SWIM-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF1193), putative

Species:

Leishmania braziliensis

UniProt:

A4HBE1_LEIBR

TriTrypDb:

LbrM.20.3810 , LBRM2903_200052400

Length:

552

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

A4HBE1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBE1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016740	transferase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	245	247	PF00675	0.497
CLV_NRD_NRD_1	318	320	PF00675	0.449
CLV_NRD_NRD_1	34	36	PF00675	0.652
CLV_NRD_NRD_1	355	357	PF00675	0.486
CLV_NRD_NRD_1	462	464	PF00675	0.390
CLV_NRD_NRD_1	503	505	PF00675	0.504
CLV_PCSK_FUR_1	460	464	PF00082	0.424
CLV_PCSK_KEX2_1	370	372	PF00082	0.522
CLV_PCSK_KEX2_1	462	464	PF00082	0.399
CLV_PCSK_PC1ET2_1	370	372	PF00082	0.522
CLV_PCSK_SKI1_1	144	148	PF00082	0.642
CLV_PCSK_SKI1_1	212	216	PF00082	0.434
CLV_PCSK_SKI1_1	225	229	PF00082	0.308
CLV_PCSK_SKI1_1	246	250	PF00082	0.377
CLV_PCSK_SKI1_1	263	267	PF00082	0.201
CLV_PCSK_SKI1_1	383	387	PF00082	0.375
DEG_APCC_DBOX_1	370	378	PF00400	0.518
DEG_SCF_FBW7_1	109	115	PF00400	0.527
DEG_SPOP_SBC_1	112	116	PF00917	0.521
DEG_SPOP_SBC_1	67	71	PF00917	0.742
DOC_CKS1_1	109	114	PF01111	0.684
DOC_CYCLIN_RxL_1	129	138	PF00134	0.285
DOC_CYCLIN_yCln2_LP_2	344	350	PF00134	0.413
DOC_MAPK_gen_1	266	276	PF00069	0.232
DOC_MAPK_gen_1	504	510	PF00069	0.453
DOC_MAPK_MEF2A_6	269	278	PF00069	0.422
DOC_MAPK_MEF2A_6	8	16	PF00069	0.529
DOC_PP1_RVXF_1	261	268	PF00149	0.418
DOC_PP2B_LxvP_1	344	347	PF13499	0.407
DOC_PP4_FxxP_1	45	48	PF00568	0.689
DOC_PP4_FxxP_1	530	533	PF00568	0.411
DOC_SPAK_OSR1_1	299	303	PF12202	0.505
DOC_USP7_MATH_1	113	117	PF00917	0.632
DOC_USP7_MATH_1	123	127	PF00917	0.413
DOC_USP7_MATH_1	171	175	PF00917	0.498
DOC_USP7_MATH_1	216	220	PF00917	0.433
DOC_USP7_MATH_1	24	28	PF00917	0.751
DOC_USP7_MATH_1	7	11	PF00917	0.731
DOC_USP7_UBL2_3	424	428	PF12436	0.459
DOC_WW_Pin1_4	108	113	PF00397	0.692
DOC_WW_Pin1_4	115	120	PF00397	0.653
DOC_WW_Pin1_4	287	292	PF00397	0.417
DOC_WW_Pin1_4	39	44	PF00397	0.732
DOC_WW_Pin1_4	8	13	PF00397	0.658
LIG_14-3-3_CanoR_1	189	194	PF00244	0.550
LIG_14-3-3_CanoR_1	269	275	PF00244	0.370
LIG_14-3-3_CanoR_1	319	326	PF00244	0.491
LIG_14-3-3_CanoR_1	460	469	PF00244	0.413
LIG_14-3-3_CanoR_1	521	530	PF00244	0.516
LIG_14-3-3_CanoR_1	78	82	PF00244	0.763
LIG_14-3-3_CanoR_1	8	12	PF00244	0.775
LIG_Actin_WH2_2	271	286	PF00022	0.397
LIG_BRCT_BRCA1_1	289	293	PF00533	0.405
LIG_BRCT_BRCA1_1	41	45	PF00533	0.472
LIG_deltaCOP1_diTrp_1	255	261	PF00928	0.474
LIG_EH1_1	234	242	PF00400	0.249
LIG_eIF4E_1	131	137	PF01652	0.286
LIG_FHA_1	1	7	PF00498	0.755
LIG_FHA_1	316	322	PF00498	0.492
LIG_FHA_1	326	332	PF00498	0.284
LIG_FHA_1	9	15	PF00498	0.787
LIG_FHA_1	92	98	PF00498	0.655
LIG_FHA_2	523	529	PF00498	0.489
LIG_FHA_2	544	550	PF00498	0.625
LIG_LIR_Apic_2	42	48	PF02991	0.585
LIG_LIR_Apic_2	528	533	PF02991	0.427
LIG_LIR_Gen_1	154	162	PF02991	0.514
LIG_LIR_Gen_1	272	283	PF02991	0.371
LIG_LIR_Gen_1	294	304	PF02991	0.447
LIG_LIR_Gen_1	341	350	PF02991	0.426
LIG_LIR_Gen_1	384	390	PF02991	0.410
LIG_LIR_Gen_1	464	472	PF02991	0.393
LIG_LIR_Gen_1	534	541	PF02991	0.550
LIG_LIR_Nem_3	154	160	PF02991	0.502
LIG_LIR_Nem_3	254	259	PF02991	0.382
LIG_LIR_Nem_3	272	278	PF02991	0.221
LIG_LIR_Nem_3	281	285	PF02991	0.283
LIG_LIR_Nem_3	294	300	PF02991	0.418
LIG_LIR_Nem_3	31	37	PF02991	0.665
LIG_LIR_Nem_3	341	346	PF02991	0.374
LIG_LIR_Nem_3	384	389	PF02991	0.395
LIG_LIR_Nem_3	443	448	PF02991	0.419
LIG_LIR_Nem_3	464	469	PF02991	0.390
LIG_LIR_Nem_3	534	538	PF02991	0.511
LIG_MYND_1	119	123	PF01753	0.636
LIG_MYND_1	58	62	PF01753	0.743
LIG_Pex14_1	257	261	PF04695	0.474
LIG_Pex14_1	296	300	PF04695	0.399
LIG_Pex14_2	293	297	PF04695	0.419
LIG_Pex14_2	445	449	PF04695	0.457
LIG_PTB_Apo_2	305	312	PF02174	0.489
LIG_PTB_Apo_2	444	451	PF02174	0.519
LIG_SH2_CRK	131	135	PF00017	0.513
LIG_SH2_CRK	289	293	PF00017	0.435
LIG_SH2_CRK	535	539	PF00017	0.557
LIG_SH2_GRB2like	306	309	PF00017	0.494
LIG_SH2_NCK_1	250	254	PF00017	0.471
LIG_SH2_SRC	359	362	PF00017	0.494
LIG_SH2_SRC	431	434	PF00017	0.422
LIG_SH2_SRC	515	518	PF00017	0.463
LIG_SH2_STAP1	172	176	PF00017	0.505
LIG_SH2_STAP1	233	237	PF00017	0.473
LIG_SH2_STAP1	317	321	PF00017	0.557
LIG_SH2_STAP1	348	352	PF00017	0.378
LIG_SH2_STAT5	176	179	PF00017	0.545
LIG_SH2_STAT5	204	207	PF00017	0.406
LIG_SH2_STAT5	282	285	PF00017	0.436
LIG_SH2_STAT5	306	309	PF00017	0.431
LIG_SH2_STAT5	317	320	PF00017	0.459
LIG_SH2_STAT5	359	362	PF00017	0.380
LIG_SH2_STAT5	431	434	PF00017	0.409
LIG_SH2_STAT5	5	8	PF00017	0.760
LIG_SH2_STAT5	515	518	PF00017	0.477
LIG_SH2_STAT5	524	527	PF00017	0.505
LIG_SH3_1	147	153	PF00018	0.567
LIG_SH3_1	38	44	PF00018	0.480
LIG_SH3_2	150	155	PF14604	0.599
LIG_SH3_2	73	78	PF14604	0.744
LIG_SH3_3	147	153	PF00018	0.503
LIG_SH3_3	174	180	PF00018	0.489
LIG_SH3_3	20	26	PF00018	0.731
LIG_SH3_3	273	279	PF00018	0.359
LIG_SH3_3	38	44	PF00018	0.722
LIG_SH3_3	45	51	PF00018	0.771
LIG_SH3_3	55	61	PF00018	0.751
LIG_SH3_3	70	76	PF00018	0.718
LIG_SH3_3	9	15	PF00018	0.749
LIG_TYR_ITIM	280	285	PF00017	0.416
LIG_TYR_ITIM	287	292	PF00017	0.435
LIG_WRC_WIRS_1	340	345	PF05994	0.413
LIG_WW_2	23	26	PF00397	0.519
LIG_WW_3	75	79	PF00397	0.750
MOD_CK1_1	315	321	PF00069	0.470
MOD_CK1_1	322	328	PF00069	0.450
MOD_CK1_1	409	415	PF00069	0.479
MOD_CK1_1	437	443	PF00069	0.448
MOD_CK1_1	498	504	PF00069	0.491
MOD_CK1_1	71	77	PF00069	0.704
MOD_CK2_1	132	138	PF00069	0.347
MOD_CK2_1	437	443	PF00069	0.447
MOD_CK2_1	461	467	PF00069	0.443
MOD_CK2_1	522	528	PF00069	0.469
MOD_GlcNHglycan	101	104	PF01048	0.713
MOD_GlcNHglycan	115	118	PF01048	0.697
MOD_GlcNHglycan	408	411	PF01048	0.526
MOD_GlcNHglycan	70	73	PF01048	0.674
MOD_GSK3_1	104	111	PF00069	0.672
MOD_GSK3_1	113	120	PF00069	0.672
MOD_GSK3_1	287	294	PF00069	0.355
MOD_GSK3_1	315	322	PF00069	0.479
MOD_GSK3_1	390	397	PF00069	0.528
MOD_GSK3_1	433	440	PF00069	0.412
MOD_GSK3_1	67	74	PF00069	0.688
MOD_GSK3_1	77	84	PF00069	0.665
MOD_N-GLC_1	189	194	PF02516	0.556
MOD_N-GLC_1	304	309	PF02516	0.465
MOD_N-GLC_1	8	13	PF02516	0.791
MOD_NEK2_1	229	234	PF00069	0.488
MOD_NEK2_1	366	371	PF00069	0.525
MOD_NEK2_1	381	386	PF00069	0.366
MOD_NEK2_1	461	466	PF00069	0.412
MOD_PIKK_1	241	247	PF00454	0.399
MOD_PIKK_1	291	297	PF00454	0.376
MOD_PKA_1	319	325	PF00069	0.269
MOD_PKA_1	462	468	PF00069	0.421
MOD_PKA_2	394	400	PF00069	0.596
MOD_PKA_2	461	467	PF00069	0.330
MOD_PKA_2	7	13	PF00069	0.743
MOD_PKA_2	77	83	PF00069	0.697
MOD_PKB_1	460	468	PF00069	0.401
MOD_Plk_1	123	129	PF00069	0.529
MOD_Plk_1	189	195	PF00069	0.504
MOD_Plk_1	322	328	PF00069	0.410
MOD_Plk_1	350	356	PF00069	0.497
MOD_Plk_1	381	387	PF00069	0.426
MOD_Plk_1	486	492	PF00069	0.521
MOD_Plk_1	543	549	PF00069	0.588
MOD_Plk_2-3	528	534	PF00069	0.482
MOD_Plk_2-3	543	549	PF00069	0.580
MOD_Plk_4	132	138	PF00069	0.445
MOD_Plk_4	236	242	PF00069	0.368
MOD_Plk_4	270	276	PF00069	0.422
MOD_Plk_4	312	318	PF00069	0.418
MOD_Plk_4	339	345	PF00069	0.373
MOD_Plk_4	350	356	PF00069	0.373
MOD_Plk_4	434	440	PF00069	0.402
MOD_Plk_4	498	504	PF00069	0.439
MOD_Plk_4	77	83	PF00069	0.657
MOD_ProDKin_1	108	114	PF00069	0.691
MOD_ProDKin_1	115	121	PF00069	0.641
MOD_ProDKin_1	287	293	PF00069	0.414
MOD_ProDKin_1	39	45	PF00069	0.731
MOD_ProDKin_1	8	14	PF00069	0.659
MOD_SUMO_rev_2	138	146	PF00179	0.504
TRG_DiLeu_BaEn_4	542	548	PF01217	0.585
TRG_DiLeu_BaLyEn_6	478	483	PF01217	0.512
TRG_ENDOCYTIC_2	131	134	PF00928	0.526
TRG_ENDOCYTIC_2	250	253	PF00928	0.429
TRG_ENDOCYTIC_2	282	285	PF00928	0.379
TRG_ENDOCYTIC_2	289	292	PF00928	0.387
TRG_ENDOCYTIC_2	429	432	PF00928	0.380
TRG_ENDOCYTIC_2	535	538	PF00928	0.467
TRG_ER_diArg_1	371	374	PF00400	0.505
TRG_ER_diArg_1	455	458	PF00400	0.409
TRG_ER_diArg_1	461	463	PF00400	0.370
TRG_ER_diArg_1	519	522	PF00400	0.521
TRG_NES_CRM1_1	125	138	PF08389	0.546
TRG_NES_CRM1_1	379	394	PF08389	0.407
TRG_NLS_Bipartite_1	356	374	PF00514	0.523
TRG_Pf-PMV_PEXEL_1	247	251	PF00026	0.255
TRG_Pf-PMV_PEXEL_1	35	39	PF00026	0.439
TRG_Pf-PMV_PEXEL_1	383	387	PF00026	0.270

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5V7	Leptomonas seymouri	68%	95%
A0A0S4IP10	Bodo saltans	26%	100%
A0A0S4J2A0	Bodo saltans	28%	67%
A0A0S4KMJ1	Bodo saltans	48%	100%
A0A1X0NU11	Trypanosomatidae	26%	100%
A0A1X0PB74	Trypanosomatidae	57%	100%
A0A3S5IRZ3	Trypanosoma rangeli	52%	100%
A0A3S7X8K5	Leishmania donovani	82%	95%
A4IAI9	Leishmania infantum	82%	95%
C9ZLP9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
C9ZS63	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	85%
E9B5L3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	95%
Q4Q2C3	Leishmania major	82%	100%
V5BQ23	Trypanosoma cruzi	24%	100%
V5BRE4	Trypanosoma cruzi	56%	100%