Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HBI6_LEIBR

TriTrypDb:

LbrM.20.4260 , LBRM2903_200025700

Length:

414

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HBI6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBI6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	349	353	PF00656	0.599
CLV_C14_Caspase3-7	52	56	PF00656	0.597
CLV_C14_Caspase3-7	93	97	PF00656	0.619
CLV_NRD_NRD_1	112	114	PF00675	0.416
CLV_NRD_NRD_1	369	371	PF00675	0.363
CLV_NRD_NRD_1	404	406	PF00675	0.622
CLV_PCSK_FUR_1	367	371	PF00082	0.405
CLV_PCSK_KEX2_1	367	369	PF00082	0.394
CLV_PCSK_SKI1_1	113	117	PF00082	0.503
CLV_PCSK_SKI1_1	405	409	PF00082	0.666
CLV_Separin_Metazoa	263	267	PF03568	0.602
DEG_APCC_DBOX_1	386	394	PF00400	0.475
DOC_CKS1_1	358	363	PF01111	0.597
DOC_CKS1_1	8	13	PF01111	0.644
DOC_CYCLIN_RxL_1	110	117	PF00134	0.616
DOC_CYCLIN_yClb3_PxF_3	198	204	PF00134	0.615
DOC_CYCLIN_yCln2_LP_2	386	392	PF00134	0.312
DOC_MAPK_gen_1	367	376	PF00069	0.686
DOC_MAPK_gen_1	403	410	PF00069	0.364
DOC_MAPK_gen_1	59	66	PF00069	0.610
DOC_PP1_RVXF_1	371	377	PF00149	0.409
DOC_PP2B_LxvP_1	386	389	PF13499	0.312
DOC_PP2B_LxvP_1	408	411	PF13499	0.361
DOC_PP4_FxxP_1	116	119	PF00568	0.734
DOC_PP4_FxxP_1	261	264	PF00568	0.676
DOC_PP4_FxxP_1	8	11	PF00568	0.644
DOC_USP7_MATH_1	121	125	PF00917	0.638
DOC_USP7_MATH_1	136	140	PF00917	0.692
DOC_USP7_MATH_1	141	145	PF00917	0.677
DOC_USP7_MATH_1	185	189	PF00917	0.703
DOC_USP7_MATH_1	215	219	PF00917	0.620
DOC_USP7_MATH_1	220	224	PF00917	0.674
DOC_USP7_MATH_1	30	34	PF00917	0.679
DOC_USP7_UBL2_3	114	118	PF12436	0.621
DOC_WW_Pin1_4	106	111	PF00397	0.661
DOC_WW_Pin1_4	149	154	PF00397	0.670
DOC_WW_Pin1_4	198	203	PF00397	0.621
DOC_WW_Pin1_4	272	277	PF00397	0.748
DOC_WW_Pin1_4	357	362	PF00397	0.601
DOC_WW_Pin1_4	54	59	PF00397	0.676
DOC_WW_Pin1_4	7	12	PF00397	0.671
DOC_WW_Pin1_4	74	79	PF00397	0.745
DOC_WW_Pin1_4	94	99	PF00397	0.598
LIG_14-3-3_CanoR_1	103	111	PF00244	0.708
LIG_14-3-3_CanoR_1	14	20	PF00244	0.651
LIG_14-3-3_CanoR_1	143	151	PF00244	0.728
LIG_14-3-3_CanoR_1	187	192	PF00244	0.677
LIG_14-3-3_CanoR_1	355	361	PF00244	0.799
LIG_14-3-3_CanoR_1	59	65	PF00244	0.683
LIG_Actin_WH2_2	173	189	PF00022	0.620
LIG_BIR_III_2	75	79	PF00653	0.622
LIG_BRCT_BRCA1_1	151	155	PF00533	0.628
LIG_BRCT_BRCA1_1	187	191	PF00533	0.735
LIG_BRCT_BRCA1_1	200	204	PF00533	0.659
LIG_CtBP_PxDLS_1	31	37	PF00389	0.609
LIG_FHA_1	110	116	PF00498	0.615
LIG_FHA_1	229	235	PF00498	0.683
LIG_FHA_1	27	33	PF00498	0.724
LIG_FHA_1	43	49	PF00498	0.570
LIG_FHA_1	86	92	PF00498	0.641
LIG_FHA_2	50	56	PF00498	0.754
LIG_FHA_2	91	97	PF00498	0.620
LIG_LIR_Apic_2	258	264	PF02991	0.710
LIG_LIR_Gen_1	201	208	PF02991	0.674
LIG_LIR_Nem_3	201	207	PF02991	0.678
LIG_NRBOX	380	386	PF00104	0.279
LIG_NRBOX	403	409	PF00104	0.414
LIG_SH2_CRK	122	126	PF00017	0.605
LIG_SH2_STAT5	206	209	PF00017	0.728
LIG_SH3_3	196	202	PF00018	0.613
LIG_TYR_ITIM	120	125	PF00017	0.610
MOD_CDC14_SPxK_1	97	100	PF00782	0.620
MOD_CDK_SPK_2	357	362	PF00069	0.601
MOD_CDK_SPK_2	54	59	PF00069	0.604
MOD_CDK_SPK_2	74	79	PF00069	0.778
MOD_CDK_SPK_2	98	103	PF00069	0.680
MOD_CDK_SPxK_1	94	100	PF00069	0.622
MOD_CDK_SPxxK_3	106	113	PF00069	0.617
MOD_CDK_SPxxK_3	272	279	PF00069	0.716
MOD_CDK_SPxxK_3	54	61	PF00069	0.605
MOD_CDK_SPxxK_3	7	14	PF00069	0.664
MOD_CK1_1	124	130	PF00069	0.627
MOD_CK1_1	170	176	PF00069	0.735
MOD_CK1_1	200	206	PF00069	0.683
MOD_CK1_1	218	224	PF00069	0.607
MOD_CK1_1	239	245	PF00069	0.640
MOD_CK1_1	254	260	PF00069	0.591
MOD_CK1_1	353	359	PF00069	0.629
MOD_CK1_1	62	68	PF00069	0.791
MOD_CK1_1	86	92	PF00069	0.719
MOD_CK2_1	155	161	PF00069	0.777
MOD_CK2_1	252	258	PF00069	0.661
MOD_GlcNHglycan	127	130	PF01048	0.419
MOD_GlcNHglycan	145	148	PF01048	0.480
MOD_GlcNHglycan	169	172	PF01048	0.569
MOD_GlcNHglycan	176	179	PF01048	0.558
MOD_GlcNHglycan	187	190	PF01048	0.458
MOD_GlcNHglycan	19	22	PF01048	0.492
MOD_GlcNHglycan	217	221	PF01048	0.478
MOD_GlcNHglycan	238	241	PF01048	0.453
MOD_GlcNHglycan	254	257	PF01048	0.385
MOD_GlcNHglycan	268	272	PF01048	0.504
MOD_GlcNHglycan	280	283	PF01048	0.454
MOD_GlcNHglycan	312	315	PF01048	0.451
MOD_GlcNHglycan	326	329	PF01048	0.357
MOD_GlcNHglycan	38	42	PF01048	0.540
MOD_GlcNHglycan	399	402	PF01048	0.591
MOD_GlcNHglycan	88	91	PF01048	0.480
MOD_GSK3_1	121	128	PF00069	0.656
MOD_GSK3_1	149	156	PF00069	0.715
MOD_GSK3_1	163	170	PF00069	0.704
MOD_GSK3_1	193	200	PF00069	0.731
MOD_GSK3_1	202	209	PF00069	0.641
MOD_GSK3_1	216	223	PF00069	0.764
MOD_GSK3_1	247	254	PF00069	0.625
MOD_GSK3_1	26	33	PF00069	0.771
MOD_GSK3_1	278	285	PF00069	0.726
MOD_GSK3_1	353	360	PF00069	0.660
MOD_GSK3_1	50	57	PF00069	0.710
MOD_GSK3_1	60	67	PF00069	0.654
MOD_GSK3_1	70	77	PF00069	0.697
MOD_GSK3_1	86	93	PF00069	0.710
MOD_GSK3_1	94	101	PF00069	0.700
MOD_N-GLC_1	141	146	PF02516	0.522
MOD_N-GLC_1	193	198	PF02516	0.421
MOD_N-GLC_1	310	315	PF02516	0.390
MOD_N-GLC_1	42	47	PF02516	0.477
MOD_N-GLC_1	49	54	PF02516	0.465
MOD_NEK2_1	155	160	PF00069	0.691
MOD_NEK2_1	267	272	PF00069	0.711
MOD_NEK2_1	397	402	PF00069	0.385
MOD_NEK2_1	49	54	PF00069	0.634
MOD_PIKK_1	104	110	PF00454	0.619
MOD_PIKK_1	283	289	PF00454	0.709
MOD_PIKK_1	350	356	PF00454	0.675
MOD_PK_1	247	253	PF00069	0.672
MOD_PKA_1	369	375	PF00069	0.601
MOD_PKA_2	142	148	PF00069	0.725
MOD_PKA_2	278	284	PF00069	0.813
MOD_PKA_2	324	330	PF00069	0.548
MOD_PKA_2	369	375	PF00069	0.601
MOD_PKB_1	367	375	PF00069	0.623
MOD_Plk_1	163	169	PF00069	0.688
MOD_Plk_1	49	55	PF00069	0.617
MOD_Plk_4	164	170	PF00069	0.662
MOD_ProDKin_1	106	112	PF00069	0.660
MOD_ProDKin_1	149	155	PF00069	0.672
MOD_ProDKin_1	198	204	PF00069	0.624
MOD_ProDKin_1	272	278	PF00069	0.749
MOD_ProDKin_1	357	363	PF00069	0.598
MOD_ProDKin_1	54	60	PF00069	0.673
MOD_ProDKin_1	7	13	PF00069	0.670
MOD_ProDKin_1	74	80	PF00069	0.745
MOD_ProDKin_1	94	100	PF00069	0.600
MOD_SUMO_rev_2	254	262	PF00179	0.673
TRG_DiLeu_BaEn_1	164	169	PF01217	0.621
TRG_ENDOCYTIC_2	122	125	PF00928	0.657
TRG_ER_diArg_1	367	370	PF00400	0.629
TRG_NES_CRM1_1	24	38	PF08389	0.679
TRG_NES_CRM1_1	380	394	PF08389	0.231

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8U0	Leptomonas seymouri	26%	95%
A0A3Q8IHI2	Leishmania donovani	56%	100%
A4I9Y1	Leishmania infantum	55%	100%
E9B4Y9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	56%	100%
Q4Q2Z7	Leishmania major	55%	100%