BRCT domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

FHA domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HBE7_LEIBR

TriTrypDb:

LbrM.20.3870 , LBRM2903_200053000

Length:

410

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HBE7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBE7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	248	252	PF00656	0.490
CLV_NRD_NRD_1	131	133	PF00675	0.708
CLV_NRD_NRD_1	195	197	PF00675	0.749
CLV_NRD_NRD_1	341	343	PF00675	0.388
CLV_PCSK_KEX2_1	195	197	PF00082	0.761
CLV_PCSK_KEX2_1	209	211	PF00082	0.544
CLV_PCSK_KEX2_1	260	262	PF00082	0.330
CLV_PCSK_PC1ET2_1	209	211	PF00082	0.625
CLV_PCSK_PC1ET2_1	260	262	PF00082	0.330
CLV_PCSK_SKI1_1	122	126	PF00082	0.538
CLV_PCSK_SKI1_1	263	267	PF00082	0.271
CLV_PCSK_SKI1_1	97	101	PF00082	0.327
CLV_Separin_Metazoa	377	381	PF03568	0.288
DEG_Nend_UBRbox_3	1	3	PF02207	0.402
DEG_SPOP_SBC_1	217	221	PF00917	0.597
DOC_CKS1_1	114	119	PF01111	0.749
DOC_CKS1_1	127	132	PF01111	0.462
DOC_CKS1_1	281	286	PF01111	0.492
DOC_CYCLIN_yClb5_NLxxxL_5	34	43	PF00134	0.400
DOC_CYCLIN_yCln2_LP_2	39	45	PF00134	0.400
DOC_MAPK_gen_1	132	139	PF00069	0.689
DOC_MAPK_gen_1	239	247	PF00069	0.352
DOC_MAPK_gen_1	287	295	PF00069	0.428
DOC_MAPK_MEF2A_6	239	247	PF00069	0.416
DOC_MAPK_MEF2A_6	287	295	PF00069	0.503
DOC_MAPK_MEF2A_6	297	304	PF00069	0.556
DOC_MAPK_MEF2A_6	77	84	PF00069	0.300
DOC_PP1_RVXF_1	348	355	PF00149	0.354
DOC_PP1_RVXF_1	95	101	PF00149	0.360
DOC_PP1_SILK_1	399	404	PF00149	0.440
DOC_USP7_MATH_1	162	166	PF00917	0.771
DOC_USP7_MATH_1	217	221	PF00917	0.707
DOC_USP7_MATH_1	300	304	PF00917	0.502
DOC_USP7_MATH_2	30	36	PF00917	0.360
DOC_WW_Pin1_4	113	118	PF00397	0.651
DOC_WW_Pin1_4	123	128	PF00397	0.557
DOC_WW_Pin1_4	148	153	PF00397	0.698
DOC_WW_Pin1_4	218	223	PF00397	0.574
DOC_WW_Pin1_4	224	229	PF00397	0.563
DOC_WW_Pin1_4	280	285	PF00397	0.446
DOC_WW_Pin1_4	38	43	PF00397	0.308
DOC_WW_Pin1_4	90	95	PF00397	0.379
LIG_14-3-3_CanoR_1	122	127	PF00244	0.758
LIG_14-3-3_CanoR_1	132	140	PF00244	0.678
LIG_14-3-3_CanoR_1	26	30	PF00244	0.344
LIG_14-3-3_CanoR_1	350	355	PF00244	0.342
LIG_Actin_WH2_2	209	227	PF00022	0.506
LIG_BIR_III_2	344	348	PF00653	0.437
LIG_FHA_1	132	138	PF00498	0.700
LIG_FHA_1	148	154	PF00498	0.453
LIG_FHA_1	281	287	PF00498	0.473
LIG_FHA_1	361	367	PF00498	0.473
LIG_FHA_1	388	394	PF00498	0.372
LIG_FHA_2	246	252	PF00498	0.502
LIG_FHA_2	310	316	PF00498	0.346
LIG_LIR_Gen_1	104	115	PF02991	0.558
LIG_LIR_Gen_1	35	44	PF02991	0.308
LIG_LIR_Gen_1	395	406	PF02991	0.334
LIG_LIR_Gen_1	4	10	PF02991	0.460
LIG_LIR_Gen_1	72	80	PF02991	0.298
LIG_LIR_Nem_3	104	110	PF02991	0.502
LIG_LIR_Nem_3	35	39	PF02991	0.308
LIG_LIR_Nem_3	395	401	PF02991	0.343
LIG_LIR_Nem_3	4	9	PF02991	0.409
LIG_LIR_Nem_3	72	76	PF02991	0.308
LIG_PTAP_UEV_1	200	205	PF05743	0.648
LIG_Rb_pABgroove_1	392	400	PF01858	0.449
LIG_SH2_CRK	398	402	PF00017	0.374
LIG_SH2_CRK	6	10	PF00017	0.440
LIG_SH2_NCK_1	331	335	PF00017	0.379
LIG_SH2_NCK_1	6	10	PF00017	0.399
LIG_SH2_STAP1	331	335	PF00017	0.350
LIG_SH2_STAP1	398	402	PF00017	0.309
LIG_SH2_STAP1	6	10	PF00017	0.440
LIG_SH2_STAT3	15	18	PF00017	0.487
LIG_SH2_STAT5	169	172	PF00017	0.629
LIG_SH2_STAT5	306	309	PF00017	0.504
LIG_SH2_STAT5	331	334	PF00017	0.416
LIG_SH3_1	198	204	PF00018	0.675
LIG_SH3_2	127	132	PF14604	0.510
LIG_SH3_2	204	209	PF14604	0.667
LIG_SH3_3	111	117	PF00018	0.739
LIG_SH3_3	124	130	PF00018	0.529
LIG_SH3_3	150	156	PF00018	0.541
LIG_SH3_3	198	204	PF00018	0.686
LIG_SH3_3	278	284	PF00018	0.451
LIG_SUMO_SIM_par_1	277	283	PF11976	0.439
LIG_SUMO_SIM_par_1	300	305	PF11976	0.502
LIG_SUMO_SIM_par_1	320	327	PF11976	0.253
LIG_TRFH_1	90	94	PF08558	0.308
LIG_TYR_ITSM	2	9	PF00017	0.453
LIG_WRC_WIRS_1	370	375	PF05994	0.252
MOD_CDK_SPK_2	218	223	PF00069	0.730
MOD_CDK_SPK_2	285	290	PF00069	0.447
MOD_CDK_SPxK_1	126	132	PF00069	0.534
MOD_CDK_SPxK_1	148	154	PF00069	0.658
MOD_CDK_SPxxK_3	113	120	PF00069	0.511
MOD_CDK_SPxxK_3	126	133	PF00069	0.463
MOD_CDK_SPxxK_3	218	225	PF00069	0.736
MOD_CDK_SPxxK_3	280	287	PF00069	0.439
MOD_CDK_SPxxK_3	90	97	PF00069	0.400
MOD_CK1_1	126	132	PF00069	0.615
MOD_CK1_1	229	235	PF00069	0.539
MOD_CK1_1	360	366	PF00069	0.500
MOD_CK2_1	208	214	PF00069	0.606
MOD_CK2_1	371	377	PF00069	0.434
MOD_GlcNHglycan	110	113	PF01048	0.438
MOD_GlcNHglycan	145	148	PF01048	0.677
MOD_GlcNHglycan	171	175	PF01048	0.760
MOD_GlcNHglycan	228	231	PF01048	0.601
MOD_GlcNHglycan	373	376	PF01048	0.531
MOD_GSK3_1	122	129	PF00069	0.557
MOD_GSK3_1	141	148	PF00069	0.677
MOD_GSK3_1	170	177	PF00069	0.622
MOD_GSK3_1	183	190	PF00069	0.601
MOD_GSK3_1	208	215	PF00069	0.652
MOD_GSK3_1	226	233	PF00069	0.564
MOD_GSK3_1	245	252	PF00069	0.381
MOD_GSK3_1	323	330	PF00069	0.418
MOD_GSK3_1	358	365	PF00069	0.498
MOD_GSK3_1	61	68	PF00069	0.288
MOD_N-GLC_1	1	6	PF02516	0.346
MOD_N-GLC_1	66	71	PF02516	0.287
MOD_NEK2_1	1	6	PF00069	0.503
MOD_NEK2_1	143	148	PF00069	0.690
MOD_NEK2_1	170	175	PF00069	0.629
MOD_NEK2_1	208	213	PF00069	0.714
MOD_NEK2_1	397	402	PF00069	0.424
MOD_NEK2_2	174	179	PF00069	0.499
MOD_PK_1	212	218	PF00069	0.502
MOD_PK_1	362	368	PF00069	0.429
MOD_PKA_2	131	137	PF00069	0.700
MOD_PKA_2	25	31	PF00069	0.400
MOD_PKB_1	120	128	PF00069	0.531
MOD_Plk_1	1	7	PF00069	0.330
MOD_Plk_1	103	109	PF00069	0.365
MOD_Plk_4	32	38	PF00069	0.308
MOD_Plk_4	397	403	PF00069	0.372
MOD_Plk_4	69	75	PF00069	0.284
MOD_ProDKin_1	113	119	PF00069	0.655
MOD_ProDKin_1	123	129	PF00069	0.556
MOD_ProDKin_1	148	154	PF00069	0.702
MOD_ProDKin_1	218	224	PF00069	0.574
MOD_ProDKin_1	280	286	PF00069	0.446
MOD_ProDKin_1	38	44	PF00069	0.308
MOD_ProDKin_1	90	96	PF00069	0.379
MOD_SUMO_for_1	324	327	PF00179	0.295
TRG_DiLeu_BaEn_2	31	37	PF01217	0.400
TRG_DiLeu_BaLyEn_6	344	349	PF01217	0.467
TRG_ENDOCYTIC_2	398	401	PF00928	0.351
TRG_ENDOCYTIC_2	6	9	PF00928	0.353
TRG_ENDOCYTIC_2	89	92	PF00928	0.430
TRG_ER_diArg_1	120	123	PF00400	0.535
TRG_ER_diArg_1	194	196	PF00400	0.797
TRG_NLS_Bipartite_1	195	213	PF00514	0.644
TRG_NLS_MonoExtC_3	208	214	PF00514	0.615
TRG_NLS_MonoExtN_4	207	213	PF00514	0.615

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILS6	Leptomonas seymouri	59%	96%
A0A3R7KTI0	Trypanosoma rangeli	37%	100%
A0A3S7X8R1	Leishmania donovani	80%	100%
A4IAJ5	Leishmania infantum	80%	100%
C9ZLP5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	95%
E9B5L9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4Q2B7	Leishmania major	80%	100%
V5BW13	Trypanosoma cruzi	37%	100%