Cyclic nucleotide-binding domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cyclic nucleotide-binding domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HBG8_LEIBR

TriTrypDb:

LbrM.20.4080 , LBRM2903_200055200

Length:

801

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HBG8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBG8

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009116	nucleoside metabolic process	4	1
GO:0009987	cellular process	1	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044281	small molecule metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0055086	nucleobase-containing small molecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901135	carbohydrate derivative metabolic process	3	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901657	glycosyl compound metabolic process	4	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	227	231	PF00656	0.750
CLV_C14_Caspase3-7	506	510	PF00656	0.381
CLV_C14_Caspase3-7	546	550	PF00656	0.376
CLV_NRD_NRD_1	143	145	PF00675	0.406
CLV_NRD_NRD_1	181	183	PF00675	0.475
CLV_NRD_NRD_1	325	327	PF00675	0.453
CLV_NRD_NRD_1	467	469	PF00675	0.509
CLV_NRD_NRD_1	603	605	PF00675	0.385
CLV_NRD_NRD_1	657	659	PF00675	0.485
CLV_NRD_NRD_1	746	748	PF00675	0.525
CLV_NRD_NRD_1	795	797	PF00675	0.475
CLV_PCSK_KEX2_1	137	139	PF00082	0.479
CLV_PCSK_KEX2_1	143	145	PF00082	0.406
CLV_PCSK_KEX2_1	234	236	PF00082	0.690
CLV_PCSK_KEX2_1	323	325	PF00082	0.486
CLV_PCSK_KEX2_1	466	468	PF00082	0.494
CLV_PCSK_KEX2_1	605	607	PF00082	0.577
CLV_PCSK_KEX2_1	746	748	PF00082	0.557
CLV_PCSK_PC1ET2_1	137	139	PF00082	0.503
CLV_PCSK_PC1ET2_1	234	236	PF00082	0.457
CLV_PCSK_PC1ET2_1	323	325	PF00082	0.565
CLV_PCSK_PC1ET2_1	466	468	PF00082	0.473
CLV_PCSK_PC1ET2_1	605	607	PF00082	0.577
CLV_PCSK_PC7_1	463	469	PF00082	0.459
CLV_PCSK_SKI1_1	134	138	PF00082	0.497
CLV_PCSK_SKI1_1	218	222	PF00082	0.451
CLV_PCSK_SKI1_1	382	386	PF00082	0.554
CLV_PCSK_SKI1_1	399	403	PF00082	0.377
CLV_PCSK_SKI1_1	447	451	PF00082	0.709
CLV_PCSK_SKI1_1	463	467	PF00082	0.537
CLV_PCSK_SKI1_1	494	498	PF00082	0.415
CLV_PCSK_SKI1_1	625	629	PF00082	0.506
CLV_PCSK_SKI1_1	659	663	PF00082	0.432
CLV_PCSK_SKI1_1	758	762	PF00082	0.468
CLV_PCSK_SKI1_1	76	80	PF00082	0.491
CLV_PCSK_SKI1_1	781	785	PF00082	0.504
CLV_PCSK_SKI1_1	792	796	PF00082	0.436
CLV_Separin_Metazoa	379	383	PF03568	0.582
DEG_APCC_DBOX_1	238	246	PF00400	0.471
DEG_APCC_DBOX_1	365	373	PF00400	0.460
DEG_APCC_DBOX_1	75	83	PF00400	0.359
DEG_APCC_DBOX_1	791	799	PF00400	0.448
DOC_CDC14_PxL_1	79	87	PF14671	0.456
DOC_CYCLIN_RxL_1	655	666	PF00134	0.485
DOC_CYCLIN_RxL_1	752	764	PF00134	0.491
DOC_CYCLIN_yClb1_LxF_4	657	662	PF00134	0.460
DOC_MAPK_gen_1	182	188	PF00069	0.468
DOC_MAPK_gen_1	234	242	PF00069	0.523
DOC_MAPK_gen_1	463	471	PF00069	0.489
DOC_MAPK_gen_1	602	612	PF00069	0.576
DOC_MAPK_HePTP_8	98	110	PF00069	0.403
DOC_MAPK_MEF2A_6	101	110	PF00069	0.403
DOC_PP1_RVXF_1	656	663	PF00149	0.459
DOC_PP2B_LxvP_1	178	181	PF13499	0.434
DOC_PP2B_LxvP_1	240	243	PF13499	0.502
DOC_USP7_MATH_1	387	391	PF00917	0.598
DOC_USP7_MATH_1	550	554	PF00917	0.597
DOC_USP7_MATH_1	71	75	PF00917	0.653
DOC_USP7_MATH_1	754	758	PF00917	0.490
DOC_USP7_UBL2_3	133	137	PF12436	0.497
DOC_USP7_UBL2_3	777	781	PF12436	0.452
DOC_WW_Pin1_4	189	194	PF00397	0.535
DOC_WW_Pin1_4	28	33	PF00397	0.766
DOC_WW_Pin1_4	371	376	PF00397	0.540
DOC_WW_Pin1_4	485	490	PF00397	0.487
DOC_WW_Pin1_4	579	584	PF00397	0.568
DOC_WW_Pin1_4	67	72	PF00397	0.698
DOC_WW_Pin1_4	686	691	PF00397	0.543
DOC_WW_Pin1_4	771	776	PF00397	0.627
LIG_14-3-3_CanoR_1	239	243	PF00244	0.541
LIG_14-3-3_CanoR_1	247	256	PF00244	0.562
LIG_14-3-3_CanoR_1	271	278	PF00244	0.490
LIG_14-3-3_CanoR_1	326	332	PF00244	0.488
LIG_14-3-3_CanoR_1	468	478	PF00244	0.560
LIG_14-3-3_CanoR_1	634	639	PF00244	0.471
LIG_Actin_WH2_2	123	139	PF00022	0.497
LIG_Actin_WH2_2	40	57	PF00022	0.697
LIG_APCC_ABBA_1	210	215	PF00400	0.468
LIG_APCC_ABBA_1	430	435	PF00400	0.449
LIG_BIR_II_1	1	5	PF00653	0.715
LIG_BRCT_BRCA1_1	191	195	PF00533	0.489
LIG_BRCT_BRCA1_1	297	301	PF00533	0.585
LIG_BRCT_BRCA1_1	403	407	PF00533	0.568
LIG_BRCT_BRCA1_1	445	449	PF00533	0.589
LIG_BRCT_BRCA1_1	556	560	PF00533	0.574
LIG_FHA_1	124	130	PF00498	0.398
LIG_FHA_1	174	180	PF00498	0.407
LIG_FHA_1	260	266	PF00498	0.481
LIG_FHA_1	272	278	PF00498	0.478
LIG_FHA_1	282	288	PF00498	0.424
LIG_FHA_1	3	9	PF00498	0.665
LIG_FHA_1	335	341	PF00498	0.441
LIG_FHA_1	344	350	PF00498	0.389
LIG_FHA_1	443	449	PF00498	0.447
LIG_FHA_1	502	508	PF00498	0.533
LIG_FHA_1	536	542	PF00498	0.498
LIG_FHA_1	670	676	PF00498	0.576
LIG_FHA_1	687	693	PF00498	0.354
LIG_FHA_1	746	752	PF00498	0.386
LIG_FHA_1	85	91	PF00498	0.508
LIG_FHA_2	14	20	PF00498	0.793
LIG_FHA_2	28	34	PF00498	0.684
LIG_FHA_2	504	510	PF00498	0.520
LIG_FHA_2	544	550	PF00498	0.497
LIG_FHA_2	559	565	PF00498	0.477
LIG_FHA_2	584	590	PF00498	0.539
LIG_FHA_2	664	670	PF00498	0.580
LIG_FHA_2	727	733	PF00498	0.512
LIG_FHA_2	87	93	PF00498	0.488
LIG_HCF-1_HBM_1	117	120	PF13415	0.497
LIG_Integrin_RGD_1	651	653	PF01839	0.420
LIG_LIR_Gen_1	102	110	PF02991	0.403
LIG_LIR_Gen_1	209	216	PF02991	0.446
LIG_LIR_Gen_1	264	272	PF02991	0.531
LIG_LIR_Gen_1	282	293	PF02991	0.424
LIG_LIR_Gen_1	400	407	PF02991	0.478
LIG_LIR_Gen_1	41	51	PF02991	0.570
LIG_LIR_Gen_1	557	568	PF02991	0.477
LIG_LIR_Nem_3	209	213	PF02991	0.422
LIG_LIR_Nem_3	264	270	PF02991	0.529
LIG_LIR_Nem_3	282	288	PF02991	0.411
LIG_LIR_Nem_3	400	405	PF02991	0.485
LIG_LIR_Nem_3	41	47	PF02991	0.573
LIG_LIR_Nem_3	524	529	PF02991	0.498
LIG_LIR_Nem_3	531	537	PF02991	0.466
LIG_LIR_Nem_3	757	762	PF02991	0.434
LIG_MYND_1	588	592	PF01753	0.348
LIG_Pex14_2	627	631	PF04695	0.291
LIG_Rb_LxCxE_1	353	374	PF01857	0.541
LIG_SH2_CRK	428	432	PF00017	0.453
LIG_SH2_CRK	722	726	PF00017	0.481
LIG_SH2_GRB2like	454	457	PF00017	0.507
LIG_SH2_PTP2	285	288	PF00017	0.538
LIG_SH2_SRC	115	118	PF00017	0.481
LIG_SH2_SRC	285	288	PF00017	0.538
LIG_SH2_STAP1	345	349	PF00017	0.435
LIG_SH2_STAT3	437	440	PF00017	0.404
LIG_SH2_STAT3	551	554	PF00017	0.606
LIG_SH2_STAT3	593	596	PF00017	0.360
LIG_SH2_STAT5	115	118	PF00017	0.457
LIG_SH2_STAT5	120	123	PF00017	0.471
LIG_SH2_STAT5	272	275	PF00017	0.467
LIG_SH2_STAT5	285	288	PF00017	0.417
LIG_SH2_STAT5	296	299	PF00017	0.564
LIG_SH2_STAT5	345	348	PF00017	0.424
LIG_SH2_STAT5	437	440	PF00017	0.485
LIG_SH2_STAT5	454	457	PF00017	0.455
LIG_SH2_STAT5	535	538	PF00017	0.466
LIG_SH2_STAT5	593	596	PF00017	0.360
LIG_SH2_STAT5	737	740	PF00017	0.442
LIG_SH2_STAT5	759	762	PF00017	0.462
LIG_SH3_2	775	780	PF14604	0.475
LIG_SH3_3	47	53	PF00018	0.599
LIG_SH3_3	651	657	PF00018	0.388
LIG_SH3_3	772	778	PF00018	0.766
LIG_SH3_4	777	784	PF00018	0.418
LIG_SUMO_SIM_anti_2	126	132	PF11976	0.408
LIG_SUMO_SIM_anti_2	176	181	PF11976	0.411
LIG_SUMO_SIM_anti_2	284	290	PF11976	0.500
LIG_SUMO_SIM_anti_2	337	343	PF11976	0.515
LIG_SUMO_SIM_anti_2	94	100	PF11976	0.574
LIG_SUMO_SIM_par_1	19	26	PF11976	0.822
LIG_SUMO_SIM_par_1	284	290	PF11976	0.450
LIG_SUMO_SIM_par_1	45	52	PF11976	0.532
LIG_SUMO_SIM_par_1	571	577	PF11976	0.530
LIG_SUMO_SIM_par_1	86	92	PF11976	0.548
LIG_TRAF2_1	310	313	PF00917	0.477
LIG_TRAF2_1	89	92	PF00917	0.591
LIG_TYR_ITIM	265	270	PF00017	0.435
LIG_TYR_ITIM	283	288	PF00017	0.351
LIG_UBA3_1	177	183	PF00899	0.390
LIG_UBA3_1	357	364	PF00899	0.517
LIG_UBA3_1	461	466	PF00899	0.405
LIG_UBA3_1	496	505	PF00899	0.578
LIG_WRC_WIRS_1	207	212	PF05994	0.494
LIG_WRC_WIRS_1	628	633	PF05994	0.475
LIG_WRC_WIRS_1	75	80	PF05994	0.536
MOD_CDC14_SPxK_1	70	73	PF00782	0.506
MOD_CDC14_SPxK_1	774	777	PF00782	0.490
MOD_CDK_SPK_2	67	72	PF00069	0.728
MOD_CDK_SPxK_1	67	73	PF00069	0.539
MOD_CDK_SPxK_1	771	777	PF00069	0.750
MOD_CK1_1	173	179	PF00069	0.390
MOD_CK1_1	2	8	PF00069	0.650
MOD_CK1_1	224	230	PF00069	0.656
MOD_CK1_1	241	247	PF00069	0.471
MOD_CK1_1	251	257	PF00069	0.511
MOD_CK1_1	579	585	PF00069	0.543
MOD_CK1_1	663	669	PF00069	0.508
MOD_CK1_1	74	80	PF00069	0.554
MOD_CK2_1	1	7	PF00069	0.702
MOD_CK2_1	13	19	PF00069	0.767
MOD_CK2_1	160	166	PF00069	0.503
MOD_CK2_1	208	214	PF00069	0.505
MOD_CK2_1	373	379	PF00069	0.577
MOD_CK2_1	405	411	PF00069	0.477
MOD_CK2_1	469	475	PF00069	0.527
MOD_CK2_1	507	513	PF00069	0.472
MOD_CK2_1	550	556	PF00069	0.502
MOD_CK2_1	558	564	PF00069	0.516
MOD_CK2_1	583	589	PF00069	0.601
MOD_CK2_1	663	669	PF00069	0.523
MOD_CK2_1	86	92	PF00069	0.496
MOD_Cter_Amidation	321	324	PF01082	0.583
MOD_GlcNHglycan	123	126	PF01048	0.391
MOD_GlcNHglycan	162	165	PF01048	0.397
MOD_GlcNHglycan	226	229	PF01048	0.708
MOD_GlcNHglycan	251	254	PF01048	0.433
MOD_GlcNHglycan	375	378	PF01048	0.554
MOD_GlcNHglycan	568	571	PF01048	0.463
MOD_GlcNHglycan	696	699	PF01048	0.539
MOD_GSK3_1	165	172	PF00069	0.392
MOD_GSK3_1	19	26	PF00069	0.610
MOD_GSK3_1	222	229	PF00069	0.635
MOD_GSK3_1	401	408	PF00069	0.505
MOD_GSK3_1	443	450	PF00069	0.618
MOD_GSK3_1	485	492	PF00069	0.413
MOD_GSK3_1	503	510	PF00069	0.519
MOD_GSK3_1	550	557	PF00069	0.570
MOD_GSK3_1	579	586	PF00069	0.553
MOD_GSK3_1	63	70	PF00069	0.704
MOD_GSK3_1	630	637	PF00069	0.424
MOD_GSK3_1	74	81	PF00069	0.507
MOD_GSK3_1	783	790	PF00069	0.471
MOD_LATS_1	142	148	PF00433	0.408
MOD_N-GLC_1	173	178	PF02516	0.491
MOD_N-GLC_1	197	202	PF02516	0.515
MOD_N-GLC_1	2	7	PF02516	0.643
MOD_N-GLC_1	279	284	PF02516	0.432
MOD_N-GLC_1	442	447	PF02516	0.548
MOD_N-GLC_1	489	494	PF02516	0.448
MOD_N-GLC_1	771	776	PF02516	0.699
MOD_N-GLC_2	354	356	PF02516	0.428
MOD_N-GLC_2	639	641	PF02516	0.284
MOD_NEK2_1	1	6	PF00069	0.737
MOD_NEK2_1	216	221	PF00069	0.469
MOD_NEK2_1	248	253	PF00069	0.493
MOD_NEK2_1	501	506	PF00069	0.447
MOD_NEK2_1	507	512	PF00069	0.454
MOD_NEK2_1	627	632	PF00069	0.454
MOD_NEK2_1	660	665	PF00069	0.450
MOD_NEK2_1	692	697	PF00069	0.574
MOD_NEK2_1	712	717	PF00069	0.461
MOD_NEK2_1	721	726	PF00069	0.450
MOD_NEK2_1	733	738	PF00069	0.385
MOD_NEK2_1	78	83	PF00069	0.465
MOD_NEK2_1	783	788	PF00069	0.327
MOD_NEK2_2	208	213	PF00069	0.552
MOD_NEK2_2	489	494	PF00069	0.537
MOD_NEK2_2	71	76	PF00069	0.554
MOD_PIKK_1	198	204	PF00454	0.559
MOD_PIKK_1	287	293	PF00454	0.519
MOD_PIKK_1	550	556	PF00454	0.353
MOD_PIKK_1	712	718	PF00454	0.532
MOD_PK_1	634	640	PF00069	0.467
MOD_PKA_2	238	244	PF00069	0.486
MOD_PKA_2	745	751	PF00069	0.510
MOD_Plk_1	165	171	PF00069	0.381
MOD_Plk_1	173	179	PF00069	0.363
MOD_Plk_1	279	285	PF00069	0.511
MOD_Plk_1	388	394	PF00069	0.673
MOD_Plk_1	420	426	PF00069	0.563
MOD_Plk_1	489	495	PF00069	0.482
MOD_Plk_1	543	549	PF00069	0.401
MOD_Plk_1	576	582	PF00069	0.410
MOD_Plk_1	612	618	PF00069	0.447
MOD_Plk_1	91	97	PF00069	0.548
MOD_Plk_2-3	503	509	PF00069	0.601
MOD_Plk_2-3	669	675	PF00069	0.532
MOD_Plk_2-3	92	98	PF00069	0.567
MOD_Plk_4	144	150	PF00069	0.446
MOD_Plk_4	173	179	PF00069	0.392
MOD_Plk_4	241	247	PF00069	0.409
MOD_Plk_4	251	257	PF00069	0.461
MOD_Plk_4	334	340	PF00069	0.497
MOD_Plk_4	457	463	PF00069	0.484
MOD_Plk_4	503	509	PF00069	0.445
MOD_Plk_4	733	739	PF00069	0.487
MOD_Plk_4	783	789	PF00069	0.552
MOD_ProDKin_1	189	195	PF00069	0.526
MOD_ProDKin_1	28	34	PF00069	0.769
MOD_ProDKin_1	371	377	PF00069	0.530
MOD_ProDKin_1	485	491	PF00069	0.492
MOD_ProDKin_1	579	585	PF00069	0.570
MOD_ProDKin_1	67	73	PF00069	0.690
MOD_ProDKin_1	686	692	PF00069	0.538
MOD_ProDKin_1	771	777	PF00069	0.630
TRG_DiLeu_BaEn_1	56	61	PF01217	0.716
TRG_DiLeu_BaEn_4	111	117	PF01217	0.460
TRG_DiLeu_BaEn_4	91	97	PF01217	0.578
TRG_DiLeu_BaLyEn_6	687	692	PF01217	0.589
TRG_ENDOCYTIC_2	103	106	PF00928	0.387
TRG_ENDOCYTIC_2	267	270	PF00928	0.578
TRG_ENDOCYTIC_2	285	288	PF00928	0.489
TRG_ENDOCYTIC_2	428	431	PF00928	0.433
TRG_ENDOCYTIC_2	533	536	PF00928	0.524
TRG_ENDOCYTIC_2	722	725	PF00928	0.442
TRG_ER_diArg_1	143	145	PF00400	0.406
TRG_ER_diArg_1	324	326	PF00400	0.452
TRG_ER_diArg_1	365	368	PF00400	0.424
TRG_ER_diArg_1	467	469	PF00400	0.508
TRG_NES_CRM1_1	347	361	PF08389	0.398
TRG_NES_CRM1_1	422	436	PF08389	0.456
TRG_NLS_MonoCore_2	322	327	PF00514	0.576
TRG_NLS_MonoExtN_4	463	470	PF00514	0.468
TRG_Pf-PMV_PEXEL_1	740	744	PF00026	0.469
TRG_Pf-PMV_PEXEL_1	796	800	PF00026	0.503

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZ14	Leptomonas seymouri	73%	100%
A0A0S4JKK7	Bodo saltans	33%	100%
A0A1X0NTY5	Trypanosomatidae	29%	82%
A0A1X0PB50	Trypanosomatidae	46%	100%
A0A3Q8IHX4	Leishmania donovani	82%	100%
A0A3R7L5E3	Trypanosoma rangeli	32%	82%
A0A3R7MMZ6	Trypanosoma rangeli	45%	100%
A4H882	Leishmania braziliensis	26%	76%
A4IAJ9	Leishmania infantum	82%	100%
E9B5N9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4Q279	Leishmania major	81%	100%
V5BRC6	Trypanosoma cruzi	47%	100%