Sjogren syndrome nuclear autoantigen 1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

13 kDa deflagellation-inducible protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HBG0_LEIBR

TriTrypDb:

LbrM.20.4000 , LBRM2903_200054400

Length:

108

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005813	centrosome	3	1
GO:0005815	microtubule organizing center	2	1
GO:0036064	ciliary basal body	3	1
GO:0110165	cellular anatomical entity	1	3
GO:0005929	cilium	4	2
GO:0031514	motile cilium	5	2
GO:0042995	cell projection	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0120025	plasma membrane bounded cell projection	3	2

Expansion

Sequence features

A4HBG0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBG0

Function

Biological processes
Term	Name	Level	Count
GO:0010468	regulation of gene expression	5	1
GO:0010608	post-transcriptional regulation of gene expression	6	1
GO:0019222	regulation of metabolic process	3	1
GO:0050789	regulation of biological process	2	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	84	88	PF00656	0.538
CLV_NRD_NRD_1	24	26	PF00675	0.427
CLV_PCSK_SKI1_1	83	87	PF00082	0.441
CLV_PCSK_SKI1_1	90	94	PF00082	0.416
DOC_CYCLIN_RxL_1	87	95	PF00134	0.480
DOC_USP7_MATH_1	102	106	PF00917	0.464
DOC_USP7_MATH_1	3	7	PF00917	0.544
DOC_USP7_MATH_1	81	85	PF00917	0.545
LIG_14-3-3_CanoR_1	73	82	PF00244	0.495
LIG_Actin_WH2_2	43	60	PF00022	0.554
LIG_BIR_II_1	1	5	PF00653	0.510
LIG_FHA_2	47	53	PF00498	0.372
LIG_FHA_2	72	78	PF00498	0.513
LIG_FHA_2	9	15	PF00498	0.424
LIG_FHA_2	93	99	PF00498	0.530
LIG_LIR_Gen_1	76	86	PF02991	0.502
LIG_LIR_Nem_3	37	43	PF02991	0.560
LIG_LIR_Nem_3	76	82	PF02991	0.471
LIG_SUMO_SIM_anti_2	11	17	PF11976	0.445
LIG_SUMO_SIM_par_1	14	20	PF11976	0.431
LIG_TRAF2_1	34	37	PF00917	0.487
LIG_TRAF2_1	49	52	PF00917	0.486
LIG_TRAF2_1	96	99	PF00917	0.537
MOD_CK2_1	102	108	PF00069	0.574
MOD_CK2_1	31	37	PF00069	0.450
MOD_CK2_1	46	52	PF00069	0.345
MOD_CK2_1	71	77	PF00069	0.473
MOD_CK2_1	8	14	PF00069	0.425
MOD_CK2_1	92	98	PF00069	0.529
MOD_GlcNHglycan	33	36	PF01048	0.453
MOD_GlcNHglycan	79	82	PF01048	0.478
MOD_GlcNHglycan	98	103	PF01048	0.379
MOD_GSK3_1	71	78	PF00069	0.468
MOD_GSK3_1	98	105	PF00069	0.378
MOD_NEK2_1	57	62	PF00069	0.464
MOD_NEK2_1	71	76	PF00069	0.402
MOD_NEK2_1	86	91	PF00069	0.406
MOD_NEK2_1	92	97	PF00069	0.409
MOD_PIKK_1	102	108	PF00454	0.343
MOD_PKA_2	57	63	PF00069	0.490
MOD_Plk_1	71	77	PF00069	0.498
MOD_Plk_1	98	104	PF00069	0.490
MOD_Plk_2-3	14	20	PF00069	0.455
MOD_Plk_2-3	46	52	PF00069	0.293
MOD_Plk_4	14	20	PF00069	0.438
MOD_Plk_4	81	87	PF00069	0.541
MOD_SUMO_for_1	96	99	PF00179	0.537
MOD_SUMO_rev_2	20	27	PF00179	0.528
TRG_DiLeu_BaEn_1	39	44	PF01217	0.451
TRG_DiLeu_BaEn_4	98	104	PF01217	0.504
TRG_ENDOCYTIC_2	40	43	PF00928	0.558
TRG_ENDOCYTIC_2	79	82	PF00928	0.548
TRG_Pf-PMV_PEXEL_1	73	77	PF00026	0.476
TRG_PTS2	1	33	PF00400	0.543

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAT9	Leptomonas seymouri	68%	100%
A0A0S4IPN0	Bodo saltans	50%	100%
A0A1X0P6Z2	Trypanosomatidae	52%	99%
A0A3S7X8K8	Leishmania donovani	91%	100%
A0A422NPR2	Trypanosoma rangeli	44%	99%
A4IAK6	Leishmania infantum	91%	100%
C9ZZY9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	83%
E9B5N1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
O43805	Homo sapiens	39%	91%
Q4Q287	Leishmania major	91%	100%
Q5E9C3	Bos taurus	39%	91%
Q9JJ94	Mus musculus	39%	91%
Q9XF62	Chlamydomonas reinhardtii	32%	97%