AB hydrolase-1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Alpha/beta hydrolase family, putative

Species:

Leishmania braziliensis

UniProt:

A4HBD5_LEIBR

TriTrypDb:

LbrM.20.3750 , LBRM2903_200051800

Length:

274

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HBD5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBD5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016787	hydrolase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	175	177	PF00675	0.462
CLV_PCSK_KEX2_1	175	177	PF00082	0.529
CLV_PCSK_SKI1_1	165	169	PF00082	0.503
CLV_PCSK_SKI1_1	185	189	PF00082	0.440
CLV_PCSK_SKI1_1	235	239	PF00082	0.456
DEG_Nend_UBRbox_2	1	3	PF02207	0.522
DOC_CYCLIN_RxL_1	180	192	PF00134	0.374
DOC_MAPK_DCC_7	250	258	PF00069	0.363
DOC_MAPK_gen_1	203	212	PF00069	0.310
DOC_MAPK_MEF2A_6	250	258	PF00069	0.363
DOC_PP2B_LxvP_1	105	108	PF13499	0.406
DOC_PP2B_LxvP_1	196	199	PF13499	0.469
DOC_PP4_FxxP_1	204	207	PF00568	0.435
DOC_USP7_MATH_1	110	114	PF00917	0.479
DOC_USP7_MATH_1	199	203	PF00917	0.521
DOC_USP7_MATH_1	61	65	PF00917	0.504
DOC_WW_Pin1_4	1	6	PF00397	0.483
DOC_WW_Pin1_4	217	222	PF00397	0.512
DOC_WW_Pin1_4	36	41	PF00397	0.394
LIG_BIR_III_4	144	148	PF00653	0.279
LIG_eIF4E_1	132	138	PF01652	0.429
LIG_EVH1_2	5	9	PF00568	0.345
LIG_FHA_1	113	119	PF00498	0.341
LIG_FHA_1	189	195	PF00498	0.516
LIG_FHA_1	39	45	PF00498	0.406
LIG_FHA_2	239	245	PF00498	0.534
LIG_LIR_Apic_2	202	207	PF02991	0.440
LIG_LIR_Gen_1	109	118	PF02991	0.366
LIG_LIR_Gen_1	21	30	PF02991	0.367
LIG_LIR_Nem_3	109	114	PF02991	0.375
LIG_LIR_Nem_3	21	25	PF02991	0.327
LIG_LIR_Nem_3	229	234	PF02991	0.466
LIG_PCNA_PIPBox_1	148	157	PF02747	0.289
LIG_PTAP_UEV_1	39	44	PF05743	0.288
LIG_SH2_STAT5	132	135	PF00017	0.384
LIG_SH2_STAT5	15	18	PF00017	0.453
LIG_SH2_STAT5	154	157	PF00017	0.469
LIG_SH2_STAT5	190	193	PF00017	0.440
LIG_SH2_STAT5	211	214	PF00017	0.450
LIG_SH2_STAT5	47	50	PF00017	0.477
LIG_SH3_1	37	43	PF00018	0.519
LIG_SH3_3	156	162	PF00018	0.388
LIG_SH3_3	37	43	PF00018	0.391
LIG_SUMO_SIM_anti_2	247	255	PF11976	0.304
LIG_SUMO_SIM_par_1	191	197	PF11976	0.276
LIG_TRAF2_1	220	223	PF00917	0.486
MOD_CDK_SPxxK_3	1	8	PF00069	0.328
MOD_CK1_1	112	118	PF00069	0.321
MOD_CK1_1	140	146	PF00069	0.437
MOD_CK1_1	18	24	PF00069	0.395
MOD_CK1_1	202	208	PF00069	0.410
MOD_CK1_1	245	251	PF00069	0.493
MOD_CK1_1	36	42	PF00069	0.420
MOD_CK2_1	217	223	PF00069	0.559
MOD_CK2_1	238	244	PF00069	0.536
MOD_GlcNHglycan	139	142	PF01048	0.288
MOD_GlcNHglycan	196	199	PF01048	0.437
MOD_GlcNHglycan	63	66	PF01048	0.444
MOD_GSK3_1	14	21	PF00069	0.381
MOD_GSK3_1	222	229	PF00069	0.332
MOD_GSK3_1	238	245	PF00069	0.488
MOD_GSK3_1	94	101	PF00069	0.381
MOD_N-GLC_1	26	31	PF02516	0.565
MOD_N-GLC_1	54	59	PF02516	0.361
MOD_NEK2_1	137	142	PF00069	0.288
MOD_NEK2_1	150	155	PF00069	0.474
MOD_NEK2_1	194	199	PF00069	0.353
MOD_NEK2_1	246	251	PF00069	0.435
MOD_NEK2_1	257	262	PF00069	0.437
MOD_NEK2_1	26	31	PF00069	0.468
MOD_NEK2_1	98	103	PF00069	0.358
MOD_PIKK_1	238	244	PF00454	0.531
MOD_PKA_2	181	187	PF00069	0.375
MOD_Plk_1	222	228	PF00069	0.364
MOD_Plk_1	26	32	PF00069	0.528
MOD_Plk_4	112	118	PF00069	0.181
MOD_Plk_4	128	134	PF00069	0.371
MOD_Plk_4	150	156	PF00069	0.493
MOD_Plk_4	205	211	PF00069	0.361
MOD_Plk_4	249	255	PF00069	0.418
MOD_Plk_4	63	69	PF00069	0.337
MOD_Plk_4	94	100	PF00069	0.409
MOD_ProDKin_1	1	7	PF00069	0.471
MOD_ProDKin_1	217	223	PF00069	0.507
MOD_ProDKin_1	36	42	PF00069	0.388
TRG_DiLeu_BaEn_1	164	169	PF01217	0.456
TRG_DiLeu_BaEn_4	222	228	PF01217	0.309
TRG_ER_diArg_1	174	176	PF00400	0.463

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7A3	Leptomonas seymouri	61%	88%
A0A0S4KLY1	Bodo saltans	29%	79%
A0A1X0PB14	Trypanosomatidae	45%	87%
A0A3Q8INV4	Leishmania donovani	82%	100%
A0A422NVB8	Trypanosoma rangeli	42%	85%
A4IAI3	Leishmania infantum	82%	100%
C9ZLQ5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	86%
E9B5K7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4Q2C9	Leishmania major	83%	100%
V5BLS2	Trypanosoma cruzi	39%	86%