Telo_bind domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HBD8_LEIBR

TriTrypDb:

LbrM.20.3780 , LBRM2903_200052100

Length:

649

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HBD8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBD8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	229	233	PF00656	0.426
CLV_NRD_NRD_1	291	293	PF00675	0.318
CLV_NRD_NRD_1	404	406	PF00675	0.495
CLV_PCSK_KEX2_1	291	293	PF00082	0.318
CLV_PCSK_KEX2_1	343	345	PF00082	0.514
CLV_PCSK_KEX2_1	615	617	PF00082	0.540
CLV_PCSK_PC1ET2_1	343	345	PF00082	0.539
CLV_PCSK_PC1ET2_1	615	617	PF00082	0.540
CLV_PCSK_SKI1_1	130	134	PF00082	0.569
CLV_PCSK_SKI1_1	219	223	PF00082	0.402
CLV_PCSK_SKI1_1	291	295	PF00082	0.451
CLV_PCSK_SKI1_1	310	314	PF00082	0.318
CLV_PCSK_SKI1_1	391	395	PF00082	0.434
CLV_PCSK_SKI1_1	508	512	PF00082	0.679
DEG_APCC_DBOX_1	309	317	PF00400	0.269
DEG_APCC_DBOX_1	404	412	PF00400	0.483
DEG_Nend_UBRbox_2	1	3	PF02207	0.502
DEG_SPOP_SBC_1	334	338	PF00917	0.330
DOC_CDC14_PxL_1	586	594	PF14671	0.378
DOC_CYCLIN_RxL_1	127	136	PF00134	0.370
DOC_CYCLIN_RxL_1	219	229	PF00134	0.485
DOC_MAPK_gen_1	346	354	PF00069	0.444
DOC_MAPK_MEF2A_6	365	374	PF00069	0.444
DOC_MAPK_MEF2A_6	466	474	PF00069	0.566
DOC_MAPK_MEF2A_6	585	593	PF00069	0.391
DOC_PP1_RVXF_1	184	190	PF00149	0.323
DOC_PP4_FxxP_1	604	607	PF00568	0.320
DOC_SPAK_OSR1_1	54	58	PF12202	0.380
DOC_USP7_MATH_1	161	165	PF00917	0.509
DOC_USP7_MATH_1	195	199	PF00917	0.659
DOC_USP7_MATH_1	333	337	PF00917	0.324
DOC_USP7_MATH_1	421	425	PF00917	0.544
DOC_USP7_MATH_1	46	50	PF00917	0.647
DOC_USP7_MATH_1	556	560	PF00917	0.443
DOC_USP7_MATH_1	618	622	PF00917	0.461
DOC_WW_Pin1_4	214	219	PF00397	0.635
DOC_WW_Pin1_4	475	480	PF00397	0.491
DOC_WW_Pin1_4	561	566	PF00397	0.489
DOC_WW_Pin1_4	632	637	PF00397	0.435
LIG_14-3-3_CanoR_1	152	158	PF00244	0.618
LIG_14-3-3_CanoR_1	346	352	PF00244	0.482
LIG_14-3-3_CanoR_1	405	415	PF00244	0.397
LIG_14-3-3_CanoR_1	527	535	PF00244	0.292
LIG_14-3-3_CanoR_1	616	626	PF00244	0.438
LIG_BIR_III_2	446	450	PF00653	0.715
LIG_BRCT_BRCA1_1	216	220	PF00533	0.554
LIG_BRCT_BRCA1_1	367	371	PF00533	0.531
LIG_BRCT_BRCA1_1	4	8	PF00533	0.405
LIG_Clathr_ClatBox_1	313	317	PF01394	0.275
LIG_deltaCOP1_diTrp_1	23	29	PF00928	0.477
LIG_deltaCOP1_diTrp_1	390	394	PF00928	0.350
LIG_EVH1_1	42	46	PF00568	0.377
LIG_FHA_1	117	123	PF00498	0.554
LIG_FHA_1	182	188	PF00498	0.463
LIG_FHA_1	31	37	PF00498	0.423
LIG_FHA_1	316	322	PF00498	0.504
LIG_FHA_1	412	418	PF00498	0.534
LIG_FHA_1	478	484	PF00498	0.447
LIG_FHA_1	532	538	PF00498	0.468
LIG_FHA_2	284	290	PF00498	0.319
LIG_FHA_2	72	78	PF00498	0.491
LIG_GBD_Chelix_1	305	313	PF00786	0.430
LIG_LIR_Apic_2	602	607	PF02991	0.342
LIG_LIR_Gen_1	368	376	PF02991	0.477
LIG_LIR_Gen_1	53	63	PF02991	0.380
LIG_LIR_Gen_1	64	72	PF02991	0.335
LIG_LIR_LC3C_4	311	315	PF02991	0.257
LIG_LIR_Nem_3	119	123	PF02991	0.405
LIG_LIR_Nem_3	368	374	PF02991	0.474
LIG_LIR_Nem_3	375	380	PF02991	0.377
LIG_LIR_Nem_3	53	59	PF02991	0.392
LIG_LIR_Nem_3	64	70	PF02991	0.320
LIG_LYPXL_yS_3	42	45	PF13949	0.558
LIG_PDZ_Class_2	644	649	PF00595	0.458
LIG_PTB_Apo_2	114	121	PF02174	0.395
LIG_SH2_CRK	467	471	PF00017	0.402
LIG_SH2_GRB2like	115	118	PF00017	0.513
LIG_SH2_PTP2	324	327	PF00017	0.437
LIG_SH2_PTP2	56	59	PF00017	0.349
LIG_SH2_STAT5	324	327	PF00017	0.515
LIG_SH2_STAT5	56	59	PF00017	0.270
LIG_SH2_STAT5	619	622	PF00017	0.559
LIG_SH3_2	461	466	PF14604	0.467
LIG_SH3_3	152	158	PF00018	0.483
LIG_SH3_3	390	396	PF00018	0.465
LIG_SH3_3	40	46	PF00018	0.548
LIG_SH3_3	455	461	PF00018	0.735
LIG_SH3_3	476	482	PF00018	0.500
LIG_SH3_3	487	493	PF00018	0.339
LIG_SH3_3	584	590	PF00018	0.402
LIG_SH3_3	65	71	PF00018	0.391
LIG_SH3_3	96	102	PF00018	0.424
LIG_SUMO_SIM_anti_2	311	318	PF11976	0.372
LIG_SUMO_SIM_par_1	311	318	PF11976	0.532
LIG_SUMO_SIM_par_1	330	338	PF11976	0.290
LIG_SUMO_SIM_par_1	470	476	PF11976	0.470
LIG_TRAF2_1	280	283	PF00917	0.469
LIG_WW_3	434	438	PF00397	0.594
MOD_CDK_SPK_2	214	219	PF00069	0.635
MOD_CK1_1	116	122	PF00069	0.510
MOD_CK1_1	136	142	PF00069	0.318
MOD_CK1_1	198	204	PF00069	0.671
MOD_CK1_1	206	212	PF00069	0.684
MOD_CK1_1	350	356	PF00069	0.482
MOD_CK1_1	409	415	PF00069	0.447
MOD_CK2_1	277	283	PF00069	0.529
MOD_CK2_1	450	456	PF00069	0.701
MOD_CK2_1	556	562	PF00069	0.456
MOD_CK2_1	57	63	PF00069	0.445
MOD_CK2_1	71	77	PF00069	0.323
MOD_GlcNHglycan	135	138	PF01048	0.540
MOD_GlcNHglycan	264	267	PF01048	0.645
MOD_GlcNHglycan	359	363	PF01048	0.622
MOD_GlcNHglycan	367	370	PF01048	0.524
MOD_GlcNHglycan	423	426	PF01048	0.647
MOD_GlcNHglycan	452	455	PF01048	0.751
MOD_GlcNHglycan	620	623	PF01048	0.638
MOD_GlcNHglycan	627	630	PF01048	0.549
MOD_GSK3_1	323	330	PF00069	0.484
MOD_GSK3_1	334	341	PF00069	0.364
MOD_GSK3_1	350	357	PF00069	0.447
MOD_GSK3_1	406	413	PF00069	0.378
MOD_GSK3_1	46	53	PF00069	0.521
MOD_GSK3_1	508	515	PF00069	0.505
MOD_GSK3_1	57	64	PF00069	0.307
MOD_GSK3_1	618	625	PF00069	0.603
MOD_GSK3_1	72	79	PF00069	0.378
MOD_LATS_1	404	410	PF00433	0.319
MOD_N-GLC_1	116	121	PF02516	0.602
MOD_N-GLC_1	203	208	PF02516	0.602
MOD_N-GLC_1	355	360	PF02516	0.539
MOD_N-GLC_1	502	507	PF02516	0.521
MOD_N-GLC_2	180	182	PF02516	0.519
MOD_NEK2_1	13	18	PF00069	0.508
MOD_NEK2_1	296	301	PF00069	0.478
MOD_NEK2_1	364	369	PF00069	0.572
MOD_NEK2_1	411	416	PF00069	0.483
MOD_NEK2_1	609	614	PF00069	0.444
MOD_NEK2_1	76	81	PF00069	0.468
MOD_PIKK_1	335	341	PF00454	0.528
MOD_PIKK_1	502	508	PF00454	0.564
MOD_PIKK_1	526	532	PF00454	0.307
MOD_PKA_2	159	165	PF00069	0.447
MOD_PKA_2	364	370	PF00069	0.647
MOD_PKA_2	404	410	PF00069	0.394
MOD_PKA_2	421	427	PF00069	0.560
MOD_PKA_2	526	532	PF00069	0.307
MOD_Plk_1	116	122	PF00069	0.502
MOD_Plk_1	277	283	PF00069	0.442
MOD_Plk_1	372	378	PF00069	0.361
MOD_Plk_1	574	580	PF00069	0.395
MOD_Plk_1	76	82	PF00069	0.513
MOD_Plk_4	136	142	PF00069	0.538
MOD_Plk_4	296	302	PF00069	0.260
MOD_Plk_4	323	329	PF00069	0.424
MOD_Plk_4	372	378	PF00069	0.399
MOD_Plk_4	556	562	PF00069	0.384
MOD_Plk_4	89	95	PF00069	0.344
MOD_ProDKin_1	214	220	PF00069	0.619
MOD_ProDKin_1	475	481	PF00069	0.493
MOD_ProDKin_1	561	567	PF00069	0.493
MOD_ProDKin_1	632	638	PF00069	0.434
MOD_SUMO_rev_2	145	150	PF00179	0.466
TRG_DiLeu_BaLyEn_6	118	123	PF01217	0.505
TRG_DiLeu_BaLyEn_6	490	495	PF01217	0.400
TRG_ENDOCYTIC_2	324	327	PF00928	0.455
TRG_ENDOCYTIC_2	42	45	PF00928	0.509
TRG_ENDOCYTIC_2	467	470	PF00928	0.415
TRG_ENDOCYTIC_2	56	59	PF00928	0.306
TRG_ER_diArg_1	247	250	PF00400	0.507
TRG_ER_diArg_1	290	292	PF00400	0.325
TRG_ER_diArg_1	344	347	PF00400	0.527
TRG_NES_CRM1_1	530	543	PF08389	0.483
TRG_Pf-PMV_PEXEL_1	121	125	PF00026	0.546
TRG_Pf-PMV_PEXEL_1	223	228	PF00026	0.446

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7E9	Leptomonas seymouri	51%	98%
A0A0S4KIT9	Bodo saltans	28%	95%
A0A1X0PA76	Trypanosomatidae	32%	100%
A0A3Q8IHL1	Leishmania donovani	76%	99%
A0A422NVA9	Trypanosoma rangeli	35%	100%
A4IAI6	Leishmania infantum	76%	99%
C9ZLQ2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9B5L0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%
Q4Q2C6	Leishmania major	76%	100%
V5DMS9	Trypanosoma cruzi	32%	100%