Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WD domain, G-beta repeat, putative

Species:

Leishmania braziliensis

UniProt:

A4HBH0_LEIBR

TriTrypDb:

LbrM.20.4100 , LBRM2903_200055400

Length:

410

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	7
GO:0032991	protein-containing complex	1	7
GO:0043226	organelle	2	7
GO:0043228	non-membrane-bounded organelle	3	7
GO:0043229	intracellular organelle	3	7
GO:0043232	intracellular non-membrane-bounded organelle	4	7
GO:0110165	cellular anatomical entity	1	7
GO:1990904	ribonucleoprotein complex	2	7
GO:0005634	nucleus	5	1
GO:0005656	nuclear pre-replicative complex	3	1
GO:0005730	nucleolus	5	1
GO:0032993	protein-DNA complex	2	1
GO:0036387	pre-replicative complex	3	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097344	Rix1 complex	2	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

A4HBH0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBH0

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006259	DNA metabolic process	4	1
GO:0006260	DNA replication	5	1
GO:0006261	DNA-templated DNA replication	6	1
GO:0006364	rRNA processing	8	1
GO:0006396	RNA processing	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0016072	rRNA metabolic process	7	1
GO:0034470	ncRNA processing	7	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034660	ncRNA metabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	201	205	PF00656	0.521
CLV_C14_Caspase3-7	373	377	PF00656	0.639
CLV_NRD_NRD_1	399	401	PF00675	0.521
CLV_PCSK_KEX2_1	355	357	PF00082	0.595
CLV_PCSK_KEX2_1	359	361	PF00082	0.579
CLV_PCSK_KEX2_1	399	401	PF00082	0.574
CLV_PCSK_KEX2_1	408	410	PF00082	0.675
CLV_PCSK_PC1ET2_1	355	357	PF00082	0.622
CLV_PCSK_PC1ET2_1	359	361	PF00082	0.621
CLV_PCSK_PC1ET2_1	408	410	PF00082	0.631
CLV_PCSK_SKI1_1	155	159	PF00082	0.344
CLV_PCSK_SKI1_1	198	202	PF00082	0.524
CLV_PCSK_SKI1_1	224	228	PF00082	0.481
CLV_PCSK_SKI1_1	297	301	PF00082	0.540
CLV_PCSK_SKI1_1	318	322	PF00082	0.335
CLV_PCSK_SKI1_1	32	36	PF00082	0.454
CLV_PCSK_SKI1_1	352	356	PF00082	0.476
CLV_PCSK_SKI1_1	66	70	PF00082	0.444
DEG_APCC_DBOX_1	9	17	PF00400	0.528
DEG_Nend_Nbox_1	1	3	PF02207	0.373
DOC_ANK_TNKS_1	22	29	PF00023	0.539
DOC_CKS1_1	16	21	PF01111	0.492
DOC_MAPK_gen_1	359	369	PF00069	0.675
DOC_PP2B_LxvP_1	254	257	PF13499	0.691
DOC_USP7_MATH_1	122	126	PF00917	0.493
DOC_USP7_MATH_1	128	132	PF00917	0.468
DOC_USP7_UBL2_3	355	359	PF12436	0.559
DOC_WW_Pin1_4	15	20	PF00397	0.479
DOC_WW_Pin1_4	261	266	PF00397	0.496
DOC_WW_Pin1_4	272	277	PF00397	0.572
DOC_WW_Pin1_4	301	306	PF00397	0.508
DOC_WW_Pin1_4	35	40	PF00397	0.509
DOC_WW_Pin1_4	66	71	PF00397	0.486
LIG_14-3-3_CanoR_1	198	203	PF00244	0.529
LIG_Clathr_ClatBox_1	13	17	PF01394	0.455
LIG_DCNL_PONY_1	1	4	PF03556	0.483
LIG_FHA_1	16	22	PF00498	0.425
LIG_FHA_1	183	189	PF00498	0.496
LIG_FHA_1	208	214	PF00498	0.412
LIG_FHA_1	273	279	PF00498	0.536
LIG_FHA_1	67	73	PF00498	0.365
LIG_FHA_1	81	87	PF00498	0.539
LIG_FHA_1	91	97	PF00498	0.488
LIG_FHA_2	127	133	PF00498	0.477
LIG_FHA_2	199	205	PF00498	0.428
LIG_FHA_2	279	285	PF00498	0.442
LIG_LIR_Nem_3	195	200	PF02991	0.398
LIG_SH2_CRK	37	41	PF00017	0.539
LIG_SH2_NCK_1	37	41	PF00017	0.512
LIG_SH2_SRC	233	236	PF00017	0.609
LIG_SH2_SRC	25	28	PF00017	0.529
LIG_SH3_2	334	339	PF14604	0.658
LIG_SH3_3	13	19	PF00018	0.466
LIG_SH3_3	331	337	PF00018	0.614
LIG_Sin3_3	319	326	PF02671	0.343
LIG_SUMO_SIM_par_1	12	18	PF11976	0.465
LIG_TYR_ITIM	35	40	PF00017	0.518
LIG_UBA3_1	266	270	PF00899	0.238
LIG_Vh1_VBS_1	72	90	PF01044	0.559
LIG_WRC_WIRS_1	288	293	PF05994	0.251
MOD_CDC14_SPxK_1	304	307	PF00782	0.538
MOD_CDK_SPxK_1	301	307	PF00069	0.517
MOD_CK1_1	131	137	PF00069	0.503
MOD_CK1_1	274	280	PF00069	0.516
MOD_CK1_1	38	44	PF00069	0.488
MOD_CK1_1	57	63	PF00069	0.250
MOD_CK2_1	126	132	PF00069	0.479
MOD_CK2_1	278	284	PF00069	0.447
MOD_DYRK1A_RPxSP_1	66	70	PF00069	0.536
MOD_GlcNHglycan	100	103	PF01048	0.480
MOD_GlcNHglycan	120	123	PF01048	0.123
MOD_GlcNHglycan	234	238	PF01048	0.497
MOD_GlcNHglycan	257	260	PF01048	0.567
MOD_GlcNHglycan	294	297	PF01048	0.368
MOD_GlcNHglycan	404	407	PF01048	0.566
MOD_GlcNHglycan	56	59	PF01048	0.495
MOD_GSK3_1	118	125	PF00069	0.469
MOD_GSK3_1	159	166	PF00069	0.517
MOD_GSK3_1	178	185	PF00069	0.345
MOD_GSK3_1	270	277	PF00069	0.481
MOD_GSK3_1	76	83	PF00069	0.481
MOD_GSK3_1	86	93	PF00069	0.455
MOD_N-GLC_1	90	95	PF02516	0.340
MOD_NEK2_1	104	109	PF00069	0.523
MOD_NEK2_1	126	131	PF00069	0.469
MOD_NEK2_1	163	168	PF00069	0.492
MOD_NEK2_1	171	176	PF00069	0.429
MOD_NEK2_1	278	283	PF00069	0.432
MOD_NEK2_1	54	59	PF00069	0.464
MOD_NEK2_1	64	69	PF00069	0.432
MOD_PIKK_1	219	225	PF00454	0.453
MOD_PIKK_1	342	348	PF00454	0.628
MOD_PIKK_1	38	44	PF00454	0.495
MOD_PIKK_1	57	63	PF00454	0.270
MOD_PKA_1	402	408	PF00069	0.613
MOD_PKB_1	400	408	PF00069	0.624
MOD_Plk_1	122	128	PF00069	0.480
MOD_Plk_1	131	137	PF00069	0.470
MOD_Plk_1	214	220	PF00069	0.431
MOD_Plk_4	122	128	PF00069	0.460
MOD_Plk_4	166	172	PF00069	0.515
MOD_Plk_4	214	220	PF00069	0.457
MOD_Plk_4	249	255	PF00069	0.449
MOD_Plk_4	274	280	PF00069	0.490
MOD_Plk_4	80	86	PF00069	0.494
MOD_Plk_4	90	96	PF00069	0.493
MOD_ProDKin_1	15	21	PF00069	0.479
MOD_ProDKin_1	261	267	PF00069	0.491
MOD_ProDKin_1	272	278	PF00069	0.566
MOD_ProDKin_1	301	307	PF00069	0.517
MOD_ProDKin_1	35	41	PF00069	0.516
MOD_ProDKin_1	66	72	PF00069	0.383
TRG_DiLeu_BaLyEn_6	294	299	PF01217	0.315
TRG_DiLeu_BaLyEn_6	306	311	PF01217	0.519
TRG_ENDOCYTIC_2	37	40	PF00928	0.532
TRG_ER_diArg_1	147	150	PF00400	0.568
TRG_ER_diArg_1	399	402	PF00400	0.589
TRG_Pf-PMV_PEXEL_1	297	301	PF00026	0.451
TRG_Pf-PMV_PEXEL_1	402	407	PF00026	0.609

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVD5	Leptomonas seymouri	65%	98%
A0A0S4IM90	Bodo saltans	29%	88%
A0A1X0NWV7	Trypanosomatidae	34%	91%
A0A3R7KUH0	Trypanosoma rangeli	21%	97%
A0A3S7WVV8	Leishmania donovani	83%	100%
A0A422N846	Trypanosoma rangeli	36%	96%
A3LNM0	Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)	23%	78%
A4HGX7	Leishmania braziliensis	24%	100%
A4HYJ4	Leishmania infantum	83%	100%
B8N9H4	Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357 / JCM 12722 / SRRC 167)	24%	90%
C9ZHT7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	93%
C9ZTV9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	75%
E8NHN2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9AUE1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	98%
O42249	Oreochromis niloticus	22%	100%
P62884	Leishmania infantum	24%	100%
Q00664	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	26%	92%
Q0P593	Bos taurus	23%	99%
Q1LV15	Danio rerio	25%	99%
Q2UGU1	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	24%	90%
Q3SZD4	Bos taurus	24%	95%
Q499N3	Rattus norvegicus	26%	95%
Q4Q7Y7	Leishmania major	24%	100%
Q4QD42	Leishmania major	84%	100%
Q4R8E7	Macaca fascicularis	25%	99%
Q4VBE8	Mus musculus	26%	95%
Q5JTN6	Homo sapiens	24%	100%
Q68EI0	Danio rerio	22%	95%
Q76LS6	Leishmania donovani	24%	100%
Q8N136	Homo sapiens	22%	99%
Q9M3B4	Arabidopsis thaliana	25%	94%