EOG090X00E0

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

EOG090X00E0

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HBE8_LEIBR

TriTrypDb:

LbrM.20.3880 , LBRM2903_200053100

Length:

591

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HBE8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBE8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	242	246	PF00656	0.598
CLV_NRD_NRD_1	101	103	PF00675	0.593
CLV_NRD_NRD_1	170	172	PF00675	0.531
CLV_NRD_NRD_1	216	218	PF00675	0.653
CLV_PCSK_KEX2_1	101	103	PF00082	0.593
CLV_PCSK_KEX2_1	147	149	PF00082	0.436
CLV_PCSK_KEX2_1	170	172	PF00082	0.531
CLV_PCSK_KEX2_1	216	218	PF00082	0.573
CLV_PCSK_KEX2_1	4	6	PF00082	0.636
CLV_PCSK_KEX2_1	61	63	PF00082	0.747
CLV_PCSK_PC1ET2_1	147	149	PF00082	0.436
CLV_PCSK_PC1ET2_1	4	6	PF00082	0.636
CLV_PCSK_PC1ET2_1	61	63	PF00082	0.761
CLV_PCSK_SKI1_1	141	145	PF00082	0.502
CLV_PCSK_SKI1_1	276	280	PF00082	0.380
CLV_PCSK_SKI1_1	367	371	PF00082	0.382
CLV_PCSK_SKI1_1	543	547	PF00082	0.508
DEG_APCC_DBOX_1	123	131	PF00400	0.517
DEG_APCC_DBOX_1	275	283	PF00400	0.475
DEG_APCC_DBOX_1	442	450	PF00400	0.303
DEG_SCF_FBW7_1	403	409	PF00400	0.457
DEG_SPOP_SBC_1	571	575	PF00917	0.595
DOC_CDC14_PxL_1	346	354	PF14671	0.521
DOC_CKS1_1	237	242	PF01111	0.705
DOC_CKS1_1	403	408	PF01111	0.606
DOC_CYCLIN_RxL_1	273	280	PF00134	0.423
DOC_CYCLIN_yCln2_LP_2	297	303	PF00134	0.537
DOC_MAPK_gen_1	170	176	PF00069	0.528
DOC_MAPK_gen_1	4	12	PF00069	0.732
DOC_MAPK_MEF2A_6	276	283	PF00069	0.408
DOC_MAPK_NFAT4_5	276	284	PF00069	0.261
DOC_MAPK_RevD_3	132	148	PF00069	0.294
DOC_PP2B_LxvP_1	20	23	PF13499	0.627
DOC_PP2B_LxvP_1	297	300	PF13499	0.528
DOC_PP2B_LxvP_1	491	494	PF13499	0.409
DOC_SPAK_OSR1_1	196	200	PF12202	0.276
DOC_USP7_MATH_1	274	278	PF00917	0.402
DOC_USP7_UBL2_3	422	426	PF12436	0.491
DOC_USP7_UBL2_3	539	543	PF12436	0.356
DOC_WW_Pin1_4	23	28	PF00397	0.746
DOC_WW_Pin1_4	233	238	PF00397	0.573
DOC_WW_Pin1_4	402	407	PF00397	0.546
DOC_WW_Pin1_4	43	48	PF00397	0.773
DOC_WW_Pin1_4	53	58	PF00397	0.694
DOC_WW_Pin1_4	575	580	PF00397	0.528
DOC_WW_Pin1_4	73	78	PF00397	0.736
DOC_WW_Pin1_4	81	86	PF00397	0.429
LIG_14-3-3_CanoR_1	124	128	PF00244	0.523
LIG_14-3-3_CanoR_1	216	220	PF00244	0.682
LIG_14-3-3_CanoR_1	268	274	PF00244	0.397
LIG_14-3-3_CanoR_1	276	282	PF00244	0.315
LIG_14-3-3_CanoR_1	41	47	PF00244	0.725
LIG_14-3-3_CanoR_1	458	466	PF00244	0.539
LIG_14-3-3_CanoR_1	5	13	PF00244	0.538
LIG_14-3-3_CanoR_1	62	72	PF00244	0.743
LIG_Actin_WH2_2	48	66	PF00022	0.519
LIG_BIR_II_1	1	5	PF00653	0.704
LIG_FHA_1	19	25	PF00498	0.644
LIG_FHA_1	242	248	PF00498	0.427
LIG_FHA_1	333	339	PF00498	0.503
LIG_FHA_1	356	362	PF00498	0.533
LIG_FHA_1	371	377	PF00498	0.388
LIG_FHA_1	460	466	PF00498	0.572
LIG_FHA_1	488	494	PF00498	0.557
LIG_FHA_2	164	170	PF00498	0.578
LIG_FHA_2	237	243	PF00498	0.649
LIG_FHA_2	331	337	PF00498	0.405
LIG_FHA_2	403	409	PF00498	0.526
LIG_FHA_2	539	545	PF00498	0.501
LIG_FHA_2	85	91	PF00498	0.716
LIG_GBD_Chelix_1	12	20	PF00786	0.680
LIG_GBD_Chelix_1	172	180	PF00786	0.530
LIG_GBD_Chelix_1	194	202	PF00786	0.518
LIG_GBD_Chelix_1	520	528	PF00786	0.390
LIG_LIR_Apic_2	73	77	PF02991	0.535
LIG_LIR_Gen_1	387	397	PF02991	0.399
LIG_LIR_Gen_1	468	478	PF02991	0.425
LIG_LIR_Gen_1	526	534	PF02991	0.413
LIG_LIR_Nem_3	287	291	PF02991	0.505
LIG_LIR_Nem_3	387	392	PF02991	0.400
LIG_LIR_Nem_3	468	474	PF02991	0.412
LIG_LIR_Nem_3	526	530	PF02991	0.396
LIG_NRBOX	274	280	PF00104	0.359
LIG_NRBOX	311	317	PF00104	0.538
LIG_PCNA_APIM_2	194	200	PF02747	0.390
LIG_PCNA_PIPBox_1	191	200	PF02747	0.529
LIG_PCNA_yPIPBox_3	191	200	PF02747	0.509
LIG_SH2_CRK	471	475	PF00017	0.348
LIG_SH2_CRK	74	78	PF00017	0.535
LIG_SH2_STAP1	471	475	PF00017	0.348
LIG_SH2_STAT5	178	181	PF00017	0.429
LIG_SH3_1	234	240	PF00018	0.535
LIG_SH3_3	21	27	PF00018	0.762
LIG_SH3_3	234	240	PF00018	0.666
LIG_SH3_3	358	364	PF00018	0.557
LIG_SH3_3	51	57	PF00018	0.664
LIG_SH3_3	79	85	PF00018	0.724
LIG_SUMO_SIM_anti_2	277	283	PF11976	0.509
LIG_SUMO_SIM_anti_2	51	56	PF11976	0.513
LIG_SUMO_SIM_anti_2	8	14	PF11976	0.750
LIG_SUMO_SIM_anti_2	95	101	PF11976	0.626
LIG_SUMO_SIM_par_1	327	333	PF11976	0.421
LIG_SUMO_SIM_par_1	444	451	PF11976	0.492
LIG_SUMO_SIM_par_1	48	53	PF11976	0.526
LIG_TRAF2_1	334	337	PF00917	0.568
LIG_TRAF2_1	483	486	PF00917	0.620
LIG_WRC_WIRS_1	394	399	PF05994	0.302
MOD_CDK_SPK_2	81	86	PF00069	0.707
MOD_CK1_1	123	129	PF00069	0.450
MOD_CK1_1	235	241	PF00069	0.643
MOD_CK1_1	269	275	PF00069	0.374
MOD_CK1_1	277	283	PF00069	0.323
MOD_CK1_1	442	448	PF00069	0.517
MOD_CK1_1	479	485	PF00069	0.467
MOD_CK1_1	533	539	PF00069	0.538
MOD_CK1_1	66	72	PF00069	0.671
MOD_CK1_1	73	79	PF00069	0.648
MOD_CK1_1	81	87	PF00069	0.429
MOD_CK2_1	123	129	PF00069	0.510
MOD_CK2_1	163	169	PF00069	0.598
MOD_CK2_1	330	336	PF00069	0.391
MOD_CK2_1	402	408	PF00069	0.565
MOD_CK2_1	428	434	PF00069	0.362
MOD_CK2_1	479	485	PF00069	0.467
MOD_CK2_1	538	544	PF00069	0.464
MOD_CK2_1	566	572	PF00069	0.729
MOD_CK2_1	575	581	PF00069	0.749
MOD_GlcNHglycan	467	470	PF01048	0.424
MOD_GlcNHglycan	481	484	PF01048	0.520
MOD_GlcNHglycan	532	535	PF01048	0.500
MOD_GlcNHglycan	568	571	PF01048	0.565
MOD_GSK3_1	119	126	PF00069	0.448
MOD_GSK3_1	232	239	PF00069	0.654
MOD_GSK3_1	255	262	PF00069	0.535
MOD_GSK3_1	33	40	PF00069	0.733
MOD_GSK3_1	355	362	PF00069	0.387
MOD_GSK3_1	380	387	PF00069	0.464
MOD_GSK3_1	402	409	PF00069	0.457
MOD_GSK3_1	435	442	PF00069	0.487
MOD_GSK3_1	481	488	PF00069	0.443
MOD_GSK3_1	504	511	PF00069	0.545
MOD_GSK3_1	529	536	PF00069	0.480
MOD_GSK3_1	566	573	PF00069	0.793
MOD_GSK3_1	62	69	PF00069	0.684
MOD_GSK3_1	76	83	PF00069	0.606
MOD_GSK3_1	84	91	PF00069	0.678
MOD_N-GLC_1	370	375	PF02516	0.374
MOD_N-GLC_1	459	464	PF02516	0.347
MOD_NEK2_1	137	142	PF00069	0.453
MOD_NEK2_1	176	181	PF00069	0.531
MOD_NEK2_1	198	203	PF00069	0.489
MOD_NEK2_1	284	289	PF00069	0.503
MOD_NEK2_1	380	385	PF00069	0.437
MOD_NEK2_1	428	433	PF00069	0.585
MOD_NEK2_1	435	440	PF00069	0.418
MOD_NEK2_1	453	458	PF00069	0.493
MOD_NEK2_1	465	470	PF00069	0.410
MOD_NEK2_1	503	508	PF00069	0.533
MOD_NEK2_1	529	534	PF00069	0.430
MOD_NEK2_2	220	225	PF00069	0.671
MOD_NEK2_2	487	492	PF00069	0.635
MOD_PIKK_1	318	324	PF00454	0.448
MOD_PIKK_1	337	343	PF00454	0.233
MOD_PKA_2	123	129	PF00069	0.547
MOD_PKA_2	215	221	PF00069	0.608
MOD_PKA_2	442	448	PF00069	0.377
MOD_PKA_2	565	571	PF00069	0.781
MOD_PKA_2	63	69	PF00069	0.660
MOD_Plk_1	150	156	PF00069	0.354
MOD_Plk_1	504	510	PF00069	0.637
MOD_Plk_4	151	157	PF00069	0.515
MOD_Plk_4	160	166	PF00069	0.550
MOD_Plk_4	176	182	PF00069	0.519
MOD_Plk_4	277	283	PF00069	0.459
MOD_Plk_4	435	441	PF00069	0.431
MOD_Plk_4	442	448	PF00069	0.506
MOD_Plk_4	476	482	PF00069	0.445
MOD_ProDKin_1	23	29	PF00069	0.748
MOD_ProDKin_1	233	239	PF00069	0.575
MOD_ProDKin_1	402	408	PF00069	0.540
MOD_ProDKin_1	43	49	PF00069	0.772
MOD_ProDKin_1	53	59	PF00069	0.693
MOD_ProDKin_1	575	581	PF00069	0.524
MOD_ProDKin_1	73	79	PF00069	0.733
MOD_ProDKin_1	81	87	PF00069	0.429
MOD_SUMO_for_1	421	424	PF00179	0.368
MOD_SUMO_rev_2	31	39	PF00179	0.568
MOD_SUMO_rev_2	540	548	PF00179	0.590
TRG_DiLeu_BaEn_1	151	156	PF01217	0.298
TRG_DiLeu_BaEn_1	544	549	PF01217	0.521
TRG_DiLeu_BaEn_1	581	586	PF01217	0.614
TRG_DiLeu_BaEn_2	128	134	PF01217	0.345
TRG_DiLeu_BaEn_2	407	413	PF01217	0.370
TRG_DiLeu_BaLyEn_6	297	302	PF01217	0.542
TRG_DiLeu_BaLyEn_6	347	352	PF01217	0.351
TRG_ENDOCYTIC_2	178	181	PF00928	0.352
TRG_ENDOCYTIC_2	470	473	PF00928	0.355
TRG_ER_diArg_1	100	102	PF00400	0.608
TRG_ER_diArg_1	170	172	PF00400	0.531
TRG_ER_FFAT_2	68	79	PF00635	0.531
TRG_Pf-PMV_PEXEL_1	86	90	PF00026	0.490

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P709	Leptomonas seymouri	38%	99%
A0A1X0PAI7	Trypanosomatidae	31%	100%
A0A3R7M5G0	Trypanosoma rangeli	30%	100%
A0A3S7X8L9	Leishmania donovani	72%	100%
A4IAJ6	Leishmania infantum	72%	100%
C9ZLP4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9B5M0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%
Q4Q2B6	Leishmania major	71%	100%
V5BRD9	Trypanosoma cruzi	31%	100%