Zinc knuckle-domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Zinc knuckle, putative

Species:

Leishmania braziliensis

UniProt:

A4HBE0_LEIBR

TriTrypDb:

LbrM.20.3800 , LBRM2903_200052300

Length:

149

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 8
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HBE0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBE0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0005488	binding	1	1
GO:0008270	zinc ion binding	6	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1
GO:0046914	transition metal ion binding	5	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	22	24	PF00082	0.472
CLV_PCSK_PC1ET2_1	22	24	PF00082	0.472
CLV_PCSK_SKI1_1	107	111	PF00082	0.623
CLV_PCSK_SKI1_1	81	85	PF00082	0.620
CLV_PCSK_SKI1_1	92	96	PF00082	0.535
DEG_Nend_Nbox_1	1	3	PF02207	0.594
DEG_SPOP_SBC_1	42	46	PF00917	0.358
DOC_CYCLIN_RxL_1	78	87	PF00134	0.441
DOC_PP1_RVXF_1	68	75	PF00149	0.687
DOC_PP4_FxxP_1	35	38	PF00568	0.441
DOC_USP7_MATH_1	134	138	PF00917	0.721
DOC_USP7_MATH_1	47	51	PF00917	0.463
DOC_USP7_UBL2_3	5	9	PF12436	0.637
DOC_WW_Pin1_4	130	135	PF00397	0.607
LIG_BRCT_BRCA1_1	70	74	PF00533	0.722
LIG_deltaCOP1_diTrp_1	31	35	PF00928	0.372
LIG_FHA_1	52	58	PF00498	0.336
LIG_FHA_1	94	100	PF00498	0.616
LIG_FHA_2	77	83	PF00498	0.571
LIG_LIR_Apic_2	34	38	PF02991	0.402
LIG_SH2_CRK	11	15	PF00017	0.570
LIG_SH2_STAP1	16	20	PF00017	0.354
LIG_SH3_3	72	78	PF00018	0.573
MOD_CK1_1	43	49	PF00069	0.388
MOD_CK2_1	25	31	PF00069	0.363
MOD_CK2_1	76	82	PF00069	0.555
MOD_GlcNHglycan	112	115	PF01048	0.687
MOD_GlcNHglycan	125	128	PF01048	0.701
MOD_GlcNHglycan	45	48	PF01048	0.418
MOD_GlcNHglycan	49	52	PF01048	0.425
MOD_GSK3_1	123	130	PF00069	0.702
MOD_GSK3_1	43	50	PF00069	0.359
MOD_GSK3_1	51	58	PF00069	0.258
MOD_N-GLC_1	18	23	PF02516	0.472
MOD_NEK2_1	57	62	PF00069	0.239
MOD_NEK2_2	51	56	PF00069	0.472
MOD_PIKK_1	57	63	PF00454	0.329
MOD_PK_1	68	74	PF00069	0.485
MOD_PK_1	9	15	PF00069	0.626
MOD_Plk_2-3	31	37	PF00069	0.344
MOD_ProDKin_1	130	136	PF00069	0.609
MOD_SUMO_for_1	103	106	PF00179	0.599
MOD_SUMO_for_1	140	143	PF00179	0.575
MOD_SUMO_rev_2	82	91	PF00179	0.567
MOD_SUMO_rev_2	98	105	PF00179	0.682
TRG_DiLeu_BaLyEn_6	120	125	PF01217	0.537
TRG_Pf-PMV_PEXEL_1	81	85	PF00026	0.644

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P713	Leptomonas seymouri	61%	97%
A0A0S4KLW4	Bodo saltans	35%	100%
A0A1X0PAA9	Trypanosomatidae	45%	100%
A0A3Q8IHW3	Leishmania donovani	77%	100%
A0A3S5IRZ4	Trypanosoma rangeli	54%	81%
A4IAI8	Leishmania infantum	78%	100%
C9ZLQ0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
Q4Q2C4	Leishmania major	76%	100%