RNA-binding protein-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Double RNA binding domain protein 7

Species:

Leishmania braziliensis

UniProt:

A4HBG2_LEIBR

TriTrypDb:

LbrM.20.4020 , LBRM2903_200054600

Length:

390

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0032991	protein-containing complex	1	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A4HBG2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBG2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	10
GO:0003723	RNA binding	4	10
GO:0005488	binding	1	10
GO:0097159	organic cyclic compound binding	2	10
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	89	91	PF00675	0.286
CLV_PCSK_SKI1_1	12	16	PF00082	0.663
CLV_PCSK_SKI1_1	149	153	PF00082	0.340
CLV_PCSK_SKI1_1	335	339	PF00082	0.503
CLV_PCSK_SKI1_1	361	365	PF00082	0.586
CLV_PCSK_SKI1_1	39	43	PF00082	0.737
CLV_PCSK_SKI1_1	77	81	PF00082	0.340
CLV_Separin_Metazoa	332	336	PF03568	0.593
DEG_Nend_UBRbox_2	1	3	PF02207	0.663
DEG_ODPH_VHL_1	311	324	PF01847	0.367
DEG_SCF_FBW7_1	107	112	PF00400	0.487
DEG_SCF_FBW7_1	277	283	PF00400	0.669
DEG_SCF_FBW7_1	41	46	PF00400	0.572
DEG_SPOP_SBC_1	109	113	PF00917	0.397
DEG_SPOP_SBC_1	280	284	PF00917	0.468
DOC_CKS1_1	106	111	PF01111	0.584
DOC_CKS1_1	277	282	PF01111	0.641
DOC_CYCLIN_RxL_1	332	340	PF00134	0.439
DOC_MAPK_gen_1	223	232	PF00069	0.458
DOC_MAPK_gen_1	80	89	PF00069	0.469
DOC_MAPK_MEF2A_6	12	19	PF00069	0.603
DOC_PP2B_LxvP_1	230	233	PF13499	0.484
DOC_PP4_FxxP_1	251	254	PF00568	0.719
DOC_PP4_FxxP_1	302	305	PF00568	0.447
DOC_PP4_FxxP_1	324	327	PF00568	0.545
DOC_USP7_MATH_1	191	195	PF00917	0.472
DOC_USP7_MATH_1	281	285	PF00917	0.485
DOC_USP7_MATH_1	43	47	PF00917	0.534
DOC_WW_Pin1_4	105	110	PF00397	0.487
DOC_WW_Pin1_4	150	155	PF00397	0.504
DOC_WW_Pin1_4	237	242	PF00397	0.620
DOC_WW_Pin1_4	243	248	PF00397	0.651
DOC_WW_Pin1_4	249	254	PF00397	0.473
DOC_WW_Pin1_4	276	281	PF00397	0.513
DOC_WW_Pin1_4	301	306	PF00397	0.591
DOC_WW_Pin1_4	39	44	PF00397	0.589
LIG_APCC_ABBA_1	119	124	PF00400	0.507
LIG_Clathr_ClatBox_1	14	18	PF01394	0.494
LIG_EVH1_1	276	280	PF00568	0.658
LIG_FHA_1	110	116	PF00498	0.457
LIG_FHA_1	184	190	PF00498	0.486
LIG_FHA_1	285	291	PF00498	0.702
LIG_FHA_1	328	334	PF00498	0.558
LIG_FHA_1	378	384	PF00498	0.528
LIG_FHA_1	40	46	PF00498	0.566
LIG_FHA_1	74	80	PF00498	0.457
LIG_LIR_Apic_2	321	327	PF02991	0.534
LIG_LIR_Nem_3	153	158	PF02991	0.449
LIG_LIR_Nem_3	174	179	PF02991	0.469
LIG_LIR_Nem_3	246	251	PF02991	0.614
LIG_LIR_Nem_3	269	275	PF02991	0.536
LIG_LIR_Nem_3	340	344	PF02991	0.530
LIG_LIR_Nem_3	65	70	PF02991	0.463
LIG_LIR_Nem_3	8	14	PF02991	0.610
LIG_MYND_1	309	313	PF01753	0.573
LIG_NRBOX	332	338	PF00104	0.327
LIG_PDZ_Class_2	385	390	PF00595	0.477
LIG_PTB_Apo_2	78	85	PF02174	0.540
LIG_SH2_CRK	11	15	PF00017	0.492
LIG_SH2_CRK	155	159	PF00017	0.540
LIG_SH2_STAP1	208	212	PF00017	0.469
LIG_SH2_STAT5	248	251	PF00017	0.588
LIG_SH3_3	267	273	PF00018	0.665
LIG_SH3_3	274	280	PF00018	0.623
LIG_SH3_3	295	301	PF00018	0.547
LIG_SH3_3	307	313	PF00018	0.635
LIG_TRAF2_1	181	184	PF00917	0.509
LIG_UBA3_1	164	172	PF00899	0.347
LIG_WW_1	300	303	PF00397	0.658
MOD_CK1_1	243	249	PF00069	0.681
MOD_CK1_1	284	290	PF00069	0.645
MOD_CK2_1	178	184	PF00069	0.324
MOD_CK2_1	337	343	PF00069	0.496
MOD_GlcNHglycan	173	176	PF01048	0.338
MOD_GlcNHglycan	20	23	PF01048	0.762
MOD_GlcNHglycan	210	213	PF01048	0.611
MOD_GlcNHglycan	283	286	PF01048	0.695
MOD_GlcNHglycan	305	308	PF01048	0.620
MOD_GlcNHglycan	324	327	PF01048	0.468
MOD_GlcNHglycan	93	96	PF01048	0.303
MOD_GSK3_1	105	112	PF00069	0.483
MOD_GSK3_1	239	246	PF00069	0.691
MOD_GSK3_1	249	256	PF00069	0.682
MOD_GSK3_1	26	33	PF00069	0.668
MOD_GSK3_1	276	283	PF00069	0.580
MOD_GSK3_1	373	380	PF00069	0.554
MOD_GSK3_1	39	46	PF00069	0.582
MOD_N-GLC_1	109	114	PF02516	0.498
MOD_N-GLC_1	30	35	PF02516	0.698
MOD_N-GLC_1	351	356	PF02516	0.585
MOD_N-GLC_1	373	378	PF02516	0.496
MOD_N-GLC_1	99	104	PF02516	0.325
MOD_NEK2_1	115	120	PF00069	0.419
MOD_NEK2_1	322	327	PF00069	0.463
MOD_NEK2_1	337	342	PF00069	0.452
MOD_NEK2_1	373	378	PF00069	0.469
MOD_PIKK_1	102	108	PF00454	0.566
MOD_PIKK_1	178	184	PF00454	0.403
MOD_PIKK_1	257	263	PF00454	0.706
MOD_PIKK_1	284	290	PF00454	0.681
MOD_PKA_2	191	197	PF00069	0.347
MOD_PKB_1	359	367	PF00069	0.542
MOD_Plk_1	109	115	PF00069	0.485
MOD_Plk_1	99	105	PF00069	0.347
MOD_Plk_2-3	193	199	PF00069	0.464
MOD_Plk_4	110	116	PF00069	0.567
MOD_Plk_4	253	259	PF00069	0.629
MOD_Plk_4	364	370	PF00069	0.413
MOD_Plk_4	373	379	PF00069	0.478
MOD_ProDKin_1	105	111	PF00069	0.482
MOD_ProDKin_1	150	156	PF00069	0.372
MOD_ProDKin_1	237	243	PF00069	0.619
MOD_ProDKin_1	249	255	PF00069	0.473
MOD_ProDKin_1	276	282	PF00069	0.516
MOD_ProDKin_1	301	307	PF00069	0.591
MOD_ProDKin_1	39	45	PF00069	0.581
MOD_SUMO_for_1	25	28	PF00179	0.774
TRG_DiLeu_BaEn_1	160	165	PF01217	0.422
TRG_DiLeu_BaEn_1	332	337	PF01217	0.589
TRG_DiLeu_BaLyEn_6	10	15	PF01217	0.493
TRG_DiLeu_LyEn_5	332	337	PF01217	0.336
TRG_ENDOCYTIC_2	11	14	PF00928	0.489
TRG_ENDOCYTIC_2	155	158	PF00928	0.379
TRG_ENDOCYTIC_2	248	251	PF00928	0.643
TRG_ENDOCYTIC_2	296	299	PF00928	0.609
TRG_ENDOCYTIC_2	341	344	PF00928	0.423
TRG_ENDOCYTIC_2	67	70	PF00928	0.385
TRG_ER_diArg_1	358	361	PF00400	0.516
TRG_Pf-PMV_PEXEL_1	137	141	PF00026	0.323
TRG_Pf-PMV_PEXEL_1	335	339	PF00026	0.433

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHL9	Leptomonas seymouri	82%	100%
A0A0S4JPT3	Bodo saltans	25%	69%
A0A1X0P4T3	Trypanosomatidae	23%	70%
A0A1X0P525	Trypanosomatidae	24%	71%
A0A1X0PA83	Trypanosomatidae	56%	100%
A0A3R7NF39	Trypanosoma rangeli	23%	67%
A0A3S7X8L4	Leishmania donovani	89%	100%
A0A422NK82	Trypanosoma rangeli	25%	71%
A4IAK8	Leishmania infantum	89%	100%
C9ZLN3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
E9B5N3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
F4HT49	Arabidopsis thaliana	27%	78%
Q4Q285	Leishmania major	88%	100%
Q6DGV1	Danio rerio	27%	75%
Q6FKG4	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	22%	67%
Q74ZS6	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	28%	67%
V5BW06	Trypanosoma cruzi	53%	97%
V5DUJ1	Trypanosoma cruzi	25%	71%