Peroxisomal membrane protein PEX16

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HBH6_LEIBR

TriTrypDb:

LbrM.20.4160 , LBRM2903_200056600

Length:

203

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HBH6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBH6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	124	126	PF00675	0.618
CLV_NRD_NRD_1	96	98	PF00675	0.432
CLV_PCSK_FUR_1	94	98	PF00082	0.449
CLV_PCSK_KEX2_1	108	110	PF00082	0.479
CLV_PCSK_KEX2_1	122	124	PF00082	0.561
CLV_PCSK_KEX2_1	22	24	PF00082	0.461
CLV_PCSK_KEX2_1	96	98	PF00082	0.432
CLV_PCSK_PC1ET2_1	108	110	PF00082	0.504
CLV_PCSK_PC1ET2_1	122	124	PF00082	0.538
CLV_PCSK_PC1ET2_1	22	24	PF00082	0.577
CLV_PCSK_PC7_1	104	110	PF00082	0.507
CLV_PCSK_SKI1_1	108	112	PF00082	0.575
CLV_PCSK_SKI1_1	138	142	PF00082	0.440
CLV_Separin_Metazoa	60	64	PF03568	0.308
DEG_Nend_Nbox_1	1	3	PF02207	0.496
DOC_CYCLIN_RxL_1	104	112	PF00134	0.539
DOC_CYCLIN_RxL_1	135	143	PF00134	0.480
DOC_MAPK_gen_1	94	103	PF00069	0.446
DOC_MAPK_MEF2A_6	147	154	PF00069	0.432
DOC_USP7_MATH_1	38	42	PF00917	0.577
DOC_WW_Pin1_4	191	196	PF00397	0.548
DOC_WW_Pin1_4	3	8	PF00397	0.694
LIG_14-3-3_CanoR_1	138	143	PF00244	0.420
LIG_14-3-3_CanoR_1	147	153	PF00244	0.418
LIG_14-3-3_CanoR_1	184	193	PF00244	0.456
LIG_BIR_III_4	55	59	PF00653	0.532
LIG_BRCT_BRCA1_1	15	19	PF00533	0.320
LIG_BRCT_BRCA1_1	86	90	PF00533	0.526
LIG_deltaCOP1_diTrp_1	12	19	PF00928	0.315
LIG_FHA_1	170	176	PF00498	0.503
LIG_FHA_1	180	186	PF00498	0.441
LIG_FHA_1	195	201	PF00498	0.561
LIG_FHA_1	73	79	PF00498	0.492
LIG_FHA_2	43	49	PF00498	0.503
LIG_LIR_Gen_1	133	144	PF02991	0.497
LIG_LIR_Gen_1	157	167	PF02991	0.507
LIG_LIR_Gen_1	45	52	PF02991	0.486
LIG_LIR_Nem_3	133	139	PF02991	0.522
LIG_LIR_Nem_3	157	162	PF02991	0.498
LIG_LIR_Nem_3	197	202	PF02991	0.499
LIG_LIR_Nem_3	45	50	PF02991	0.475
LIG_NRBOX	141	147	PF00104	0.463
LIG_NRBOX	87	93	PF00104	0.532
LIG_SH2_CRK	136	140	PF00017	0.479
LIG_SH2_CRK	159	163	PF00017	0.473
LIG_SH2_NCK_1	170	174	PF00017	0.516
LIG_SH2_PTP2	149	152	PF00017	0.490
LIG_SH2_PTP2	199	202	PF00017	0.464
LIG_SH2_STAP1	136	140	PF00017	0.479
LIG_SH2_STAT5	144	147	PF00017	0.350
LIG_SH2_STAT5	149	152	PF00017	0.378
LIG_SH2_STAT5	199	202	PF00017	0.441
LIG_SH3_3	147	153	PF00018	0.448
LIG_SH3_3	31	37	PF00018	0.486
LIG_SH3_3	8	14	PF00018	0.537
LIG_SUMO_SIM_par_1	138	143	PF11976	0.460
MOD_CK1_1	166	172	PF00069	0.323
MOD_CK1_1	194	200	PF00069	0.605
MOD_CK1_1	3	9	PF00069	0.658
MOD_CK1_1	42	48	PF00069	0.514
MOD_GlcNHglycan	163	166	PF01048	0.583
MOD_GlcNHglycan	186	189	PF01048	0.543
MOD_GlcNHglycan	3	6	PF01048	0.553
MOD_GlcNHglycan	41	44	PF01048	0.568
MOD_GlcNHglycan	63	66	PF01048	0.575
MOD_GSK3_1	109	116	PF00069	0.589
MOD_GSK3_1	13	20	PF00069	0.560
MOD_GSK3_1	38	45	PF00069	0.523
MOD_GSK3_1	68	75	PF00069	0.491
MOD_GSK3_1	82	89	PF00069	0.464
MOD_N-GLC_1	179	184	PF02516	0.467
MOD_NEK2_1	1	6	PF00069	0.666
MOD_NEK2_1	148	153	PF00069	0.453
MOD_NEK2_1	17	22	PF00069	0.395
MOD_NEK2_1	61	66	PF00069	0.458
MOD_NEK2_1	82	87	PF00069	0.452
MOD_PIKK_1	194	200	PF00454	0.493
MOD_PKA_2	32	38	PF00069	0.610
MOD_Plk_1	179	185	PF00069	0.444
MOD_Plk_4	13	19	PF00069	0.525
MOD_Plk_4	42	48	PF00069	0.489
MOD_Plk_4	86	92	PF00069	0.418
MOD_ProDKin_1	191	197	PF00069	0.560
MOD_ProDKin_1	3	9	PF00069	0.689
MOD_SUMO_rev_2	121	131	PF00179	0.474
TRG_DiLeu_BaLyEn_6	106	111	PF01217	0.572
TRG_ENDOCYTIC_2	136	139	PF00928	0.482
TRG_ENDOCYTIC_2	149	152	PF00928	0.374
TRG_ENDOCYTIC_2	159	162	PF00928	0.421
TRG_ENDOCYTIC_2	199	202	PF00928	0.441
TRG_ENDOCYTIC_2	47	50	PF00928	0.481
TRG_ER_diArg_1	123	125	PF00400	0.639
TRG_ER_diArg_1	96	98	PF00400	0.444
TRG_NES_CRM1_1	143	157	PF08389	0.452
TRG_NLS_Bipartite_1	108	126	PF00514	0.665
TRG_NLS_MonoCore_2	121	126	PF00514	0.617
TRG_NLS_MonoExtC_3	121	127	PF00514	0.594
TRG_Pf-PMV_PEXEL_1	124	128	PF00026	0.704
TRG_Pf-PMV_PEXEL_1	138	143	PF00026	0.473
TRG_Pf-PMV_PEXEL_1	184	189	PF00026	0.287

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HX14	Leptomonas seymouri	75%	100%
A0A0S4IPP5	Bodo saltans	25%	99%
A0A1X0NWK9	Trypanosomatidae	36%	100%
A0A3R7K4I3	Trypanosoma rangeli	39%	100%
A0A3S5H778	Leishmania donovani	86%	100%
A4HYK0	Leishmania infantum	86%	100%
C9ZHU5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AUE7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4QD37	Leishmania major	88%	100%