LeishMANIAdb
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Inner membrane protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Inner membrane protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4HBG3_LEIBR
TriTrypDb:
LbrM.20.4030 , LBRM2903_200054700 *
Length:
119

Annotations

LeishMANIAdb annotations

A very conserved Kinetoplastid protein with no relatives in other life forms

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0016020 membrane 2 10
GO:0110165 cellular anatomical entity 1 10

Expansion

Sequence features

A4HBG3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBG3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 111 113 PF00675 0.424
CLV_NRD_NRD_1 43 45 PF00675 0.420
CLV_PCSK_KEX2_1 43 45 PF00082 0.410
CLV_PCSK_SKI1_1 113 117 PF00082 0.448
CLV_PCSK_SKI1_1 21 25 PF00082 0.378
CLV_PCSK_SKI1_1 44 48 PF00082 0.466
CLV_PCSK_SKI1_1 51 55 PF00082 0.410
DEG_APCC_DBOX_1 43 51 PF00400 0.627
DEG_Nend_UBRbox_1 1 4 PF02207 0.363
DOC_CYCLIN_RxL_1 40 49 PF00134 0.542
DOC_MAPK_gen_1 48 57 PF00069 0.639
DOC_PP1_RVXF_1 19 25 PF00149 0.378
DOC_PP1_RVXF_1 46 53 PF00149 0.672
DOC_PP4_FxxP_1 85 88 PF00568 0.477
LIG_Actin_WH2_2 32 50 PF00022 0.383
LIG_eIF4E_1 34 40 PF01652 0.355
LIG_FHA_1 68 74 PF00498 0.447
LIG_LIR_Apic_2 84 88 PF02991 0.476
LIG_LIR_Gen_1 49 60 PF02991 0.535
LIG_LIR_Nem_3 17 22 PF02991 0.389
LIG_LIR_Nem_3 30 36 PF02991 0.271
LIG_PDZ_Class_2 114 119 PF00595 0.642
LIG_Pex14_2 33 37 PF04695 0.405
LIG_SH2_CRK 97 101 PF00017 0.355
LIG_SH2_GRB2like 8 11 PF00017 0.349
LIG_SH2_STAT5 107 110 PF00017 0.408
LIG_SH2_STAT5 34 37 PF00017 0.378
LIG_SH2_STAT5 59 62 PF00017 0.378
LIG_SUMO_SIM_anti_2 70 75 PF11976 0.355
LIG_TYR_ITIM 57 62 PF00017 0.383
LIG_WRC_WIRS_1 82 87 PF05994 0.516
MOD_CK1_1 14 20 PF00069 0.328
MOD_Cter_Amidation 110 113 PF01082 0.510
MOD_GlcNHglycan 97 100 PF01048 0.381
MOD_GSK3_1 111 118 PF00069 0.594
MOD_GSK3_1 23 30 PF00069 0.377
MOD_NEK2_1 58 63 PF00069 0.466
MOD_NEK2_1 95 100 PF00069 0.349
MOD_NEK2_2 102 107 PF00069 0.354
MOD_PKA_2 111 117 PF00069 0.533
MOD_Plk_1 11 17 PF00069 0.528
MOD_Plk_4 111 117 PF00069 0.512
MOD_Plk_4 14 20 PF00069 0.422
TRG_DiLeu_BaLyEn_6 18 23 PF01217 0.408
TRG_DiLeu_BaLyEn_6 41 46 PF01217 0.509
TRG_ENDOCYTIC_2 34 37 PF00928 0.335
TRG_ENDOCYTIC_2 59 62 PF00928 0.342
TRG_ENDOCYTIC_2 97 100 PF00928 0.335
TRG_ER_diArg_1 43 45 PF00400 0.515

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PC58 Leptomonas seymouri 68% 100%
A0A0S4IQ54 Bodo saltans 33% 99%
A0A1X0PAC4 Trypanosomatidae 45% 100%
A0A3R7KFI4 Trypanosoma rangeli 46% 100%
A0A3S7X8T4 Leishmania donovani 87% 100%
A4IAK9 Leishmania infantum 87% 100%
C9ZLN1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 47% 100%
E9B5N4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 86% 100%
Q4Q284 Leishmania major 84% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS