Histone-lysine N-methyltransferase, H3 lysine-79 specific

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Histone-lysine N-methyltransferase, H3 lysine-76 specific

Species:

Leishmania braziliensis

UniProt:

A4HBH1_LEIBR

TriTrypDb:

LbrM.20.4110 , LBRM2903_200055500

Length:

279

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 22
NetGPI	no	yes: 0, no: 22

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	23
GO:0043226	organelle	2	23
GO:0043227	membrane-bounded organelle	3	23
GO:0043229	intracellular organelle	3	23
GO:0043231	intracellular membrane-bounded organelle	4	23
GO:0110165	cellular anatomical entity	1	23
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1

Expansion

Sequence features

A4HBH1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBH1

Function

Biological processes
Term	Name	Level	Count
GO:0006325	chromatin organization	4	23
GO:0006479	protein methylation	4	23
GO:0006807	nitrogen compound metabolic process	2	23
GO:0008152	metabolic process	1	23
GO:0008213	protein alkylation	5	23
GO:0009987	cellular process	1	23
GO:0016043	cellular component organization	3	23
GO:0016570	histone modification	5	23
GO:0016571	histone methylation	5	23
GO:0018022	peptidyl-lysine methylation	5	23
GO:0018193	peptidyl-amino acid modification	5	23
GO:0018205	peptidyl-lysine modification	6	23
GO:0019538	protein metabolic process	3	23
GO:0032259	methylation	2	23
GO:0034729	histone H3-K79 methylation	7	23
GO:0034968	histone lysine methylation	6	23
GO:0036211	protein modification process	4	23
GO:0043170	macromolecule metabolic process	3	23
GO:0043412	macromolecule modification	4	23
GO:0043414	macromolecule methylation	3	23
GO:0044237	cellular metabolic process	2	23
GO:0044238	primary metabolic process	2	23
GO:0044260	obsolete cellular macromolecule metabolic process	3	23
GO:0050789	regulation of biological process	2	23
GO:0050794	regulation of cellular process	3	23
GO:0051726	regulation of cell cycle	4	23
GO:0065007	biological regulation	1	23
GO:0071704	organic substance metabolic process	2	23
GO:0071840	cellular component organization or biogenesis	2	23
GO:1901564	organonitrogen compound metabolic process	3	23
GO:0000075	cell cycle checkpoint signaling	4	2
GO:0000077	DNA damage checkpoint signaling	5	2
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006259	DNA metabolic process	4	2
GO:0006281	DNA repair	5	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006950	response to stress	2	2
GO:0006974	DNA damage response	4	2
GO:0007165	signal transduction	2	2
GO:0009605	response to external stimulus	2	1
GO:0009607	response to biotic stimulus	2	1
GO:0010564	regulation of cell cycle process	5	2
GO:0010948	negative regulation of cell cycle process	6	2
GO:0020033	antigenic variation	7	1
GO:0031570	DNA integrity checkpoint signaling	5	2
GO:0033554	cellular response to stress	3	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0035556	intracellular signal transduction	3	2
GO:0042770	signal transduction in response to DNA damage	4	2
GO:0042783	evasion of host immune response	6	1
GO:0043207	response to external biotic stimulus	3	1
GO:0044403	biological process involved in symbiotic interaction	2	1
GO:0044419	biological process involved in interspecies interaction between organisms	1	1
GO:0045786	negative regulation of cell cycle	5	2
GO:0046483	heterocycle metabolic process	3	2
GO:0048519	negative regulation of biological process	3	2
GO:0048523	negative regulation of cellular process	4	2
GO:0050896	response to stimulus	1	2
GO:0051098	regulation of binding	3	2
GO:0051101	regulation of DNA binding	4	2
GO:0051701	biological process involved in interaction with host	3	1
GO:0051707	response to other organism	2	1
GO:0051716	cellular response to stimulus	2	2
GO:0052173	response to defenses of other organism	3	1
GO:0052200	response to host defenses	4	1
GO:0052572	response to host immune response	5	1
GO:0065009	regulation of molecular function	2	2
GO:0075136	response to host	3	1
GO:0090304	nucleic acid metabolic process	4	2
GO:1901360	organic cyclic compound metabolic process	3	2
GO:1901987	regulation of cell cycle phase transition	6	2
GO:1901988	negative regulation of cell cycle phase transition	7	2
GO:2000677	regulation of transcription regulatory region DNA binding	5	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	23
GO:0008168	methyltransferase activity	4	23
GO:0008170	N-methyltransferase activity	5	23
GO:0008276	protein methyltransferase activity	3	23
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	23
GO:0016278	lysine N-methyltransferase activity	6	23
GO:0016279	protein-lysine N-methyltransferase activity	4	23
GO:0016740	transferase activity	2	23
GO:0016741	transferase activity, transferring one-carbon groups	3	23
GO:0018024	obsolete histone lysine N-methyltransferase activity	5	23
GO:0031151	histone H3K79 methyltransferase activity	6	23
GO:0042054	histone methyltransferase activity	4	23
GO:0140096	catalytic activity, acting on a protein	2	23

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	33	37	PF00656	0.502
CLV_NRD_NRD_1	6	8	PF00675	0.625
CLV_PCSK_FUR_1	168	172	PF00082	0.174
CLV_PCSK_FUR_1	4	8	PF00082	0.635
CLV_PCSK_KEX2_1	170	172	PF00082	0.390
CLV_PCSK_KEX2_1	277	279	PF00082	0.342
CLV_PCSK_KEX2_1	3	5	PF00082	0.593
CLV_PCSK_KEX2_1	6	8	PF00082	0.633
CLV_PCSK_KEX2_1	83	85	PF00082	0.379
CLV_PCSK_KEX2_1	91	93	PF00082	0.407
CLV_PCSK_PC1ET2_1	170	172	PF00082	0.427
CLV_PCSK_PC1ET2_1	277	279	PF00082	0.393
CLV_PCSK_PC1ET2_1	3	5	PF00082	0.598
CLV_PCSK_PC1ET2_1	83	85	PF00082	0.387
CLV_PCSK_PC1ET2_1	91	93	PF00082	0.410
CLV_PCSK_SKI1_1	162	166	PF00082	0.361
CLV_PCSK_SKI1_1	17	21	PF00082	0.711
CLV_PCSK_SKI1_1	171	175	PF00082	0.385
CLV_PCSK_SKI1_1	271	275	PF00082	0.457
CLV_PCSK_SKI1_1	97	101	PF00082	0.390
DOC_CKS1_1	192	197	PF01111	0.341
DOC_MAPK_gen_1	168	177	PF00069	0.324
DOC_MAPK_MEF2A_6	168	177	PF00069	0.290
DOC_PP2B_LxvP_1	203	206	PF13499	0.290
DOC_PP4_FxxP_1	160	163	PF00568	0.269
DOC_PP4_FxxP_1	192	195	PF00568	0.428
DOC_USP7_MATH_1	51	55	PF00917	0.390
DOC_WW_Pin1_4	191	196	PF00397	0.367
DOC_WW_Pin1_4	35	40	PF00397	0.398
LIG_14-3-3_CanoR_1	171	176	PF00244	0.368
LIG_14-3-3_CanoR_1	216	221	PF00244	0.411
LIG_Actin_WH2_2	202	220	PF00022	0.262
LIG_BRCT_BRCA1_1	127	131	PF00533	0.290
LIG_deltaCOP1_diTrp_1	156	165	PF00928	0.370
LIG_deltaCOP1_diTrp_1	255	265	PF00928	0.290
LIG_FHA_1	103	109	PF00498	0.396
LIG_FHA_1	172	178	PF00498	0.339
LIG_FHA_1	192	198	PF00498	0.410
LIG_FHA_1	29	35	PF00498	0.365
LIG_FHA_1	84	90	PF00498	0.483
LIG_FHA_2	116	122	PF00498	0.322
LIG_HCF-1_HBM_1	74	77	PF13415	0.495
LIG_LIR_Apic_2	41	46	PF02991	0.395
LIG_LIR_Gen_1	156	165	PF02991	0.302
LIG_LIR_Gen_1	181	190	PF02991	0.307
LIG_LIR_Gen_1	246	256	PF02991	0.249
LIG_LIR_Gen_1	74	82	PF02991	0.397
LIG_LIR_Nem_3	117	122	PF02991	0.292
LIG_LIR_Nem_3	156	161	PF02991	0.302
LIG_LIR_Nem_3	181	185	PF02991	0.307
LIG_LIR_Nem_3	246	251	PF02991	0.236
LIG_LIR_Nem_3	269	275	PF02991	0.312
LIG_LIR_Nem_3	74	80	PF02991	0.370
LIG_Pex14_2	165	169	PF04695	0.349
LIG_Rb_LxCxE_1	224	244	PF01857	0.387
LIG_SH2_CRK	43	47	PF00017	0.485
LIG_SH2_CRK	77	81	PF00017	0.398
LIG_SH2_STAP1	77	81	PF00017	0.398
LIG_SH2_STAT3	256	259	PF00017	0.315
LIG_SH2_STAT5	191	194	PF00017	0.428
LIG_SH2_STAT5	212	215	PF00017	0.277
LIG_SH2_STAT5	275	278	PF00017	0.316
LIG_SH2_STAT5	65	68	PF00017	0.276
LIG_SH3_2	39	44	PF14604	0.377
LIG_SH3_3	36	42	PF00018	0.400
LIG_SH3_3	9	15	PF00018	0.677
LIG_SUMO_SIM_anti_2	174	179	PF11976	0.295
LIG_SUMO_SIM_par_1	29	36	PF11976	0.571
LIG_WRC_WIRS_1	27	32	PF05994	0.398
MOD_CDC14_SPxK_1	41	44	PF00782	0.558
MOD_CDK_SPK_2	35	40	PF00069	0.457
MOD_CDK_SPxK_1	38	44	PF00069	0.531
MOD_GSK3_1	233	240	PF00069	0.320
MOD_LATS_1	235	241	PF00433	0.320
MOD_N-GLC_1	125	130	PF02516	0.293
MOD_N-GLC_1	51	56	PF02516	0.365
MOD_NEK2_2	60	65	PF00069	0.272
MOD_OFUCOSY	59	64	PF10250	0.404
MOD_PIKK_1	10	16	PF00454	0.450
MOD_PIKK_1	264	270	PF00454	0.177
MOD_PK_1	216	222	PF00069	0.383
MOD_PKA_1	83	89	PF00069	0.392
MOD_PKA_2	221	227	PF00069	0.430
MOD_PKA_2	83	89	PF00069	0.392
MOD_Plk_4	115	121	PF00069	0.181
MOD_Plk_4	125	131	PF00069	0.325
MOD_Plk_4	181	187	PF00069	0.350
MOD_Plk_4	95	101	PF00069	0.343
MOD_ProDKin_1	191	197	PF00069	0.367
MOD_ProDKin_1	35	41	PF00069	0.399
MOD_SUMO_for_1	82	85	PF00179	0.504
TRG_DiLeu_BaLyEn_6	103	108	PF01217	0.350
TRG_ENDOCYTIC_2	77	80	PF00928	0.371
TRG_ER_diArg_1	4	7	PF00400	0.648
TRG_NLS_MonoExtC_3	2	7	PF00514	0.642
TRG_Pf-PMV_PEXEL_1	162	166	PF00026	0.453
TRG_Pf-PMV_PEXEL_1	171	176	PF00026	0.380

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P397	Leptomonas seymouri	53%	94%
A0A0N0P563	Leptomonas seymouri	70%	100%
A0A0S4IIL9	Bodo saltans	48%	89%
A0A0S4IQV1	Bodo saltans	50%	97%
A0A1X0NK69	Trypanosomatidae	53%	95%
A0A1X0NY45	Trypanosomatidae	58%	98%
A0A3R7LQU8	Trypanosoma rangeli	60%	100%
A0A3S5H5V6	Leishmania donovani	54%	93%
A0A3S7WVS5	Leishmania donovani	85%	100%
A0A422NTB2	Trypanosoma rangeli	55%	95%
A4H4U6	Leishmania braziliensis	49%	100%
A4HT24	Leishmania infantum	54%	93%
A4HYJ5	Leishmania infantum	84%	100%
C9ZHT8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	100%
C9ZUW8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	95%
E9AL12	Leishmania mexicana (strain MHOM/GT/2001/U1103)	50%	93%
E9AUE2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4QD41	Leishmania major	86%	100%
Q4QIU2	Leishmania major	54%	100%
V5ATA1	Trypanosoma cruzi	54%	96%
V5BVL1	Trypanosoma cruzi	57%	100%