Phosphate transporter

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphate-repressible phosphate permease

Species:

Leishmania braziliensis

UniProt:

A4HBH2_LEIBR

TriTrypDb:

LbrM.20.4120 , LBRM2903_200056200

Length:

542

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 23
NetGPI	no	yes: 0, no: 23

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	24
GO:0110165	cellular anatomical entity	1	24

Expansion

Sequence features

A4HBH2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBH2

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	24
GO:0006811	monoatomic ion transport	4	24
GO:0006817	phosphate ion transport	7	24
GO:0006820	monoatomic anion transport	5	24
GO:0015698	inorganic anion transport	6	24
GO:0051179	localization	1	24
GO:0051234	establishment of localization	2	24
GO:0009987	cellular process	1	3
GO:0034220	monoatomic ion transmembrane transport	3	3
GO:0035435	phosphate ion transmembrane transport	6	3
GO:0055085	transmembrane transport	2	3
GO:0098656	monoatomic anion transmembrane transport	4	3
GO:0098660	inorganic ion transmembrane transport	4	3
GO:0098661	inorganic anion transmembrane transport	5	3

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	24
GO:0005315	inorganic phosphate transmembrane transporter activity	4	24
GO:0015291	secondary active transmembrane transporter activity	4	24
GO:0015293	symporter activity	5	24
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	24
GO:0022804	active transmembrane transporter activity	3	24
GO:0022857	transmembrane transporter activity	2	24

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	135	139	PF00656	0.199
CLV_C14_Caspase3-7	265	269	PF00656	0.451
CLV_NRD_NRD_1	340	342	PF00675	0.327
CLV_PCSK_SKI1_1	187	191	PF00082	0.270
CLV_PCSK_SKI1_1	3	7	PF00082	0.364
CLV_PCSK_SKI1_1	39	43	PF00082	0.321
DEG_SPOP_SBC_1	110	114	PF00917	0.303
DEG_SPOP_SBC_1	482	486	PF00917	0.293
DOC_CKS1_1	264	269	PF01111	0.364
DOC_CKS1_1	456	461	PF01111	0.568
DOC_CYCLIN_yCln2_LP_2	190	196	PF00134	0.218
DOC_MAPK_gen_1	248	258	PF00069	0.527
DOC_MAPK_MEF2A_6	187	196	PF00069	0.460
DOC_MAPK_MEF2A_6	251	260	PF00069	0.400
DOC_MAPK_MEF2A_6	507	514	PF00069	0.570
DOC_MAPK_NFAT4_5	187	195	PF00069	0.399
DOC_MAPK_NFAT4_5	507	515	PF00069	0.564
DOC_PP1_RVXF_1	213	219	PF00149	0.301
DOC_PP2B_LxvP_1	107	110	PF13499	0.485
DOC_PP2B_LxvP_1	190	193	PF13499	0.218
DOC_PP4_FxxP_1	157	160	PF00568	0.334
DOC_USP7_MATH_1	110	114	PF00917	0.334
DOC_USP7_MATH_1	13	17	PF00917	0.351
DOC_USP7_MATH_1	231	235	PF00917	0.290
DOC_USP7_MATH_1	307	311	PF00917	0.392
DOC_USP7_MATH_1	313	317	PF00917	0.529
DOC_USP7_MATH_1	319	323	PF00917	0.405
DOC_USP7_MATH_1	407	411	PF00917	0.362
DOC_USP7_MATH_1	482	486	PF00917	0.293
DOC_USP7_MATH_1	526	530	PF00917	0.369
DOC_WW_Pin1_4	156	161	PF00397	0.334
DOC_WW_Pin1_4	263	268	PF00397	0.418
DOC_WW_Pin1_4	303	308	PF00397	0.471
DOC_WW_Pin1_4	455	460	PF00397	0.493
LIG_14-3-3_CanoR_1	180	186	PF00244	0.443
LIG_14-3-3_CanoR_1	187	193	PF00244	0.480
LIG_14-3-3_CanoR_1	323	329	PF00244	0.364
LIG_Actin_WH2_2	167	182	PF00022	0.237
LIG_BIR_II_1	1	5	PF00653	0.384
LIG_BIR_III_1	1	5	PF00653	0.279
LIG_BIR_III_3	1	5	PF00653	0.279
LIG_BRCT_BRCA1_1	158	162	PF00533	0.189
LIG_BRCT_BRCA1_1	237	241	PF00533	0.363
LIG_BRCT_BRCA1_1	28	32	PF00533	0.494
LIG_BRCT_BRCA1_1	459	463	PF00533	0.339
LIG_BRCT_BRCA1_1	528	532	PF00533	0.388
LIG_CaM_NSCaTE_8	426	433	PF13499	0.364
LIG_FHA_1	106	112	PF00498	0.455
LIG_FHA_1	161	167	PF00498	0.430
LIG_FHA_1	189	195	PF00498	0.526
LIG_FHA_1	197	203	PF00498	0.340
LIG_FHA_1	299	305	PF00498	0.491
LIG_FHA_1	349	355	PF00498	0.456
LIG_FHA_1	412	418	PF00498	0.317
LIG_FHA_1	439	445	PF00498	0.324
LIG_FHA_1	484	490	PF00498	0.355
LIG_FHA_1	64	70	PF00498	0.278
LIG_FHA_2	370	376	PF00498	0.465
LIG_HCF-1_HBM_1	81	84	PF13415	0.294
LIG_LIR_Apic_2	155	160	PF02991	0.334
LIG_LIR_Apic_2	477	482	PF02991	0.349
LIG_LIR_Gen_1	105	111	PF02991	0.537
LIG_LIR_Gen_1	203	212	PF02991	0.334
LIG_LIR_Gen_1	521	532	PF02991	0.290
LIG_LIR_Gen_1	81	91	PF02991	0.252
LIG_LIR_LC3C_4	468	473	PF02991	0.361
LIG_LIR_Nem_3	105	109	PF02991	0.537
LIG_LIR_Nem_3	141	146	PF02991	0.278
LIG_LIR_Nem_3	159	165	PF02991	0.382
LIG_LIR_Nem_3	173	179	PF02991	0.206
LIG_LIR_Nem_3	203	209	PF02991	0.334
LIG_LIR_Nem_3	238	244	PF02991	0.364
LIG_LIR_Nem_3	375	381	PF02991	0.479
LIG_LIR_Nem_3	521	527	PF02991	0.377
LIG_NRBOX	445	451	PF00104	0.494
LIG_Pex14_2	201	205	PF04695	0.335
LIG_Pex14_2	520	524	PF04695	0.170
LIG_SH2_CRK	378	382	PF00017	0.494
LIG_SH2_CRK	479	483	PF00017	0.391
LIG_SH2_CRK	88	92	PF00017	0.368
LIG_SH2_STAT3	370	373	PF00017	0.364
LIG_SH2_STAT5	380	383	PF00017	0.334
LIG_SH2_STAT5	84	87	PF00017	0.334
LIG_SH3_3	261	267	PF00018	0.364
LIG_SH3_3	301	307	PF00018	0.448
LIG_SH3_3	453	459	PF00018	0.568
LIG_Sin3_3	469	476	PF02671	0.439
LIG_SUMO_SIM_anti_2	44	51	PF11976	0.436
LIG_SUMO_SIM_anti_2	452	458	PF11976	0.568
LIG_SUMO_SIM_par_1	194	199	PF11976	0.371
LIG_SUMO_SIM_par_1	350	356	PF11976	0.389
LIG_SUMO_SIM_par_1	39	44	PF11976	0.504
LIG_SUMO_SIM_par_1	45	51	PF11976	0.324
LIG_TYR_ITIM	126	131	PF00017	0.170
LIG_UBA3_1	509	513	PF00899	0.477
LIG_WRC_WIRS_1	14	19	PF05994	0.361
LIG_WRC_WIRS_1	202	207	PF05994	0.288
LIG_WRC_WIRS_1	439	444	PF05994	0.391
LIG_WRC_WIRS_1	472	477	PF05994	0.363
MOD_CDK_SPxK_1	455	461	PF00069	0.493
MOD_CK1_1	113	119	PF00069	0.303
MOD_CK1_1	16	22	PF00069	0.359
MOD_CK1_1	322	328	PF00069	0.456
MOD_CK1_1	396	402	PF00069	0.276
MOD_CK1_1	474	480	PF00069	0.349
MOD_CK1_1	60	66	PF00069	0.302
MOD_CK2_1	350	356	PF00069	0.526
MOD_CK2_1	360	366	PF00069	0.442
MOD_CK2_1	369	375	PF00069	0.421
MOD_CK2_1	48	54	PF00069	0.345
MOD_GlcNHglycan	233	236	PF01048	0.280
MOD_GlcNHglycan	362	365	PF01048	0.378
MOD_GlcNHglycan	463	466	PF01048	0.330
MOD_GlcNHglycan	467	470	PF01048	0.327
MOD_GlcNHglycan	528	531	PF01048	0.346
MOD_GlcNHglycan	62	65	PF01048	0.491
MOD_GlcNHglycan	69	72	PF01048	0.471
MOD_GSK3_1	105	112	PF00069	0.458
MOD_GSK3_1	152	159	PF00069	0.345
MOD_GSK3_1	231	238	PF00069	0.290
MOD_GSK3_1	298	305	PF00069	0.507
MOD_GSK3_1	356	363	PF00069	0.582
MOD_GSK3_1	407	414	PF00069	0.247
MOD_GSK3_1	457	464	PF00069	0.471
MOD_GSK3_1	483	490	PF00069	0.317
MOD_GSK3_1	518	525	PF00069	0.365
MOD_GSK3_1	63	70	PF00069	0.297
MOD_N-GLC_1	348	353	PF02516	0.190
MOD_NEK2_1	201	206	PF00069	0.309
MOD_NEK2_1	32	37	PF00069	0.494
MOD_NEK2_1	369	374	PF00069	0.494
MOD_NEK2_1	41	46	PF00069	0.360
MOD_NEK2_1	471	476	PF00069	0.349
MOD_NEK2_1	48	53	PF00069	0.388
MOD_NEK2_1	522	527	PF00069	0.384
MOD_NEK2_2	350	355	PF00069	0.364
MOD_NEK2_2	407	412	PF00069	0.205
MOD_PIKK_1	369	375	PF00454	0.364
MOD_PIKK_1	41	47	PF00454	0.439
MOD_PKA_2	322	328	PF00069	0.364
MOD_Plk_1	348	354	PF00069	0.481
MOD_Plk_2-3	132	138	PF00069	0.190
MOD_Plk_4	102	108	PF00069	0.354
MOD_Plk_4	13	19	PF00069	0.361
MOD_Plk_4	152	158	PF00069	0.320
MOD_Plk_4	201	207	PF00069	0.307
MOD_Plk_4	407	413	PF00069	0.199
MOD_Plk_4	418	424	PF00069	0.182
MOD_ProDKin_1	156	162	PF00069	0.334
MOD_ProDKin_1	263	269	PF00069	0.418
MOD_ProDKin_1	303	309	PF00069	0.471
MOD_ProDKin_1	455	461	PF00069	0.493
TRG_DiLeu_BaLyEn_6	240	245	PF01217	0.319
TRG_DiLeu_BaLyEn_6	445	450	PF01217	0.464
TRG_ENDOCYTIC_2	128	131	PF00928	0.205
TRG_ENDOCYTIC_2	378	381	PF00928	0.461
TRG_ENDOCYTIC_2	84	87	PF00928	0.337
TRG_ENDOCYTIC_2	88	91	PF00928	0.330
TRG_Pf-PMV_PEXEL_1	448	452	PF00026	0.250

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4S5	Leptomonas seymouri	70%	100%
A0A1X0NXY5	Trypanosomatidae	58%	100%
A0A3Q8I8Y3	Leishmania donovani	61%	100%
A0A3Q8IBK1	Leishmania donovani	80%	100%
A0A3R7K4N2	Trypanosoma rangeli	52%	100%
A0A3R7L5P3	Trypanosoma rangeli	26%	90%
A0A3S5H545	Leishmania donovani	46%	95%
A1A4I1	Bos taurus	28%	84%
A4H5Y5	Leishmania braziliensis	61%	91%
A4H6C2	Leishmania braziliensis	61%	91%
A4HH06	Leishmania braziliensis	45%	97%
A4HUP5	Leishmania infantum	61%	100%
A4HYJ6	Leishmania infantum	80%	100%
C9ZHT9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	100%
C9ZHU1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	100%
E9ACJ5	Leishmania major	45%	100%
E9AG39	Leishmania infantum	46%	95%
E9AJT3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	100%
E9AN09	Leishmania mexicana (strain MHOM/GT/2001/U1103)	61%	100%
E9ANE4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	60%	100%
E9AUE3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	95%
P0AFJ7	Escherichia coli (strain K12)	22%	100%
P0AFJ8	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	22%	100%
P0AFJ9	Escherichia coli O157:H7	22%	100%
P15710	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	30%	92%
P38361	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	94%
Q4QH82	Leishmania major	61%	91%
Q4QHL7	Leishmania major	61%	91%
Q6NV12	Danio rerio	29%	83%
V5DS90	Trypanosoma cruzi	55%	100%