Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HBD3_LEIBR

TriTrypDb:

LbrM.20.3730 , LBRM2903_200051600

Length:

308

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HBD3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBD3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	226	228	PF00675	0.420
CLV_PCSK_FUR_1	224	228	PF00082	0.524
CLV_PCSK_KEX2_1	226	228	PF00082	0.420
CLV_PCSK_KEX2_1	58	60	PF00082	0.334
CLV_PCSK_PC1ET2_1	58	60	PF00082	0.334
CLV_PCSK_SKI1_1	142	146	PF00082	0.537
CLV_PCSK_SKI1_1	210	214	PF00082	0.572
CLV_PCSK_SKI1_1	274	278	PF00082	0.479
CLV_PCSK_SKI1_1	47	51	PF00082	0.547
CLV_PCSK_SKI1_1	58	62	PF00082	0.403
CLV_Separin_Metazoa	161	165	PF03568	0.466
DOC_CYCLIN_RxL_1	47	57	PF00134	0.488
DOC_MAPK_gen_1	118	125	PF00069	0.373
DOC_MAPK_gen_1	47	56	PF00069	0.466
DOC_MAPK_gen_1	5	14	PF00069	0.592
DOC_MAPK_MEF2A_6	118	127	PF00069	0.369
DOC_PP4_FxxP_1	14	17	PF00568	0.512
DOC_WW_Pin1_4	191	196	PF00397	0.353
DOC_WW_Pin1_4	211	216	PF00397	0.464
LIG_14-3-3_CanoR_1	224	232	PF00244	0.448
LIG_14-3-3_CanoR_1	274	279	PF00244	0.397
LIG_eIF4E_1	115	121	PF01652	0.382
LIG_FHA_1	226	232	PF00498	0.486
LIG_FHA_1	280	286	PF00498	0.409
LIG_FHA_1	289	295	PF00498	0.389
LIG_FHA_2	253	259	PF00498	0.582
LIG_FHA_2	94	100	PF00498	0.456
LIG_LIR_Gen_1	77	83	PF02991	0.420
LIG_LIR_Nem_3	110	116	PF02991	0.493
LIG_LIR_Nem_3	230	235	PF02991	0.357
LIG_LIR_Nem_3	269	273	PF02991	0.353
LIG_LIR_Nem_3	284	289	PF02991	0.306
LIG_LIR_Nem_3	77	81	PF02991	0.424
LIG_Pex14_1	203	207	PF04695	0.460
LIG_Pex14_2	209	213	PF04695	0.519
LIG_PTB_Apo_2	264	271	PF02174	0.443
LIG_PTB_Phospho_1	264	270	PF10480	0.440
LIG_Rb_LxCxE_1	297	308	PF01857	0.322
LIG_SH2_GRB2like	265	268	PF00017	0.444
LIG_SH2_NCK_1	289	293	PF00017	0.354
LIG_SH2_SRC	88	91	PF00017	0.429
LIG_SH2_STAP1	241	245	PF00017	0.414
LIG_SH2_STAP1	289	293	PF00017	0.258
LIG_SH2_STAP1	67	71	PF00017	0.509
LIG_SH2_STAT3	235	238	PF00017	0.409
LIG_SH2_STAT3	67	70	PF00017	0.517
LIG_SH2_STAT5	115	118	PF00017	0.435
LIG_SH2_STAT5	235	238	PF00017	0.442
LIG_SH2_STAT5	265	268	PF00017	0.565
LIG_SH2_STAT5	289	292	PF00017	0.338
LIG_SH3_3	193	199	PF00018	0.554
LIG_SUMO_SIM_par_1	119	124	PF11976	0.490
LIG_TRAF2_1	187	190	PF00917	0.399
LIG_TRAF2_1	96	99	PF00917	0.512
LIG_WRC_WIRS_1	270	275	PF05994	0.434
MOD_CK1_1	211	217	PF00069	0.593
MOD_CK1_1	269	275	PF00069	0.491
MOD_CK2_1	184	190	PF00069	0.431
MOD_CK2_1	252	258	PF00069	0.526
MOD_CK2_1	93	99	PF00069	0.523
MOD_GlcNHglycan	135	138	PF01048	0.487
MOD_GlcNHglycan	210	213	PF01048	0.665
MOD_GlcNHglycan	242	245	PF01048	0.491
MOD_GSK3_1	184	191	PF00069	0.492
MOD_N-GLC_1	266	271	PF02516	0.430
MOD_N-GLC_1	294	299	PF02516	0.502
MOD_NEK2_1	266	271	PF00069	0.441
MOD_NEK2_1	287	292	PF00069	0.402
MOD_NEK2_1	294	299	PF00069	0.375
MOD_PIKK_1	107	113	PF00454	0.472
MOD_PIKK_1	81	87	PF00454	0.533
MOD_PK_1	119	125	PF00069	0.367
MOD_PK_1	259	265	PF00069	0.341
MOD_PKA_2	107	113	PF00069	0.564
MOD_PKA_2	225	231	PF00069	0.498
MOD_PKA_2	258	264	PF00069	0.460
MOD_Plk_1	259	265	PF00069	0.549
MOD_Plk_1	266	272	PF00069	0.516
MOD_Plk_1	294	300	PF00069	0.411
MOD_Plk_2-3	150	156	PF00069	0.478
MOD_Plk_4	172	178	PF00069	0.507
MOD_ProDKin_1	191	197	PF00069	0.360
MOD_ProDKin_1	211	217	PF00069	0.459
MOD_SUMO_rev_2	41	49	PF00179	0.345
TRG_DiLeu_BaLyEn_6	70	75	PF01217	0.336
TRG_ENDOCYTIC_2	270	273	PF00928	0.483
TRG_ENDOCYTIC_2	88	91	PF00928	0.420
TRG_ER_diArg_1	223	226	PF00400	0.538
TRG_Pf-PMV_PEXEL_1	186	190	PF00026	0.406

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILS3	Leptomonas seymouri	72%	100%
A0A0S4KKA1	Bodo saltans	37%	93%
A0A1X0PBI9	Trypanosomatidae	42%	100%
A0A3R7M5H3	Trypanosoma rangeli	45%	100%
A0A3S7X8I2	Leishmania donovani	83%	100%
A4IAI1	Leishmania infantum	83%	100%
C9ZLQ8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9B5K5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4Q2D1	Leishmania major	82%	100%
V5BRF3	Trypanosoma cruzi	45%	100%