Anti-silencing protein asf 1-like

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

histone chaperone ASF1A

Species:

Leishmania braziliensis

UniProt:

A4HBH4_LEIBR

TriTrypDb:

LbrM.20.4140 , LBRM2903_200056400

Length:

165

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043231	intracellular membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12
GO:0005829	cytosol	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1

Expansion

Sequence features

A4HBH4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBH4

Function

Biological processes
Term	Name	Level	Count
GO:0006325	chromatin organization	4	12
GO:0009987	cellular process	1	12
GO:0016043	cellular component organization	3	12
GO:0071840	cellular component organization or biogenesis	2	12
GO:0006335	DNA replication-dependent chromatin assembly	5	1

Molecular functions
Term	Name	Level	Count
GO:0005198	structural molecule activity	1	12
GO:0030527	structural constituent of chromatin	2	12
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0042393	histone binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	16	20	PF00656	0.325
CLV_C14_Caspase3-7	36	40	PF00656	0.112
CLV_NRD_NRD_1	105	107	PF00675	0.348
CLV_PCSK_KEX2_1	105	107	PF00082	0.190
CLV_PCSK_SKI1_1	135	139	PF00082	0.375
DOC_MAPK_gen_1	105	112	PF00069	0.190
DOC_USP7_MATH_1	20	24	PF00917	0.381
DOC_USP7_MATH_1	33	37	PF00917	0.442
DOC_USP7_MATH_1	51	55	PF00917	0.416
DOC_USP7_MATH_2	153	159	PF00917	0.190
DOC_WW_Pin1_4	149	154	PF00397	0.287
LIG_BIR_II_1	1	5	PF00653	0.496
LIG_BIR_III_1	1	5	PF00653	0.557
LIG_BIR_III_3	1	5	PF00653	0.557
LIG_BRCT_BRCA1_1	41	45	PF00533	0.296
LIG_Clathr_ClatBox_1	8	12	PF01394	0.296
LIG_FHA_1	87	93	PF00498	0.313
LIG_FHA_1	94	100	PF00498	0.299
LIG_FHA_2	150	156	PF00498	0.419
LIG_IRF3_LxIS_1	95	101	PF10401	0.296
LIG_LIR_Gen_1	108	115	PF02991	0.297
LIG_LIR_Gen_1	42	51	PF02991	0.304
LIG_LIR_Gen_1	53	63	PF02991	0.279
LIG_LIR_Nem_3	108	112	PF02991	0.297
LIG_LIR_Nem_3	155	159	PF02991	0.348
LIG_LIR_Nem_3	42	48	PF02991	0.292
LIG_LIR_Nem_3	53	59	PF02991	0.273
LIG_SH2_CRK	115	119	PF00017	0.296
LIG_SH2_CRK	56	60	PF00017	0.232
LIG_SH2_NCK_1	115	119	PF00017	0.296
LIG_SH2_STAP1	115	119	PF00017	0.296
LIG_SH2_STAP1	21	25	PF00017	0.353
LIG_SH2_STAP1	56	60	PF00017	0.195
LIG_SH2_STAT3	104	107	PF00017	0.296
LIG_SH2_STAT3	114	117	PF00017	0.296
LIG_SH2_STAT3	159	162	PF00017	0.418
LIG_SH2_STAT3	21	24	PF00017	0.405
LIG_SH2_STAT5	115	118	PF00017	0.296
LIG_SH2_STAT5	120	123	PF00017	0.296
LIG_SH2_STAT5	21	24	PF00017	0.312
LIG_SH3_2	130	135	PF14604	0.381
LIG_SH3_3	127	133	PF00018	0.296
LIG_SH3_3	139	145	PF00018	0.296
LIG_SUMO_SIM_anti_2	10	16	PF11976	0.296
LIG_SUMO_SIM_anti_2	96	101	PF11976	0.296
LIG_SUMO_SIM_par_1	7	12	PF11976	0.296
LIG_SUMO_SIM_par_1	95	101	PF11976	0.296
LIG_WRC_WIRS_1	99	104	PF05994	0.296
LIG_WW_2	130	133	PF00397	0.443
MOD_CK1_1	50	56	PF00069	0.287
MOD_CK2_1	149	155	PF00069	0.365
MOD_GlcNHglycan	49	52	PF01048	0.299
MOD_GSK3_1	47	54	PF00069	0.302
MOD_NEK2_1	93	98	PF00069	0.277
MOD_PIKK_1	113	119	PF00454	0.296
MOD_PIKK_1	20	26	PF00454	0.198
MOD_PIKK_1	51	57	PF00454	0.416
MOD_Plk_1	73	79	PF00069	0.300
MOD_Plk_4	41	47	PF00069	0.399
MOD_Plk_4	93	99	PF00069	0.290
MOD_ProDKin_1	149	155	PF00069	0.287
TRG_ENDOCYTIC_2	115	118	PF00928	0.296
TRG_ENDOCYTIC_2	56	59	PF00928	0.210
TRG_ER_diArg_1	104	106	PF00400	0.190
TRG_ER_diArg_1	27	30	PF00400	0.282

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0I1	Leptomonas seymouri	39%	91%
A0A0N1I2C8	Leptomonas seymouri	86%	100%
A0A0S4IIL8	Bodo saltans	62%	94%
A0A0S4JR86	Bodo saltans	37%	77%
A0A1X0NWK6	Trypanosomatidae	71%	100%
A0A1X0P1H0	Trypanosomatidae	34%	82%
A0A3Q8IAD9	Leishmania donovani	31%	89%
A0A3Q8IBF3	Leishmania donovani	89%	100%
A0A3R7M8V4	Trypanosoma rangeli	69%	100%
A0A422ND92	Trypanosoma rangeli	34%	81%
A4H8C7	Leishmania braziliensis	33%	100%
A4HWP9	Leishmania infantum	31%	89%
A4HYJ8	Leishmania infantum	90%	100%
C9ZHU3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	70%	96%
C9ZW62	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	74%
E9AQF6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	89%
E9AUE5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
P0CM26	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	38%	80%
P0CM27	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	38%	79%
Q17603	Caenorhabditis elegans	33%	67%
Q17QJ0	Bos taurus	37%	82%
Q2KIG1	Bos taurus	40%	81%
Q3C1E9	Gallus gallus	40%	81%
Q4PBU8	Ustilago maydis (strain 521 / FGSC 9021)	35%	95%
Q4QF20	Leishmania major	32%	73%
Q54N45	Dictyostelium discoideum	34%	100%
Q59MV1	Candida albicans (strain SC5314 / ATCC MYA-2876)	32%	67%
Q69DB9	Xenopus laevis	40%	82%
Q6DIP1	Xenopus tropicalis	41%	82%
Q6NY34	Danio rerio	39%	84%
Q6NYY4	Danio rerio	39%	84%
Q7T0M6	Xenopus laevis	40%	82%
Q9BJ46	Leishmania major	90%	100%
Q9C9M6	Arabidopsis thaliana	38%	84%
Q9CQE6	Mus musculus	40%	81%
Q9DAP7	Mus musculus	39%	82%
Q9LS09	Arabidopsis thaliana	38%	76%
Q9NVP2	Homo sapiens	37%	82%
Q9V464	Drosophila melanogaster	39%	76%
Q9Y294	Homo sapiens	40%	81%
V5B915	Trypanosoma cruzi	37%	82%
V5C0E3	Trypanosoma cruzi	71%	100%