H/ACA ribonucleoprotein complex subunit

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

nucleolar protein family a, putative

Species:

Leishmania braziliensis

UniProt:

A4HBF1_LEIBR

TriTrypDb:

LbrM.20.3910 , LBRM2903_200053400

Length:

225

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 1
NetGPI	no	yes: 0, no: 1

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	2
GO:0032991	protein-containing complex	1	2
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2
GO:1990904	ribonucleoprotein complex	2	2

Expansion

Sequence features

A4HBF1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBF1

Function

Biological processes
Term	Name	Level	Count
GO:0001522	pseudouridine synthesis	6	2
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006364	rRNA processing	8	2
GO:0006396	RNA processing	6	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009451	RNA modification	5	2
GO:0009987	cellular process	1	2
GO:0016070	RNA metabolic process	5	2
GO:0016072	rRNA metabolic process	7	2
GO:0034470	ncRNA processing	7	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0034660	ncRNA metabolic process	6	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0046483	heterocycle metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:0090304	nucleic acid metabolic process	4	2
GO:1901360	organic cyclic compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003723	RNA binding	4	2
GO:0005488	binding	1	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	149	153	PF00082	0.767
DOC_CKS1_1	144	149	PF01111	0.508
DOC_PP4_FxxP_1	151	154	PF00568	0.775
DOC_PP4_FxxP_1	20	23	PF00568	0.803
DOC_WW_Pin1_4	121	126	PF00397	0.508
DOC_WW_Pin1_4	143	148	PF00397	0.508
LIG_14-3-3_CanoR_1	149	154	PF00244	0.770
LIG_BIR_II_1	1	5	PF00653	0.813
LIG_FHA_1	112	118	PF00498	0.508
LIG_LIR_Nem_3	142	148	PF02991	0.508
LIG_SH2_STAT5	139	142	PF00017	0.508
LIG_SH2_STAT5	97	100	PF00017	0.508
LIG_SH3_3	151	157	PF00018	0.779
LIG_WRC_WIRS_1	68	73	PF05994	0.508
MOD_CDK_SPxK_1	143	149	PF00069	0.508
MOD_CK2_1	128	134	PF00069	0.508
MOD_CK2_1	70	76	PF00069	0.508
MOD_GlcNHglycan	33	36	PF01048	0.795
MOD_GlcNHglycan	72	75	PF01048	0.508
MOD_GSK3_1	117	124	PF00069	0.508
MOD_GSK3_1	139	146	PF00069	0.508
MOD_N-GLC_1	112	117	PF02516	0.508
MOD_NEK2_2	81	86	PF00069	0.508
MOD_PKA_2	197	203	PF00069	0.803
MOD_PKA_2	31	37	PF00069	0.795
MOD_Plk_4	67	73	PF00069	0.508
MOD_ProDKin_1	121	127	PF00069	0.508
MOD_ProDKin_1	143	149	PF00069	0.508
TRG_DiLeu_BaEn_3	66	72	PF01217	0.508
TRG_ER_diArg_1	157	160	PF00400	0.796

Homologs


Protein	Taxonomy	Sequence identity	Coverage
Q8VZT0	Arabidopsis thaliana	42%	100%