MORN repeat-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphatidylinositol-4-phosphate 5-kinase related

Species:

Leishmania braziliensis

UniProt:

A4HBI1_LEIBR

TriTrypDb:

LbrM.20.4210 , LBRM2903_200057100

Length:

444

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 2, no: 9
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HBI1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBI1

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016310	phosphorylation	5	1
GO:0044237	cellular metabolic process	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016301	kinase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	143	147	PF00656	0.325
CLV_C14_Caspase3-7	190	194	PF00656	0.362
CLV_C14_Caspase3-7	307	311	PF00656	0.392
CLV_NRD_NRD_1	197	199	PF00675	0.421
CLV_NRD_NRD_1	3	5	PF00675	0.571
CLV_NRD_NRD_1	388	390	PF00675	0.576
CLV_PCSK_KEX2_1	197	199	PF00082	0.410
CLV_PCSK_KEX2_1	3	5	PF00082	0.571
CLV_PCSK_KEX2_1	388	390	PF00082	0.576
CLV_PCSK_KEX2_1	413	415	PF00082	0.629
CLV_PCSK_PC1ET2_1	413	415	PF00082	0.701
CLV_PCSK_SKI1_1	154	158	PF00082	0.315
CLV_PCSK_SKI1_1	22	26	PF00082	0.492
CLV_PCSK_SKI1_1	35	39	PF00082	0.463
CLV_PCSK_SKI1_1	353	357	PF00082	0.533
CLV_PCSK_SKI1_1	407	411	PF00082	0.547
CLV_PCSK_SKI1_1	438	442	PF00082	0.620
DEG_Nend_Nbox_1	1	3	PF02207	0.515
DEG_SCF_FBW7_1	201	207	PF00400	0.396
DOC_ANK_TNKS_1	216	223	PF00023	0.281
DOC_CKS1_1	201	206	PF01111	0.398
DOC_PP1_RVXF_1	152	158	PF00149	0.281
DOC_PP1_RVXF_1	230	236	PF00149	0.387
DOC_PP1_RVXF_1	382	388	PF00149	0.649
DOC_PP4_FxxP_1	412	415	PF00568	0.656
DOC_PP4_FxxP_1	440	443	PF00568	0.481
DOC_PP4_FxxP_1	56	59	PF00568	0.522
DOC_USP7_MATH_1	417	421	PF00917	0.624
DOC_WW_Pin1_4	200	205	PF00397	0.389
DOC_WW_Pin1_4	413	418	PF00397	0.774
DOC_WW_Pin1_4	438	443	PF00397	0.618
LIG_14-3-3_CanoR_1	130	140	PF00244	0.299
LIG_14-3-3_CanoR_1	232	236	PF00244	0.500
LIG_14-3-3_CanoR_1	4	10	PF00244	0.619
LIG_Actin_WH2_2	6	24	PF00022	0.315
LIG_FHA_1	102	108	PF00498	0.427
LIG_FHA_1	112	118	PF00498	0.288
LIG_FHA_1	157	163	PF00498	0.309
LIG_FHA_1	223	229	PF00498	0.547
LIG_FHA_1	29	35	PF00498	0.530
LIG_FHA_2	120	126	PF00498	0.396
LIG_FHA_2	132	138	PF00498	0.323
LIG_FHA_2	319	325	PF00498	0.631
LIG_FHA_2	397	403	PF00498	0.447
LIG_LIR_Apic_2	411	415	PF02991	0.652
LIG_LIR_Apic_2	54	59	PF02991	0.559
LIG_LIR_Gen_1	182	192	PF02991	0.353
LIG_LIR_Gen_1	362	370	PF02991	0.439
LIG_LIR_Gen_1	402	412	PF02991	0.539
LIG_LIR_Nem_3	182	188	PF02991	0.368
LIG_LIR_Nem_3	234	238	PF02991	0.500
LIG_LIR_Nem_3	362	366	PF02991	0.522
LIG_LIR_Nem_3	402	408	PF02991	0.530
LIG_LIR_Nem_3	47	53	PF02991	0.290
LIG_LIR_Nem_3	92	97	PF02991	0.466
LIG_Pex14_2	235	239	PF04695	0.399
LIG_Pex14_2	408	412	PF04695	0.552
LIG_Pex14_2	74	78	PF04695	0.382
LIG_REV1ctd_RIR_1	165	175	PF16727	0.385
LIG_SH2_CRK	363	367	PF00017	0.379
LIG_SH2_CRK	50	54	PF00017	0.472
LIG_SH2_CRK	94	98	PF00017	0.463
LIG_SH2_NCK_1	363	367	PF00017	0.379
LIG_SH2_NCK_1	50	54	PF00017	0.304
LIG_SH2_SRC	50	53	PF00017	0.299
LIG_SH2_STAP1	305	309	PF00017	0.531
LIG_SH2_STAP1	363	367	PF00017	0.379
LIG_SH2_STAT5	187	190	PF00017	0.325
LIG_SH2_STAT5	202	205	PF00017	0.393
LIG_SH2_STAT5	206	209	PF00017	0.374
LIG_SH2_STAT5	226	229	PF00017	0.431
LIG_SH2_STAT5	286	289	PF00017	0.622
LIG_SH3_3	105	111	PF00018	0.409
LIG_SH3_3	21	27	PF00018	0.401
LIG_TRAF2_1	161	164	PF00917	0.330
LIG_TYR_ITSM	90	97	PF00017	0.482
MOD_CDK_SPxK_1	438	444	PF00069	0.622
MOD_CK1_1	416	422	PF00069	0.650
MOD_CK2_1	301	307	PF00069	0.641
MOD_CK2_1	58	64	PF00069	0.410
MOD_GlcNHglycan	367	370	PF01048	0.662
MOD_GlcNHglycan	394	399	PF01048	0.565
MOD_GlcNHglycan	419	422	PF01048	0.699
MOD_GlcNHglycan	46	49	PF01048	0.432
MOD_GlcNHglycan	53	56	PF01048	0.488
MOD_GSK3_1	200	207	PF00069	0.434
MOD_GSK3_1	413	420	PF00069	0.785
MOD_GSK3_1	5	12	PF00069	0.558
MOD_GSK3_1	97	104	PF00069	0.270
MOD_N-GLC_1	111	116	PF02516	0.435
MOD_NEK2_1	119	124	PF00069	0.482
MOD_NEK2_1	233	238	PF00069	0.385
MOD_NEK2_1	270	275	PF00069	0.463
MOD_NEK2_1	301	306	PF00069	0.560
MOD_NEK2_1	5	10	PF00069	0.563
MOD_PIKK_1	131	137	PF00454	0.361
MOD_PIKK_1	58	64	PF00454	0.519
MOD_PKA_1	197	203	PF00069	0.497
MOD_PKA_2	131	137	PF00069	0.350
MOD_PKA_2	197	203	PF00069	0.497
MOD_PKA_2	231	237	PF00069	0.488
MOD_Plk_1	277	283	PF00069	0.565
MOD_Plk_4	163	169	PF00069	0.402
MOD_Plk_4	197	203	PF00069	0.465
MOD_Plk_4	222	228	PF00069	0.281
MOD_Plk_4	28	34	PF00069	0.526
MOD_Plk_4	5	11	PF00069	0.656
MOD_ProDKin_1	200	206	PF00069	0.391
MOD_ProDKin_1	413	419	PF00069	0.774
MOD_ProDKin_1	438	444	PF00069	0.622
MOD_SUMO_for_1	179	182	PF00179	0.345
MOD_SUMO_rev_2	175	179	PF00179	0.493
MOD_SUMO_rev_2	190	196	PF00179	0.281
MOD_SUMO_rev_2	406	415	PF00179	0.465
TRG_DiLeu_BaEn_4	64	70	PF01217	0.533
TRG_ENDOCYTIC_2	363	366	PF00928	0.379
TRG_ENDOCYTIC_2	50	53	PF00928	0.424
TRG_ENDOCYTIC_2	94	97	PF00928	0.468
TRG_ER_diArg_1	129	132	PF00400	0.288
TRG_ER_diArg_1	196	198	PF00400	0.421
TRG_ER_diArg_1	2	4	PF00400	0.581
TRG_ER_diArg_1	387	389	PF00400	0.580

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4S2	Leptomonas seymouri	77%	100%
A0A0S4JFV2	Bodo saltans	50%	100%
A0A1X0NX05	Trypanosomatidae	59%	100%
A0A3S7WVR3	Leishmania donovani	89%	100%
A0A422N7V9	Trypanosoma rangeli	58%	100%
A4HYK3	Leishmania infantum	89%	100%
C9ZHV2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	100%
E9AUF3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QD31	Leishmania major	87%	100%
V5C0D1	Trypanosoma cruzi	59%	100%