329	Leishmania major	47%	99%
Q4Q333	Leishmania major	48%	99%
Q4Q335	Leishmania major	49%	99%
Q4Q337	Leishmania major	52%	100%
Q4Q339	Leishmania major	48%	99%
Q4Q341	Leishmania major	55%	100%
Q4Q397	Leishmania major	54%	73%
Q4Q3A7	Leishmania major	30%	100%
Q4Q3A8	Leishmania major	31%	100%
Q4Q3A9	Leishmania major	54%	100%
Q4Q3F7	Leishmania major	51%	100%
Q4Q6L8	Leishmania major	43%	100%
Q4Q7L6	Leishmania major	25%	100%
Q4QAK5	Leishmania major	30%	100%
Q4QAK6	Leishmania major	30%	100%
Q4QI84	Leishmania major	49%	100%
Q4QI85	Leishmania major	47%	100%
Q4QI86	Leishmania major	47%	100%
Q4QI87	Leishmania major	46%	100%
Q4QI88	Leishmania major	47%	100%
Q4QI92	Leishmania major	48%	100%
Q4QI93	Leishmania major	46%	100%
Q4QI95	Leishmania major	45%	100%
Q4QI97	Leishmania major	46%	100%
Q4QIA0	Leishmania major	46%	100%
Q4QIA1	Leishmania major	46%	100%