LeishMANIAdb
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Kinesin motor domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Kinesin motor domain-containing protein
Gene product:
flagellar attachment zone protein, putative
Species:
Leishmania braziliensis
UniProt:
A4HBI8_LEIBR
TriTrypDb:
LbrM.20.4280 , LBRM2903_200013300 *
Length:
1033

Annotations

LeishMANIAdb annotations

A family of very long coiled-coil proteins, likely performing cytoskeletal functions.. Two varieties have evolved, one with an N-terminal FYVE domain (Non-TM) and another with a C-terminal PDZ domain (might be TM)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 25
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 12
NetGPI no yes: 0, no: 12
Cellular components
Term Name Level Count
GO:0016020 membrane 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4HBI8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBI8

Function

Biological processes
Term Name Level Count
GO:0007017 microtubule-based process 2 5
GO:0007018 microtubule-based movement 3 5
GO:0009987 cellular process 1 6
GO:0007165 signal transduction 2 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0065007 biological regulation 1 1
Molecular functions
Term Name Level Count
GO:0003774 cytoskeletal motor activity 1 5
GO:0003777 microtubule motor activity 2 5
GO:0003824 catalytic activity 1 2
GO:0016787 hydrolase activity 2 2
GO:0140657 ATP-dependent activity 1 5

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 138 142 PF00656 0.496
CLV_NRD_NRD_1 123 125 PF00675 0.383
CLV_NRD_NRD_1 154 156 PF00675 0.487
CLV_NRD_NRD_1 206 208 PF00675 0.395
CLV_PCSK_FUR_1 121 125 PF00082 0.413
CLV_PCSK_KEX2_1 123 125 PF00082 0.427
CLV_PCSK_SKI1_1 155 159 PF00082 0.496
CLV_PCSK_SKI1_1 207 211 PF00082 0.384
DEG_Nend_Nbox_1 1 3 PF02207 0.436
DOC_CDC14_PxL_1 21 29 PF14671 0.428
DOC_MAPK_gen_1 153 160 PF00069 0.484
DOC_MAPK_gen_1 83 90 PF00069 0.343
DOC_PIKK_1 212 220 PF02985 0.372
DOC_PIKK_1 268 276 PF02985 0.377
DOC_PIKK_1 324 332 PF02985 0.398
DOC_PIKK_1 380 388 PF02985 0.469
DOC_PIKK_1 436 444 PF02985 0.423
DOC_PIKK_1 492 500 PF02985 0.384
DOC_PIKK_1 548 556 PF02985 0.382
DOC_PIKK_1 590 598 PF02985 0.383
DOC_PIKK_1 646 654 PF02985 0.395
DOC_PIKK_1 688 696 PF02985 0.437
DOC_PIKK_1 744 752 PF02985 0.424
DOC_PIKK_1 800 808 PF02985 0.434
DOC_PIKK_1 842 850 PF02985 0.415
DOC_PIKK_1 884 892 PF02985 0.387
DOC_PP4_FxxP_1 3 6 PF00568 0.395
DOC_USP7_MATH_1 37 41 PF00917 0.492
DOC_USP7_MATH_1 975 979 PF00917 0.372
DOC_USP7_UBL2_3 911 915 PF12436 0.369
DOC_WW_Pin1_4 141 146 PF00397 0.496
DOC_WW_Pin1_4 33 38 PF00397 0.475
LIG_14-3-3_CanoR_1 9 15 PF00244 0.426
LIG_14-3-3_CanoR_1 933 941 PF00244 0.363
LIG_Actin_WH2_2 976 993 PF00022 0.354
LIG_CaM_IQ_9 100 116 PF13499 0.357
LIG_CSK_EPIYA_1 175 179 PF00017 0.435
LIG_CSK_EPIYA_1 44 48 PF00017 0.471
LIG_FHA_1 105 111 PF00498 0.353
LIG_FHA_1 162 168 PF00498 0.460
LIG_FHA_1 24 30 PF00498 0.442
LIG_FHA_1 6 12 PF00498 0.416
LIG_FHA_2 1002 1008 PF00498 0.381
LIG_FHA_2 1023 1029 PF00498 0.476
LIG_FHA_2 136 142 PF00498 0.476
LIG_FHA_2 179 185 PF00498 0.497
LIG_FHA_2 48 54 PF00498 0.443
LIG_LIR_Gen_1 13 24 PF02991 0.529
LIG_LIR_Gen_1 184 192 PF02991 0.370
LIG_LIR_Gen_1 961 970 PF02991 0.344
LIG_LIR_Gen_1 977 987 PF02991 0.328
LIG_LIR_Nem_3 13 19 PF02991 0.531
LIG_LIR_Nem_3 184 188 PF02991 0.369
LIG_LIR_Nem_3 961 966 PF02991 0.339
LIG_LIR_Nem_3 977 983 PF02991 0.333
LIG_NRBOX 10 16 PF00104 0.427
LIG_NRBOX 84 90 PF00104 0.344
LIG_PCNA_yPIPBox_3 989 1001 PF02747 0.375
LIG_RPA_C_Fungi 119 131 PF08784 0.371
LIG_SH2_NCK_1 61 65 PF00017 0.363
LIG_SH2_NCK_1 934 938 PF00017 0.365
LIG_SH2_SRC 61 64 PF00017 0.364
LIG_SH2_STAP1 178 182 PF00017 0.461
LIG_SH2_STAP1 47 51 PF00017 0.431
LIG_SH2_STAT5 16 19 PF00017 0.440
LIG_SH2_STAT5 28 31 PF00017 0.443
LIG_SH3_3 163 169 PF00018 0.486
LIG_SH3_3 31 37 PF00018 0.497
LIG_SH3_3 39 45 PF00018 0.465
LIG_SUMO_SIM_anti_2 20 26 PF11976 0.419
LIG_SUMO_SIM_anti_2 977 986 PF11976 0.378
LIG_TRAF2_1 1025 1028 PF00917 0.478
LIG_TRAF2_1 222 225 PF00917 0.421
LIG_TRAF2_1 237 240 PF00917 0.387
LIG_TRAF2_1 278 281 PF00917 0.449
LIG_TRAF2_1 293 296 PF00917 0.435
LIG_TRAF2_1 334 337 PF00917 0.493
LIG_TRAF2_1 349 352 PF00917 0.428
LIG_TRAF2_1 390 393 PF00917 0.575
LIG_TRAF2_1 405 408 PF00917 0.479
LIG_TRAF2_1 41 44 PF00917 0.491
LIG_TRAF2_1 446 449 PF00917 0.457
LIG_TRAF2_1 461 464 PF00917 0.429
LIG_TRAF2_1 517 520 PF00917 0.395
LIG_TRAF2_1 600 603 PF00917 0.428
LIG_TRAF2_1 615 618 PF00917 0.402
LIG_TRAF2_1 698 701 PF00917 0.531
LIG_TRAF2_1 713 716 PF00917 0.448
LIG_TRAF2_1 754 757 PF00917 0.487
LIG_TRAF2_1 769 772 PF00917 0.446
LIG_TRAF2_1 810 813 PF00917 0.468
LIG_TRAF2_1 852 855 PF00917 0.422
LIG_TRAF2_1 867 870 PF00917 0.445
LIG_TRAF2_1 894 897 PF00917 0.429
LIG_TRAF2_1 936 939 PF00917 0.378
LIG_TYR_ITIM 14 19 PF00017 0.430
LIG_UBA3_1 984 991 PF00899 0.365
MOD_CK1_1 1022 1028 PF00069 0.484
MOD_CK1_1 144 150 PF00069 0.513
MOD_CK1_1 946 952 PF00069 0.343
MOD_CK2_1 1001 1007 PF00069 0.367
MOD_CK2_1 1022 1028 PF00069 0.472
MOD_CK2_1 178 184 PF00069 0.512
MOD_CK2_1 219 225 PF00069 0.418
MOD_CK2_1 229 235 PF00069 0.443
MOD_CK2_1 275 281 PF00069 0.455
MOD_CK2_1 285 291 PF00069 0.411
MOD_CK2_1 331 337 PF00069 0.489
MOD_CK2_1 341 347 PF00069 0.455
MOD_CK2_1 37 43 PF00069 0.486
MOD_CK2_1 387 393 PF00069 0.568
MOD_CK2_1 397 403 PF00069 0.524
MOD_CK2_1 443 449 PF00069 0.465
MOD_CK2_1 47 53 PF00069 0.427
MOD_CK2_1 597 603 PF00069 0.422
MOD_CK2_1 695 701 PF00069 0.483
MOD_CK2_1 751 757 PF00069 0.521
MOD_CK2_1 807 813 PF00069 0.546
MOD_CK2_1 849 855 PF00069 0.434
MOD_CK2_1 891 897 PF00069 0.416
MOD_CK2_1 933 939 PF00069 0.387
MOD_GlcNHglycan 1019 1024 PF01048 0.479
MOD_GlcNHglycan 39 42 PF01048 0.550
MOD_GlcNHglycan 917 920 PF01048 0.362
MOD_GlcNHglycan 935 938 PF01048 0.375
MOD_GSK3_1 10 17 PF00069 0.473
MOD_GSK3_1 1018 1025 PF00069 0.489
MOD_GSK3_1 19 26 PF00069 0.448
MOD_GSK3_1 33 40 PF00069 0.449
MOD_NEK2_1 151 156 PF00069 0.523
MOD_NEK2_1 19 24 PF00069 0.481
MOD_NEK2_1 985 990 PF00069 0.357
MOD_NEK2_2 178 183 PF00069 0.402
MOD_PIKK_1 109 115 PF00454 0.350
MOD_PIKK_1 946 952 PF00454 0.343
MOD_Plk_1 17 23 PF00069 0.447
MOD_Plk_1 946 952 PF00069 0.373
MOD_Plk_2-3 219 225 PF00069 0.386
MOD_Plk_2-3 275 281 PF00069 0.381
MOD_Plk_2-3 331 337 PF00069 0.405
MOD_Plk_2-3 387 393 PF00069 0.494
MOD_Plk_2-3 443 449 PF00069 0.427
MOD_Plk_2-3 597 603 PF00069 0.393
MOD_Plk_2-3 695 701 PF00069 0.451
MOD_Plk_2-3 751 757 PF00069 0.437
MOD_Plk_2-3 807 813 PF00069 0.483
MOD_Plk_2-3 849 855 PF00069 0.437
MOD_Plk_2-3 891 897 PF00069 0.406
MOD_Plk_4 10 16 PF00069 0.540
MOD_Plk_4 19 25 PF00069 0.416
MOD_Plk_4 77 83 PF00069 0.339
MOD_ProDKin_1 141 147 PF00069 0.496
MOD_ProDKin_1 33 39 PF00069 0.476
MOD_SUMO_for_1 71 74 PF00179 0.378
MOD_SUMO_rev_2 70 80 PF00179 0.378
TRG_DiLeu_BaEn_1 947 952 PF01217 0.354
TRG_DiLeu_BaEn_4 218 224 PF01217 0.386
TRG_DiLeu_BaEn_4 225 231 PF01217 0.388
TRG_DiLeu_BaEn_4 239 245 PF01217 0.378
TRG_DiLeu_BaEn_4 274 280 PF01217 0.394
TRG_DiLeu_BaEn_4 281 287 PF01217 0.399
TRG_DiLeu_BaEn_4 295 301 PF01217 0.413
TRG_DiLeu_BaEn_4 330 336 PF01217 0.417
TRG_DiLeu_BaEn_4 337 343 PF01217 0.422
TRG_DiLeu_BaEn_4 351 357 PF01217 0.414
TRG_DiLeu_BaEn_4 386 392 PF01217 0.502
TRG_DiLeu_BaEn_4 393 399 PF01217 0.488
TRG_DiLeu_BaEn_4 407 413 PF01217 0.479
TRG_DiLeu_BaEn_4 442 448 PF01217 0.434
TRG_DiLeu_BaEn_4 449 455 PF01217 0.426
TRG_DiLeu_BaEn_4 463 469 PF01217 0.425
TRG_DiLeu_BaEn_4 498 504 PF01217 0.401
TRG_DiLeu_BaEn_4 505 511 PF01217 0.399
TRG_DiLeu_BaEn_4 519 525 PF01217 0.374
TRG_DiLeu_BaEn_4 554 560 PF01217 0.401
TRG_DiLeu_BaEn_4 561 567 PF01217 0.395
TRG_DiLeu_BaEn_4 596 602 PF01217 0.397
TRG_DiLeu_BaEn_4 603 609 PF01217 0.402
TRG_DiLeu_BaEn_4 617 623 PF01217 0.395
TRG_DiLeu_BaEn_4 652 658 PF01217 0.419
TRG_DiLeu_BaEn_4 659 665 PF01217 0.414
TRG_DiLeu_BaEn_4 694 700 PF01217 0.456
TRG_DiLeu_BaEn_4 701 707 PF01217 0.468
TRG_DiLeu_BaEn_4 715 721 PF01217 0.435
TRG_DiLeu_BaEn_4 750 756 PF01217 0.443
TRG_DiLeu_BaEn_4 757 763 PF01217 0.446
TRG_DiLeu_BaEn_4 771 777 PF01217 0.430
TRG_DiLeu_BaEn_4 806 812 PF01217 0.451
TRG_DiLeu_BaEn_4 813 819 PF01217 0.441
TRG_DiLeu_BaEn_4 848 854 PF01217 0.413
TRG_DiLeu_BaEn_4 855 861 PF01217 0.399
TRG_DiLeu_BaEn_4 890 896 PF01217 0.402
TRG_DiLeu_BaEn_4 897 903 PF01217 0.397
TRG_ENDOCYTIC_2 16 19 PF00928 0.539
TRG_ENDOCYTIC_2 185 188 PF00928 0.370
TRG_ENDOCYTIC_2 963 966 PF00928 0.346
TRG_ER_diArg_1 120 123 PF00400 0.364
TRG_NES_CRM1_1 79 91 PF08389 0.339
TRG_NES_CRM1_1 950 964 PF08389 0.336
TRG_Pf-PMV_PEXEL_1 207 212 PF00026 0.385

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3S7X6W4 Leishmania donovani 34% 100%
A4H7T4 Leishmania braziliensis 35% 100%
A4H8S4 Leishmania braziliensis 30% 100%
A4H8S5 Leishmania braziliensis 29% 100%
A4HAW9 Leishmania braziliensis 40% 72%
A4HW56 Leishmania infantum 38% 100%
A4I9N9 Leishmania infantum 61% 78%
A4IAN8 Leishmania infantum 60% 68%
E8NHK1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 100%
E8NHK3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 35% 100%
E9B4N7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 27% 100%
Q6P5D4 Mus musculus 25% 91%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS