Palmitoyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DHHC palmitoyltransferase, putative

Species:

Leishmania braziliensis

UniProt:

A4HBF2_LEIBR

TriTrypDb:

LbrM.20.3920 , LBRM2903_200053500

Length:

265

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 8
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10
GO:0005783	endoplasmic reticulum	5	1
GO:0005794	Golgi apparatus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4HBF2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBF2

Function

Biological processes
Term	Name	Level	Count
GO:0006497	protein lipidation	5	1
GO:0006605	protein targeting	5	1
GO:0006612	protein targeting to membrane	5	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006810	transport	3	1
GO:0006886	intracellular protein transport	4	1
GO:0008104	protein localization	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018198	peptidyl-cysteine modification	6	1
GO:0018230	peptidyl-L-cysteine S-palmitoylation	7	1
GO:0018231	peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine	7	1
GO:0018345	protein palmitoylation	6	1
GO:0019538	protein metabolic process	3	1
GO:0033036	macromolecule localization	2	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043543	protein acylation	5	1
GO:0044238	primary metabolic process	2	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0051668	localization within membrane	3	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071704	organic substance metabolic process	2	1
GO:0071705	nitrogen compound transport	4	1
GO:0072657	protein localization to membrane	4	1
GO:0090150	establishment of protein localization to membrane	4	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0016409	palmitoyltransferase activity	5	10
GO:0016417	S-acyltransferase activity	5	10
GO:0016740	transferase activity	2	10
GO:0016746	acyltransferase activity	3	10
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	10
GO:0019706	protein-cysteine S-palmitoyltransferase activity	4	10
GO:0019707	protein-cysteine S-acyltransferase activity	3	10
GO:0140096	catalytic activity, acting on a protein	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	163	165	PF00675	0.457
CLV_NRD_NRD_1	17	19	PF00675	0.436
CLV_NRD_NRD_1	226	228	PF00675	0.385
CLV_PCSK_FUR_1	14	18	PF00082	0.473
CLV_PCSK_KEX2_1	14	16	PF00082	0.465
CLV_PCSK_KEX2_1	163	165	PF00082	0.500
CLV_PCSK_KEX2_1	17	19	PF00082	0.426
CLV_PCSK_KEX2_1	225	227	PF00082	0.363
CLV_PCSK_SKI1_1	173	177	PF00082	0.571
CLV_PCSK_SKI1_1	18	22	PF00082	0.341
CLV_PCSK_SKI1_1	245	249	PF00082	0.420
DEG_APCC_DBOX_1	225	233	PF00400	0.619
DEG_Nend_UBRbox_2	1	3	PF02207	0.651
DEG_SCF_FBW7_1	50	57	PF00400	0.386
DOC_CDC14_PxL_1	36	44	PF14671	0.447
DOC_CKS1_1	51	56	PF01111	0.467
DOC_MAPK_FxFP_2	252	255	PF00069	0.521
DOC_MAPK_gen_1	185	195	PF00069	0.345
DOC_MAPK_gen_1	225	232	PF00069	0.515
DOC_MAPK_gen_1	63	73	PF00069	0.211
DOC_MAPK_HePTP_8	65	77	PF00069	0.233
DOC_MAPK_MEF2A_6	188	197	PF00069	0.392
DOC_MAPK_MEF2A_6	63	71	PF00069	0.359
DOC_PP1_RVXF_1	186	193	PF00149	0.254
DOC_PP4_FxxP_1	252	255	PF00568	0.701
DOC_WW_Pin1_4	183	188	PF00397	0.297
DOC_WW_Pin1_4	50	55	PF00397	0.447
LIG_14-3-3_CanoR_1	185	191	PF00244	0.291
LIG_14-3-3_CanoR_1	212	216	PF00244	0.511
LIG_14-3-3_CanoR_1	245	255	PF00244	0.678
LIG_Actin_WH2_2	197	214	PF00022	0.447
LIG_Actin_WH2_2	229	247	PF00022	0.625
LIG_APCC_ABBA_1	67	72	PF00400	0.272
LIG_APCC_ABBAyCdc20_2	66	72	PF00400	0.233
LIG_BRCT_BRCA1_1	236	240	PF00533	0.629
LIG_BRCT_BRCA1_1	248	252	PF00533	0.655
LIG_eIF4E_1	132	138	PF01652	0.444
LIG_FHA_1	47	53	PF00498	0.347
LIG_FHA_1	62	68	PF00498	0.306
LIG_LIR_Apic_2	249	255	PF02991	0.697
LIG_LIR_Gen_1	189	200	PF02991	0.262
LIG_LIR_Gen_1	207	216	PF02991	0.410
LIG_LIR_Nem_3	189	195	PF02991	0.294
LIG_LIR_Nem_3	207	211	PF02991	0.410
LIG_LIR_Nem_3	214	218	PF02991	0.541
LIG_NRBOX	81	87	PF00104	0.446
LIG_Pex14_2	248	252	PF04695	0.610
LIG_PTB_Apo_2	148	155	PF02174	0.444
LIG_SH2_CRK	156	160	PF00017	0.308
LIG_SH2_CRK	213	217	PF00017	0.591
LIG_SH2_NCK_1	258	262	PF00017	0.531
LIG_SH2_STAP1	213	217	PF00017	0.591
LIG_SH2_STAT5	132	135	PF00017	0.444
LIG_SH2_STAT5	213	216	PF00017	0.535
LIG_SH3_3	227	233	PF00018	0.660
LIG_SH3_3	48	54	PF00018	0.447
LIG_SH3_3	85	91	PF00018	0.471
LIG_SUMO_SIM_par_1	196	201	PF11976	0.468
LIG_SUMO_SIM_par_1	48	53	PF11976	0.322
LIG_SUMO_SIM_par_1	84	90	PF11976	0.444
LIG_TRAF2_1	58	61	PF00917	0.276
LIG_TYR_ITIM	211	216	PF00017	0.444
LIG_WRC_WIRS_1	205	210	PF05994	0.485
MOD_CDK_SPK_2	183	188	PF00069	0.211
MOD_CK1_1	169	175	PF00069	0.354
MOD_CK1_1	186	192	PF00069	0.361
MOD_CK1_1	56	62	PF00069	0.362
MOD_CK2_1	232	238	PF00069	0.495
MOD_GlcNHglycan	118	121	PF01048	0.322
MOD_GlcNHglycan	4	7	PF01048	0.366
MOD_GlcNHglycan	77	80	PF01048	0.467
MOD_GSK3_1	179	186	PF00069	0.320
MOD_GSK3_1	2	9	PF00069	0.724
MOD_GSK3_1	200	207	PF00069	0.437
MOD_GSK3_1	246	253	PF00069	0.567
MOD_GSK3_1	46	53	PF00069	0.342
MOD_N-GLC_1	250	255	PF02516	0.466
MOD_N-GLC_2	129	131	PF02516	0.361
MOD_NEK2_1	193	198	PF00069	0.319
MOD_NEK2_1	211	216	PF00069	0.463
MOD_NEK2_1	240	245	PF00069	0.577
MOD_NEK2_2	220	225	PF00069	0.619
MOD_PIKK_1	56	62	PF00454	0.268
MOD_PK_1	16	22	PF00069	0.518
MOD_PKA_1	16	22	PF00069	0.518
MOD_PKA_1	163	169	PF00069	0.211
MOD_PKA_2	16	22	PF00069	0.671
MOD_PKA_2	163	169	PF00069	0.357
MOD_PKA_2	211	217	PF00069	0.481
MOD_PKB_1	14	22	PF00069	0.527
MOD_Plk_1	250	256	PF00069	0.529
MOD_Plk_4	193	199	PF00069	0.238
MOD_Plk_4	200	206	PF00069	0.242
MOD_Plk_4	211	217	PF00069	0.376
MOD_Plk_4	46	52	PF00069	0.291
MOD_ProDKin_1	183	189	PF00069	0.297
MOD_ProDKin_1	50	56	PF00069	0.444
MOD_SUMO_rev_2	56	65	PF00179	0.265
TRG_DiLeu_BaEn_2	79	85	PF01217	0.339
TRG_ENDOCYTIC_2	132	135	PF00928	0.405
TRG_ENDOCYTIC_2	156	159	PF00928	0.300
TRG_ENDOCYTIC_2	213	216	PF00928	0.531
TRG_ENDOCYTIC_2	218	221	PF00928	0.599
TRG_ER_diArg_1	14	17	PF00400	0.680
TRG_ER_diArg_1	162	164	PF00400	0.297
TRG_ER_diArg_1	224	227	PF00400	0.572

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0L0	Leptomonas seymouri	49%	100%
A0A1X0PBJ7	Trypanosomatidae	28%	100%
A0A3R7M6T4	Trypanosoma rangeli	27%	100%
A0A3S7X8K2	Leishmania donovani	71%	100%
A4IAK1	Leishmania infantum	74%	100%
E9B5M5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	100%
Q4Q2B1	Leishmania major	70%	100%
V5BW09	Trypanosoma cruzi	28%	100%