Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

wd40 repeat domain-containing protein

Species:

Leishmania braziliensis

UniProt:

A4HBI4_LEIBR

TriTrypDb:

LbrM.20.4240 , LBRM2903_200057400

Length:

804

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005815	microtubule organizing center	2	1
GO:0036064	ciliary basal body	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HBI4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBI4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	200	204	PF00656	0.536
CLV_C14_Caspase3-7	478	482	PF00656	0.593
CLV_C14_Caspase3-7	578	582	PF00656	0.641
CLV_NRD_NRD_1	654	656	PF00675	0.399
CLV_PCSK_KEX2_1	654	656	PF00082	0.452
CLV_PCSK_KEX2_1	661	663	PF00082	0.474
CLV_PCSK_KEX2_1	783	785	PF00082	0.593
CLV_PCSK_PC1ET2_1	661	663	PF00082	0.547
CLV_PCSK_PC1ET2_1	783	785	PF00082	0.563
CLV_PCSK_SKI1_1	219	223	PF00082	0.320
CLV_PCSK_SKI1_1	258	262	PF00082	0.444
CLV_PCSK_SKI1_1	380	384	PF00082	0.465
CLV_PCSK_SKI1_1	441	445	PF00082	0.613
CLV_PCSK_SKI1_1	509	513	PF00082	0.531
CLV_PCSK_SKI1_1	616	620	PF00082	0.588
CLV_PCSK_SKI1_1	630	634	PF00082	0.480
CLV_PCSK_SKI1_1	655	659	PF00082	0.497
CLV_PCSK_SKI1_1	720	724	PF00082	0.503
CLV_PCSK_SKI1_1	756	760	PF00082	0.450
CLV_Separin_Metazoa	189	193	PF03568	0.318
DEG_APCC_DBOX_1	379	387	PF00400	0.456
DEG_APCC_DBOX_1	508	516	PF00400	0.458
DEG_APCC_DBOX_1	705	713	PF00400	0.406
DEG_Nend_Nbox_1	1	3	PF02207	0.561
DEG_SPOP_SBC_1	74	78	PF00917	0.586
DOC_CKS1_1	308	313	PF01111	0.456
DOC_CYCLIN_RxL_1	438	447	PF00134	0.614
DOC_MAPK_FxFP_2	362	365	PF00069	0.408
DOC_MAPK_gen_1	563	571	PF00069	0.572
DOC_MAPK_gen_1	752	759	PF00069	0.397
DOC_MAPK_MEF2A_6	223	232	PF00069	0.292
DOC_MAPK_MEF2A_6	284	291	PF00069	0.438
DOC_MAPK_MEF2A_6	565	573	PF00069	0.550
DOC_PP4_FxxP_1	362	365	PF00568	0.408
DOC_USP7_MATH_1	114	118	PF00917	0.493
DOC_USP7_MATH_1	17	21	PF00917	0.458
DOC_USP7_MATH_1	342	346	PF00917	0.512
DOC_USP7_MATH_1	449	453	PF00917	0.492
DOC_USP7_MATH_1	455	459	PF00917	0.450
DOC_USP7_MATH_1	747	751	PF00917	0.376
DOC_WW_Pin1_4	307	312	PF00397	0.601
DOC_WW_Pin1_4	76	81	PF00397	0.554
LIG_14-3-3_CanoR_1	103	108	PF00244	0.434
LIG_14-3-3_CanoR_1	320	329	PF00244	0.447
LIG_14-3-3_CanoR_1	331	335	PF00244	0.320
LIG_14-3-3_CanoR_1	548	553	PF00244	0.455
LIG_14-3-3_CanoR_1	654	658	PF00244	0.415
LIG_14-3-3_CanoR_1	680	688	PF00244	0.359
LIG_14-3-3_CanoR_1	706	710	PF00244	0.639
LIG_14-3-3_CanoR_1	725	733	PF00244	0.403
LIG_14-3-3_CanoR_1	756	766	PF00244	0.478
LIG_14-3-3_CanoR_1	92	99	PF00244	0.520
LIG_Actin_WH2_2	479	496	PF00022	0.535
LIG_APCC_ABBA_1	153	158	PF00400	0.467
LIG_BIR_III_4	217	221	PF00653	0.496
LIG_BRCT_BRCA1_1	354	358	PF00533	0.399
LIG_BRCT_BRCA1_1	360	364	PF00533	0.389
LIG_BRCT_BRCA1_1	671	675	PF00533	0.545
LIG_Clathr_ClatBox_1	221	225	PF01394	0.466
LIG_FAT_LD_1	532	540	PF03623	0.551
LIG_FHA_1	186	192	PF00498	0.407
LIG_FHA_1	244	250	PF00498	0.439
LIG_FHA_1	276	282	PF00498	0.405
LIG_FHA_1	291	297	PF00498	0.413
LIG_FHA_1	321	327	PF00498	0.500
LIG_FHA_1	397	403	PF00498	0.553
LIG_FHA_1	544	550	PF00498	0.451
LIG_FHA_1	596	602	PF00498	0.509
LIG_FHA_1	65	71	PF00498	0.512
LIG_FHA_2	240	246	PF00498	0.406
LIG_FHA_2	34	40	PF00498	0.458
LIG_FHA_2	410	416	PF00498	0.728
LIG_FHA_2	518	524	PF00498	0.617
LIG_FHA_2	548	554	PF00498	0.564
LIG_FHA_2	665	671	PF00498	0.449
LIG_FHA_2	727	733	PF00498	0.574
LIG_LIR_Apic_2	272	277	PF02991	0.441
LIG_LIR_Apic_2	361	365	PF02991	0.405
LIG_LIR_Apic_2	42	48	PF02991	0.597
LIG_LIR_Gen_1	102	113	PF02991	0.376
LIG_LIR_Gen_1	132	139	PF02991	0.454
LIG_LIR_Gen_1	184	195	PF02991	0.410
LIG_LIR_Gen_1	245	255	PF02991	0.464
LIG_LIR_Gen_1	285	291	PF02991	0.331
LIG_LIR_Nem_3	102	108	PF02991	0.510
LIG_LIR_Nem_3	132	138	PF02991	0.383
LIG_LIR_Nem_3	184	190	PF02991	0.409
LIG_LIR_Nem_3	245	251	PF02991	0.470
LIG_LIR_Nem_3	261	267	PF02991	0.412
LIG_LIR_Nem_3	27	33	PF02991	0.514
LIG_LIR_Nem_3	285	291	PF02991	0.402
LIG_LIR_Nem_3	361	367	PF02991	0.461
LIG_NRBOX	439	445	PF00104	0.583
LIG_Pex14_2	30	34	PF04695	0.571
LIG_Pex14_2	358	362	PF04695	0.395
LIG_SH2_CRK	264	268	PF00017	0.458
LIG_SH2_CRK	274	278	PF00017	0.324
LIG_SH2_NCK_1	82	86	PF00017	0.472
LIG_SH2_PTP2	248	251	PF00017	0.411
LIG_SH2_SRC	156	159	PF00017	0.509
LIG_SH2_SRC	248	251	PF00017	0.411
LIG_SH2_SRC	46	49	PF00017	0.344
LIG_SH2_STAP1	214	218	PF00017	0.349
LIG_SH2_STAP1	26	30	PF00017	0.486
LIG_SH2_STAP1	82	86	PF00017	0.472
LIG_SH2_STAT5	248	251	PF00017	0.411
LIG_SH2_STAT5	26	29	PF00017	0.396
LIG_SH2_STAT5	286	289	PF00017	0.252
LIG_SH2_STAT5	82	85	PF00017	0.320
LIG_SH3_1	143	149	PF00018	0.490
LIG_SH3_3	11	17	PF00018	0.530
LIG_SH3_3	143	149	PF00018	0.655
LIG_SH3_3	305	311	PF00018	0.461
LIG_SUMO_SIM_anti_2	510	516	PF11976	0.422
LIG_SUMO_SIM_anti_2	557	563	PF11976	0.571
LIG_SUMO_SIM_par_1	238	246	PF11976	0.354
LIG_SUMO_SIM_par_1	510	516	PF11976	0.422
LIG_TRAF2_1	155	158	PF00917	0.500
LIG_TRAF2_1	412	415	PF00917	0.647
LIG_TRFH_1	105	109	PF08558	0.310
LIG_TYR_ITSM	244	251	PF00017	0.412
LIG_UBA3_1	2	11	PF00899	0.538
LIG_WRC_WIRS_1	748	753	PF05994	0.561
LIG_WW_2	146	149	PF00397	0.488
MOD_CK1_1	117	123	PF00069	0.604
MOD_CK1_1	204	210	PF00069	0.504
MOD_CK1_1	324	330	PF00069	0.445
MOD_CK1_1	333	339	PF00069	0.515
MOD_CK1_1	458	464	PF00069	0.452
MOD_CK1_1	543	549	PF00069	0.608
MOD_CK1_1	634	640	PF00069	0.506
MOD_CK1_1	669	675	PF00069	0.548
MOD_CK1_1	76	82	PF00069	0.578
MOD_CK2_1	337	343	PF00069	0.273
MOD_CK2_1	409	415	PF00069	0.737
MOD_CK2_1	510	516	PF00069	0.583
MOD_CK2_1	517	523	PF00069	0.545
MOD_CK2_1	539	545	PF00069	0.580
MOD_CK2_1	547	553	PF00069	0.511
MOD_CK2_1	670	676	PF00069	0.500
MOD_CK2_1	705	711	PF00069	0.615
MOD_GlcNHglycan	171	174	PF01048	0.398
MOD_GlcNHglycan	197	200	PF01048	0.635
MOD_GlcNHglycan	206	209	PF01048	0.638
MOD_GlcNHglycan	255	258	PF01048	0.627
MOD_GlcNHglycan	343	347	PF01048	0.490
MOD_GlcNHglycan	354	357	PF01048	0.338
MOD_GlcNHglycan	450	454	PF01048	0.502
MOD_GlcNHglycan	469	473	PF01048	0.584
MOD_GlcNHglycan	690	694	PF01048	0.516
MOD_GSK3_1	125	132	PF00069	0.406
MOD_GSK3_1	2	9	PF00069	0.573
MOD_GSK3_1	239	246	PF00069	0.444
MOD_GSK3_1	265	272	PF00069	0.396
MOD_GSK3_1	320	327	PF00069	0.400
MOD_GSK3_1	330	337	PF00069	0.407
MOD_GSK3_1	387	394	PF00069	0.513
MOD_GSK3_1	405	412	PF00069	0.635
MOD_GSK3_1	432	439	PF00069	0.568
MOD_GSK3_1	47	54	PF00069	0.408
MOD_GSK3_1	535	542	PF00069	0.412
MOD_GSK3_1	543	550	PF00069	0.641
MOD_GSK3_1	579	586	PF00069	0.606
MOD_GSK3_1	59	66	PF00069	0.629
MOD_GSK3_1	620	627	PF00069	0.477
MOD_GSK3_1	630	637	PF00069	0.465
MOD_GSK3_1	666	673	PF00069	0.559
MOD_GSK3_1	743	750	PF00069	0.387
MOD_GSK3_1	76	83	PF00069	0.520
MOD_GSK3_1	87	94	PF00069	0.484
MOD_LATS_1	411	417	PF00433	0.482
MOD_N-GLC_1	405	410	PF02516	0.597
MOD_N-GLC_1	539	544	PF02516	0.608
MOD_NEK2_1	2	7	PF00069	0.565
MOD_NEK2_1	232	237	PF00069	0.462
MOD_NEK2_1	263	268	PF00069	0.480
MOD_NEK2_1	299	304	PF00069	0.525
MOD_NEK2_1	330	335	PF00069	0.396
MOD_NEK2_1	358	363	PF00069	0.435
MOD_NEK2_1	396	401	PF00069	0.522
MOD_NEK2_1	432	437	PF00069	0.555
MOD_NEK2_1	456	461	PF00069	0.427
MOD_NEK2_1	486	491	PF00069	0.568
MOD_NEK2_1	51	56	PF00069	0.382
MOD_NEK2_1	535	540	PF00069	0.509
MOD_NEK2_1	653	658	PF00069	0.632
MOD_NEK2_1	681	686	PF00069	0.464
MOD_NEK2_1	75	80	PF00069	0.584
MOD_NEK2_1	751	756	PF00069	0.524
MOD_NEK2_2	747	752	PF00069	0.511
MOD_OFUCOSY	125	130	PF10250	0.279
MOD_OFUCOSY	537	544	PF10250	0.423
MOD_PIKK_1	396	402	PF00454	0.533
MOD_PIKK_1	405	411	PF00454	0.563
MOD_PIKK_1	6	12	PF00454	0.524
MOD_PIKK_1	631	637	PF00454	0.522
MOD_PIKK_1	64	70	PF00454	0.480
MOD_PIKK_1	681	687	PF00454	0.500
MOD_PIKK_1	726	732	PF00454	0.527
MOD_PKA_2	324	330	PF00069	0.443
MOD_PKA_2	358	364	PF00069	0.441
MOD_PKA_2	547	553	PF00069	0.426
MOD_PKA_2	579	585	PF00069	0.694
MOD_PKA_2	653	659	PF00069	0.370
MOD_PKA_2	705	711	PF00069	0.600
MOD_PKA_2	91	97	PF00069	0.445
MOD_Plk_1	258	264	PF00069	0.448
MOD_Plk_1	269	275	PF00069	0.436
MOD_Plk_1	544	550	PF00069	0.729
MOD_Plk_1	593	599	PF00069	0.445
MOD_Plk_1	669	675	PF00069	0.506
MOD_Plk_1	68	74	PF00069	0.475
MOD_Plk_1	735	741	PF00069	0.363
MOD_Plk_1	770	776	PF00069	0.465
MOD_Plk_1	777	783	PF00069	0.524
MOD_Plk_2-3	510	516	PF00069	0.579
MOD_Plk_2-3	670	676	PF00069	0.541
MOD_Plk_2-3	736	742	PF00069	0.518
MOD_Plk_4	103	109	PF00069	0.453
MOD_Plk_4	232	238	PF00069	0.476
MOD_Plk_4	334	340	PF00069	0.311
MOD_Plk_4	358	364	PF00069	0.454
MOD_Plk_4	391	397	PF00069	0.531
MOD_Plk_4	398	404	PF00069	0.495
MOD_Plk_4	510	516	PF00069	0.595
MOD_Plk_4	670	676	PF00069	0.556
MOD_Plk_4	694	700	PF00069	0.512
MOD_Plk_4	736	742	PF00069	0.544
MOD_Plk_4	770	776	PF00069	0.347
MOD_ProDKin_1	307	313	PF00069	0.602
MOD_ProDKin_1	76	82	PF00069	0.541
MOD_SUMO_rev_2	211	221	PF00179	0.368
MOD_SUMO_rev_2	611	620	PF00179	0.406
MOD_SUMO_rev_2	623	632	PF00179	0.354
TRG_DiLeu_BaEn_1	531	536	PF01217	0.667
TRG_DiLeu_BaEn_1	557	562	PF01217	0.579
TRG_DiLeu_BaEn_4	557	563	PF01217	0.579
TRG_ENDOCYTIC_2	105	108	PF00928	0.321
TRG_ENDOCYTIC_2	156	159	PF00928	0.509
TRG_ENDOCYTIC_2	248	251	PF00928	0.416
TRG_ENDOCYTIC_2	264	267	PF00928	0.310
TRG_ENDOCYTIC_2	286	289	PF00928	0.252
TRG_ENDOCYTIC_2	429	432	PF00928	0.539
TRG_ER_diArg_1	491	494	PF00400	0.567
TRG_ER_diArg_1	562	565	PF00400	0.579
TRG_ER_diArg_1	653	655	PF00400	0.406
TRG_Pf-PMV_PEXEL_1	616	621	PF00026	0.614
TRG_Pf-PMV_PEXEL_1	725	730	PF00026	0.530

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVC8	Leptomonas seymouri	39%	99%
A0A3Q8IKB9	Leishmania donovani	74%	100%
A0A422MW62	Trypanosoma rangeli	25%	100%
A4HYK7	Leishmania infantum	74%	100%
E9AUF6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	100%
Q4QD28	Leishmania major	73%	100%