Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HBI7_LEIBR

TriTrypDb:

LbrM.20.4270 , LBRM2903_200031800

Length:

618

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HBI7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBI7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	144	148	PF00656	0.593
CLV_C14_Caspase3-7	242	246	PF00656	0.410
CLV_C14_Caspase3-7	377	381	PF00656	0.551
CLV_C14_Caspase3-7	442	446	PF00656	0.548
CLV_C14_Caspase3-7	57	61	PF00656	0.461
CLV_NRD_NRD_1	101	103	PF00675	0.594
CLV_NRD_NRD_1	243	245	PF00675	0.538
CLV_NRD_NRD_1	55	57	PF00675	0.498
CLV_PCSK_FUR_1	241	245	PF00082	0.555
CLV_PCSK_KEX2_1	101	103	PF00082	0.575
CLV_PCSK_KEX2_1	168	170	PF00082	0.364
CLV_PCSK_KEX2_1	243	245	PF00082	0.520
CLV_PCSK_KEX2_1	54	56	PF00082	0.379
CLV_PCSK_PC1ET2_1	168	170	PF00082	0.364
CLV_PCSK_PC7_1	97	103	PF00082	0.342
CLV_PCSK_SKI1_1	205	209	PF00082	0.556
CLV_PCSK_SKI1_1	35	39	PF00082	0.558
CLV_PCSK_SKI1_1	390	394	PF00082	0.541
CLV_PCSK_SKI1_1	412	416	PF00082	0.804
CLV_PCSK_SKI1_1	47	51	PF00082	0.479
CLV_PCSK_SKI1_1	545	549	PF00082	0.563
CLV_PCSK_SKI1_1	97	101	PF00082	0.507
DEG_APCC_DBOX_1	96	104	PF00400	0.339
DEG_SCF_FBW7_1	470	476	PF00400	0.622
DEG_SPOP_SBC_1	424	428	PF00917	0.604
DEG_SPOP_SBC_1	446	450	PF00917	0.597
DOC_CKS1_1	470	475	PF01111	0.628
DOC_CYCLIN_RxL_1	542	550	PF00134	0.528
DOC_MAPK_gen_1	87	96	PF00069	0.387
DOC_MAPK_MEF2A_6	29	38	PF00069	0.501
DOC_MAPK_MEF2A_6	90	98	PF00069	0.369
DOC_PP1_RVXF_1	33	39	PF00149	0.330
DOC_PP1_RVXF_1	410	417	PF00149	0.554
DOC_USP7_MATH_1	136	140	PF00917	0.458
DOC_USP7_MATH_1	337	341	PF00917	0.557
DOC_USP7_MATH_1	374	378	PF00917	0.660
DOC_USP7_MATH_1	379	383	PF00917	0.637
DOC_USP7_MATH_1	473	477	PF00917	0.657
DOC_USP7_UBL2_3	487	491	PF12436	0.663
DOC_WW_Pin1_4	194	199	PF00397	0.363
DOC_WW_Pin1_4	309	314	PF00397	0.621
DOC_WW_Pin1_4	469	474	PF00397	0.633
LIG_14-3-3_CanoR_1	262	267	PF00244	0.568
LIG_14-3-3_CanoR_1	323	328	PF00244	0.783
LIG_14-3-3_CanoR_1	390	395	PF00244	0.595
LIG_14-3-3_CanoR_1	47	53	PF00244	0.557
LIG_14-3-3_CanoR_1	54	63	PF00244	0.478
LIG_14-3-3_CanoR_1	610	616	PF00244	0.493
LIG_14-3-3_CanoR_1	85	94	PF00244	0.621
LIG_Actin_WH2_2	34	52	PF00022	0.366
LIG_BIR_II_1	1	5	PF00653	0.432
LIG_BRCT_BRCA1_1	585	589	PF00533	0.501
LIG_FHA_1	261	267	PF00498	0.512
LIG_FHA_1	3	9	PF00498	0.654
LIG_FHA_1	31	37	PF00498	0.493
LIG_FHA_2	142	148	PF00498	0.599
LIG_FHA_2	440	446	PF00498	0.623
LIG_FHA_2	453	459	PF00498	0.685
LIG_FHA_2	522	528	PF00498	0.675
LIG_GBD_Chelix_1	62	70	PF00786	0.349
LIG_LIR_Gen_1	284	294	PF02991	0.497
LIG_LIR_Gen_1	42	53	PF02991	0.380
LIG_LIR_Gen_1	448	457	PF02991	0.526
LIG_LIR_Nem_3	108	114	PF02991	0.505
LIG_LIR_Nem_3	208	213	PF02991	0.556
LIG_LIR_Nem_3	284	289	PF02991	0.472
LIG_LIR_Nem_3	42	48	PF02991	0.388
LIG_LIR_Nem_3	448	454	PF02991	0.531
LIG_LIR_Nem_3	488	493	PF02991	0.436
LIG_LIR_Nem_3	502	507	PF02991	0.530
LIG_NRBOX	169	175	PF00104	0.353
LIG_Pex14_1	206	210	PF04695	0.544
LIG_PTB_Apo_2	282	289	PF02174	0.443
LIG_PTB_Phospho_1	282	288	PF10480	0.442
LIG_Rb_LxCxE_1	495	516	PF01857	0.661
LIG_SH2_CRK	11	15	PF00017	0.616
LIG_SH2_CRK	175	179	PF00017	0.517
LIG_SH2_GRB2like	511	514	PF00017	0.675
LIG_SH2_NCK_1	175	179	PF00017	0.548
LIG_SH2_NCK_1	190	194	PF00017	0.391
LIG_SH2_SRC	383	386	PF00017	0.534
LIG_SH2_STAP1	45	49	PF00017	0.377
LIG_SH2_STAP1	511	515	PF00017	0.565
LIG_SH2_STAT5	182	185	PF00017	0.499
LIG_SH2_STAT5	276	279	PF00017	0.638
LIG_SH2_STAT5	288	291	PF00017	0.440
LIG_SH2_STAT5	383	386	PF00017	0.534
LIG_SH2_STAT5	600	603	PF00017	0.709
LIG_SH3_3	336	342	PF00018	0.681
LIG_SH3_3	368	374	PF00018	0.775
LIG_SH3_3	460	466	PF00018	0.737
LIG_SH3_3	467	473	PF00018	0.745
LIG_TRAF2_1	18	21	PF00917	0.639
LIG_TRAF2_1	193	196	PF00917	0.403
LIG_TRAF2_1	524	527	PF00917	0.674
LIG_TYR_ITIM	173	178	PF00017	0.517
LIG_UBA3_1	37	43	PF00899	0.371
LIG_WRC_WIRS_1	324	329	PF05994	0.567
MOD_CDK_SPK_2	309	314	PF00069	0.560
MOD_CK1_1	139	145	PF00069	0.507
MOD_CK1_1	184	190	PF00069	0.520
MOD_CK1_1	191	197	PF00069	0.508
MOD_CK1_1	2	8	PF00069	0.423
MOD_CK1_1	233	239	PF00069	0.611
MOD_CK1_1	295	301	PF00069	0.469
MOD_CK1_1	322	328	PF00069	0.593
MOD_CK1_1	386	392	PF00069	0.695
MOD_CK1_1	452	458	PF00069	0.734
MOD_CK1_1	65	71	PF00069	0.467
MOD_CK1_1	81	87	PF00069	0.683
MOD_CK2_1	174	180	PF00069	0.480
MOD_CK2_1	236	242	PF00069	0.527
MOD_CK2_1	379	385	PF00069	0.556
MOD_CK2_1	521	527	PF00069	0.630
MOD_GlcNHglycan	120	123	PF01048	0.469
MOD_GlcNHglycan	124	127	PF01048	0.454
MOD_GlcNHglycan	153	156	PF01048	0.575
MOD_GlcNHglycan	191	194	PF01048	0.351
MOD_GlcNHglycan	2	5	PF01048	0.443
MOD_GlcNHglycan	238	241	PF01048	0.491
MOD_GlcNHglycan	328	331	PF01048	0.620
MOD_GlcNHglycan	417	420	PF01048	0.663
MOD_GlcNHglycan	427	430	PF01048	0.753
MOD_GlcNHglycan	473	476	PF01048	0.646
MOD_GlcNHglycan	549	552	PF01048	0.565
MOD_GlcNHglycan	586	589	PF01048	0.633
MOD_GlcNHglycan	613	616	PF01048	0.506
MOD_GSK3_1	118	125	PF00069	0.580
MOD_GSK3_1	136	143	PF00069	0.297
MOD_GSK3_1	184	191	PF00069	0.527
MOD_GSK3_1	232	239	PF00069	0.585
MOD_GSK3_1	258	265	PF00069	0.556
MOD_GSK3_1	295	302	PF00069	0.479
MOD_GSK3_1	319	326	PF00069	0.627
MOD_GSK3_1	379	386	PF00069	0.623
MOD_GSK3_1	390	397	PF00069	0.747
MOD_GSK3_1	415	422	PF00069	0.643
MOD_GSK3_1	431	438	PF00069	0.482
MOD_GSK3_1	445	452	PF00069	0.655
MOD_GSK3_1	469	476	PF00069	0.647
MOD_GSK3_1	511	518	PF00069	0.553
MOD_GSK3_1	611	618	PF00069	0.502
MOD_GSK3_1	81	88	PF00069	0.688
MOD_N-GLC_1	438	443	PF02516	0.556
MOD_N-GLC_1	573	578	PF02516	0.738
MOD_N-GLC_2	421	423	PF02516	0.547
MOD_NEK2_1	140	145	PF00069	0.456
MOD_NEK2_1	151	156	PF00069	0.473
MOD_NEK2_1	174	179	PF00069	0.518
MOD_NEK2_1	183	188	PF00069	0.431
MOD_NEK2_1	299	304	PF00069	0.655
MOD_NEK2_1	425	430	PF00069	0.770
MOD_NEK2_1	48	53	PF00069	0.369
MOD_NEK2_1	547	552	PF00069	0.550
MOD_NEK2_1	583	588	PF00069	0.608
MOD_NEK2_1	72	77	PF00069	0.579
MOD_NEK2_2	383	388	PF00069	0.535
MOD_PIKK_1	112	118	PF00454	0.606
MOD_PIKK_1	191	197	PF00454	0.571
MOD_PIKK_1	230	236	PF00454	0.392
MOD_PIKK_1	260	266	PF00454	0.547
MOD_PIKK_1	452	458	PF00454	0.657
MOD_PIKK_1	515	521	PF00454	0.455
MOD_PIKK_1	540	546	PF00454	0.466
MOD_PKA_1	243	249	PF00069	0.535
MOD_PKA_1	54	60	PF00069	0.491
MOD_PKA_2	243	249	PF00069	0.539
MOD_PKA_2	281	287	PF00069	0.453
MOD_PKA_2	292	298	PF00069	0.634
MOD_PKA_2	322	328	PF00069	0.770
MOD_PKA_2	343	349	PF00069	0.730
MOD_PKA_2	374	380	PF00069	0.679
MOD_PKA_2	434	440	PF00069	0.562
MOD_PKA_2	54	60	PF00069	0.374
MOD_PKB_1	241	249	PF00069	0.536
MOD_Plk_1	184	190	PF00069	0.466
MOD_Plk_1	319	325	PF00069	0.670
MOD_Plk_1	342	348	PF00069	0.625
MOD_Plk_1	602	608	PF00069	0.703
MOD_Plk_2-3	292	298	PF00069	0.521
MOD_Plk_4	136	142	PF00069	0.633
MOD_Plk_4	379	385	PF00069	0.759
MOD_Plk_4	390	396	PF00069	0.536
MOD_Plk_4	48	54	PF00069	0.402
MOD_Plk_4	493	499	PF00069	0.650
MOD_ProDKin_1	194	200	PF00069	0.354
MOD_ProDKin_1	309	315	PF00069	0.622
MOD_ProDKin_1	469	475	PF00069	0.631
MOD_SUMO_for_1	355	358	PF00179	0.711
MOD_SUMO_rev_2	409	417	PF00179	0.743
MOD_SUMO_rev_2	502	512	PF00179	0.563
TRG_DiLeu_BaEn_4	20	26	PF01217	0.620
TRG_DiLeu_BaEn_4	502	508	PF01217	0.659
TRG_DiLeu_BaLyEn_6	147	152	PF01217	0.503
TRG_DiLeu_BaLyEn_6	169	174	PF01217	0.361
TRG_DiLeu_BaLyEn_6	44	49	PF01217	0.377
TRG_ENDOCYTIC_2	175	178	PF00928	0.466
TRG_ENDOCYTIC_2	45	48	PF00928	0.384
TRG_ENDOCYTIC_2	504	507	PF00928	0.555
TRG_ER_diArg_1	100	102	PF00400	0.599
TRG_ER_diArg_1	53	56	PF00400	0.380
TRG_Pf-PMV_PEXEL_1	172	176	PF00026	0.598
TRG_Pf-PMV_PEXEL_1	505	509	PF00026	0.410
TRG_Pf-PMV_PEXEL_1	76	80	PF00026	0.422

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMJ7	Leptomonas seymouri	42%	99%
A0A3Q8IIM3	Leishmania donovani	66%	100%
A4IA31	Leishmania infantum	66%	100%
E9B546	Leishmania mexicana (strain MHOM/GT/2001/U1103)	64%	100%
Q4Q2U0	Leishmania major	66%	100%