Proteasome subunit beta

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

20s proteasome beta 7 subunit, (putative)

Species:

Leishmania braziliensis

UniProt:

A4HBF5_LEIBR

TriTrypDb:

LbrM.20.3950 , LBRM2903_200053900

Length:

220

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 28

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	13
GO:0005737	cytoplasm	2	13
GO:0005839	proteasome core complex	3	13
GO:0032991	protein-containing complex	1	13
GO:0043226	organelle	2	13
GO:0043227	membrane-bounded organelle	3	13
GO:0043229	intracellular organelle	3	13
GO:0043231	intracellular membrane-bounded organelle	4	13
GO:0110165	cellular anatomical entity	1	13
GO:0140535	intracellular protein-containing complex	2	13
GO:1902494	catalytic complex	2	13
GO:0019774	proteasome core complex, beta-subunit complex	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

A4HBF5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBF5

PDB structure(s): 6qm7_b , 6qm7_N , 6qm8_b , 6qm8_N , 6tcz_n , 6td5_n

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	13
GO:0006807	nitrogen compound metabolic process	2	13
GO:0008152	metabolic process	1	13
GO:0019538	protein metabolic process	3	13
GO:0043170	macromolecule metabolic process	3	13
GO:0044238	primary metabolic process	2	13
GO:0051603	proteolysis involved in protein catabolic process	5	13
GO:0071704	organic substance metabolic process	2	13
GO:1901564	organonitrogen compound metabolic process	3	13
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0010498	proteasomal protein catabolic process	5	1
GO:0030163	protein catabolic process	4	1
GO:1901565	organonitrogen compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004175	endopeptidase activity	4	11
GO:0004298	threonine-type endopeptidase activity	5	11
GO:0008233	peptidase activity	3	11
GO:0016787	hydrolase activity	2	11
GO:0070003	threonine-type peptidase activity	4	11
GO:0140096	catalytic activity, acting on a protein	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	61	63	PF00082	0.329
CLV_PCSK_KEX2_1	95	97	PF00082	0.293
CLV_PCSK_PC1ET2_1	61	63	PF00082	0.230
CLV_PCSK_PC1ET2_1	95	97	PF00082	0.293
CLV_PCSK_SKI1_1	115	119	PF00082	0.279
CLV_PCSK_SKI1_1	147	151	PF00082	0.311
CLV_PCSK_SKI1_1	171	175	PF00082	0.317
DOC_CYCLIN_RxL_1	168	177	PF00134	0.511
DOC_MAPK_DCC_7	31	40	PF00069	0.493
DOC_MAPK_MEF2A_6	31	40	PF00069	0.493
DOC_PP1_RVXF_1	169	175	PF00149	0.492
DOC_USP7_MATH_1	49	53	PF00917	0.562
DOC_USP7_MATH_2	81	87	PF00917	0.562
LIG_BIR_II_1	1	5	PF00653	0.511
LIG_BIR_III_4	188	192	PF00653	0.456
LIG_BRCT_BRCA1_1	196	200	PF00533	0.447
LIG_deltaCOP1_diTrp_1	203	213	PF00928	0.450
LIG_eIF4E_1	12	18	PF01652	0.512
LIG_FHA_1	165	171	PF00498	0.558
LIG_FHA_1	214	220	PF00498	0.436
LIG_FHA_2	124	130	PF00498	0.540
LIG_LIR_Gen_1	50	60	PF02991	0.492
LIG_LIR_Gen_1	83	93	PF02991	0.527
LIG_LIR_Nem_3	25	29	PF02991	0.493
LIG_LIR_Nem_3	50	56	PF02991	0.492
LIG_LIR_Nem_3	83	88	PF02991	0.529
LIG_SH2_CRK	26	30	PF00017	0.493
LIG_SH2_GRB2like	73	76	PF00017	0.575
LIG_SH2_STAT5	87	90	PF00017	0.511
LIG_SH3_3	30	36	PF00018	0.493
LIG_TYR_ITIM	24	29	PF00017	0.493
MOD_CK1_1	25	31	PF00069	0.493
MOD_CK1_1	3	9	PF00069	0.496
MOD_CK2_1	123	129	PF00069	0.541
MOD_CK2_1	155	161	PF00069	0.421
MOD_GlcNHglycan	2	5	PF01048	0.293
MOD_GlcNHglycan	44	47	PF01048	0.361
MOD_NEK2_1	213	218	PF00069	0.452
MOD_NEK2_1	88	93	PF00069	0.585
MOD_Plk_1	213	219	PF00069	0.426
MOD_Plk_4	113	119	PF00069	0.579
MOD_Plk_4	19	25	PF00069	0.493
MOD_Plk_4	3	9	PF00069	0.504
TRG_DiLeu_BaLyEn_6	141	146	PF01217	0.493
TRG_ENDOCYTIC_2	26	29	PF00928	0.493
TRG_ENDOCYTIC_2	53	56	PF00928	0.492
TRG_ENDOCYTIC_2	73	76	PF00928	0.392
TRG_Pf-PMV_PEXEL_1	90	94	PF00026	0.414

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4IKM4	Bodo saltans	60%	89%
A0A1X0PA78	Trypanosomatidae	65%	100%
A0A381MU64	Leishmania infantum	87%	100%
A0A3Q8IIL6	Leishmania donovani	87%	100%
A0A3Q8INX1	Leishmania donovani	88%	100%
A0A3R7K5Z0	Trypanosoma rangeli	71%	100%
A0RU86	Cenarchaeum symbiosum (strain A)	25%	100%
A1RX71	Thermofilum pendens (strain DSM 2475 / Hrk 5)	24%	100%
A4HBF8	Leishmania braziliensis	100%	100%
A4IAL6	Leishmania infantum	88%	100%
A8AA46	Ignicoccus hospitalis (strain KIN4/I / DSM 18386 / JCM 14125)	24%	100%
C5A2D5	Thermococcus gammatolerans (strain DSM 15229 / JCM 11827 / EJ3)	27%	100%
C9ZLN7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	68%	100%
E9B5M9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
O57983	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	27%	100%
P28024	Xenopus laevis	37%	91%
P28070	Homo sapiens	41%	83%
P30657	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	83%
P34067	Rattus norvegicus	39%	84%
P99026	Mus musculus	40%	83%
Q3T108	Bos taurus	41%	83%
Q4Q289	Leishmania major	88%	100%
Q556Q0	Dictyostelium discoideum	43%	85%
Q5JHL8	Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)	26%	100%
Q7DLR9	Arabidopsis thaliana	39%	89%
Q8SS01	Encephalitozoon cuniculi (strain GB-M1)	31%	97%
Q8TW10	Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)	25%	100%
Q8U4C9	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)	28%	100%
Q9USQ9	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	33%	84%
Q9V247	Pyrococcus abyssi (strain GE5 / Orsay)	28%	100%
Q9VNA5	Drosophila melanogaster	33%	82%
Q9YER0	Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)	26%	100%
Q9YES4	Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)	24%	100%