Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HBG7_LEIBR

TriTrypDb:

LbrM.20.4070 , LBRM2903_200055100

Length:

555

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HBG7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBG7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	104	106	PF00675	0.614
CLV_NRD_NRD_1	347	349	PF00675	0.697
CLV_NRD_NRD_1	460	462	PF00675	0.704
CLV_NRD_NRD_1	477	479	PF00675	0.634
CLV_NRD_NRD_1	505	507	PF00675	0.562
CLV_NRD_NRD_1	542	544	PF00675	0.511
CLV_NRD_NRD_1	553	555	PF00675	0.666
CLV_PCSK_FUR_1	100	104	PF00082	0.692
CLV_PCSK_FUR_1	502	506	PF00082	0.555
CLV_PCSK_KEX2_1	102	104	PF00082	0.610
CLV_PCSK_KEX2_1	153	155	PF00082	0.671
CLV_PCSK_KEX2_1	347	349	PF00082	0.697
CLV_PCSK_KEX2_1	479	481	PF00082	0.683
CLV_PCSK_KEX2_1	504	506	PF00082	0.580
CLV_PCSK_KEX2_1	553	555	PF00082	0.469
CLV_PCSK_PC1ET2_1	153	155	PF00082	0.671
CLV_PCSK_PC1ET2_1	479	481	PF00082	0.683
CLV_PCSK_PC1ET2_1	504	506	PF00082	0.571
CLV_PCSK_PC7_1	100	106	PF00082	0.610
CLV_PCSK_PC7_1	343	349	PF00082	0.719
CLV_PCSK_SKI1_1	104	108	PF00082	0.718
CLV_PCSK_SKI1_1	165	169	PF00082	0.574
CLV_PCSK_SKI1_1	343	347	PF00082	0.508
CLV_PCSK_SKI1_1	485	489	PF00082	0.692
CLV_PCSK_SKI1_1	506	510	PF00082	0.536
CLV_PCSK_SKI1_1	543	547	PF00082	0.601
CLV_PCSK_SKI1_1	65	69	PF00082	0.652
CLV_Separin_Metazoa	344	348	PF03568	0.754
DEG_APCC_DBOX_1	102	110	PF00400	0.499
DEG_APCC_DBOX_1	342	350	PF00400	0.505
DEG_APCC_DBOX_1	505	513	PF00400	0.537
DEG_Nend_Nbox_1	1	3	PF02207	0.676
DEG_SPOP_SBC_1	334	338	PF00917	0.542
DOC_CYCLIN_yCln2_LP_2	311	317	PF00134	0.720
DOC_MAPK_gen_1	347	357	PF00069	0.590
DOC_MAPK_gen_1	502	511	PF00069	0.541
DOC_MAPK_MEF2A_6	444	453	PF00069	0.738
DOC_PP1_RVXF_1	260	267	PF00149	0.421
DOC_PP2B_LxvP_1	226	229	PF13499	0.640
DOC_SPAK_OSR1_1	265	269	PF12202	0.438
DOC_USP7_MATH_1	115	119	PF00917	0.581
DOC_USP7_MATH_1	137	141	PF00917	0.591
DOC_USP7_MATH_1	255	259	PF00917	0.455
DOC_USP7_MATH_1	30	34	PF00917	0.617
DOC_USP7_MATH_1	334	338	PF00917	0.673
DOC_USP7_MATH_1	396	400	PF00917	0.710
DOC_USP7_MATH_1	437	441	PF00917	0.656
DOC_WW_Pin1_4	276	281	PF00397	0.588
DOC_WW_Pin1_4	296	301	PF00397	0.437
DOC_WW_Pin1_4	335	340	PF00397	0.749
LIG_14-3-3_CanoR_1	138	142	PF00244	0.476
LIG_14-3-3_CanoR_1	170	175	PF00244	0.718
LIG_14-3-3_CanoR_1	237	244	PF00244	0.592
LIG_14-3-3_CanoR_1	256	264	PF00244	0.579
LIG_14-3-3_CanoR_1	274	280	PF00244	0.402
LIG_14-3-3_CanoR_1	291	295	PF00244	0.507
LIG_14-3-3_CanoR_1	348	357	PF00244	0.483
LIG_14-3-3_CanoR_1	505	509	PF00244	0.428
LIG_APCC_ABBA_1	388	393	PF00400	0.593
LIG_BRCT_BRCA1_1	32	36	PF00533	0.531
LIG_DLG_GKlike_1	170	177	PF00625	0.712
LIG_EH1_1	46	54	PF00400	0.692
LIG_FHA_1	1	7	PF00498	0.761
LIG_FHA_1	105	111	PF00498	0.644
LIG_FHA_1	225	231	PF00498	0.502
LIG_FHA_1	282	288	PF00498	0.579
LIG_FHA_1	291	297	PF00498	0.609
LIG_FHA_1	350	356	PF00498	0.486
LIG_FHA_1	407	413	PF00498	0.622
LIG_FHA_1	448	454	PF00498	0.462
LIG_FHA_1	544	550	PF00498	0.625
LIG_FHA_1	64	70	PF00498	0.657
LIG_FHA_1	75	81	PF00498	0.646
LIG_FHA_2	230	236	PF00498	0.706
LIG_FHA_2	246	252	PF00498	0.437
LIG_FHA_2	505	511	PF00498	0.503
LIG_FHA_2	517	523	PF00498	0.417
LIG_Integrin_RGD_1	465	467	PF01839	0.684
LIG_LIR_Gen_1	507	516	PF02991	0.405
LIG_LIR_Nem_3	178	184	PF02991	0.551
LIG_LIR_Nem_3	507	511	PF02991	0.396
LIG_MYND_1	314	318	PF01753	0.715
LIG_Pex14_2	36	40	PF04695	0.574
LIG_SH2_CRK	297	301	PF00017	0.520
LIG_SH2_NCK_1	297	301	PF00017	0.520
LIG_SH2_STAP1	2	6	PF00017	0.737
LIG_SH2_STAT3	531	534	PF00017	0.644
LIG_SH2_STAT5	2	5	PF00017	0.755
LIG_SH2_STAT5	297	300	PF00017	0.527
LIG_SH2_STAT5	315	318	PF00017	0.634
LIG_SH2_STAT5	531	534	PF00017	0.644
LIG_SUMO_SIM_anti_2	510	516	PF11976	0.377
LIG_SUMO_SIM_par_1	21	27	PF11976	0.703
LIG_SUMO_SIM_par_1	513	523	PF11976	0.458
LIG_TRAF2_1	233	236	PF00917	0.701
LIG_TRAF2_1	248	251	PF00917	0.459
LIG_UBA3_1	470	479	PF00899	0.653
LIG_WRC_WIRS_1	160	165	PF05994	0.585
LIG_WRC_WIRS_1	407	412	PF05994	0.652
LIG_WW_3	62	66	PF00397	0.734
MOD_CK1_1	11	17	PF00069	0.644
MOD_CK1_1	173	179	PF00069	0.453
MOD_CK1_1	26	32	PF00069	0.561
MOD_CK1_1	290	296	PF00069	0.574
MOD_CK1_1	333	339	PF00069	0.713
MOD_CK1_1	34	40	PF00069	0.768
MOD_CK1_1	406	412	PF00069	0.722
MOD_CK1_1	41	47	PF00069	0.461
MOD_CK1_1	78	84	PF00069	0.758
MOD_CK2_1	137	143	PF00069	0.476
MOD_CK2_1	229	235	PF00069	0.617
MOD_CK2_1	245	251	PF00069	0.592
MOD_CK2_1	380	386	PF00069	0.489
MOD_CK2_1	504	510	PF00069	0.599
MOD_CK2_1	516	522	PF00069	0.472
MOD_GlcNHglycan	10	13	PF01048	0.671
MOD_GlcNHglycan	238	241	PF01048	0.479
MOD_GlcNHglycan	28	31	PF01048	0.637
MOD_GlcNHglycan	33	36	PF01048	0.602
MOD_GlcNHglycan	332	335	PF01048	0.546
MOD_GlcNHglycan	382	385	PF01048	0.663
MOD_GlcNHglycan	414	417	PF01048	0.634
MOD_GlcNHglycan	49	52	PF01048	0.739
MOD_GSK3_1	104	111	PF00069	0.641
MOD_GSK3_1	115	122	PF00069	0.581
MOD_GSK3_1	142	149	PF00069	0.679
MOD_GSK3_1	26	33	PF00069	0.580
MOD_GSK3_1	276	283	PF00069	0.590
MOD_GSK3_1	286	293	PF00069	0.562
MOD_GSK3_1	330	337	PF00069	0.710
MOD_GSK3_1	34	41	PF00069	0.599
MOD_GSK3_1	361	368	PF00069	0.539
MOD_GSK3_1	394	401	PF00069	0.701
MOD_GSK3_1	402	409	PF00069	0.674
MOD_GSK3_1	488	495	PF00069	0.422
MOD_GSK3_1	543	550	PF00069	0.534
MOD_GSK3_1	70	77	PF00069	0.675
MOD_LATS_1	483	489	PF00433	0.501
MOD_N-GLC_1	170	175	PF02516	0.616
MOD_N-GLC_1	437	442	PF02516	0.544
MOD_NEK2_1	110	115	PF00069	0.610
MOD_NEK2_1	119	124	PF00069	0.518
MOD_NEK2_1	146	151	PF00069	0.437
MOD_NEK2_1	287	292	PF00069	0.571
MOD_NEK2_1	36	41	PF00069	0.629
MOD_NEK2_1	548	553	PF00069	0.643
MOD_NEK2_1	98	103	PF00069	0.678
MOD_NEK2_2	115	120	PF00069	0.467
MOD_PIKK_1	327	333	PF00454	0.716
MOD_PIKK_1	365	371	PF00454	0.527
MOD_PIKK_1	38	44	PF00454	0.618
MOD_PIKK_1	486	492	PF00454	0.448
MOD_PIKK_1	537	543	PF00454	0.384
MOD_PKA_1	104	110	PF00069	0.718
MOD_PKA_1	504	510	PF00069	0.429
MOD_PKA_1	543	549	PF00069	0.383
MOD_PKA_2	104	110	PF00069	0.718
MOD_PKA_2	119	125	PF00069	0.461
MOD_PKA_2	137	143	PF00069	0.476
MOD_PKA_2	236	242	PF00069	0.697
MOD_PKA_2	255	261	PF00069	0.378
MOD_PKA_2	290	296	PF00069	0.574
MOD_PKA_2	349	355	PF00069	0.578
MOD_PKA_2	391	397	PF00069	0.772
MOD_PKA_2	504	510	PF00069	0.429
MOD_PKA_2	8	14	PF00069	0.743
MOD_PKB_1	102	110	PF00069	0.713
MOD_Plk_1	124	130	PF00069	0.557
MOD_Plk_1	142	148	PF00069	0.683
MOD_Plk_1	170	176	PF00069	0.615
MOD_Plk_1	437	443	PF00069	0.543
MOD_Plk_1	444	450	PF00069	0.479
MOD_Plk_1	492	498	PF00069	0.391
MOD_Plk_1	81	87	PF00069	0.744
MOD_Plk_4	142	148	PF00069	0.683
MOD_Plk_4	204	210	PF00069	0.602
MOD_Plk_4	283	289	PF00069	0.577
MOD_Plk_4	492	498	PF00069	0.391
MOD_ProDKin_1	276	282	PF00069	0.581
MOD_ProDKin_1	296	302	PF00069	0.440
MOD_ProDKin_1	335	341	PF00069	0.751
MOD_SUMO_rev_2	50	59	PF00179	0.704
MOD_SUMO_rev_2	520	528	PF00179	0.543
TRG_DiLeu_BaEn_1	191	196	PF01217	0.701
TRG_DiLeu_BaLyEn_6	226	231	PF01217	0.609
TRG_DiLeu_BaLyEn_6	419	424	PF01217	0.647
TRG_ENDOCYTIC_2	342	345	PF00928	0.523
TRG_ER_diArg_1	100	103	PF00400	0.615
TRG_ER_diArg_1	104	106	PF00400	0.598
TRG_ER_diArg_1	346	348	PF00400	0.708
TRG_ER_diArg_1	420	423	PF00400	0.652
TRG_ER_diArg_1	552	554	PF00400	0.437
TRG_NLS_Bipartite_1	461	483	PF00514	0.510
TRG_NLS_MonoExtC_3	477	482	PF00514	0.669
TRG_NLS_MonoExtN_4	476	483	PF00514	0.678
TRG_NLS_MonoExtN_4	502	508	PF00514	0.537
TRG_Pf-PMV_PEXEL_1	265	269	PF00026	0.588

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2P1	Leptomonas seymouri	42%	99%
A0A3S7X8N2	Leishmania donovani	74%	100%
A4IAL3	Leishmania infantum	73%	100%
E9B5N8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	100%
Q4Q280	Leishmania major	73%	100%