GRIP domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

GRIP domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HBD2_LEIBR

TriTrypDb:

LbrM.20.3720 , LBRM2903_200051500

Length:

434

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HBD2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBD2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	212	216	PF00656	0.634
CLV_C14_Caspase3-7	75	79	PF00656	0.538
CLV_NRD_NRD_1	365	367	PF00675	0.503
CLV_NRD_NRD_1	372	374	PF00675	0.682
CLV_NRD_NRD_1	9	11	PF00675	0.574
CLV_PCSK_FUR_1	363	367	PF00082	0.384
CLV_PCSK_KEX2_1	112	114	PF00082	0.588
CLV_PCSK_KEX2_1	365	367	PF00082	0.407
CLV_PCSK_KEX2_1	372	374	PF00082	0.590
CLV_PCSK_PC1ET2_1	112	114	PF00082	0.583
CLV_PCSK_SKI1_1	19	23	PF00082	0.670
CLV_PCSK_SKI1_1	289	293	PF00082	0.432
CLV_PCSK_SKI1_1	29	33	PF00082	0.533
CLV_PCSK_SKI1_1	296	300	PF00082	0.470
CLV_PCSK_SKI1_1	409	413	PF00082	0.369
CLV_PCSK_SKI1_1	427	431	PF00082	0.369
CLV_PCSK_SKI1_1	95	99	PF00082	0.617
CLV_Separin_Metazoa	360	364	PF03568	0.370
DEG_APCC_DBOX_1	28	36	PF00400	0.467
DEG_APCC_DBOX_1	408	416	PF00400	0.444
DEG_Nend_UBRbox_1	1	4	PF02207	0.549
DOC_CYCLIN_RxL_1	286	294	PF00134	0.492
DOC_CYCLIN_RxL_1	406	416	PF00134	0.401
DOC_MAPK_DCC_7	29	37	PF00069	0.648
DOC_MAPK_gen_1	363	371	PF00069	0.592
DOC_MAPK_MEF2A_6	29	37	PF00069	0.648
DOC_PP2B_LxvP_1	154	157	PF13499	0.457
DOC_USP7_MATH_1	224	228	PF00917	0.533
DOC_USP7_MATH_1	240	244	PF00917	0.684
DOC_USP7_MATH_1	318	322	PF00917	0.760
DOC_USP7_MATH_1	50	54	PF00917	0.510
DOC_USP7_UBL2_3	427	431	PF12436	0.339
DOC_WW_Pin1_4	80	85	PF00397	0.690
LIG_14-3-3_CanoR_1	372	378	PF00244	0.488
LIG_14-3-3_CanoR_1	397	403	PF00244	0.364
LIG_Actin_WH2_2	337	355	PF00022	0.417
LIG_Actin_WH2_2	404	422	PF00022	0.444
LIG_Actin_WH2_2	90	107	PF00022	0.582
LIG_BRCT_BRCA1_1	350	354	PF00533	0.388
LIG_CaM_IQ_9	90	105	PF13499	0.624
LIG_FHA_1	113	119	PF00498	0.616
LIG_FHA_1	120	126	PF00498	0.566
LIG_FHA_1	7	13	PF00498	0.545
LIG_FHA_2	138	144	PF00498	0.538
LIG_FHA_2	174	180	PF00498	0.590
LIG_FHA_2	253	259	PF00498	0.574
LIG_FHA_2	318	324	PF00498	0.757
LIG_FHA_2	362	368	PF00498	0.575
LIG_FHA_2	420	426	PF00498	0.449
LIG_FHA_2	86	92	PF00498	0.656
LIG_GBD_Chelix_1	394	402	PF00786	0.485
LIG_LIR_Gen_1	257	267	PF02991	0.515
LIG_LIR_Gen_1	328	337	PF02991	0.599
LIG_LIR_Nem_3	257	263	PF02991	0.503
LIG_LIR_Nem_3	328	334	PF02991	0.613
LIG_LIR_Nem_3	351	357	PF02991	0.606
LIG_NRBOX	414	420	PF00104	0.344
LIG_SH2_GRB2like	260	263	PF00017	0.382
LIG_SH2_SRC	45	48	PF00017	0.615
LIG_SH2_STAP1	191	195	PF00017	0.522
LIG_SH2_STAP1	45	49	PF00017	0.640
LIG_SH2_STAT3	36	39	PF00017	0.681
LIG_SH2_STAT5	260	263	PF00017	0.593
LIG_SH2_STAT5	36	39	PF00017	0.647
LIG_SH2_STAT5	390	393	PF00017	0.344
LIG_SH3_3	234	240	PF00018	0.654
LIG_SUMO_SIM_par_1	4	9	PF11976	0.549
LIG_TRAF2_2	68	73	PF00917	0.655
LIG_UBA3_1	291	296	PF00899	0.503
LIG_UBA3_1	411	420	PF00899	0.444
MOD_CDC14_SPxK_1	83	86	PF00782	0.544
MOD_CDK_SPxK_1	80	86	PF00069	0.569
MOD_CK1_1	145	151	PF00069	0.506
MOD_CK1_1	252	258	PF00069	0.451
MOD_CK1_1	309	315	PF00069	0.718
MOD_CK1_1	79	85	PF00069	0.746
MOD_CK2_1	111	117	PF00069	0.418
MOD_CK2_1	128	134	PF00069	0.340
MOD_CK2_1	137	143	PF00069	0.453
MOD_CK2_1	173	179	PF00069	0.543
MOD_CK2_1	318	324	PF00069	0.609
MOD_CK2_1	361	367	PF00069	0.632
MOD_CK2_1	85	91	PF00069	0.662
MOD_GlcNHglycan	191	194	PF01048	0.347
MOD_GlcNHglycan	227	230	PF01048	0.427
MOD_GlcNHglycan	251	254	PF01048	0.513
MOD_GlcNHglycan	300	303	PF01048	0.654
MOD_GlcNHglycan	320	323	PF01048	0.663
MOD_GlcNHglycan	78	81	PF01048	0.778
MOD_GSK3_1	137	144	PF00069	0.443
MOD_GSK3_1	225	232	PF00069	0.685
MOD_GSK3_1	308	315	PF00069	0.694
MOD_GSK3_1	318	325	PF00069	0.733
MOD_GSK3_1	372	379	PF00069	0.614
MOD_GSK3_1	72	79	PF00069	0.807
MOD_N-GLC_1	145	150	PF02516	0.602
MOD_N-GLC_1	312	317	PF02516	0.675
MOD_NEK2_1	111	116	PF00069	0.456
MOD_NEK2_1	142	147	PF00069	0.402
MOD_NEK2_1	173	178	PF00069	0.573
MOD_NEK2_1	22	27	PF00069	0.574
MOD_NEK2_1	361	366	PF00069	0.509
MOD_NEK2_1	371	376	PF00069	0.560
MOD_NEK2_1	398	403	PF00069	0.414
MOD_PIKK_1	182	188	PF00454	0.599
MOD_PIKK_1	322	328	PF00454	0.725
MOD_PKA_1	112	118	PF00069	0.618
MOD_PKA_1	372	378	PF00069	0.718
MOD_PKA_2	112	118	PF00069	0.610
MOD_PKA_2	137	143	PF00069	0.510
MOD_PKA_2	182	188	PF00069	0.482
MOD_PKA_2	371	377	PF00069	0.553
MOD_PKA_2	85	91	PF00069	0.511
MOD_Plk_1	128	134	PF00069	0.638
MOD_Plk_1	145	151	PF00069	0.524
MOD_Plk_1	173	179	PF00069	0.424
MOD_Plk_1	22	28	PF00069	0.648
MOD_Plk_1	312	318	PF00069	0.658
MOD_Plk_1	348	354	PF00069	0.484
MOD_Plk_1	56	62	PF00069	0.653
MOD_Plk_4	414	420	PF00069	0.366
MOD_Plk_4	50	56	PF00069	0.507
MOD_Plk_4	85	91	PF00069	0.515
MOD_ProDKin_1	80	86	PF00069	0.684
MOD_SUMO_rev_2	160	165	PF00179	0.600
MOD_SUMO_rev_2	265	270	PF00179	0.466
MOD_SUMO_rev_2	423	429	PF00179	0.344
TRG_DiLeu_BaEn_1	17	22	PF01217	0.410
TRG_ENDOCYTIC_2	260	263	PF00928	0.494
TRG_ENDOCYTIC_2	267	270	PF00928	0.464
TRG_ER_diArg_1	175	178	PF00400	0.575
TRG_ER_diArg_1	362	365	PF00400	0.483
TRG_ER_diArg_1	371	373	PF00400	0.688
TRG_Pf-PMV_PEXEL_1	10	14	PF00026	0.560
TRG_Pf-PMV_PEXEL_1	19	23	PF00026	0.648
TRG_Pf-PMV_PEXEL_1	293	297	PF00026	0.570
TRG_Pf-PMV_PEXEL_1	345	349	PF00026	0.587

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PF68	Leptomonas seymouri	42%	92%
A0A1X0PB65	Trypanosomatidae	25%	95%
A0A3S7X8J7	Leishmania donovani	66%	100%
A4IAI0	Leishmania infantum	66%	89%
C9ZLQ9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	94%
E9B5K4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	64%	100%
Q4Q2D2	Leishmania major	64%	100%
V5BW28	Trypanosoma cruzi	27%	92%