DNA polymerase delta subunit 3

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HBE4_LEIBR

TriTrypDb:

LbrM.20.3840 , LBRM2903_200052700

Length:

498

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HBE4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBE4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	281	285	PF00656	0.560
CLV_NRD_NRD_1	261	263	PF00675	0.639
CLV_NRD_NRD_1	66	68	PF00675	0.676
CLV_PCSK_KEX2_1	223	225	PF00082	0.664
CLV_PCSK_KEX2_1	261	263	PF00082	0.639
CLV_PCSK_KEX2_1	474	476	PF00082	0.529
CLV_PCSK_PC1ET2_1	223	225	PF00082	0.653
CLV_PCSK_PC1ET2_1	261	263	PF00082	0.554
CLV_PCSK_PC1ET2_1	474	476	PF00082	0.529
CLV_PCSK_SKI1_1	12	16	PF00082	0.475
CLV_PCSK_SKI1_1	242	246	PF00082	0.594
CLV_PCSK_SKI1_1	487	491	PF00082	0.536
DEG_APCC_DBOX_1	11	19	PF00400	0.326
DEG_Nend_UBRbox_2	1	3	PF02207	0.443
DEG_SIAH_1	131	139	PF03145	0.490
DEG_SPOP_SBC_1	90	94	PF00917	0.468
DOC_CKS1_1	186	191	PF01111	0.548
DOC_CKS1_1	348	353	PF01111	0.656
DOC_CYCLIN_RxL_1	484	491	PF00134	0.432
DOC_CYCLIN_yCln2_LP_2	129	135	PF00134	0.493
DOC_CYCLIN_yCln2_LP_2	141	147	PF00134	0.472
DOC_PP2B_LxvP_1	141	144	PF13499	0.494
DOC_PP2B_LxvP_1	174	177	PF13499	0.641
DOC_PP2B_LxvP_1	203	206	PF13499	0.494
DOC_PP4_FxxP_1	492	495	PF00568	0.436
DOC_USP7_MATH_1	103	107	PF00917	0.545
DOC_USP7_MATH_1	111	115	PF00917	0.444
DOC_USP7_MATH_1	123	127	PF00917	0.439
DOC_USP7_MATH_1	156	160	PF00917	0.610
DOC_USP7_MATH_1	178	182	PF00917	0.536
DOC_USP7_MATH_1	257	261	PF00917	0.557
DOC_USP7_MATH_1	440	444	PF00917	0.605
DOC_USP7_MATH_1	57	61	PF00917	0.591
DOC_USP7_UBL2_3	242	246	PF12436	0.695
DOC_USP7_UBL2_3	306	310	PF12436	0.495
DOC_WW_Pin1_4	134	139	PF00397	0.512
DOC_WW_Pin1_4	167	172	PF00397	0.649
DOC_WW_Pin1_4	185	190	PF00397	0.827
DOC_WW_Pin1_4	204	209	PF00397	0.668
DOC_WW_Pin1_4	310	315	PF00397	0.471
DOC_WW_Pin1_4	344	349	PF00397	0.632
DOC_WW_Pin1_4	441	446	PF00397	0.629
DOC_WW_Pin1_4	453	458	PF00397	0.564
DOC_WW_Pin1_4	481	486	PF00397	0.760
LIG_14-3-3_CanoR_1	12	18	PF00244	0.479
LIG_14-3-3_CanoR_1	121	130	PF00244	0.629
LIG_BRCT_BRCA1_1	278	282	PF00533	0.655
LIG_BRCT_BRCA1_1	312	316	PF00533	0.467
LIG_EVH1_1	345	349	PF00568	0.548
LIG_EVH1_2	335	339	PF00568	0.515
LIG_FHA_1	220	226	PF00498	0.634
LIG_FHA_1	248	254	PF00498	0.552
LIG_FHA_1	377	383	PF00498	0.397
LIG_FHA_1	414	420	PF00498	0.476
LIG_FHA_1	427	433	PF00498	0.485
LIG_FHA_1	60	66	PF00498	0.581
LIG_FHA_2	114	120	PF00498	0.470
LIG_FHA_2	14	20	PF00498	0.464
LIG_FHA_2	147	153	PF00498	0.645
LIG_FHA_2	209	215	PF00498	0.552
LIG_FHA_2	243	249	PF00498	0.714
LIG_FHA_2	442	448	PF00498	0.630
LIG_FHA_2	450	456	PF00498	0.728
LIG_LIR_Apic_2	332	336	PF02991	0.424
LIG_LIR_Apic_2	491	495	PF02991	0.433
LIG_LIR_Gen_1	211	221	PF02991	0.598
LIG_LIR_Gen_1	313	323	PF02991	0.457
LIG_LIR_Gen_1	76	85	PF02991	0.595
LIG_LIR_Nem_3	313	319	PF02991	0.465
LIG_LIR_Nem_3	43	49	PF02991	0.464
LIG_LIR_Nem_3	76	82	PF02991	0.594
LIG_LYPXL_yS_3	110	113	PF13949	0.599
LIG_PCNA_PIPBox_1	370	379	PF02747	0.537
LIG_PDZ_Class_1	493	498	PF00595	0.502
LIG_PTB_Apo_2	397	404	PF02174	0.417
LIG_REV1ctd_RIR_1	490	494	PF16727	0.546
LIG_SH2_CRK	333	337	PF00017	0.429
LIG_SH2_CRK	46	50	PF00017	0.427
LIG_SH2_CRK	79	83	PF00017	0.601
LIG_SH2_SRC	333	336	PF00017	0.426
LIG_SH2_STAT5	294	297	PF00017	0.721
LIG_SH2_STAT5	388	391	PF00017	0.444
LIG_SH3_1	454	460	PF00018	0.518
LIG_SH3_3	136	142	PF00018	0.585
LIG_SH3_3	155	161	PF00018	0.553
LIG_SH3_3	316	322	PF00018	0.641
LIG_SH3_3	338	344	PF00018	0.625
LIG_SH3_3	345	351	PF00018	0.652
LIG_SH3_3	454	460	PF00018	0.698
LIG_SH3_4	233	240	PF00018	0.676
LIG_Sin3_3	78	85	PF02671	0.444
LIG_SUMO_SIM_par_1	13	19	PF11976	0.396
LIG_TRAF2_1	52	55	PF00917	0.529
LIG_UBA3_1	212	217	PF00899	0.577
LIG_WRC_WIRS_1	373	378	PF05994	0.545
LIG_WRC_WIRS_1	489	494	PF05994	0.549
MOD_CDC14_SPxK_1	484	487	PF00782	0.455
MOD_CDK_SPxK_1	349	355	PF00069	0.675
MOD_CDK_SPxK_1	481	487	PF00069	0.548
MOD_CDK_SPxxK_3	349	356	PF00069	0.676
MOD_CDK_SPxxK_3	441	448	PF00069	0.753
MOD_CK1_1	268	274	PF00069	0.670
MOD_CK1_1	275	281	PF00069	0.552
MOD_CK1_1	298	304	PF00069	0.652
MOD_CK1_1	347	353	PF00069	0.769
MOD_CK1_1	449	455	PF00069	0.639
MOD_CK2_1	113	119	PF00069	0.538
MOD_CK2_1	13	19	PF00069	0.540
MOD_CK2_1	146	152	PF00069	0.646
MOD_CK2_1	242	248	PF00069	0.718
MOD_CK2_1	293	299	PF00069	0.598
MOD_CK2_1	321	327	PF00069	0.575
MOD_CK2_1	412	418	PF00069	0.510
MOD_CK2_1	441	447	PF00069	0.511
MOD_CK2_1	449	455	PF00069	0.633
MOD_CK2_1	49	55	PF00069	0.532
MOD_DYRK1A_RPxSP_1	204	208	PF00069	0.562
MOD_GlcNHglycan	101	104	PF01048	0.678
MOD_GlcNHglycan	157	161	PF01048	0.637
MOD_GlcNHglycan	190	193	PF01048	0.609
MOD_GlcNHglycan	267	270	PF01048	0.662
MOD_GlcNHglycan	274	277	PF01048	0.512
MOD_GlcNHglycan	358	361	PF01048	0.655
MOD_GlcNHglycan	438	441	PF01048	0.640
MOD_GlcNHglycan	57	60	PF01048	0.589
MOD_GlcNHglycan	74	79	PF01048	0.707
MOD_GSK3_1	113	120	PF00069	0.419
MOD_GSK3_1	163	170	PF00069	0.548
MOD_GSK3_1	184	191	PF00069	0.715
MOD_GSK3_1	204	211	PF00069	0.593
MOD_GSK3_1	244	251	PF00069	0.594
MOD_GSK3_1	268	275	PF00069	0.649
MOD_GSK3_1	289	296	PF00069	0.643
MOD_GSK3_1	298	305	PF00069	0.545
MOD_GSK3_1	34	41	PF00069	0.462
MOD_GSK3_1	372	379	PF00069	0.388
MOD_GSK3_1	432	439	PF00069	0.567
MOD_GSK3_1	446	453	PF00069	0.768
MOD_GSK3_1	481	488	PF00069	0.503
MOD_GSK3_1	55	62	PF00069	0.477
MOD_GSK3_1	80	87	PF00069	0.566
MOD_GSK3_1	99	106	PF00069	0.558
MOD_N-GLC_1	248	253	PF02516	0.548
MOD_N-GLC_1	88	93	PF02516	0.625
MOD_NEK2_1	24	29	PF00069	0.460
MOD_NEK2_1	376	381	PF00069	0.454
MOD_NEK2_1	384	389	PF00069	0.344
MOD_NEK2_1	432	437	PF00069	0.627
MOD_NEK2_1	8	13	PF00069	0.424
MOD_NEK2_1	84	89	PF00069	0.570
MOD_NEK2_2	103	108	PF00069	0.488
MOD_NEK2_2	208	213	PF00069	0.555
MOD_PIKK_1	123	129	PF00454	0.491
MOD_PIKK_1	24	30	PF00454	0.322
MOD_PIKK_1	366	372	PF00454	0.472
MOD_PKA_1	242	248	PF00069	0.514
MOD_PKA_1	355	361	PF00069	0.587
MOD_PKA_2	257	263	PF00069	0.619
MOD_Plk_1	248	254	PF00069	0.547
MOD_Plk_1	289	295	PF00069	0.512
MOD_Plk_1	446	452	PF00069	0.773
MOD_Plk_1	74	80	PF00069	0.640
MOD_Plk_2-3	418	424	PF00069	0.394
MOD_Plk_4	13	19	PF00069	0.331
MOD_Plk_4	208	214	PF00069	0.577
MOD_Plk_4	249	255	PF00069	0.496
MOD_Plk_4	278	284	PF00069	0.542
MOD_Plk_4	290	296	PF00069	0.512
MOD_Plk_4	372	378	PF00069	0.506
MOD_Plk_4	384	390	PF00069	0.357
MOD_Plk_4	485	491	PF00069	0.499
MOD_ProDKin_1	134	140	PF00069	0.511
MOD_ProDKin_1	167	173	PF00069	0.650
MOD_ProDKin_1	185	191	PF00069	0.829
MOD_ProDKin_1	204	210	PF00069	0.670
MOD_ProDKin_1	310	316	PF00069	0.472
MOD_ProDKin_1	344	350	PF00069	0.635
MOD_ProDKin_1	441	447	PF00069	0.633
MOD_ProDKin_1	453	459	PF00069	0.567
MOD_ProDKin_1	481	487	PF00069	0.754
MOD_SUMO_for_1	154	157	PF00179	0.520
MOD_SUMO_for_1	197	200	PF00179	0.720
MOD_SUMO_for_1	396	399	PF00179	0.429
MOD_SUMO_rev_2	391	398	PF00179	0.485
TRG_DiLeu_BaEn_2	398	404	PF01217	0.496
TRG_DiLeu_BaLyEn_6	10	15	PF01217	0.494
TRG_ENDOCYTIC_2	110	113	PF00928	0.539
TRG_ENDOCYTIC_2	46	49	PF00928	0.412
TRG_ENDOCYTIC_2	79	82	PF00928	0.584
TRG_ER_diArg_1	224	227	PF00400	0.553
TRG_NLS_MonoCore_2	260	265	PF00514	0.492
TRG_NLS_MonoExtC_3	473	479	PF00514	0.528
TRG_NLS_MonoExtN_4	258	265	PF00514	0.530

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYZ0	Leptomonas seymouri	42%	97%
A0A1X0PAH9	Trypanosomatidae	28%	95%
A0A3S7X8I7	Leishmania donovani	64%	100%
A4IAJ2	Leishmania infantum	64%	100%
E9B5L6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	62%	100%
Q4Q2C0	Leishmania major	62%	97%