J domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DnaJ domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HBD1_LEIBR

TriTrypDb:

LbrM.20.3710 , LBRM2903_200051400

Length:

255

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A4HBD1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBD1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	107	109	PF00675	0.455
CLV_NRD_NRD_1	218	220	PF00675	0.656
CLV_NRD_NRD_1	3	5	PF00675	0.434
CLV_NRD_NRD_1	47	49	PF00675	0.270
CLV_NRD_NRD_1	83	85	PF00675	0.402
CLV_PCSK_KEX2_1	107	109	PF00082	0.455
CLV_PCSK_KEX2_1	218	220	PF00082	0.593
CLV_PCSK_KEX2_1	3	5	PF00082	0.434
CLV_PCSK_KEX2_1	49	51	PF00082	0.339
CLV_PCSK_KEX2_1	83	85	PF00082	0.402
CLV_PCSK_PC1ET2_1	218	220	PF00082	0.584
CLV_PCSK_PC1ET2_1	49	51	PF00082	0.339
CLV_PCSK_SKI1_1	53	57	PF00082	0.394
CLV_PCSK_SKI1_1	90	94	PF00082	0.550
DEG_Nend_Nbox_1	1	3	PF02207	0.729
DOC_MAPK_gen_1	197	205	PF00069	0.449
DOC_MAPK_gen_1	48	58	PF00069	0.562
DOC_MAPK_MEF2A_6	49	58	PF00069	0.597
DOC_USP7_MATH_1	182	186	PF00917	0.405
DOC_USP7_MATH_1	228	232	PF00917	0.420
DOC_USP7_MATH_1	245	249	PF00917	0.536
DOC_USP7_MATH_1	251	255	PF00917	0.573
DOC_USP7_UBL2_3	45	49	PF12436	0.571
LIG_14-3-3_CanoR_1	120	128	PF00244	0.652
LIG_14-3-3_CanoR_1	129	134	PF00244	0.577
LIG_14-3-3_CanoR_1	163	169	PF00244	0.462
LIG_14-3-3_CanoR_1	3	7	PF00244	0.549
LIG_BRCT_BRCA1_1	65	69	PF00533	0.516
LIG_CSL_BTD_1	186	189	PF09270	0.414
LIG_deltaCOP1_diTrp_1	184	190	PF00928	0.494
LIG_FHA_1	113	119	PF00498	0.621
LIG_FHA_2	41	47	PF00498	0.661
LIG_FHA_2	69	75	PF00498	0.482
LIG_LIR_Gen_1	135	143	PF02991	0.339
LIG_LIR_Gen_1	66	75	PF02991	0.572
LIG_LIR_Nem_3	127	131	PF02991	0.581
LIG_LIR_Nem_3	135	139	PF02991	0.345
LIG_LIR_Nem_3	66	72	PF02991	0.568
LIG_Pex14_2	139	143	PF04695	0.271
LIG_PTB_Apo_2	122	129	PF02174	0.587
LIG_PTB_Phospho_1	122	128	PF10480	0.586
LIG_SH2_CRK	111	115	PF00017	0.670
LIG_SH2_STAP1	155	159	PF00017	0.413
LIG_SH2_STAP1	168	172	PF00017	0.487
LIG_SH2_STAT3	155	158	PF00017	0.329
LIG_SH2_STAT5	150	153	PF00017	0.462
LIG_SH2_STAT5	155	158	PF00017	0.376
LIG_SH3_3	218	224	PF00018	0.405
LIG_SUMO_SIM_anti_2	201	207	PF11976	0.453
LIG_WRC_WIRS_1	128	133	PF05994	0.516
LIG_WW_1	223	226	PF00397	0.463
MOD_CK1_1	164	170	PF00069	0.449
MOD_CK2_1	164	170	PF00069	0.442
MOD_CK2_1	68	74	PF00069	0.491
MOD_CMANNOS	187	190	PF00535	0.617
MOD_GlcNHglycan	18	21	PF01048	0.514
MOD_GlcNHglycan	230	233	PF01048	0.639
MOD_NEK2_1	114	119	PF00069	0.624
MOD_NEK2_1	151	156	PF00069	0.316
MOD_NEK2_1	2	7	PF00069	0.646
MOD_NEK2_1	206	211	PF00069	0.386
MOD_NEK2_1	78	83	PF00069	0.611
MOD_PIKK_1	154	160	PF00454	0.276
MOD_PKA_2	119	125	PF00069	0.622
MOD_PKA_2	164	170	PF00069	0.436
MOD_PKA_2	2	8	PF00069	0.633
MOD_Plk_4	182	188	PF00069	0.331
MOD_Plk_4	222	228	PF00069	0.376
MOD_Plk_4	29	35	PF00069	0.566
MOD_SUMO_for_1	95	98	PF00179	0.779
TRG_DiLeu_BaEn_1	74	79	PF01217	0.569
TRG_ENDOCYTIC_2	11	14	PF00928	0.670
TRG_ENDOCYTIC_2	111	114	PF00928	0.634
TRG_ENDOCYTIC_2	128	131	PF00928	0.537
TRG_ER_diArg_1	106	108	PF00400	0.663
TRG_ER_diArg_1	162	165	PF00400	0.452
TRG_ER_diArg_1	2	4	PF00400	0.660
TRG_ER_diArg_1	47	50	PF00400	0.471
TRG_NLS_MonoExtN_4	45	52	PF00514	0.598

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILG9	Leptomonas seymouri	73%	98%
A0A0S4KRJ1	Bodo saltans	44%	100%
A0A1X0PA98	Trypanosomatidae	55%	100%
A0A3S7X8J5	Leishmania donovani	84%	96%
A0A422NVC0	Trypanosoma rangeli	55%	100%
A4IAH9	Leishmania infantum	84%	96%
C9ZLR0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	100%
E9B5K3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	97%
Q4Q2D3	Leishmania major	82%	100%