NB-ARC domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NADH-ubiquinone oxidoreductase complex I subunit, putative

Species:

Leishmania braziliensis

UniProt:

A4HBI0_LEIBR

TriTrypDb:

LbrM.20.4200 , LBRM2903_200057000

Length:

556

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005747	mitochondrial respiratory chain complex I	4	1
GO:0030964	NADH dehydrogenase complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0045271	respiratory chain complex I	4	1
GO:0098796	membrane protein complex	2	1
GO:0098798	mitochondrial protein-containing complex	2	1
GO:0098800	inner mitochondrial membrane protein complex	3	1
GO:0098803	respiratory chain complex	3	1
GO:1902494	catalytic complex	2	1
GO:1902495	transmembrane transporter complex	3	1
GO:1990204	oxidoreductase complex	3	1
GO:1990351	transporter complex	2	1

Expansion

Sequence features

A4HBI0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBI0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	280	284	PF00656	0.361
CLV_C14_Caspase3-7	546	550	PF00656	0.381
CLV_NRD_NRD_1	124	126	PF00675	0.466
CLV_NRD_NRD_1	2	4	PF00675	0.664
CLV_NRD_NRD_1	237	239	PF00675	0.560
CLV_NRD_NRD_1	418	420	PF00675	0.405
CLV_PCSK_KEX2_1	2	4	PF00082	0.653
CLV_PCSK_KEX2_1	237	239	PF00082	0.507
CLV_PCSK_SKI1_1	108	112	PF00082	0.383
CLV_PCSK_SKI1_1	128	132	PF00082	0.377
CLV_PCSK_SKI1_1	14	18	PF00082	0.577
CLV_PCSK_SKI1_1	184	188	PF00082	0.321
CLV_PCSK_SKI1_1	2	6	PF00082	0.660
CLV_PCSK_SKI1_1	267	271	PF00082	0.417
CLV_PCSK_SKI1_1	389	393	PF00082	0.339
DEG_APCC_DBOX_1	183	191	PF00400	0.312
DEG_APCC_DBOX_1	266	274	PF00400	0.444
DEG_Nend_UBRbox_1	1	4	PF02207	0.696
DEG_ODPH_VHL_1	475	488	PF01847	0.333
DEG_SPOP_SBC_1	164	168	PF00917	0.429
DOC_CDC14_PxL_1	203	211	PF14671	0.389
DOC_CYCLIN_RxL_1	432	443	PF00134	0.342
DOC_CYCLIN_yCln2_LP_2	326	332	PF00134	0.410
DOC_MAPK_gen_1	123	133	PF00069	0.368
DOC_MAPK_gen_1	234	244	PF00069	0.507
DOC_MAPK_MEF2A_6	125	134	PF00069	0.351
DOC_MAPK_MEF2A_6	499	507	PF00069	0.523
DOC_PP1_RVXF_1	434	441	PF00149	0.335
DOC_PP2B_LxvP_1	535	538	PF13499	0.512
DOC_USP7_MATH_1	110	114	PF00917	0.488
DOC_USP7_MATH_1	180	184	PF00917	0.478
DOC_WW_Pin1_4	136	141	PF00397	0.501
DOC_WW_Pin1_4	176	181	PF00397	0.397
DOC_WW_Pin1_4	305	310	PF00397	0.426
DOC_WW_Pin1_4	421	426	PF00397	0.445
LIG_14-3-3_CanoR_1	14	22	PF00244	0.650
LIG_14-3-3_CanoR_1	184	192	PF00244	0.386
LIG_14-3-3_CanoR_1	271	278	PF00244	0.432
LIG_14-3-3_CanoR_1	32	40	PF00244	0.629
LIG_14-3-3_CanoR_1	389	394	PF00244	0.351
LIG_14-3-3_CanoR_1	499	504	PF00244	0.391
LIG_14-3-3_CanoR_1	98	105	PF00244	0.337
LIG_BRCT_BRCA1_1	182	186	PF00533	0.386
LIG_BRCT_BRCA1_1	22	26	PF00533	0.682
LIG_BRCT_BRCA1_1	389	393	PF00533	0.360
LIG_BRCT_BRCA1_1	95	99	PF00533	0.424
LIG_Clathr_ClatBox_1	131	135	PF01394	0.325
LIG_Clathr_ClatBox_1	500	504	PF01394	0.330
LIG_FHA_1	173	179	PF00498	0.514
LIG_FHA_1	3	9	PF00498	0.641
LIG_FHA_1	363	369	PF00498	0.286
LIG_FHA_1	516	522	PF00498	0.337
LIG_FHA_2	15	21	PF00498	0.718
LIG_FHA_2	383	389	PF00498	0.450
LIG_LIR_Gen_1	152	162	PF02991	0.382
LIG_LIR_Gen_1	518	524	PF02991	0.342
LIG_LIR_Gen_1	60	66	PF02991	0.408
LIG_LIR_Gen_1	96	105	PF02991	0.340
LIG_LIR_LC3C_4	129	134	PF02991	0.406
LIG_LIR_Nem_3	197	203	PF02991	0.396
LIG_LIR_Nem_3	518	523	PF02991	0.335
LIG_LIR_Nem_3	60	65	PF02991	0.401
LIG_LIR_Nem_3	96	102	PF02991	0.372
LIG_NRBOX	226	232	PF00104	0.369
LIG_NRP_CendR_1	554	556	PF00754	0.616
LIG_PCNA_PIPBox_1	112	121	PF02747	0.389
LIG_PCNA_yPIPBox_3	108	119	PF02747	0.381
LIG_Pex14_1	409	413	PF04695	0.361
LIG_Pex14_1	516	520	PF04695	0.452
LIG_PTB_Apo_2	199	206	PF02174	0.442
LIG_PTB_Phospho_1	199	205	PF10480	0.444
LIG_SH2_CRK	42	46	PF00017	0.490
LIG_SH2_CRK	71	75	PF00017	0.358
LIG_SH2_NCK_1	366	370	PF00017	0.306
LIG_SH2_PTP2	205	208	PF00017	0.357
LIG_SH2_SRC	478	481	PF00017	0.356
LIG_SH2_STAP1	413	417	PF00017	0.414
LIG_SH2_STAT5	154	157	PF00017	0.397
LIG_SH2_STAT5	205	208	PF00017	0.357
LIG_SH2_STAT5	366	369	PF00017	0.299
LIG_SH2_STAT5	478	481	PF00017	0.371
LIG_SH3_3	134	140	PF00018	0.357
LIG_SH3_3	474	480	PF00018	0.318
LIG_SUMO_SIM_anti_2	129	136	PF11976	0.344
LIG_SUMO_SIM_anti_2	141	149	PF11976	0.375
LIG_SUMO_SIM_anti_2	490	497	PF11976	0.478
LIG_SUMO_SIM_anti_2	502	507	PF11976	0.508
LIG_SUMO_SIM_par_1	129	136	PF11976	0.331
LIG_SUMO_SIM_par_1	499	504	PF11976	0.320
LIG_TRAF2_1	139	142	PF00917	0.354
LIG_TRAF2_1	33	36	PF00917	0.618
LIG_TRAF2_1	508	511	PF00917	0.526
LIG_TRFH_1	316	320	PF08558	0.355
LIG_TYR_ITIM	203	208	PF00017	0.355
LIG_UBA3_1	437	442	PF00899	0.485
LIG_UBA3_1	519	526	PF00899	0.395
MOD_CDK_SPK_2	305	310	PF00069	0.396
MOD_CK1_1	176	182	PF00069	0.470
MOD_CK1_1	188	194	PF00069	0.438
MOD_CK1_1	279	285	PF00069	0.277
MOD_CK1_1	34	40	PF00069	0.389
MOD_CK1_1	424	430	PF00069	0.499
MOD_CK1_1	465	471	PF00069	0.522
MOD_CK2_1	136	142	PF00069	0.383
MOD_CK2_1	14	20	PF00069	0.695
MOD_CK2_1	25	31	PF00069	0.678
MOD_CK2_1	415	421	PF00069	0.425
MOD_CK2_1	461	467	PF00069	0.474
MOD_CK2_1	484	490	PF00069	0.503
MOD_Cter_Amidation	123	126	PF01082	0.393
MOD_GlcNHglycan	159	162	PF01048	0.428
MOD_GlcNHglycan	175	178	PF01048	0.295
MOD_GlcNHglycan	222	225	PF01048	0.313
MOD_GlcNHglycan	244	247	PF01048	0.466
MOD_GlcNHglycan	27	30	PF01048	0.562
MOD_GlcNHglycan	388	392	PF01048	0.337
MOD_GlcNHglycan	464	467	PF01048	0.386
MOD_GSK3_1	14	21	PF00069	0.578
MOD_GSK3_1	172	179	PF00069	0.457
MOD_GSK3_1	2	9	PF00069	0.551
MOD_GSK3_1	242	249	PF00069	0.357
MOD_GSK3_1	295	302	PF00069	0.493
MOD_GSK3_1	383	390	PF00069	0.226
MOD_GSK3_1	461	468	PF00069	0.388
MOD_GSK3_1	89	96	PF00069	0.375
MOD_N-GLC_1	14	19	PF02516	0.472
MOD_N-GLC_1	484	489	PF02516	0.384
MOD_NEK2_1	118	123	PF00069	0.438
MOD_NEK2_1	156	161	PF00069	0.333
MOD_NEK2_1	165	170	PF00069	0.414
MOD_NEK2_1	173	178	PF00069	0.356
MOD_NEK2_1	232	237	PF00069	0.362
MOD_NEK2_1	242	247	PF00069	0.385
MOD_NEK2_1	259	264	PF00069	0.213
MOD_NEK2_1	297	302	PF00069	0.443
MOD_NEK2_1	387	392	PF00069	0.334
MOD_NEK2_1	89	94	PF00069	0.480
MOD_PIKK_1	110	116	PF00454	0.490
MOD_PIKK_1	190	196	PF00454	0.527
MOD_PIKK_1	299	305	PF00454	0.387
MOD_PIKK_1	93	99	PF00454	0.380
MOD_PK_1	499	505	PF00069	0.471
MOD_PKA_1	2	8	PF00069	0.577
MOD_PKA_2	2	8	PF00069	0.522
MOD_PKA_2	31	37	PF00069	0.699
MOD_PKA_2	97	103	PF00069	0.353
MOD_Plk_1	188	194	PF00069	0.535
MOD_Plk_1	232	238	PF00069	0.514
MOD_Plk_1	259	265	PF00069	0.556
MOD_Plk_1	295	301	PF00069	0.485
MOD_Plk_1	484	490	PF00069	0.472
MOD_Plk_2-3	31	37	PF00069	0.574
MOD_Plk_4	149	155	PF00069	0.403
MOD_Plk_4	195	201	PF00069	0.403
MOD_Plk_4	211	217	PF00069	0.420
MOD_Plk_4	246	252	PF00069	0.448
MOD_Plk_4	341	347	PF00069	0.398
MOD_Plk_4	375	381	PF00069	0.371
MOD_Plk_4	389	395	PF00069	0.341
MOD_Plk_4	484	490	PF00069	0.505
MOD_Plk_4	515	521	PF00069	0.365
MOD_ProDKin_1	136	142	PF00069	0.508
MOD_ProDKin_1	176	182	PF00069	0.391
MOD_ProDKin_1	305	311	PF00069	0.442
MOD_ProDKin_1	421	427	PF00069	0.437
MOD_SUMO_for_1	309	312	PF00179	0.573
TRG_DiLeu_BaEn_1	127	132	PF01217	0.348
TRG_DiLeu_BaEn_1	142	147	PF01217	0.436
TRG_DiLeu_BaEn_1	433	438	PF01217	0.334
TRG_DiLeu_BaLyEn_6	204	209	PF01217	0.329
TRG_DiLeu_BaLyEn_6	226	231	PF01217	0.256
TRG_DiLeu_LyEn_5	36	41	PF01217	0.589
TRG_DiLeu_LyEn_5	433	438	PF01217	0.334
TRG_ENDOCYTIC_2	154	157	PF00928	0.369
TRG_ENDOCYTIC_2	205	208	PF00928	0.337
TRG_ENDOCYTIC_2	359	362	PF00928	0.453
TRG_ENDOCYTIC_2	71	74	PF00928	0.462
TRG_ER_diArg_1	1	3	PF00400	0.697
TRG_ER_diArg_1	236	238	PF00400	0.501
TRG_Pf-PMV_PEXEL_1	229	233	PF00026	0.502
TRG_Pf-PMV_PEXEL_1	324	328	PF00026	0.253
TRG_Pf-PMV_PEXEL_1	429	433	PF00026	0.463
TRG_Pf-PMV_PEXEL_1	59	63	PF00026	0.444

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P560	Leptomonas seymouri	71%	100%
A0A0S4JGE1	Bodo saltans	34%	94%
A0A1X0NY36	Trypanosomatidae	45%	98%
A0A3S7WVT1	Leishmania donovani	86%	100%
A0A422N7U6	Trypanosoma rangeli	39%	100%
A4HYK2	Leishmania infantum	86%	100%
C9ZHV1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	98%
E9AUF2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4QD32	Leishmania major	86%	100%
V5BAF5	Trypanosoma cruzi	46%	99%