ER membrane protein complex subunit 1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF1620), putative

Species:

Leishmania braziliensis

UniProt:

A4HBD6_LEIBR

TriTrypDb:

LbrM.20.3760 , LBRM2903_200051900

Length:

815

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 10, no: 1
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	12
GO:0072546	EMC complex	3	12
GO:0098796	membrane protein complex	2	12
GO:0140534	endoplasmic reticulum protein-containing complex	2	12

Expansion

Sequence features

A4HBD6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBD6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	224	228	PF00656	0.385
CLV_NRD_NRD_1	253	255	PF00675	0.422
CLV_NRD_NRD_1	330	332	PF00675	0.568
CLV_NRD_NRD_1	435	437	PF00675	0.612
CLV_NRD_NRD_1	540	542	PF00675	0.503
CLV_NRD_NRD_1	684	686	PF00675	0.442
CLV_NRD_NRD_1	741	743	PF00675	0.569
CLV_NRD_NRD_1	806	808	PF00675	0.254
CLV_PCSK_KEX2_1	152	154	PF00082	0.568
CLV_PCSK_KEX2_1	330	332	PF00082	0.578
CLV_PCSK_KEX2_1	540	542	PF00082	0.503
CLV_PCSK_KEX2_1	646	648	PF00082	0.455
CLV_PCSK_PC1ET2_1	152	154	PF00082	0.568
CLV_PCSK_PC1ET2_1	646	648	PF00082	0.456
CLV_PCSK_SKI1_1	357	361	PF00082	0.471
CLV_PCSK_SKI1_1	436	440	PF00082	0.542
CLV_PCSK_SKI1_1	703	707	PF00082	0.507
CLV_PCSK_SKI1_1	737	741	PF00082	0.478
CLV_PCSK_SKI1_1	742	746	PF00082	0.452
CLV_PCSK_SKI1_1	784	788	PF00082	0.465
CLV_PCSK_SKI1_1	807	811	PF00082	0.276
CLV_Separin_Metazoa	514	518	PF03568	0.375
DEG_Nend_Nbox_1	1	3	PF02207	0.532
DEG_SPOP_SBC_1	767	771	PF00917	0.274
DOC_CYCLIN_RxL_1	683	694	PF00134	0.301
DOC_CYCLIN_RxL_1	781	789	PF00134	0.242
DOC_MAPK_DCC_7	652	661	PF00069	0.256
DOC_MAPK_gen_1	652	661	PF00069	0.256
DOC_MAPK_gen_1	717	726	PF00069	0.338
DOC_MAPK_MEF2A_6	652	661	PF00069	0.242
DOC_MAPK_RevD_3	632	647	PF00069	0.335
DOC_MIT_MIM_1	325	335	PF04212	0.204
DOC_PP1_RVXF_1	735	741	PF00149	0.278
DOC_PP2B_LxvP_1	283	286	PF13499	0.315
DOC_PP2B_LxvP_1	500	503	PF13499	0.305
DOC_PP2B_LxvP_1	724	727	PF13499	0.365
DOC_PP4_FxxP_1	667	670	PF00568	0.329
DOC_PP4_FxxP_1	782	785	PF00568	0.346
DOC_USP7_MATH_1	132	136	PF00917	0.376
DOC_USP7_MATH_1	372	376	PF00917	0.314
DOC_USP7_MATH_1	508	512	PF00917	0.348
DOC_USP7_MATH_1	624	628	PF00917	0.306
DOC_USP7_MATH_1	684	688	PF00917	0.259
DOC_USP7_MATH_1	91	95	PF00917	0.221
DOC_WW_Pin1_4	169	174	PF00397	0.288
DOC_WW_Pin1_4	620	625	PF00397	0.303
LIG_14-3-3_CanoR_1	275	279	PF00244	0.360
LIG_14-3-3_CanoR_1	436	442	PF00244	0.405
LIG_14-3-3_CanoR_1	540	544	PF00244	0.386
LIG_14-3-3_CanoR_1	685	689	PF00244	0.265
LIG_14-3-3_CanoR_1	719	727	PF00244	0.337
LIG_14-3-3_CanoR_1	742	748	PF00244	0.275
LIG_14-3-3_CanoR_1	768	775	PF00244	0.231
LIG_14-3-3_CanoR_1	80	90	PF00244	0.301
LIG_Actin_WH2_2	260	277	PF00022	0.418
LIG_BRCT_BRCA1_1	727	731	PF00533	0.335
LIG_Clathr_ClatBox_1	297	301	PF01394	0.298
LIG_EH1_1	427	435	PF00400	0.291
LIG_FHA_1	111	117	PF00498	0.338
LIG_FHA_1	183	189	PF00498	0.305
LIG_FHA_1	194	200	PF00498	0.256
LIG_FHA_1	271	277	PF00498	0.348
LIG_FHA_1	437	443	PF00498	0.291
LIG_FHA_1	449	455	PF00498	0.408
LIG_FHA_1	495	501	PF00498	0.372
LIG_FHA_1	516	522	PF00498	0.398
LIG_FHA_1	571	577	PF00498	0.350
LIG_FHA_1	675	681	PF00498	0.284
LIG_FHA_1	692	698	PF00498	0.285
LIG_FHA_1	9	15	PF00498	0.419
LIG_FHA_2	105	111	PF00498	0.359
LIG_FHA_2	222	228	PF00498	0.384
LIG_FHA_2	376	382	PF00498	0.356
LIG_FHA_2	565	571	PF00498	0.269
LIG_FHA_2	643	649	PF00498	0.335
LIG_FHA_2	747	753	PF00498	0.264
LIG_LIR_Apic_2	780	785	PF02991	0.345
LIG_LIR_Nem_3	78	82	PF02991	0.322
LIG_LYPXL_S_1	526	530	PF13949	0.556
LIG_LYPXL_yS_3	527	530	PF13949	0.356
LIG_NRBOX	701	707	PF00104	0.256
LIG_PCNA_yPIPBox_3	302	311	PF02747	0.211
LIG_Pex14_2	382	386	PF04695	0.219
LIG_PTB_Apo_2	776	783	PF02174	0.240
LIG_SH2_CRK	170	174	PF00017	0.258
LIG_SH2_CRK	369	373	PF00017	0.254
LIG_SH2_CRK	472	476	PF00017	0.281
LIG_SH2_NCK_1	170	174	PF00017	0.359
LIG_SH2_SRC	602	605	PF00017	0.278
LIG_SH2_STAT3	120	123	PF00017	0.388
LIG_SH2_STAT5	181	184	PF00017	0.354
LIG_SH2_STAT5	257	260	PF00017	0.318
LIG_SH2_STAT5	472	475	PF00017	0.307
LIG_SH2_STAT5	56	59	PF00017	0.283
LIG_SH2_STAT5	602	605	PF00017	0.313
LIG_SH2_STAT5	610	613	PF00017	0.352
LIG_SH2_STAT5	766	769	PF00017	0.252
LIG_SH2_STAT5	803	806	PF00017	0.431
LIG_Sin3_3	249	256	PF02671	0.212
LIG_SUMO_SIM_anti_2	306	314	PF11976	0.338
LIG_SUMO_SIM_anti_2	406	412	PF11976	0.245
LIG_SUMO_SIM_anti_2	567	573	PF11976	0.324
LIG_SUMO_SIM_par_1	104	110	PF11976	0.313
LIG_SUMO_SIM_par_1	317	322	PF11976	0.230
LIG_SUMO_SIM_par_1	358	363	PF11976	0.289
LIG_SUMO_SIM_par_1	429	435	PF11976	0.363
LIG_SUMO_SIM_par_1	590	595	PF11976	0.270
LIG_SUMO_SIM_par_1	657	663	PF11976	0.290
LIG_SUMO_SIM_par_1	784	789	PF11976	0.246
LIG_TRAF2_1	159	162	PF00917	0.426
LIG_TRAF2_1	557	560	PF00917	0.369
LIG_TYR_ITIM	470	475	PF00017	0.291
LIG_TYR_ITIM	598	603	PF00017	0.274
LIG_WRC_WIRS_1	638	643	PF05994	0.242
LIG_WRC_WIRS_1	726	731	PF05994	0.278
MOD_CK1_1	112	118	PF00069	0.329
MOD_CK1_1	157	163	PF00069	0.411
MOD_CK1_1	213	219	PF00069	0.312
MOD_CK1_1	281	287	PF00069	0.397
MOD_CK1_1	375	381	PF00069	0.331
MOD_CK1_1	422	428	PF00069	0.375
MOD_CK1_1	440	446	PF00069	0.298
MOD_CK1_1	651	657	PF00069	0.263
MOD_CK2_1	319	325	PF00069	0.360
MOD_CK2_1	484	490	PF00069	0.251
MOD_CK2_1	508	514	PF00069	0.321
MOD_CK2_1	528	534	PF00069	0.444
MOD_CK2_1	554	560	PF00069	0.356
MOD_CK2_1	642	648	PF00069	0.335
MOD_CK2_1	746	752	PF00069	0.235
MOD_GlcNHglycan	125	128	PF01048	0.664
MOD_GlcNHglycan	212	215	PF01048	0.471
MOD_GlcNHglycan	260	264	PF01048	0.510
MOD_GlcNHglycan	292	295	PF01048	0.497
MOD_GlcNHglycan	313	316	PF01048	0.538
MOD_GlcNHglycan	321	324	PF01048	0.490
MOD_GlcNHglycan	421	424	PF01048	0.583
MOD_GlcNHglycan	425	428	PF01048	0.568
MOD_GlcNHglycan	43	46	PF01048	0.602
MOD_GlcNHglycan	479	482	PF01048	0.541
MOD_GlcNHglycan	503	506	PF01048	0.571
MOD_GlcNHglycan	510	513	PF01048	0.570
MOD_GlcNHglycan	530	533	PF01048	0.637
MOD_GlcNHglycan	759	762	PF01048	0.446
MOD_GlcNHglycan	770	773	PF01048	0.466
MOD_GlcNHglycan	811	814	PF01048	0.262
MOD_GlcNHglycan	83	86	PF01048	0.584
MOD_GSK3_1	112	119	PF00069	0.372
MOD_GSK3_1	121	128	PF00069	0.346
MOD_GSK3_1	132	139	PF00069	0.197
MOD_GSK3_1	142	149	PF00069	0.377
MOD_GSK3_1	157	164	PF00069	0.413
MOD_GSK3_1	206	213	PF00069	0.319
MOD_GSK3_1	255	262	PF00069	0.338
MOD_GSK3_1	270	277	PF00069	0.321
MOD_GSK3_1	281	288	PF00069	0.329
MOD_GSK3_1	419	426	PF00069	0.350
MOD_GSK3_1	436	443	PF00069	0.336
MOD_GSK3_1	458	465	PF00069	0.381
MOD_GSK3_1	473	480	PF00069	0.330
MOD_GSK3_1	560	567	PF00069	0.286
MOD_GSK3_1	572	579	PF00069	0.350
MOD_GSK3_1	620	627	PF00069	0.295
MOD_GSK3_1	647	654	PF00069	0.269
MOD_GSK3_1	742	749	PF00069	0.289
MOD_N-GLC_1	289	294	PF02516	0.537
MOD_N-GLC_1	528	533	PF02516	0.547
MOD_N-GLC_1	75	80	PF02516	0.583
MOD_NEK2_1	154	159	PF00069	0.359
MOD_NEK2_1	210	215	PF00069	0.341
MOD_NEK2_1	274	279	PF00069	0.356
MOD_NEK2_1	289	294	PF00069	0.388
MOD_NEK2_1	300	305	PF00069	0.365
MOD_NEK2_1	310	315	PF00069	0.334
MOD_NEK2_1	319	324	PF00069	0.287
MOD_NEK2_1	360	365	PF00069	0.278
MOD_NEK2_1	564	569	PF00069	0.275
MOD_NEK2_1	577	582	PF00069	0.369
MOD_NEK2_1	642	647	PF00069	0.265
MOD_NEK2_1	674	679	PF00069	0.256
MOD_NEK2_1	730	735	PF00069	0.270
MOD_NEK2_1	750	755	PF00069	0.264
MOD_NEK2_1	786	791	PF00069	0.275
MOD_NEK2_2	458	463	PF00069	0.388
MOD_PIKK_1	146	152	PF00454	0.223
MOD_PIKK_1	375	381	PF00454	0.275
MOD_PIKK_1	384	390	PF00454	0.414
MOD_PIKK_1	91	97	PF00454	0.319
MOD_PKA_1	436	442	PF00069	0.372
MOD_PKA_1	742	748	PF00069	0.278
MOD_PKA_2	274	280	PF00069	0.365
MOD_PKA_2	462	468	PF00069	0.331
MOD_PKA_2	494	500	PF00069	0.401
MOD_PKA_2	539	545	PF00069	0.387
MOD_PKA_2	651	657	PF00069	0.256
MOD_PKA_2	684	690	PF00069	0.274
MOD_PKA_2	767	773	PF00069	0.264
MOD_Plk_1	116	122	PF00069	0.300
MOD_Plk_1	154	160	PF00069	0.369
MOD_Plk_1	161	167	PF00069	0.477
MOD_Plk_1	193	199	PF00069	0.436
MOD_Plk_1	281	287	PF00069	0.416
MOD_Plk_1	458	464	PF00069	0.390
MOD_Plk_1	75	81	PF00069	0.389
MOD_Plk_2-3	484	490	PF00069	0.391
MOD_Plk_4	104	110	PF00069	0.305
MOD_Plk_4	182	188	PF00069	0.319
MOD_Plk_4	437	443	PF00069	0.298
MOD_Plk_4	470	476	PF00069	0.378
MOD_Plk_4	560	566	PF00069	0.274
MOD_Plk_4	572	578	PF00069	0.281
MOD_Plk_4	637	643	PF00069	0.231
MOD_Plk_4	684	690	PF00069	0.260
MOD_Plk_4	725	731	PF00069	0.284
MOD_Plk_4	746	752	PF00069	0.350
MOD_Plk_4	795	801	PF00069	0.300
MOD_ProDKin_1	169	175	PF00069	0.288
MOD_ProDKin_1	620	626	PF00069	0.303
MOD_SUMO_rev_2	432	439	PF00179	0.381
MOD_SUMO_rev_2	586	592	PF00179	0.385
TRG_DiLeu_BaEn_1	560	565	PF01217	0.286
TRG_DiLeu_BaEn_1	701	706	PF01217	0.291
TRG_DiLeu_BaLyEn_6	782	787	PF01217	0.335
TRG_ENDOCYTIC_2	472	475	PF00928	0.375
TRG_ENDOCYTIC_2	527	530	PF00928	0.423
TRG_ENDOCYTIC_2	600	603	PF00928	0.231
TRG_ER_diArg_1	329	331	PF00400	0.370
TRG_ER_diArg_1	539	541	PF00400	0.315
TRG_Pf-PMV_PEXEL_1	533	537	PF00026	0.638

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0K5	Leptomonas seymouri	66%	93%
A0A0S4KM87	Bodo saltans	31%	95%
A0A1X0PA62	Trypanosomatidae	39%	99%
A0A3S7X8I3	Leishmania donovani	83%	100%
A0A422NVA5	Trypanosoma rangeli	42%	100%
A4IAI4	Leishmania infantum	83%	100%
C9ZLQ4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9B5K8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4Q2C8	Leishmania major	82%	100%
V5BW22	Trypanosoma cruzi	41%	100%