Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HBH7_LEIBR

TriTrypDb:

LbrM.20.4170 , LBRM2903_200056700

Length:

575

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HBH7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBH7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	367	371	PF00656	0.493
CLV_NRD_NRD_1	157	159	PF00675	0.548
CLV_NRD_NRD_1	20	22	PF00675	0.581
CLV_NRD_NRD_1	405	407	PF00675	0.459
CLV_NRD_NRD_1	484	486	PF00675	0.548
CLV_NRD_NRD_1	85	87	PF00675	0.430
CLV_PCSK_KEX2_1	157	159	PF00082	0.548
CLV_PCSK_KEX2_1	405	407	PF00082	0.474
CLV_PCSK_KEX2_1	484	486	PF00082	0.504
CLV_PCSK_PC7_1	401	407	PF00082	0.452
CLV_PCSK_SKI1_1	125	129	PF00082	0.573
CLV_PCSK_SKI1_1	157	161	PF00082	0.548
CLV_PCSK_SKI1_1	269	273	PF00082	0.655
CLV_PCSK_SKI1_1	34	38	PF00082	0.570
CLV_PCSK_SKI1_1	401	405	PF00082	0.448
CLV_PCSK_SKI1_1	477	481	PF00082	0.634
CLV_PCSK_SKI1_1	501	505	PF00082	0.422
DEG_Nend_UBRbox_3	1	3	PF02207	0.664
DEG_SCF_FBW7_1	306	313	PF00400	0.616
DEG_SPOP_SBC_1	310	314	PF00917	0.508
DOC_CKS1_1	218	223	PF01111	0.563
DOC_CKS1_1	285	290	PF01111	0.803
DOC_CKS1_1	307	312	PF01111	0.717
DOC_CKS1_1	497	502	PF01111	0.442
DOC_CYCLIN_yCln2_LP_2	292	298	PF00134	0.739
DOC_CYCLIN_yCln2_LP_2	377	383	PF00134	0.527
DOC_MAPK_gen_1	157	165	PF00069	0.534
DOC_MAPK_gen_1	409	417	PF00069	0.579
DOC_MAPK_HePTP_8	134	146	PF00069	0.489
DOC_MAPK_MEF2A_6	129	138	PF00069	0.402
DOC_MAPK_MEF2A_6	167	176	PF00069	0.525
DOC_MAPK_MEF2A_6	504	513	PF00069	0.566
DOC_PP1_RVXF_1	155	162	PF00149	0.552
DOC_PP1_RVXF_1	373	380	PF00149	0.454
DOC_USP7_MATH_1	153	157	PF00917	0.541
DOC_USP7_MATH_1	24	28	PF00917	0.638
DOC_USP7_MATH_1	310	314	PF00917	0.639
DOC_USP7_MATH_1	371	375	PF00917	0.500
DOC_USP7_UBL2_3	121	125	PF12436	0.647
DOC_USP7_UBL2_3	457	461	PF12436	0.738
DOC_USP7_UBL2_3	515	519	PF12436	0.540
DOC_USP7_UBL2_3	529	533	PF12436	0.620
DOC_WW_Pin1_4	217	222	PF00397	0.600
DOC_WW_Pin1_4	275	280	PF00397	0.668
DOC_WW_Pin1_4	284	289	PF00397	0.652
DOC_WW_Pin1_4	306	311	PF00397	0.739
DOC_WW_Pin1_4	496	501	PF00397	0.459
DOC_WW_Pin1_4	505	510	PF00397	0.416
DOC_WW_Pin1_4	69	74	PF00397	0.462
LIG_14-3-3_CanoR_1	157	162	PF00244	0.542
LIG_14-3-3_CanoR_1	247	255	PF00244	0.462
LIG_14-3-3_CanoR_1	78	83	PF00244	0.523
LIG_BRCT_BRCA1_1	27	31	PF00533	0.639
LIG_BRCT_BRCA1_1	358	362	PF00533	0.450
LIG_BRCT_BRCA1_1	418	422	PF00533	0.559
LIG_Clathr_ClatBox_1	548	552	PF01394	0.441
LIG_eIF4E_1	248	254	PF01652	0.555
LIG_eIF4E_1	543	549	PF01652	0.386
LIG_FHA_1	102	108	PF00498	0.473
LIG_FHA_1	221	227	PF00498	0.495
LIG_FHA_1	249	255	PF00498	0.462
LIG_FHA_1	260	266	PF00498	0.643
LIG_FHA_1	315	321	PF00498	0.666
LIG_FHA_1	506	512	PF00498	0.419
LIG_FHA_1	533	539	PF00498	0.574
LIG_FHA_1	62	68	PF00498	0.465
LIG_FHA_2	497	503	PF00498	0.441
LIG_LIR_Apic_2	215	221	PF02991	0.619
LIG_LIR_Gen_1	382	391	PF02991	0.415
LIG_LIR_Gen_1	470	479	PF02991	0.566
LIG_LIR_Gen_1	544	551	PF02991	0.383
LIG_LIR_Gen_1	81	90	PF02991	0.568
LIG_LIR_Nem_3	189	195	PF02991	0.588
LIG_LIR_Nem_3	382	386	PF02991	0.404
LIG_LIR_Nem_3	470	475	PF02991	0.562
LIG_LIR_Nem_3	544	548	PF02991	0.374
LIG_LIR_Nem_3	81	85	PF02991	0.519
LIG_NBox_RRM_1	428	438	PF00076	0.653
LIG_PCNA_TLS_4	466	473	PF02747	0.614
LIG_Pex14_1	379	383	PF04695	0.406
LIG_SH2_CRK	231	235	PF00017	0.531
LIG_SH2_CRK	545	549	PF00017	0.343
LIG_SH2_CRK	82	86	PF00017	0.558
LIG_SH2_GRB2like	524	527	PF00017	0.544
LIG_SH2_NCK_1	231	235	PF00017	0.525
LIG_SH2_SRC	524	527	PF00017	0.544
LIG_SH2_SRC	543	546	PF00017	0.383
LIG_SH2_STAP1	231	235	PF00017	0.531
LIG_SH2_STAP1	543	547	PF00017	0.393
LIG_SH2_STAT5	11	14	PF00017	0.486
LIG_SH2_STAT5	248	251	PF00017	0.547
LIG_SH2_STAT5	407	410	PF00017	0.562
LIG_SH2_STAT5	524	527	PF00017	0.544
LIG_SH3_3	136	142	PF00018	0.542
LIG_SH3_3	276	282	PF00018	0.746
LIG_SH3_3	285	291	PF00018	0.709
LIG_SH3_3	443	449	PF00018	0.725
LIG_SH3_5	537	541	PF00018	0.545
LIG_SUMO_SIM_anti_2	101	109	PF11976	0.421
LIG_SUMO_SIM_anti_2	145	150	PF11976	0.470
LIG_SUMO_SIM_anti_2	173	179	PF11976	0.402
MOD_CDK_SPK_2	496	501	PF00069	0.459
MOD_CK1_1	179	185	PF00069	0.484
MOD_CK1_1	270	276	PF00069	0.637
MOD_CK1_1	299	305	PF00069	0.725
MOD_CK1_1	314	320	PF00069	0.578
MOD_CK1_1	416	422	PF00069	0.441
MOD_CK1_1	532	538	PF00069	0.574
MOD_CK1_1	61	67	PF00069	0.447
MOD_CK1_1	72	78	PF00069	0.454
MOD_CK2_1	233	239	PF00069	0.503
MOD_CK2_1	312	318	PF00069	0.703
MOD_CK2_1	347	353	PF00069	0.529
MOD_CK2_1	464	470	PF00069	0.581
MOD_CK2_1	496	502	PF00069	0.433
MOD_CK2_1	92	98	PF00069	0.541
MOD_CMANNOS	222	225	PF00535	0.389
MOD_GlcNHglycan	235	238	PF01048	0.475
MOD_GlcNHglycan	269	272	PF01048	0.620
MOD_GlcNHglycan	27	30	PF01048	0.526
MOD_GlcNHglycan	279	282	PF01048	0.664
MOD_GlcNHglycan	298	301	PF01048	0.624
MOD_GlcNHglycan	314	317	PF01048	0.584
MOD_GlcNHglycan	60	63	PF01048	0.537
MOD_GSK3_1	140	147	PF00069	0.490
MOD_GSK3_1	153	160	PF00069	0.481
MOD_GSK3_1	212	219	PF00069	0.618
MOD_GSK3_1	229	236	PF00069	0.488
MOD_GSK3_1	25	32	PF00069	0.532
MOD_GSK3_1	302	309	PF00069	0.667
MOD_GSK3_1	310	317	PF00069	0.604
MOD_GSK3_1	344	351	PF00069	0.538
MOD_GSK3_1	460	467	PF00069	0.597
MOD_GSK3_1	487	494	PF00069	0.585
MOD_GSK3_1	57	64	PF00069	0.566
MOD_GSK3_1	74	81	PF00069	0.492
MOD_LATS_1	527	533	PF00433	0.606
MOD_N-GLC_1	179	184	PF02516	0.537
MOD_N-GLC_1	216	221	PF02516	0.633
MOD_N-GLC_1	259	264	PF02516	0.704
MOD_N-GLC_1	34	39	PF02516	0.551
MOD_N-GLC_1	410	415	PF02516	0.550
MOD_N-GLC_1	505	510	PF02516	0.416
MOD_N-GLC_1	69	74	PF02516	0.462
MOD_NEK2_1	144	149	PF00069	0.449
MOD_NEK2_1	212	217	PF00069	0.687
MOD_NEK2_1	249	254	PF00069	0.528
MOD_NEK2_1	422	427	PF00069	0.540
MOD_NEK2_1	479	484	PF00069	0.655
MOD_NEK2_1	57	62	PF00069	0.444
MOD_NEK2_1	92	97	PF00069	0.478
MOD_NEK2_2	29	34	PF00069	0.380
MOD_NEK2_2	491	496	PF00069	0.572
MOD_PIKK_1	286	292	PF00454	0.795
MOD_PIKK_1	327	333	PF00454	0.668
MOD_PIKK_1	416	422	PF00454	0.489
MOD_PIKK_1	80	86	PF00454	0.442
MOD_PKA_1	157	163	PF00069	0.539
MOD_PKA_2	157	163	PF00069	0.539
MOD_PKA_2	213	219	PF00069	0.672
MOD_Plk_1	100	106	PF00069	0.536
MOD_Plk_1	259	265	PF00069	0.707
MOD_Plk_1	34	40	PF00069	0.554
MOD_Plk_1	413	419	PF00069	0.425
MOD_Plk_4	229	235	PF00069	0.541
MOD_Plk_4	249	255	PF00069	0.503
MOD_Plk_4	302	308	PF00069	0.638
MOD_Plk_4	336	342	PF00069	0.575
MOD_Plk_4	386	392	PF00069	0.432
MOD_Plk_4	491	497	PF00069	0.438
MOD_ProDKin_1	217	223	PF00069	0.589
MOD_ProDKin_1	275	281	PF00069	0.670
MOD_ProDKin_1	284	290	PF00069	0.652
MOD_ProDKin_1	306	312	PF00069	0.737
MOD_ProDKin_1	496	502	PF00069	0.448
MOD_ProDKin_1	505	511	PF00069	0.413
MOD_ProDKin_1	69	75	PF00069	0.460
MOD_SUMO_rev_2	118	127	PF00179	0.601
MOD_SUMO_rev_2	14	24	PF00179	0.600
MOD_SUMO_rev_2	345	350	PF00179	0.630
TRG_DiLeu_BaEn_2	467	473	PF01217	0.570
TRG_ENDOCYTIC_2	192	195	PF00928	0.564
TRG_ENDOCYTIC_2	231	234	PF00928	0.525
TRG_ENDOCYTIC_2	545	548	PF00928	0.358
TRG_ENDOCYTIC_2	556	559	PF00928	0.381
TRG_ENDOCYTIC_2	82	85	PF00928	0.523
TRG_ENDOCYTIC_2	89	92	PF00928	0.498
TRG_ER_diArg_1	157	159	PF00400	0.548
TRG_ER_diArg_1	404	406	PF00400	0.449
TRG_ER_diArg_1	483	485	PF00400	0.478
TRG_Pf-PMV_PEXEL_1	129	133	PF00026	0.515
TRG_Pf-PMV_PEXEL_1	477	481	PF00026	0.634

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3N5	Leptomonas seymouri	80%	99%
A0A1X0NX92	Trypanosomatidae	34%	90%
A0A3Q8IEP3	Leishmania donovani	93%	100%
A0A422N7W1	Trypanosoma rangeli	34%	91%
C9ZHU6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	94%
E9AGT8	Leishmania infantum	93%	100%
E9AUE8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4QD36	Leishmania major	93%	100%
V5C0D6	Trypanosoma cruzi	33%	92%